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Entry version 156 (10 Apr 2019)
Sequence version 2 (18 May 2010)
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Protein

pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

Gene

FTSJ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.UniRule annotation1 Publication
(Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system (PubMed:30626973). RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5 (PubMed:30626973). Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine (PubMed:30626973). Recruited to HIV-1 RNA via interaction with TARBP2/TRBP (PubMed:30626973).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei58S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1
Binding sitei117S-adenosyl-L-methionineUniRule annotation1 Publication1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei157Proton acceptorUniRule annotation1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3UniRule annotation (EC:2.1.1.-UniRule annotation1 Publication)
Alternative name(s):
Protein ftsJ homolog 3UniRule annotation
Putative rRNA methyltransferase 3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FTSJ3UniRule annotation
ORF Names:SB92
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000108592.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17136 FTSJ3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY81

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi31K → A: Abolishes RNA 2'-O-methyltransferase activity; when associated with A-117 and A-157. 1 Publication1
Mutagenesisi117D → A: Abolishes RNA 2'-O-methyltransferase activity; when associated with A-31 and A-157. 1 Publication1
Mutagenesisi157K → A: Abolishes RNA 2'-O-methyltransferase activity; when associated with A-31 and A-117. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
117246

Open Targets

More...
OpenTargetsi
ENSG00000108592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28419

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FTSJ3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452883

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001555771 – 847pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3Add BLAST847

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei333PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392CitrullineBy similarity1
Modified residuei549PhosphoserineCombined sources1
Modified residuei573PhosphothreonineCombined sources1
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei584PhosphoserineCombined sources1
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei644PhosphoserineCombined sources1
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei676PhosphoserineCombined sources1
Cross-linki678Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei688PhosphoserineCombined sources1
Cross-linki710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei783CitrullineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IY81

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IY81

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IY81

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IY81

PeptideAtlas

More...
PeptideAtlasi
Q8IY81

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY81

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71121

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q8IY81

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY81

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY81

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IY81

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000108592 Expressed in 203 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IY81 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IY81 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055544
HPA062628

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NIP7.UniRule annotation1 Publication
(Microbial infection) Interacts with TARBP2/TRBP in case of infection by HIV-1; leading to recruitment to HIV-1 TAR RNA (PubMed:30626973). The complex formed with TARBP2/TRBP is independent of DICER (PubMed:30626973).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125581, 153 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY81, 43 interactors

Molecular INTeraction database

More...
MINTi
Q8IY81

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000396673

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IY81

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IY81

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili355 – 407UniRule annotationAdd BLAST53
Coiled coili739 – 777UniRule annotationAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1098 Eukaryota
COG0293 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075004

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG075246

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY81

KEGG Orthology (KO)

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KOi
K14857

Identification of Orthologs from Complete Genome Data

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OMAi
QVASKYM

Database of Orthologous Groups

More...
OrthoDBi
1362679at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY81

TreeFam database of animal gene trees

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TreeFami
TF106102

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01547 RNA_methyltr_E, 1 hit
MF_03163 RNA_methyltr_E_SPB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR012920 rRNA_MeTfrase_Spb1_C
IPR024576 rRNA_MeTfrase_Spb1_DUF3381
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
IPR028589 Spb1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11861 DUF3381, 1 hit
PF01728 FtsJ, 1 hit
PF07780 Spb1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q8IY81-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD
60 70 80 90 100
LCAAPGGWLQ VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ QDITTERCRQ
110 120 130 140 150
ALRKELKTWK VDVVLNDGAP NVGASWVHDA YSQAHLTLMA LRLACDFLAR
160 170 180 190 200
GGSFITKVFR SRDYQPLLWI FQQLFRRVQA TKPQASRHES AEIFVVCQGF
210 220 230 240 250
LAPDKVDSKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG YAEGDLTLYH
260 270 280 290 300
RTSVTDFLRA ANPVDFLSKA SEIMVDDEEL AQHPATTEDI RVCCQDIRVL
310 320 330 340 350
GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSGEED EGDEEDSTAG
360 370 380 390 400
TTKQPSKEEE EEEEEEQLNQ TLAEMKAQEV AELKRKKKKL LREQRKQRER
410 420 430 440 450
VELKMDLPGV SIADEGETGM FSLSTIRGHQ LLEEVTQGDM SAADTFLSDL
460 470 480 490 500
PRDDIYVSDV EDDGDDTSLD SDLDPEELAG VRGHQGLRDQ KRMRLTEVQD
510 520 530 540 550
DKEEEEEENP LLVPLEEKAV LQEEQANLWF SKGSFAGIED DADEALEISQ
560 570 580 590 600
AQLLFENRRK GRQQQQKQQL PQTPPSCLKT EIMSPLYQDE APKGTEASSG
610 620 630 640 650
TEAATGLEGE EKDGISDSDS STSSEEEESW EPLRGKKRSR GPKSDDDGFE
660 670 680 690 700
IVPIEDPAKH RILDPEGLAL GAVIASSKKA KRDLIDNSFN RYTFNEDEGE
710 720 730 740 750
LPEWFVQEEK QHRIRQLPVG KKEVEHYRKR WREINARPIK KVAEAKARKK
760 770 780 790 800
RRMLKRLEQT RKKAEAVVNT VDISEREKVA QLRSLYKKAG LGKEKRHVTY
810 820 830 840
VVAKKGVGRK VRRPAGVRGH FKVVDSRMKK DQRAQQRKEQ KKKHKRK
Length:847
Mass (Da):96,558
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i06B2F4D28A48026F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KS36J3KS36_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSE2J3QSE2_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS74J3KS74_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRS5J3QRS5_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR05J3QR05_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRY4J3KRY4_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKT6J3QKT6_HUMAN
pre-rRNA-processing protein FTSJ3
FTSJ3
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278E → I in AAL56015 (Ref. 1) Curated1
Sequence conflicti278E → I in BAA90924 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02328491Q → E3 PublicationsCorresponds to variant dbSNP:rs2584625Ensembl.1
Natural variantiVAR_023285424S → C4 PublicationsCorresponds to variant dbSNP:rs2727288Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF327355 mRNA Translation: AAL56015.1
AK000069 mRNA Translation: BAA90924.1 Different initiation.
AK315010 mRNA Translation: BAG37502.1
AC015651 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94273.1
CH471109 Genomic DNA Translation: EAW94274.1
CH471109 Genomic DNA Translation: EAW94275.1
BC000131 mRNA Translation: AAH00131.2
BC036710 mRNA Translation: AAH36710.1
AL834482 mRNA Translation: CAD39141.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11644.1

NCBI Reference Sequences

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RefSeqi
NP_060117.3, NM_017647.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.463785

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000427159; ENSP00000396673; ENSG00000108592

Database of genes from NCBI RefSeq genomes

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GeneIDi
117246

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:117246

UCSC genome browser

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UCSCi
uc002jca.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327355 mRNA Translation: AAL56015.1
AK000069 mRNA Translation: BAA90924.1 Different initiation.
AK315010 mRNA Translation: BAG37502.1
AC015651 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94273.1
CH471109 Genomic DNA Translation: EAW94274.1
CH471109 Genomic DNA Translation: EAW94275.1
BC000131 mRNA Translation: AAH00131.2
BC036710 mRNA Translation: AAH36710.1
AL834482 mRNA Translation: CAD39141.1
CCDSiCCDS11644.1
RefSeqiNP_060117.3, NM_017647.3
UniGeneiHs.463785

3D structure databases

ProteinModelPortaliQ8IY81
SMRiQ8IY81
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125581, 153 interactors
IntActiQ8IY81, 43 interactors
MINTiQ8IY81
STRINGi9606.ENSP00000396673

PTM databases

iPTMnetiQ8IY81
PhosphoSitePlusiQ8IY81
SwissPalmiQ8IY81

Polymorphism and mutation databases

BioMutaiFTSJ3
DMDMi296452883

2D gel databases

SWISS-2DPAGEiQ8IY81

Proteomic databases

EPDiQ8IY81
jPOSTiQ8IY81
MaxQBiQ8IY81
PaxDbiQ8IY81
PeptideAtlasiQ8IY81
PRIDEiQ8IY81
ProteomicsDBi71121

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
117246
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427159; ENSP00000396673; ENSG00000108592
GeneIDi117246
KEGGihsa:117246
UCSCiuc002jca.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
117246
DisGeNETi117246
EuPathDBiHostDB:ENSG00000108592.16

GeneCards: human genes, protein and diseases

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GeneCardsi
FTSJ3
HGNCiHGNC:17136 FTSJ3
HPAiHPA055544
HPA062628
neXtProtiNX_Q8IY81
OpenTargetsiENSG00000108592
PharmGKBiPA28419

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1098 Eukaryota
COG0293 LUCA
GeneTreeiENSGT00550000075004
HOVERGENiHBG075246
InParanoidiQ8IY81
KOiK14857
OMAiQVASKYM
OrthoDBi1362679at2759
PhylomeDBiQ8IY81
TreeFamiTF106102

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FTSJ3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FTSJ3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
117246

Protein Ontology

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PROi
PR:Q8IY81

Gene expression databases

BgeeiENSG00000108592 Expressed in 203 organ(s), highest expression level in testis
ExpressionAtlasiQ8IY81 baseline and differential
GenevisibleiQ8IY81 HS

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
MF_03163 RNA_methyltr_E_SPB1, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR012920 rRNA_MeTfrase_Spb1_C
IPR024576 rRNA_MeTfrase_Spb1_DUF3381
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
IPR028589 Spb1
PfamiView protein in Pfam
PF11861 DUF3381, 1 hit
PF01728 FtsJ, 1 hit
PF07780 Spb1_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY81
Secondary accession number(s): B2RCA5
, D3DU22, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: April 10, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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