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Protein

Dynein regulatory complex subunit 7

Gene

DRC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein regulatory complex subunit 7
Alternative name(s):
Coiled-coil domain-containing protein 135
Coiled-coil domain-containing protein lobo homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRC7
Synonyms:C16orf50, CCDC135
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000159625.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25289 DRC7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY82

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000159625

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381380

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DRC7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373462

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002794341 – 874Dynein regulatory complex subunit 7Add BLAST874

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY82

PeptideAtlas

More...
PeptideAtlasi
Q8IY82

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY82

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71122
71123 [Q8IY82-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY82

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159625 Expressed in 80 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC135

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IY82 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY82 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC). Interacts with TCTE1/DRC5.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MBIPQ9NS73-53EBI-10262896,EBI-10182361

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123962, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY82, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353942

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IY82

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 67Sequence analysisAdd BLAST67
Coiled coili257 – 297Sequence analysisAdd BLAST41
Coiled coili688 – 711Sequence analysisAdd BLAST24
Coiled coili781 – 807Sequence analysisAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DRC7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IERK Eukaryota
ENOG410XS7V LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007476

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107597

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY82

Identification of Orthologs from Complete Genome Data

More...
OMAi
LRYHCRD

Database of Orthologous Groups

More...
OrthoDBi
535554at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY82

TreeFam database of animal gene trees

More...
TreeFami
TF323665

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033551 DRC7/lobo
IPR038765 Papain_like_cys_pep_sf

The PANTHER Classification System

More...
PANTHERi
PTHR35249 PTHR35249, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IY82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVLREKVEE EEEAEREEAA EWAEWARMEK MMRPVEVRKE EITLKQETLR
60 70 80 90 100
DLEKKLSEIQ ITVSAELPAF TKDTIDISKL PISYKTNTPK EEHLLQVADN
110 120 130 140 150
FSRQYSHLCP DRVPLFLHPL NECEVPKFVS TTLRPTLMPY PELYNWDSCA
160 170 180 190 200
QFVSDFLTMV PLPDPLKPPS HLYSSTTVLK YQKGNCFDFS TLLCSMLIGS
210 220 230 240 250
GYDAYCVNGY GSLDLCHMDL TREVCPLTVK PKETIKKEEK VLPKKYTIKP
260 270 280 290 300
PRDLCSRFEQ EQEVKKQQEI RAQEKKRLRE EEERLMEAEK AKPDALHGLR
310 320 330 340 350
VHSWVLVLSG KREVPENFFI DPFTGHSYST QDEHFLGIES LWNHKNYWIN
360 370 380 390 400
MQDCWNCCKD LIFDLGDPVR WEYMLLGTDK SQLSLTEEDD SGINDEDDVE
410 420 430 440 450
NLGKEDEDKS FDMPHSWVEQ IEISPEAFET RCPNGKKVIQ YKRAKLEKWA
460 470 480 490 500
PYLNSNGLVS RLTTYEDLQC TNILEIKEWY QNREDMLELK HINKTTDLKT
510 520 530 540 550
DYFKPGHPQA LRVHSYKSMQ PEMDRVIEFY ETARVDGLMK REETPRTMTE
560 570 580 590 600
YYQGRPDFLS YRHASFGPRV KKLTLSSAES NPRPIVKITE RFFRNPAKPA
610 620 630 640 650
EEDVAERVFL VAEERIQLRY HCREDHITAS KREFLRRTEV DSKGNKIIMT
660 670 680 690 700
PDMCISFEVE PMEHTKKLLY QYEAMMHLKR EEKLSRHQVW ESELEVLEIL
710 720 730 740 750
KLREEEEAAH TLTISIYDTK RNEKSKEYRE AMERMMHEEH LRQVETQLDY
760 770 780 790 800
LAPFLAQLPP GEKLTCWQAV RLKDECLSDF KQRLINKANL IQARFEKETQ
810 820 830 840 850
ELQKKQQWYQ ENQVTLTPED EDLYLSYCSQ AMFRIRILEQ RLNRHKELAP
860 870
LKYLALEEKL YKDPRLGELQ KIFA
Length:874
Mass (Da):103,497
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i14838304EFD10EC5
GO
Isoform 2 (identifier: Q8IY82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-233: Missing.

Show »
Length:809
Mass (Da):96,300
Checksum:i7A13193C1538EC7A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUK0H3BUK0_HUMAN
Dynein regulatory complex subunit 7
DRC7
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRR8H3BRR8_HUMAN
Dynein regulatory complex subunit 7
DRC7
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRN2H3BRN2_HUMAN
Dynein regulatory complex subunit 7
DRC7
427Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN79H3BN79_HUMAN
Dynein regulatory complex subunit 7
DRC7
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRX1H3BRX1_HUMAN
Dynein regulatory complex subunit 7
DRC7
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQY5H3BQY5_HUMAN
Dynein regulatory complex subunit 7
DRC7
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti440Q → R in BAC04026 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06158051D → N. Corresponds to variant dbSNP:rs55645458Ensembl.1
Natural variantiVAR_050738120L → M. Corresponds to variant dbSNP:rs11649000Ensembl.1
Natural variantiVAR_030898186C → S1 PublicationCorresponds to variant dbSNP:rs7196016Ensembl.1
Natural variantiVAR_061581241V → E. Corresponds to variant dbSNP:rs58373934Ensembl.1
Natural variantiVAR_030899433P → L1 PublicationCorresponds to variant dbSNP:rs3809611Ensembl.1
Natural variantiVAR_055286521P → H1 PublicationCorresponds to variant dbSNP:rs17853687Ensembl.1
Natural variantiVAR_030900581N → K. Corresponds to variant dbSNP:rs2923144Ensembl.1
Natural variantiVAR_030901766C → R1 PublicationCorresponds to variant dbSNP:rs2923147Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023438169 – 233Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093035 mRNA Translation: BAC04026.1
AK292558 mRNA Translation: BAF85247.1
AC018552 Genomic DNA No translation available.
BC036667 mRNA Translation: AAH36667.1
AL136907 mRNA Translation: CAB66841.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10787.1 [Q8IY82-1]
CCDS73894.1 [Q8IY82-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001276091.1, NM_001289162.1 [Q8IY82-1]
NP_001276092.1, NM_001289163.1 [Q8IY82-2]
NP_115645.4, NM_032269.5 [Q8IY82-1]
XP_011521680.1, XM_011523378.1 [Q8IY82-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.513635

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336825; ENSP00000338938; ENSG00000159625 [Q8IY82-2]
ENST00000360716; ENSP00000353942; ENSG00000159625 [Q8IY82-1]
ENST00000394337; ENSP00000377869; ENSG00000159625 [Q8IY82-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84229

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84229

UCSC genome browser

More...
UCSCi
uc002emi.4 human [Q8IY82-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093035 mRNA Translation: BAC04026.1
AK292558 mRNA Translation: BAF85247.1
AC018552 Genomic DNA No translation available.
BC036667 mRNA Translation: AAH36667.1
AL136907 mRNA Translation: CAB66841.2
CCDSiCCDS10787.1 [Q8IY82-1]
CCDS73894.1 [Q8IY82-2]
RefSeqiNP_001276091.1, NM_001289162.1 [Q8IY82-1]
NP_001276092.1, NM_001289163.1 [Q8IY82-2]
NP_115645.4, NM_032269.5 [Q8IY82-1]
XP_011521680.1, XM_011523378.1 [Q8IY82-2]
UniGeneiHs.513635

3D structure databases

ProteinModelPortaliQ8IY82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123962, 2 interactors
IntActiQ8IY82, 3 interactors
STRINGi9606.ENSP00000353942

PTM databases

iPTMnetiQ8IY82
PhosphoSitePlusiQ8IY82

Polymorphism and mutation databases

BioMutaiDRC7
DMDMi317373462

Proteomic databases

PaxDbiQ8IY82
PeptideAtlasiQ8IY82
PRIDEiQ8IY82
ProteomicsDBi71122
71123 [Q8IY82-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84229
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336825; ENSP00000338938; ENSG00000159625 [Q8IY82-2]
ENST00000360716; ENSP00000353942; ENSG00000159625 [Q8IY82-1]
ENST00000394337; ENSP00000377869; ENSG00000159625 [Q8IY82-1]
GeneIDi84229
KEGGihsa:84229
UCSCiuc002emi.4 human [Q8IY82-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84229
EuPathDBiHostDB:ENSG00000159625.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DRC7
HGNCiHGNC:25289 DRC7
neXtProtiNX_Q8IY82
OpenTargetsiENSG00000159625
PharmGKBiPA162381380

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IERK Eukaryota
ENOG410XS7V LUCA
GeneTreeiENSGT00390000004913
HOGENOMiHOG000007476
HOVERGENiHBG107597
InParanoidiQ8IY82
OMAiLRYHCRD
OrthoDBi535554at2759
PhylomeDBiQ8IY82
TreeFamiTF323665

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Coiled-coil_domain-containing_protein_135

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84229

Protein Ontology

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PROi
PR:Q8IY82

Gene expression databases

BgeeiENSG00000159625 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_CCDC135
ExpressionAtlasiQ8IY82 baseline and differential
GenevisibleiQ8IY82 HS

Family and domain databases

InterProiView protein in InterPro
IPR033551 DRC7/lobo
IPR038765 Papain_like_cys_pep_sf
PANTHERiPTHR35249 PTHR35249, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRC7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY82
Secondary accession number(s): A8K943, Q8NAA0, Q9H080
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 11, 2011
Last modified: January 16, 2019
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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