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UniProtKB - Q8IY50 (S35F3_HUMAN)
Protein
Putative thiamine transporter SLC35F3
Gene
SLC35F3
Organism
Homo sapiens (Human)
Status
Functioni
May be a thiamine transporter.
1 PublicationMiscellaneous
Promotes thiamine uptake when expressed in E.coli. Individuals with blood hypertension and a SLC35F3 risk allele T/T homozygosity (intronic variant rs17514104) show a significant reduction in blood thiamine content.1 Publication
GO - Biological processi
- thiamine transport Source: UniProtKB
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8IY50 |
Protein family/group databases
TCDBi | 2.A.7.24.8, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Putative thiamine transporter SLC35F3CuratedAlternative name(s): Solute carrier family 35 member F3 |
Gene namesi | Name:SLC35F3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23616, SLC35F3 |
neXtProti | NX_Q8IY50 |
VEuPathDBi | HostDB:ENSG00000183780 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 266 – 286 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 326 – 346 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 352 – 372 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 148641 |
OpenTargetsi | ENSG00000183780 |
PharmGKBi | PA134938022 |
Miscellaneous databases
Pharosi | Q8IY50, Tbio |
Genetic variation databases
BioMutai | SLC35F3 |
DMDMi | 160177558 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307879 | 1 – 421 | Putative thiamine transporter SLC35F3Add BLAST | 421 |
Proteomic databases
jPOSTi | Q8IY50 |
MassIVEi | Q8IY50 |
MaxQBi | Q8IY50 |
PaxDbi | Q8IY50 |
PeptideAtlasi | Q8IY50 |
PRIDEi | Q8IY50 |
ProteomicsDBi | 71109 [Q8IY50-1] 71110 [Q8IY50-2] |
PTM databases
iPTMneti | Q8IY50 |
PhosphoSitePlusi | Q8IY50 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183780, Expressed in cerebellar vermis and 138 other tissues |
Genevisiblei | Q8IY50, HS |
Organism-specific databases
HPAi | ENSG00000183780, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127158, 2 interactors |
STRINGi | 9606.ENSP00000355577 |
Miscellaneous databases
RNActi | Q8IY50, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 45 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 393 – 421 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the SLC35F solute transporter family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4314, Eukaryota |
GeneTreei | ENSGT00390000008727 |
HOGENOMi | CLU_022280_0_1_1 |
InParanoidi | Q8IY50 |
OMAi | GAHFMGM |
OrthoDBi | 639186at2759 |
PhylomeDBi | Q8IY50 |
TreeFami | TF313798 |
Family and domain databases
InterProi | View protein in InterPro IPR000620, EamA_dom IPR026505, Solute_c_fam_35_mem_F3/F4 |
PANTHERi | PTHR19346, PTHR19346, 1 hit |
Pfami | View protein in Pfam PF00892, EamA, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IY50-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKHSARVAP LSACNSPVLT LTKVEGEERP RDSPGPAEAQ APAGVEAGGR
60 70 80 90 100
ASRRCWTCSR AQLKKIFWGV AVVLCVCSSW AGSTQLAKLT FRKFDAPFTL
110 120 130 140 150
TWFATNWNFL FFPLYYVGHV CKSTEKQSVK QRYRECCRFF GDNGLTLKVF
160 170 180 190 200
FTKAAPFGVL WTLTNYLYLH AIKKINTTDV SVLFCCNKAF VFLLSWIVLR
210 220 230 240 250
DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVA SASMSALYKV
260 270 280 290 300
LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPIILYFTK VEYWSSFDDI
310 320 330 340 350
PWGNLCGFSV LLLTFNIVLN FGIAVTYPTL MSLGIVLSIP VNAVIDHYTS
360 370 380 390 400
QIVFNGVRVI AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEEPAEG
410 420
AADLSSGPQS KNRRARPSFA R
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036700 | 231 | S → C1 PublicationCorresponds to variant dbSNP:rs17853780Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028850 | 1 – 26 | MKKHS…TKVEG → MGIREFPSGAPRGKSIAVGM RRSPDVSPRRLSDISPQLRQ LKYLVVDEAIKEDLKWSRSV EDLTSGPVGLTSIEERILRI TGYYGYQPWAASCKR in isoform 2. 1 PublicationAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095031 mRNA Translation: BAC04479.1 AL713868 Genomic DNA No translation available. AL122008 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69991.1 BC037878 mRNA Translation: AAH37878.1 |
CCDSi | CCDS1600.1 [Q8IY50-2] CCDS73050.1 [Q8IY50-1] |
RefSeqi | NP_001287774.1, NM_001300845.1 [Q8IY50-1] NP_775779.1, NM_173508.3 [Q8IY50-2] |
Genome annotation databases
Ensembli | ENST00000366617; ENSP00000355576; ENSG00000183780 ENST00000366618; ENSP00000355577; ENSG00000183780 [Q8IY50-2] |
GeneIDi | 148641 |
KEGGi | hsa:148641 |
MANE-Selecti | ENST00000366618.8; ENSP00000355577.3; NM_173508.4; NP_775779.1 [Q8IY50-2] |
UCSCi | uc001hvy.1, human [Q8IY50-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095031 mRNA Translation: BAC04479.1 AL713868 Genomic DNA No translation available. AL122008 Genomic DNA No translation available. CH471098 Genomic DNA Translation: EAW69991.1 BC037878 mRNA Translation: AAH37878.1 |
CCDSi | CCDS1600.1 [Q8IY50-2] CCDS73050.1 [Q8IY50-1] |
RefSeqi | NP_001287774.1, NM_001300845.1 [Q8IY50-1] NP_775779.1, NM_173508.3 [Q8IY50-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127158, 2 interactors |
STRINGi | 9606.ENSP00000355577 |
Protein family/group databases
TCDBi | 2.A.7.24.8, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | Q8IY50 |
PhosphoSitePlusi | Q8IY50 |
Genetic variation databases
BioMutai | SLC35F3 |
DMDMi | 160177558 |
Proteomic databases
jPOSTi | Q8IY50 |
MassIVEi | Q8IY50 |
MaxQBi | Q8IY50 |
PaxDbi | Q8IY50 |
PeptideAtlasi | Q8IY50 |
PRIDEi | Q8IY50 |
ProteomicsDBi | 71109 [Q8IY50-1] 71110 [Q8IY50-2] |
Protocols and materials databases
Antibodypediai | 34691, 44 antibodies from 16 providers |
DNASUi | 148641 |
Genome annotation databases
Ensembli | ENST00000366617; ENSP00000355576; ENSG00000183780 ENST00000366618; ENSP00000355577; ENSG00000183780 [Q8IY50-2] |
GeneIDi | 148641 |
KEGGi | hsa:148641 |
MANE-Selecti | ENST00000366618.8; ENSP00000355577.3; NM_173508.4; NP_775779.1 [Q8IY50-2] |
UCSCi | uc001hvy.1, human [Q8IY50-1] |
Organism-specific databases
CTDi | 148641 |
DisGeNETi | 148641 |
GeneCardsi | SLC35F3 |
HGNCi | HGNC:23616, SLC35F3 |
HPAi | ENSG00000183780, Tissue enriched (brain) |
neXtProti | NX_Q8IY50 |
OpenTargetsi | ENSG00000183780 |
PharmGKBi | PA134938022 |
VEuPathDBi | HostDB:ENSG00000183780 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4314, Eukaryota |
GeneTreei | ENSGT00390000008727 |
HOGENOMi | CLU_022280_0_1_1 |
InParanoidi | Q8IY50 |
OMAi | GAHFMGM |
OrthoDBi | 639186at2759 |
PhylomeDBi | Q8IY50 |
TreeFami | TF313798 |
Enzyme and pathway databases
PathwayCommonsi | Q8IY50 |
Miscellaneous databases
BioGRID-ORCSi | 148641, 4 hits in 1035 CRISPR screens |
ChiTaRSi | SLC35F3, human |
GenomeRNAii | 148641 |
Pharosi | Q8IY50, Tbio |
PROi | PR:Q8IY50 |
RNActi | Q8IY50, protein |
Gene expression databases
Bgeei | ENSG00000183780, Expressed in cerebellar vermis and 138 other tissues |
Genevisiblei | Q8IY50, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000620, EamA_dom IPR026505, Solute_c_fam_35_mem_F3/F4 |
PANTHERi | PTHR19346, PTHR19346, 1 hit |
Pfami | View protein in Pfam PF00892, EamA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35F3_HUMAN | |
Accessioni | Q8IY50Primary (citable) accession number: Q8IY50 Secondary accession number(s): Q5TDD6, Q8N9C9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 117 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families