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Entry version 117 (23 Feb 2022)
Sequence version 2 (23 Oct 2007)
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Protein

Putative thiamine transporter SLC35F3

Gene

SLC35F3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a thiamine transporter.

1 Publication

Miscellaneous

Promotes thiamine uptake when expressed in E.coli. Individuals with blood hypertension and a SLC35F3 risk allele T/T homozygosity (intronic variant rs17514104) show a significant reduction in blood thiamine content.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IY50

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.24.8, the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative thiamine transporter SLC35F3Curated
Alternative name(s):
Solute carrier family 35 member F3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC35F3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23616, SLC35F3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY50

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000183780

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei266 – 286HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
148641

Open Targets

More...
OpenTargetsi
ENSG00000183780

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938022

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IY50, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC35F3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160177558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003078791 – 421Putative thiamine transporter SLC35F3Add BLAST421

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IY50

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IY50

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IY50

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY50

PeptideAtlas

More...
PeptideAtlasi
Q8IY50

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY50

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71109 [Q8IY50-1]
71110 [Q8IY50-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY50

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY50

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183780, Expressed in cerebellar vermis and 138 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY50, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183780, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127158, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355577

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IY50, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 45DisorderedSequence analysisAdd BLAST21
Regioni393 – 421DisorderedSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4314, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008727

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022280_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY50

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAHFMGM

Database of Orthologous Groups

More...
OrthoDBi
639186at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY50

TreeFam database of animal gene trees

More...
TreeFami
TF313798

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000620, EamA_dom
IPR026505, Solute_c_fam_35_mem_F3/F4

The PANTHER Classification System

More...
PANTHERi
PTHR19346, PTHR19346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00892, EamA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IY50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKHSARVAP LSACNSPVLT LTKVEGEERP RDSPGPAEAQ APAGVEAGGR
60 70 80 90 100
ASRRCWTCSR AQLKKIFWGV AVVLCVCSSW AGSTQLAKLT FRKFDAPFTL
110 120 130 140 150
TWFATNWNFL FFPLYYVGHV CKSTEKQSVK QRYRECCRFF GDNGLTLKVF
160 170 180 190 200
FTKAAPFGVL WTLTNYLYLH AIKKINTTDV SVLFCCNKAF VFLLSWIVLR
210 220 230 240 250
DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVA SASMSALYKV
260 270 280 290 300
LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPIILYFTK VEYWSSFDDI
310 320 330 340 350
PWGNLCGFSV LLLTFNIVLN FGIAVTYPTL MSLGIVLSIP VNAVIDHYTS
360 370 380 390 400
QIVFNGVRVI AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEEPAEG
410 420
AADLSSGPQS KNRRARPSFA R
Length:421
Mass (Da):46,817
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D365662E28AE251
GO
Isoform 2 (identifier: Q8IY50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKKHSARVAPLSACNSPVLTLTKVEG → MGIREFPSGA...YQPWAASCKR

Show »
Length:490
Mass (Da):54,773
Checksum:i96412343FDC55D0A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036700231S → C1 PublicationCorresponds to variant dbSNP:rs17853780Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0288501 – 26MKKHS…TKVEG → MGIREFPSGAPRGKSIAVGM RRSPDVSPRRLSDISPQLRQ LKYLVVDEAIKEDLKWSRSV EDLTSGPVGLTSIEERILRI TGYYGYQPWAASCKR in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK095031 mRNA Translation: BAC04479.1
AL713868 Genomic DNA No translation available.
AL122008 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69991.1
BC037878 mRNA Translation: AAH37878.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1600.1 [Q8IY50-2]
CCDS73050.1 [Q8IY50-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001287774.1, NM_001300845.1 [Q8IY50-1]
NP_775779.1, NM_173508.3 [Q8IY50-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366617; ENSP00000355576; ENSG00000183780
ENST00000366618; ENSP00000355577; ENSG00000183780 [Q8IY50-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
148641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:148641

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000366618.8; ENSP00000355577.3; NM_173508.4; NP_775779.1 [Q8IY50-2]

UCSC genome browser

More...
UCSCi
uc001hvy.1, human [Q8IY50-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095031 mRNA Translation: BAC04479.1
AL713868 Genomic DNA No translation available.
AL122008 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69991.1
BC037878 mRNA Translation: AAH37878.1
CCDSiCCDS1600.1 [Q8IY50-2]
CCDS73050.1 [Q8IY50-1]
RefSeqiNP_001287774.1, NM_001300845.1 [Q8IY50-1]
NP_775779.1, NM_173508.3 [Q8IY50-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127158, 2 interactors
STRINGi9606.ENSP00000355577

Protein family/group databases

TCDBi2.A.7.24.8, the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ8IY50
PhosphoSitePlusiQ8IY50

Genetic variation databases

BioMutaiSLC35F3
DMDMi160177558

Proteomic databases

jPOSTiQ8IY50
MassIVEiQ8IY50
MaxQBiQ8IY50
PaxDbiQ8IY50
PeptideAtlasiQ8IY50
PRIDEiQ8IY50
ProteomicsDBi71109 [Q8IY50-1]
71110 [Q8IY50-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34691, 44 antibodies from 16 providers

The DNASU plasmid repository

More...
DNASUi
148641

Genome annotation databases

EnsembliENST00000366617; ENSP00000355576; ENSG00000183780
ENST00000366618; ENSP00000355577; ENSG00000183780 [Q8IY50-2]
GeneIDi148641
KEGGihsa:148641
MANE-SelectiENST00000366618.8; ENSP00000355577.3; NM_173508.4; NP_775779.1 [Q8IY50-2]
UCSCiuc001hvy.1, human [Q8IY50-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
148641
DisGeNETi148641

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC35F3
HGNCiHGNC:23616, SLC35F3
HPAiENSG00000183780, Tissue enriched (brain)
neXtProtiNX_Q8IY50
OpenTargetsiENSG00000183780
PharmGKBiPA134938022
VEuPathDBiHostDB:ENSG00000183780

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4314, Eukaryota
GeneTreeiENSGT00390000008727
HOGENOMiCLU_022280_0_1_1
InParanoidiQ8IY50
OMAiGAHFMGM
OrthoDBi639186at2759
PhylomeDBiQ8IY50
TreeFamiTF313798

Enzyme and pathway databases

PathwayCommonsiQ8IY50

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
148641, 4 hits in 1035 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC35F3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
148641
PharosiQ8IY50, Tbio

Protein Ontology

More...
PROi
PR:Q8IY50
RNActiQ8IY50, protein

Gene expression databases

BgeeiENSG00000183780, Expressed in cerebellar vermis and 138 other tissues
GenevisibleiQ8IY50, HS

Family and domain databases

InterProiView protein in InterPro
IPR000620, EamA_dom
IPR026505, Solute_c_fam_35_mem_F3/F4
PANTHERiPTHR19346, PTHR19346, 1 hit
PfamiView protein in Pfam
PF00892, EamA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS35F3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY50
Secondary accession number(s): Q5TDD6, Q8N9C9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: February 23, 2022
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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