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Entry version 141 (10 Feb 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Angiomotin-like protein 1

Gene

AMOTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IY63

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2028269, Signaling by Hippo

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiomotin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMOTL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17811, AMOTL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614657, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY63

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000166025.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
154810

Open Targets

More...
OpenTargetsi
ENSG00000166025

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24774

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IY63, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMOTL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001906701 – 956Angiomotin-like protein 1Add BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei241PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei793PhosphoserineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei902PhosphothreonineCombined sources1
Modified residuei906PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by NEDD4, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IY63

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IY63

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IY63

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IY63

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY63

PeptideAtlas

More...
PeptideAtlasi
Q8IY63

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY63

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71115 [Q8IY63-1]
71116 [Q8IY63-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY63

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY63

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166025, Expressed in quadriceps femoris and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IY63, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY63, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166025, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127559, 56 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IY63

Database of interacting proteins

More...
DIPi
DIP-50682N

Protein interaction database and analysis system

More...
IntActi
Q8IY63, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000387739

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IY63, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IY63

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili259 – 279Sequence analysisAdd BLAST21
Coiled coili438 – 639Sequence analysisAdd BLAST202
Coiled coili665 – 694Sequence analysisAdd BLAST30
Coiled coili729 – 762Sequence analysisAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi953 – 956PDZ-binding4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the angiomotin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QVI5, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000160158

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009937_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY63

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMPEYNA

Database of Orthologous Groups

More...
OrthoDBi
369983at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY63

TreeFam database of animal gene trees

More...
TreeFami
TF333368

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009114, Angiomotin
IPR024646, Angiomotin_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12240, Angiomotin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01807, ANGIOMOTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IY63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE
60 70 80 90 100
TSALTVEATS SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ
110 120 130 140 150
RLIQEQLRYG TPTENMNLLA IQHQATGSAG PAHPTNNFSS TENLTQEDPQ
160 170 180 190 200
MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ PQQNNEELPT YEEAKAQSQF
210 220 230 240 250
FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN SGQAHKDEAL
260 270 280 290 300
KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA
310 320 330 340 350
GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP
360 370 380 390 400
APQPVRTDVA VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG
410 420 430 440 450
PLHSVSLPLP LPMALGAPQP PPAASPSQQL GPDAFAIVER AQQMVEILTE
460 470 480 490 500
ENRVLHQELQ GYYDNADKLH KFEKELQRIS EAYESLVKST TKRESLDKAM
510 520 530 540 550
RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK AAEGHYASQN
560 570 580 590 600
KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR
610 620 630 640 650
EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH
660 670 680 690 700
GNGQPANMPE YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF
710 720 730 740 750
AMNAAATAAA ERDTTIINHS RNGSYGESSL EAHIWQEEEE VVQANRRCQD
760 770 780 790 800
MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA GKTDSSSLRP ARSVPSIAAA
810 820 830 840 850
TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH ASAPLLPPPP
860 870 880 890 900
TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS
910 920 930 940 950
TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE

MMEVLI
Length:956
Mass (Da):106,574
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F47AE3A13816E95
GO
Isoform 2 (identifier: Q8IY63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-66: Missing.

Show »
Length:906
Mass (Da):101,179
Checksum:i8CFA1AE879538953
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDH4F8WDH4_HUMAN
Angiomotin-like protein 1
AMOTL1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84910 differs from that shown. Reason: Frameshift.Curated
The sequence BAB84910 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti459 – 460LQ → HE in AAH14126 (PubMed:15489334).Curated2
Sequence conflicti649K → E in CAH56180 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033498847P → L. Corresponds to variant dbSNP:rs11020968Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01571017 – 66Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074084 mRNA Translation: BAB84910.1 Sequence problems.
AL833833 mRNA Translation: CAD38693.1
AP001152 Genomic DNA No translation available.
AP002376 Genomic DNA No translation available.
BX648729 mRNA Translation: CAH56180.1
BC014126 mRNA Translation: AAH14126.1
BC037539 mRNA Translation: AAH37539.1
AF453742 mRNA Translation: AAL49764.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44712.1 [Q8IY63-1]
CCDS73368.1 [Q8IY63-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001287936.1, NM_001301007.1 [Q8IY63-2]
NP_570899.1, NM_130847.2 [Q8IY63-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317829; ENSP00000320968; ENSG00000166025 [Q8IY63-2]
ENST00000433060; ENSP00000387739; ENSG00000166025 [Q8IY63-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
154810

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:154810

UCSC genome browser

More...
UCSCi
uc001pfb.4, human [Q8IY63-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074084 mRNA Translation: BAB84910.1 Sequence problems.
AL833833 mRNA Translation: CAD38693.1
AP001152 Genomic DNA No translation available.
AP002376 Genomic DNA No translation available.
BX648729 mRNA Translation: CAH56180.1
BC014126 mRNA Translation: AAH14126.1
BC037539 mRNA Translation: AAH37539.1
AF453742 mRNA Translation: AAL49764.1
CCDSiCCDS44712.1 [Q8IY63-1]
CCDS73368.1 [Q8IY63-2]
RefSeqiNP_001287936.1, NM_001301007.1 [Q8IY63-2]
NP_570899.1, NM_130847.2 [Q8IY63-1]

3D structure databases

SMRiQ8IY63
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127559, 56 interactors
CORUMiQ8IY63
DIPiDIP-50682N
IntActiQ8IY63, 25 interactors
STRINGi9606.ENSP00000387739

PTM databases

iPTMnetiQ8IY63
PhosphoSitePlusiQ8IY63

Genetic variation databases

BioMutaiAMOTL1
DMDMi74728292

Proteomic databases

EPDiQ8IY63
jPOSTiQ8IY63
MassIVEiQ8IY63
MaxQBiQ8IY63
PaxDbiQ8IY63
PeptideAtlasiQ8IY63
PRIDEiQ8IY63
ProteomicsDBi71115 [Q8IY63-1]
71116 [Q8IY63-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
654, 124 antibodies

The DNASU plasmid repository

More...
DNASUi
154810

Genome annotation databases

EnsembliENST00000317829; ENSP00000320968; ENSG00000166025 [Q8IY63-2]
ENST00000433060; ENSP00000387739; ENSG00000166025 [Q8IY63-1]
GeneIDi154810
KEGGihsa:154810
UCSCiuc001pfb.4, human [Q8IY63-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
154810
DisGeNETi154810

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMOTL1
HGNCiHGNC:17811, AMOTL1
HPAiENSG00000166025, Tissue enhanced (skeletal)
MIMi614657, gene
neXtProtiNX_Q8IY63
OpenTargetsiENSG00000166025
PharmGKBiPA24774
VEuPathDBiHostDB:ENSG00000166025.17

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QVI5, Eukaryota
GeneTreeiENSGT00940000160158
HOGENOMiCLU_009937_1_0_1
InParanoidiQ8IY63
OMAiGMPEYNA
OrthoDBi369983at2759
PhylomeDBiQ8IY63
TreeFamiTF333368

Enzyme and pathway databases

PathwayCommonsiQ8IY63
ReactomeiR-HSA-2028269, Signaling by Hippo

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
154810, 8 hits in 877 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AMOTL1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AMOTL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
154810
PharosiQ8IY63, Tbio

Protein Ontology

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PROi
PR:Q8IY63
RNActiQ8IY63, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000166025, Expressed in quadriceps femoris and 223 other tissues
ExpressionAtlasiQ8IY63, baseline and differential
GenevisibleiQ8IY63, HS

Family and domain databases

InterProiView protein in InterPro
IPR009114, Angiomotin
IPR024646, Angiomotin_C
PfamiView protein in Pfam
PF12240, Angiomotin_C, 1 hit
PRINTSiPR01807, ANGIOMOTIN

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMOL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY63
Secondary accession number(s): Q63HK7
, Q8NDN0, Q8TEN8, Q8WXD1, Q96CM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: February 10, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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