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Entry version 137 (13 Feb 2019)
Sequence version 2 (18 May 2010)
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Protein

Tigger transposable element-derived protein 4

Gene

TIGD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi39 – 59H-T-H motifBy similarityAdd BLAST21
DNA bindingi108 – 139H-T-H motifBy similarityAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tigger transposable element-derived protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIGD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169989.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18335 TIGD4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY51

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000169989

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38528

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TIGD4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452928

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002726161 – 512Tigger transposable element-derived protein 4Add BLAST512

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY51

PeptideAtlas

More...
PeptideAtlasi
Q8IY51

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY51

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY51

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY51

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169989 Expressed in 103 organ(s), highest expression level in sperm

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY51 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035649

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128403, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY51, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355162

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IY51

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IY51

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 63HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini75 – 146HTH CENPB-typePROSITE-ProRule annotationAdd BLAST72
Domaini174 – 375DDE-1Sequence analysisAdd BLAST202

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3105 Eukaryota
ENOG4110CDI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160195

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154580

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG086852

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY51

Identification of Orthologs from Complete Genome Data

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OMAi
WLDRFKS

Database of Orthologous Groups

More...
OrthoDBi
1343623at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY51

TreeFam database of animal gene trees

More...
TreeFami
TF101131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00674 CENPB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IY51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEASVDAST LPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK
60 70 80 90 100
NSLSSIMKNK DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC
110 120 130 140 150
LNVPVNGPML RLKANDFAQK LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE
160 170 180 190 200
ATGVPVDPST VWYQNVLPYY LNDYHPKNVF NIKETGLLYR MLPTNTFAFK
210 220 230 240 250
GETCSVGKLC KDRITLVVGT NMDGSEKLPL LVIGKKRTPH CFKGLKSLPV
260 270 280 290 300
CYEANRMAWM TSDVFEQWMR KLDEEFQAQQ RRVVIFVESF PAHPEVKNLK
310 320 330 340 350
SIELAFFPSC LSSKCIAMKQ GVIKSLKIKY RHCLIKKFLS SVEGSKEFTF
360 370 380 390 400
SLLDAVDTLH LCWRAVTPET IVKSYEEAGF KSQKGESDIT NAEKDTGLDL
410 420 430 440 450
VADALGAGVE FPEGLSIEEY AALDDDLETC EAAPNGDSIC TKESKSDETG
460 470 480 490 500
FYTSDEEDDD GSPGTELPLP SKSEAITALD TLKKFLRSQD MNDGLQNSLA
510
DLENFINSLS PK
Length:512
Mass (Da):57,468
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i212034AE45493CD2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB71642 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti91L → LSR in BAB71642 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057509432A → T. Corresponds to variant dbSNP:rs34432931Ensembl.1
Natural variantiVAR_030042439I → V1 PublicationCorresponds to variant dbSNP:rs4696354Ensembl.1
Natural variantiVAR_057510489Q → R. Corresponds to variant dbSNP:rs35581576Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC106882 Genomic DNA No translation available.
BC037869 mRNA Translation: AAH37869.1
AK058054 mRNA Translation: BAB71642.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34079.1

NCBI Reference Sequences

More...
RefSeqi
NP_663772.1, NM_145720.3
XP_005262864.1, XM_005262807.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.301243

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304337; ENSP00000355162; ENSG00000169989

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
201798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:201798

UCSC genome browser

More...
UCSCi
uc003imy.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106882 Genomic DNA No translation available.
BC037869 mRNA Translation: AAH37869.1
AK058054 mRNA Translation: BAB71642.1 Different initiation.
CCDSiCCDS34079.1
RefSeqiNP_663772.1, NM_145720.3
XP_005262864.1, XM_005262807.4
UniGeneiHs.301243

3D structure databases

ProteinModelPortaliQ8IY51
SMRiQ8IY51
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128403, 2 interactors
IntActiQ8IY51, 1 interactor
STRINGi9606.ENSP00000355162

PTM databases

iPTMnetiQ8IY51
PhosphoSitePlusiQ8IY51

Polymorphism and mutation databases

BioMutaiTIGD4
DMDMi296452928

Proteomic databases

PaxDbiQ8IY51
PeptideAtlasiQ8IY51
PRIDEiQ8IY51
ProteomicsDBi71111

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
201798
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304337; ENSP00000355162; ENSG00000169989
GeneIDi201798
KEGGihsa:201798
UCSCiuc003imy.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
201798
EuPathDBiHostDB:ENSG00000169989.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TIGD4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004573
HGNCiHGNC:18335 TIGD4
HPAiHPA035649
neXtProtiNX_Q8IY51
OpenTargetsiENSG00000169989
PharmGKBiPA38528

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00940000160195
HOGENOMiHOG000154580
HOVERGENiHBG086852
InParanoidiQ8IY51
OMAiWLDRFKS
OrthoDBi1343623at2759
PhylomeDBiQ8IY51
TreeFamiTF101131

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
201798

Protein Ontology

More...
PROi
PR:Q8IY51

Gene expression databases

BgeeiENSG00000169989 Expressed in 103 organ(s), highest expression level in sperm
GenevisibleiQ8IY51 HS

Family and domain databases

InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIGD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY51
Secondary accession number(s): Q96LP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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