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Entry version 131 (31 Jul 2019)
Sequence version 2 (31 Aug 2004)
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Protein

Monocyte to macrophage differentiation factor 2

Gene

MMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.113.2.3 the hly iii (hly iii) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Monocyte to macrophage differentiation factor 2
Alternative name(s):
Progestin and adipoQ receptor family member 101 Publication
Progestin and adipoQ receptor family member X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MMD2Imported
Synonyms:PAQR101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30133 MMD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614581 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY49

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 65LumenalSequence analysis6
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 102CytoplasmicSequence analysisAdd BLAST16
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 132LumenalSequence analysis9
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 182CytoplasmicSequence analysisAdd BLAST29
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205LumenalSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 233CytoplasmicSequence analysis7
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 270LumenalSequence analysisAdd BLAST16

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000136297

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134910250

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MMD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
51701810

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002188571 – 270Monocyte to macrophage differentiation factor 2Add BLAST270

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY49

PeptideAtlas

More...
PeptideAtlasi
Q8IY49

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY49

ProteomicsDB human proteome resource

More...
ProteomicsDBi
5944
71107 [Q8IY49-1]
71108 [Q8IY49-2]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Shows restricted expression with highest levels in brain and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136297 Expressed in 91 organ(s), highest expression level in C1 segment of cervical spinal cord

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY49 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128770, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q8IY49, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384690

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4243 Eukaryota
COG1272 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039440

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY49

KEGG Orthology (KO)

More...
KOi
K11064

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAWTHLV

Database of Orthologous Groups

More...
OrthoDBi
1487730at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY49

TreeFam database of animal gene trees

More...
TreeFami
TF313370

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004254 AdipoR/HlyIII-related

The PANTHER Classification System

More...
PANTHERi
PTHR20855 PTHR20855, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03006 HlyIII, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IY49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI
60 70 80 90 100
LGSSNLYFLS DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE
110 120 130 140 150
HCLHMFDRMV IYFFIAASYA PWLNLRELGP WASHMRWLVW IMASVGTIYV
160 170 180 190 200
FFFHERTGSC VQFLRGEACP KAGTACLPAR YKLVELLCYV VMGFFPALVI
210 220 230 240 250
LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH LFVAFGAGTH
260 270
YYAIWRYLYL PSTLQTKVSK
Length:270
Mass (Da):31,264
Last modified:August 31, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA726231D6283A2DA
GO
Isoform 2 (identifier: Q8IY49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.

Show »
Length:246
Mass (Da):28,845
Checksum:iF944D5B94B7E68A9
GO
Isoform 3 (identifier: Q8IY49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
     204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):22,730
Checksum:i14147EF0A8A50C78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9F → L in AAR08376 (PubMed:16044242).Curated1
Sequence conflicti99V → L in AAH37881 (PubMed:15489334).Curated1
Sequence conflicti103L → I in AAH67905 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011486156 – 179Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_045589204 – 270PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY424288 mRNA Translation: AAR08376.1
AC053546 Genomic DNA No translation available.
AC092032 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87307.1
BC037881 mRNA Translation: AAH37881.2
BC048346 mRNA No translation available.
BC067905 mRNA Translation: AAH67905.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47529.1 [Q8IY49-1]
CCDS47530.1 [Q8IY49-2]
CCDS59047.1 [Q8IY49-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001094070.1, NM_001100600.1 [Q8IY49-1]
NP_001257304.1, NM_001270375.1 [Q8IY49-3]
NP_940685.3, NM_198403.3 [Q8IY49-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000401401; ENSP00000384141; ENSG00000136297 [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297 [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297 [Q8IY49-3]
ENST00000612910; ENSP00000484193; ENSG00000136297 [Q8IY49-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
221938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:221938

UCSC genome browser

More...
UCSCi
uc003snn.5 human [Q8IY49-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424288 mRNA Translation: AAR08376.1
AC053546 Genomic DNA No translation available.
AC092032 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87307.1
BC037881 mRNA Translation: AAH37881.2
BC048346 mRNA No translation available.
BC067905 mRNA Translation: AAH67905.1
CCDSiCCDS47529.1 [Q8IY49-1]
CCDS47530.1 [Q8IY49-2]
CCDS59047.1 [Q8IY49-3]
RefSeqiNP_001094070.1, NM_001100600.1 [Q8IY49-1]
NP_001257304.1, NM_001270375.1 [Q8IY49-3]
NP_940685.3, NM_198403.3 [Q8IY49-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi128770, 1 interactor
IntActiQ8IY49, 6 interactors
STRINGi9606.ENSP00000384690

Protein family/group databases

TCDBi1.C.113.2.3 the hly iii (hly iii) family

PTM databases

PhosphoSitePlusiQ8IY49

Polymorphism and mutation databases

BioMutaiMMD2
DMDMi51701810

Proteomic databases

PaxDbiQ8IY49
PeptideAtlasiQ8IY49
PRIDEiQ8IY49
ProteomicsDBi5944
71107 [Q8IY49-1]
71108 [Q8IY49-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401401; ENSP00000384141; ENSG00000136297 [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297 [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297 [Q8IY49-3]
ENST00000612910; ENSP00000484193; ENSG00000136297 [Q8IY49-3]
GeneIDi221938
KEGGihsa:221938
UCSCiuc003snn.5 human [Q8IY49-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221938

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MMD2
HGNCiHGNC:30133 MMD2
MIMi614581 gene
neXtProtiNX_Q8IY49
OpenTargetsiENSG00000136297
PharmGKBiPA134910250

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4243 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00940000157972
HOGENOMiHOG000039440
InParanoidiQ8IY49
KOiK11064
OMAiNAWTHLV
OrthoDBi1487730at2759
PhylomeDBiQ8IY49
TreeFamiTF313370

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MMD2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
221938

Protein Ontology

More...
PROi
PR:Q8IY49

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136297 Expressed in 91 organ(s), highest expression level in C1 segment of cervical spinal cord
GenevisibleiQ8IY49 HS

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAQRA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY49
Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 31, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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