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UniProtKB - Q8IY51 (TIGD4_HUMAN)
Protein
Tigger transposable element-derived protein 4
Gene
TIGD4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 39 – 59 | H-T-H motifBy similarityAdd BLAST | 21 | |
DNA bindingi | 108 – 139 | H-T-H motifBy similarityAdd BLAST | 32 |
GO - Molecular functioni
- DNA binding Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IY51 |
SignaLinki | Q8IY51 |
Names & Taxonomyi
Protein namesi | Recommended name: Tigger transposable element-derived protein 4 |
Gene namesi | Name:TIGD4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18335, TIGD4 |
neXtProti | NX_Q8IY51 |
VEuPathDBi | HostDB:ENSG00000169989 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 201798 |
OpenTargetsi | ENSG00000169989 |
PharmGKBi | PA38528 |
Miscellaneous databases
Pharosi | Q8IY51, Tdark |
Genetic variation databases
BioMutai | TIGD4 |
DMDMi | 296452928 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000272616 | 1 – 512 | Tigger transposable element-derived protein 4Add BLAST | 512 |
Proteomic databases
MassIVEi | Q8IY51 |
PaxDbi | Q8IY51 |
PeptideAtlasi | Q8IY51 |
PRIDEi | Q8IY51 |
ProteomicsDBi | 71111 |
PTM databases
GlyGeni | Q8IY51, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8IY51 |
PhosphoSitePlusi | Q8IY51 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169989, Expressed in sperm and 122 other tissues |
Genevisiblei | Q8IY51, HS |
Organism-specific databases
HPAi | ENSG00000169989, Tissue enriched (retina) |
Interactioni
Binary interactionsi
Q8IY51
With | #Exp. | IntAct |
---|---|---|
TRAF2 [Q12933] | 3 | EBI-12117432,EBI-355744 |
Protein-protein interaction databases
BioGRIDi | 128403, 24 interactors |
IntActi | Q8IY51, 3 interactors |
STRINGi | 9606.ENSP00000355162 |
Miscellaneous databases
RNActi | Q8IY51, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 63 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 75 – 146 | HTH CENPB-typePROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 174 – 375 | DDE-1Sequence analysisAdd BLAST | 202 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 434 – 472 | DisorderedSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Belongs to the tigger transposable element derived protein family.Curated
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000160195 |
HOGENOMi | CLU_018294_0_4_1 |
InParanoidi | Q8IY51 |
OMAi | QWMQKLD |
OrthoDBi | 1343623at2759 |
PhylomeDBi | Q8IY51 |
TreeFami | TF101131 |
Family and domain databases
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8IY51-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEASVDAST LPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK
60 70 80 90 100
NSLSSIMKNK DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC
110 120 130 140 150
LNVPVNGPML RLKANDFAQK LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE
160 170 180 190 200
ATGVPVDPST VWYQNVLPYY LNDYHPKNVF NIKETGLLYR MLPTNTFAFK
210 220 230 240 250
GETCSVGKLC KDRITLVVGT NMDGSEKLPL LVIGKKRTPH CFKGLKSLPV
260 270 280 290 300
CYEANRMAWM TSDVFEQWMR KLDEEFQAQQ RRVVIFVESF PAHPEVKNLK
310 320 330 340 350
SIELAFFPSC LSSKCIAMKQ GVIKSLKIKY RHCLIKKFLS SVEGSKEFTF
360 370 380 390 400
SLLDAVDTLH LCWRAVTPET IVKSYEEAGF KSQKGESDIT NAEKDTGLDL
410 420 430 440 450
VADALGAGVE FPEGLSIEEY AALDDDLETC EAAPNGDSIC TKESKSDETG
460 470 480 490 500
FYTSDEEDDD GSPGTELPLP SKSEAITALD TLKKFLRSQD MNDGLQNSLA
510
DLENFINSLS PK
Sequence cautioni
The sequence BAB71642 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 | L → LSR in BAB71642 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057509 | 432 | A → T. Corresponds to variant dbSNP:rs34432931Ensembl. | 1 | |
Natural variantiVAR_030042 | 439 | I → V1 PublicationCorresponds to variant dbSNP:rs4696354Ensembl. | 1 | |
Natural variantiVAR_057510 | 489 | Q → R. Corresponds to variant dbSNP:rs35581576Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC106882 Genomic DNA No translation available. BC037869 mRNA Translation: AAH37869.1 AK058054 mRNA Translation: BAB71642.1 Different initiation. |
CCDSi | CCDS34079.1 |
RefSeqi | NP_663772.1, NM_145720.3 XP_005262864.1, XM_005262807.4 |
Genome annotation databases
Ensembli | ENST00000304337.3; ENSP00000355162.2; ENSG00000169989.3 |
GeneIDi | 201798 |
KEGGi | hsa:201798 |
MANE-Selecti | ENST00000304337.3; ENSP00000355162.2; NM_145720.4; NP_663772.1 |
UCSCi | uc003imy.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC106882 Genomic DNA No translation available. BC037869 mRNA Translation: AAH37869.1 AK058054 mRNA Translation: BAB71642.1 Different initiation. |
CCDSi | CCDS34079.1 |
RefSeqi | NP_663772.1, NM_145720.3 XP_005262864.1, XM_005262807.4 |
3D structure databases
AlphaFoldDBi | Q8IY51 |
SMRi | Q8IY51 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128403, 24 interactors |
IntActi | Q8IY51, 3 interactors |
STRINGi | 9606.ENSP00000355162 |
PTM databases
GlyGeni | Q8IY51, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8IY51 |
PhosphoSitePlusi | Q8IY51 |
Genetic variation databases
BioMutai | TIGD4 |
DMDMi | 296452928 |
Proteomic databases
MassIVEi | Q8IY51 |
PaxDbi | Q8IY51 |
PeptideAtlasi | Q8IY51 |
PRIDEi | Q8IY51 |
ProteomicsDBi | 71111 |
Protocols and materials databases
Antibodypediai | 27816, 86 antibodies from 21 providers |
DNASUi | 201798 |
Genome annotation databases
Ensembli | ENST00000304337.3; ENSP00000355162.2; ENSG00000169989.3 |
GeneIDi | 201798 |
KEGGi | hsa:201798 |
MANE-Selecti | ENST00000304337.3; ENSP00000355162.2; NM_145720.4; NP_663772.1 |
UCSCi | uc003imy.3, human |
Organism-specific databases
CTDi | 201798 |
DisGeNETi | 201798 |
GeneCardsi | TIGD4 |
HGNCi | HGNC:18335, TIGD4 |
HPAi | ENSG00000169989, Tissue enriched (retina) |
neXtProti | NX_Q8IY51 |
OpenTargetsi | ENSG00000169989 |
PharmGKBi | PA38528 |
VEuPathDBi | HostDB:ENSG00000169989 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000160195 |
HOGENOMi | CLU_018294_0_4_1 |
InParanoidi | Q8IY51 |
OMAi | QWMQKLD |
OrthoDBi | 1343623at2759 |
PhylomeDBi | Q8IY51 |
TreeFami | TF101131 |
Enzyme and pathway databases
PathwayCommonsi | Q8IY51 |
SignaLinki | Q8IY51 |
Miscellaneous databases
BioGRID-ORCSi | 201798, 20 hits in 1037 CRISPR screens |
GenomeRNAii | 201798 |
Pharosi | Q8IY51, Tdark |
PROi | PR:Q8IY51 |
RNActi | Q8IY51, protein |
Gene expression databases
Bgeei | ENSG00000169989, Expressed in sperm and 122 other tissues |
Genevisiblei | Q8IY51, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TIGD4_HUMAN | |
Accessioni | Q8IY51Primary (citable) accession number: Q8IY51 Secondary accession number(s): Q96LP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families