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Protein

YY1-associated factor 2

Gene

YAF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 48RanBP2-typePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
YY1-associated factor 2
Gene namesi
Name:YAF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000015153.14
HGNCiHGNC:17363 YAF2
MIMi607534 gene
neXtProtiNX_Q8IY57

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10138
OpenTargetsiENSG00000015153
PharmGKBiPA38236

Polymorphism and mutation databases

BioMutaiYAF2
DMDMi215274199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000661131 – 180YY1-associated factor 2Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY57
MaxQBiQ8IY57
PeptideAtlasiQ8IY57
PRIDEiQ8IY57
ProteomicsDBi71112
71114 [Q8IY57-3]

PTM databases

iPTMnetiQ8IY57
PhosphoSitePlusiQ8IY57

Expressioni

Gene expression databases

BgeeiENSG00000015153 Expressed in 160 organ(s), highest expression level in right atrium auricular region
CleanExiHS_YAF2
ExpressionAtlasiQ8IY57 baseline and differential
GenevisibleiQ8IY57 HS

Organism-specific databases

HPAiHPA026867

Interactioni

Subunit structurei

Interacts with MYC, MYCN, RNF2/RING1B and YY1. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115441, 62 interactors
CORUMiQ8IY57
DIPiDIP-44919N
IntActiQ8IY57, 55 interactors
MINTiQ8IY57

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IY57
SMRiQ8IY57
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IY57

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 48RanBP2-typePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000013995
HOGENOMiHOG000007553
HOVERGENiHBG001768
InParanoidiQ8IY57
KOiK11468
OMAiSHKKMRP
OrthoDBiEOG091G10HB
PhylomeDBiQ8IY57
TreeFamiTF350501

Family and domain databases

InterProiView protein in InterPro
IPR039958 RYBP/YAF2
IPR038039 YAF2
IPR033774 YAF2_RYBP
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR12920 PTHR12920, 1 hit
PTHR12920:SF2 PTHR12920:SF2, 1 hit
PfamiView protein in Pfam
PF17219 YAF2_RYBP, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IY57-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDKKSPTRP KRQPKPSSDE GYWDCSVCTF RNSAEAFKCM MCDVRKGTST
60 70 80 90 100
RKPRPVSQLV AQQVTQQFVP PTQSKKEKKD KVEKEKSEKE TTSKKNSHKK
110 120 130 140 150
TRPRLKNVDR SSAQHLEVTV GDLTVIITDF KEKTKSPPAS SAASADQHSQ
160 170 180
SGSSSDNTER GMSRSSSPRG EASSLNGESH
Length:180
Mass (Da):19,901
Last modified:November 25, 2008 - v3
Checksum:i199A56EE06BB4FBE
GO
Isoform 2 (identifier: Q8IY57-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-50: T → TRSTLFEVIVSASRTKEPLKFPISG

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):22,546
Checksum:i16C4D290C18BD880
GO
Isoform 3 (identifier: Q8IY57-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-49: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,115
Checksum:i3E1E2E64F1003EC5
GO
Isoform 4 (identifier: Q8IY57-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-117: KPRPVSQLVA...VDRSSAQHLE → DSKEGGKLVS...QRSGPSLKEA
     118-180: Missing.

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):12,738
Checksum:i7A8B9E3A734AF65F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VRE5F8VRE5_HUMAN
YY1-associated factor 2
YAF2
72Annotation score:
G3V212G3V212_HUMAN
YY1 associated factor 2, isoform CR...
YAF2 hCG_1997687
120Annotation score:
G3V219G3V219_HUMAN
YY1 associated factor 2, isoform CR...
YAF2 hCG_1997687
96Annotation score:
G3V1X5G3V1X5_HUMAN
YY1 associated factor 2, isoform CR...
YAF2 hCG_1997687
56Annotation score:
A0A0B4J255A0A0B4J255_HUMAN
YY1-associated factor 2
YAF2
67Annotation score:
F8VZR2F8VZR2_HUMAN
YY1-associated factor 2
YAF2
34Annotation score:
F8W0B9F8W0B9_HUMAN
YY1-associated factor 2
YAF2
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 14QP → HA in AAC51116 (PubMed:9016636).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0434158 – 49Missing in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_05565950T → TRSTLFEVIVSASRTKEPLK FPISG in isoform 2. 1 Publication1
Alternative sequenceiVSP_04459852 – 117KPRPV…AQHLE → DSKEGGKLVSYSTASLGVRG TLRNRVGGGSSEEKKQAEYL APGRRRNIVHRGVGPGQRSG PSLKEA in isoform 4. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_044599118 – 180Missing in isoform 4. 1 PublicationAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72209 mRNA Translation: AAC51116.1
AK127531 mRNA No translation available.
AK291355 mRNA Translation: BAF84044.1
AK294260 mRNA Translation: BAG57554.1
AC020629 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW57839.1
BC037777 mRNA Translation: AAH37777.1
CCDSiCCDS31775.1 [Q8IY57-1]
CCDS53778.1 [Q8IY57-3]
CCDS53779.1 [Q8IY57-5]
CCDS53780.1 [Q8IY57-4]
RefSeqiNP_001177906.1, NM_001190977.2 [Q8IY57-3]
NP_001177908.1, NM_001190979.2 [Q8IY57-5]
NP_001177909.1, NM_001190980.2 [Q8IY57-4]
NP_005739.2, NM_005748.5 [Q8IY57-1]
UniGeneiHs.649195
Hs.708084

Genome annotation databases

EnsembliENST00000327791; ENSP00000328004; ENSG00000015153 [Q8IY57-5]
ENST00000380790; ENSP00000370167; ENSG00000015153 [Q8IY57-3]
ENST00000534854; ENSP00000439256; ENSG00000015153 [Q8IY57-1]
ENST00000555248; ENSP00000451626; ENSG00000015153 [Q8IY57-4]
GeneIDi10138
KEGGihsa:10138
UCSCiuc001rmv.4 human [Q8IY57-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72209 mRNA Translation: AAC51116.1
AK127531 mRNA No translation available.
AK291355 mRNA Translation: BAF84044.1
AK294260 mRNA Translation: BAG57554.1
AC020629 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW57839.1
BC037777 mRNA Translation: AAH37777.1
CCDSiCCDS31775.1 [Q8IY57-1]
CCDS53778.1 [Q8IY57-3]
CCDS53779.1 [Q8IY57-5]
CCDS53780.1 [Q8IY57-4]
RefSeqiNP_001177906.1, NM_001190977.2 [Q8IY57-3]
NP_001177908.1, NM_001190979.2 [Q8IY57-5]
NP_001177909.1, NM_001190980.2 [Q8IY57-4]
NP_005739.2, NM_005748.5 [Q8IY57-1]
UniGeneiHs.649195
Hs.708084

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9GNMR-A19-58[»]
ProteinModelPortaliQ8IY57
SMRiQ8IY57
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115441, 62 interactors
CORUMiQ8IY57
DIPiDIP-44919N
IntActiQ8IY57, 55 interactors
MINTiQ8IY57

PTM databases

iPTMnetiQ8IY57
PhosphoSitePlusiQ8IY57

Polymorphism and mutation databases

BioMutaiYAF2
DMDMi215274199

Proteomic databases

EPDiQ8IY57
MaxQBiQ8IY57
PeptideAtlasiQ8IY57
PRIDEiQ8IY57
ProteomicsDBi71112
71114 [Q8IY57-3]

Protocols and materials databases

DNASUi10138
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327791; ENSP00000328004; ENSG00000015153 [Q8IY57-5]
ENST00000380790; ENSP00000370167; ENSG00000015153 [Q8IY57-3]
ENST00000534854; ENSP00000439256; ENSG00000015153 [Q8IY57-1]
ENST00000555248; ENSP00000451626; ENSG00000015153 [Q8IY57-4]
GeneIDi10138
KEGGihsa:10138
UCSCiuc001rmv.4 human [Q8IY57-1]

Organism-specific databases

CTDi10138
DisGeNETi10138
EuPathDBiHostDB:ENSG00000015153.14
GeneCardsiYAF2
HGNCiHGNC:17363 YAF2
HPAiHPA026867
MIMi607534 gene
neXtProtiNX_Q8IY57
OpenTargetsiENSG00000015153
PharmGKBiPA38236
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000013995
HOGENOMiHOG000007553
HOVERGENiHBG001768
InParanoidiQ8IY57
KOiK11468
OMAiSHKKMRP
OrthoDBiEOG091G10HB
PhylomeDBiQ8IY57
TreeFamiTF350501

Enzyme and pathway databases

ReactomeiR-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8953750 Transcriptional Regulation by E2F6

Miscellaneous databases

ChiTaRSiYAF2 human
EvolutionaryTraceiQ8IY57
GeneWikiiYAF2
GenomeRNAii10138
PROiPR:Q8IY57
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000015153 Expressed in 160 organ(s), highest expression level in right atrium auricular region
CleanExiHS_YAF2
ExpressionAtlasiQ8IY57 baseline and differential
GenevisibleiQ8IY57 HS

Family and domain databases

InterProiView protein in InterPro
IPR039958 RYBP/YAF2
IPR038039 YAF2
IPR033774 YAF2_RYBP
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR12920 PTHR12920, 1 hit
PTHR12920:SF2 PTHR12920:SF2, 1 hit
PfamiView protein in Pfam
PF17219 YAF2_RYBP, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYAF2_HUMAN
AccessioniPrimary (citable) accession number: Q8IY57
Secondary accession number(s): A8K5P0
, B4DFU3, G3V465, Q99710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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