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Protein

Dynein regulatory complex subunit 7

Gene

DRC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex subunit 7
Alternative name(s):
Coiled-coil domain-containing protein 135
Coiled-coil domain-containing protein lobo homolog
Gene namesi
Name:DRC7
Synonyms:C16orf50, CCDC135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000159625.14
HGNCiHGNC:25289 DRC7
neXtProtiNX_Q8IY82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159625
PharmGKBiPA162381380

Polymorphism and mutation databases

BioMutaiCCDC135
DMDMi317373462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794341 – 874Dynein regulatory complex subunit 7Add BLAST874

Proteomic databases

PaxDbiQ8IY82
PeptideAtlasiQ8IY82
PRIDEiQ8IY82
ProteomicsDBi71122
71123 [Q8IY82-2]

PTM databases

iPTMnetiQ8IY82
PhosphoSitePlusiQ8IY82

Expressioni

Gene expression databases

BgeeiENSG00000159625 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_CCDC135
ExpressionAtlasiQ8IY82 baseline and differential
GenevisibleiQ8IY82 HS

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC). Interacts with TCTE1/DRC5.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MBIPQ9NS73-53EBI-10262896,EBI-10182361

Protein-protein interaction databases

BioGridi123962, 2 interactors
IntActiQ8IY82, 3 interactors
STRINGi9606.ENSP00000353942

Structurei

3D structure databases

ProteinModelPortaliQ8IY82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 67Sequence analysisAdd BLAST67
Coiled coili257 – 297Sequence analysisAdd BLAST41
Coiled coili688 – 711Sequence analysisAdd BLAST24
Coiled coili781 – 807Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the DRC7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IERK Eukaryota
ENOG410XS7V LUCA
GeneTreeiENSGT00390000004913
HOGENOMiHOG000007476
HOVERGENiHBG107597
InParanoidiQ8IY82
OMAiKCWYKEF
OrthoDBiEOG091G0C1W
PhylomeDBiQ8IY82
TreeFamiTF323665

Family and domain databases

InterProiView protein in InterPro
IPR033551 DRC7/lobo
IPR038765 Papain_like_cys_pep_sf
PANTHERiPTHR35249 PTHR35249, 1 hit
SUPFAMiSSF54001 SSF54001, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IY82-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVLREKVEE EEEAEREEAA EWAEWARMEK MMRPVEVRKE EITLKQETLR
60 70 80 90 100
DLEKKLSEIQ ITVSAELPAF TKDTIDISKL PISYKTNTPK EEHLLQVADN
110 120 130 140 150
FSRQYSHLCP DRVPLFLHPL NECEVPKFVS TTLRPTLMPY PELYNWDSCA
160 170 180 190 200
QFVSDFLTMV PLPDPLKPPS HLYSSTTVLK YQKGNCFDFS TLLCSMLIGS
210 220 230 240 250
GYDAYCVNGY GSLDLCHMDL TREVCPLTVK PKETIKKEEK VLPKKYTIKP
260 270 280 290 300
PRDLCSRFEQ EQEVKKQQEI RAQEKKRLRE EEERLMEAEK AKPDALHGLR
310 320 330 340 350
VHSWVLVLSG KREVPENFFI DPFTGHSYST QDEHFLGIES LWNHKNYWIN
360 370 380 390 400
MQDCWNCCKD LIFDLGDPVR WEYMLLGTDK SQLSLTEEDD SGINDEDDVE
410 420 430 440 450
NLGKEDEDKS FDMPHSWVEQ IEISPEAFET RCPNGKKVIQ YKRAKLEKWA
460 470 480 490 500
PYLNSNGLVS RLTTYEDLQC TNILEIKEWY QNREDMLELK HINKTTDLKT
510 520 530 540 550
DYFKPGHPQA LRVHSYKSMQ PEMDRVIEFY ETARVDGLMK REETPRTMTE
560 570 580 590 600
YYQGRPDFLS YRHASFGPRV KKLTLSSAES NPRPIVKITE RFFRNPAKPA
610 620 630 640 650
EEDVAERVFL VAEERIQLRY HCREDHITAS KREFLRRTEV DSKGNKIIMT
660 670 680 690 700
PDMCISFEVE PMEHTKKLLY QYEAMMHLKR EEKLSRHQVW ESELEVLEIL
710 720 730 740 750
KLREEEEAAH TLTISIYDTK RNEKSKEYRE AMERMMHEEH LRQVETQLDY
760 770 780 790 800
LAPFLAQLPP GEKLTCWQAV RLKDECLSDF KQRLINKANL IQARFEKETQ
810 820 830 840 850
ELQKKQQWYQ ENQVTLTPED EDLYLSYCSQ AMFRIRILEQ RLNRHKELAP
860 870
LKYLALEEKL YKDPRLGELQ KIFA
Length:874
Mass (Da):103,497
Last modified:January 11, 2011 - v3
Checksum:i14838304EFD10EC5
GO
Isoform 2 (identifier: Q8IY82-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-233: Missing.

Show »
Length:809
Mass (Da):96,300
Checksum:i7A13193C1538EC7A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BUK0H3BUK0_HUMAN
Dynein regulatory complex subunit 7
DRC7
170Annotation score:
H3BRR8H3BRR8_HUMAN
Dynein regulatory complex subunit 7
DRC7
159Annotation score:
H3BRN2H3BRN2_HUMAN
Dynein regulatory complex subunit 7
DRC7
427Annotation score:
H3BRX1H3BRX1_HUMAN
Dynein regulatory complex subunit 7
DRC7
94Annotation score:
H3BN79H3BN79_HUMAN
Dynein regulatory complex subunit 7
DRC7
70Annotation score:
H3BQY5H3BQY5_HUMAN
Dynein regulatory complex subunit 7
DRC7
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440Q → R in BAC04026 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06158051D → N. Corresponds to variant dbSNP:rs55645458Ensembl.1
Natural variantiVAR_050738120L → M. Corresponds to variant dbSNP:rs11649000Ensembl.1
Natural variantiVAR_030898186C → S1 PublicationCorresponds to variant dbSNP:rs7196016Ensembl.1
Natural variantiVAR_061581241V → E. Corresponds to variant dbSNP:rs58373934Ensembl.1
Natural variantiVAR_030899433P → L1 PublicationCorresponds to variant dbSNP:rs3809611Ensembl.1
Natural variantiVAR_055286521P → H1 PublicationCorresponds to variant dbSNP:rs17853687Ensembl.1
Natural variantiVAR_030900581N → K. Corresponds to variant dbSNP:rs2923144Ensembl.1
Natural variantiVAR_030901766C → R1 PublicationCorresponds to variant dbSNP:rs2923147Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023438169 – 233Missing in isoform 2. 1 PublicationAdd BLAST65

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093035 mRNA Translation: BAC04026.1
AK292558 mRNA Translation: BAF85247.1
AC018552 Genomic DNA No translation available.
BC036667 mRNA Translation: AAH36667.1
AL136907 mRNA Translation: CAB66841.2
CCDSiCCDS10787.1 [Q8IY82-1]
CCDS73894.1 [Q8IY82-2]
RefSeqiNP_001276091.1, NM_001289162.1 [Q8IY82-1]
NP_001276092.1, NM_001289163.1 [Q8IY82-2]
NP_115645.4, NM_032269.5 [Q8IY82-1]
XP_011521680.1, XM_011523378.1 [Q8IY82-2]
UniGeneiHs.513635

Genome annotation databases

EnsembliENST00000336825; ENSP00000338938; ENSG00000159625 [Q8IY82-2]
ENST00000360716; ENSP00000353942; ENSG00000159625 [Q8IY82-1]
ENST00000394337; ENSP00000377869; ENSG00000159625 [Q8IY82-1]
GeneIDi84229
KEGGihsa:84229
UCSCiuc002emi.4 human [Q8IY82-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093035 mRNA Translation: BAC04026.1
AK292558 mRNA Translation: BAF85247.1
AC018552 Genomic DNA No translation available.
BC036667 mRNA Translation: AAH36667.1
AL136907 mRNA Translation: CAB66841.2
CCDSiCCDS10787.1 [Q8IY82-1]
CCDS73894.1 [Q8IY82-2]
RefSeqiNP_001276091.1, NM_001289162.1 [Q8IY82-1]
NP_001276092.1, NM_001289163.1 [Q8IY82-2]
NP_115645.4, NM_032269.5 [Q8IY82-1]
XP_011521680.1, XM_011523378.1 [Q8IY82-2]
UniGeneiHs.513635

3D structure databases

ProteinModelPortaliQ8IY82
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123962, 2 interactors
IntActiQ8IY82, 3 interactors
STRINGi9606.ENSP00000353942

PTM databases

iPTMnetiQ8IY82
PhosphoSitePlusiQ8IY82

Polymorphism and mutation databases

BioMutaiCCDC135
DMDMi317373462

Proteomic databases

PaxDbiQ8IY82
PeptideAtlasiQ8IY82
PRIDEiQ8IY82
ProteomicsDBi71122
71123 [Q8IY82-2]

Protocols and materials databases

DNASUi84229
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336825; ENSP00000338938; ENSG00000159625 [Q8IY82-2]
ENST00000360716; ENSP00000353942; ENSG00000159625 [Q8IY82-1]
ENST00000394337; ENSP00000377869; ENSG00000159625 [Q8IY82-1]
GeneIDi84229
KEGGihsa:84229
UCSCiuc002emi.4 human [Q8IY82-1]

Organism-specific databases

CTDi84229
EuPathDBiHostDB:ENSG00000159625.14
GeneCardsiDRC7
HGNCiHGNC:25289 DRC7
neXtProtiNX_Q8IY82
OpenTargetsiENSG00000159625
PharmGKBiPA162381380
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IERK Eukaryota
ENOG410XS7V LUCA
GeneTreeiENSGT00390000004913
HOGENOMiHOG000007476
HOVERGENiHBG107597
InParanoidiQ8IY82
OMAiKCWYKEF
OrthoDBiEOG091G0C1W
PhylomeDBiQ8IY82
TreeFamiTF323665

Miscellaneous databases

GeneWikiiCoiled-coil_domain-containing_protein_135
GenomeRNAii84229
PROiPR:Q8IY82

Gene expression databases

BgeeiENSG00000159625 Expressed in 80 organ(s), highest expression level in testis
CleanExiHS_CCDC135
ExpressionAtlasiQ8IY82 baseline and differential
GenevisibleiQ8IY82 HS

Family and domain databases

InterProiView protein in InterPro
IPR033551 DRC7/lobo
IPR038765 Papain_like_cys_pep_sf
PANTHERiPTHR35249 PTHR35249, 1 hit
SUPFAMiSSF54001 SSF54001, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiDRC7_HUMAN
AccessioniPrimary (citable) accession number: Q8IY82
Secondary accession number(s): A8K943, Q8NAA0, Q9H080
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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