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Entry version 145 (17 Jun 2020)
Sequence version 2 (25 Jul 2003)
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Protein

Kelch repeat and BTB domain-containing protein 2

Gene

KBTBD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch repeat and BTB domain-containing protein 2
Alternative name(s):
BTB and kelch domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KBTBD2
Synonyms:BKLHD1, KIAA1489
ORF Names:CGI-73
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170852.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21751 KBTBD2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY47

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25948

Open Targets

More...
OpenTargetsi
ENSG00000170852

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134892896

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IY47 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KBTBD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33301029

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190771 – 623Kelch repeat and BTB domain-containing protein 2Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei300PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IY47

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IY47

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IY47

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IY47

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY47

PeptideAtlas

More...
PeptideAtlasi
Q8IY47

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY47

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71106

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY47

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY47

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170852 Expressed in amniotic fluid and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IY47 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY47 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000170852 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117443, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY47, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302586

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IY47 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 98BTBPROSITE-ProRule annotationAdd BLAST68
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati317 – 380Kelch 1Add BLAST64
Repeati381 – 429Kelch 2Add BLAST49
Repeati431 – 469Kelch 3Add BLAST39
Repeati470 – 529Kelch 4Add BLAST60
Repeati535 – 581Kelch 5Add BLAST47

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4441 Eukaryota
ENOG410XNX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156069

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY47

KEGG Orthology (KO)

More...
KOi
K10470

Identification of Orthologs from Complete Genome Data

More...
OMAi
KPSLVYC

Database of Orthologous Groups

More...
OrthoDBi
249821at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY47

TreeFam database of animal gene trees

More...
TreeFami
TF332672

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q8IY47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTQDERQIN TEYAVSLLEQ LKLFYEQQLF TDIVLIVEGT EFPCHKMVLA
60 70 80 90 100
TCSSYFRAMF MSGLSESKQT HVHLRNVDAA TLQIIITYAY TGNLAMNDST
110 120 130 140 150
VEQLYETACF LQVEDVLQRC REYLIKKINA ENCVRLLSFA DLFSCEELKQ
160 170 180 190 200
SAKRMVEHKF TAVYHQDAFM QLSHDLLIDI LSSDNLNVEK EETVREAAML
210 220 230 240 250
WLEYNTESRS QYLSSVLSQI RIDALSEVTQ RAWFQGLPPN DKSVVVQGLY
260 270 280 290 300
KSMPKFFKPR LGMTKEEMMI FIEASSENPC SLYSSVCYSP QAEKVYKLCS
310 320 330 340 350
PPADLHKVGT VVTPDNDIYI AGGQVPLKNT KTNHSKTSKL QTAFRTVNCF
360 370 380 390 400
YWFDAQQNTW FPKTPMLFVR IKPSLVCCEG YIYAIGGDSV GGELNRRTVE
410 420 430 440 450
RYDTEKDEWT MVSPLPCAWQ WSAAVVVHDC IYVMTLNLMY CYFPRSDSWV
460 470 480 490 500
EMAMRQTSRS FASAAAFGDK IFYIGGLHIA TNSGIRLPSG TVDGSSVTVE
510 520 530 540 550
IYDVNKNEWK MAANIPAKRY SDPCVRAVVI SNSLCVFMRE THLNERAKYV
560 570 580 590 600
TYQYDLELDR WSLRQHISER VLWDLGRDFR CTVGKLYPSC LEESPWKPPT
610 620
YLFSTDGTEE FELDGEMVAL PPV
Length:623
Mass (Da):71,331
Last modified:July 25, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA999ED0429B92772
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXP9A0A087WXP9_HUMAN
Kelch repeat and BTB domain-contain...
KBTBD2
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JI11C9JI11_HUMAN
Kelch repeat and BTB domain-contain...
KBTBD2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZ29C9JZ29_HUMAN
Kelch repeat and BTB domain-contain...
KBTBD2
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUE5C9JUE5_HUMAN
Kelch repeat and BTB domain-contain...
KBTBD2
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34068 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti167D → V in AAD34068 (PubMed:10810093).Curated1
Sequence conflicti181L → F in AAD34068 (PubMed:10810093).Curated1
Sequence conflicti276S → A in CAB55994 (PubMed:17974005).Curated1
Sequence conflicti543L → S in CAB55994 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037766166Q → K1 PublicationCorresponds to variant dbSNP:rs17853781Ensembl.1
Natural variantiVAR_037767189E → G1 PublicationCorresponds to variant dbSNP:rs17854425Ensembl.1
Natural variantiVAR_037768193T → P. Corresponds to variant dbSNP:rs35477666Ensembl.1
Natural variantiVAR_037769254P → R1 PublicationCorresponds to variant dbSNP:rs17857323Ensembl.1
Natural variantiVAR_037770301P → R1 PublicationCorresponds to variant dbSNP:rs17857324Ensembl.1
Natural variantiVAR_037771534L → I1 PublicationCorresponds to variant dbSNP:rs17854424Ensembl.1
Natural variantiVAR_037772594S → Y1 PublicationCorresponds to variant dbSNP:rs17853783Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK292802 mRNA Translation: BAF85491.1
CH471073 Genomic DNA Translation: EAW94000.1
BC037887 mRNA Translation: AAH37887.1
BC047107 mRNA Translation: AAH47107.1
AF151831 mRNA Translation: AAD34068.1 Frameshift.
AB040922 mRNA Translation: BAA96013.1
AL117562 mRNA Translation: CAB55994.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34614.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17304

NCBI Reference Sequences

More...
RefSeqi
NP_056298.2, NM_015483.2
XP_005249753.1, XM_005249696.2
XP_011513558.1, XM_011515256.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304056; ENSP00000302586; ENSG00000170852

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25948

UCSC genome browser

More...
UCSCi
uc003tdb.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292802 mRNA Translation: BAF85491.1
CH471073 Genomic DNA Translation: EAW94000.1
BC037887 mRNA Translation: AAH37887.1
BC047107 mRNA Translation: AAH47107.1
AF151831 mRNA Translation: AAD34068.1 Frameshift.
AB040922 mRNA Translation: BAA96013.1
AL117562 mRNA Translation: CAB55994.1
CCDSiCCDS34614.1
PIRiT17304
RefSeqiNP_056298.2, NM_015483.2
XP_005249753.1, XM_005249696.2
XP_011513558.1, XM_011515256.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117443, 8 interactors
IntActiQ8IY47, 4 interactors
STRINGi9606.ENSP00000302586

PTM databases

iPTMnetiQ8IY47
PhosphoSitePlusiQ8IY47

Polymorphism and mutation databases

BioMutaiKBTBD2
DMDMi33301029

Proteomic databases

EPDiQ8IY47
jPOSTiQ8IY47
MassIVEiQ8IY47
MaxQBiQ8IY47
PaxDbiQ8IY47
PeptideAtlasiQ8IY47
PRIDEiQ8IY47
ProteomicsDBi71106

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12767 70 antibodies

The DNASU plasmid repository

More...
DNASUi
25948

Genome annotation databases

EnsembliENST00000304056; ENSP00000302586; ENSG00000170852
GeneIDi25948
KEGGihsa:25948
UCSCiuc003tdb.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25948
DisGeNETi25948
EuPathDBiHostDB:ENSG00000170852.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KBTBD2
HGNCiHGNC:21751 KBTBD2
HPAiENSG00000170852 Low tissue specificity
neXtProtiNX_Q8IY47
OpenTargetsiENSG00000170852
PharmGKBiPA134892896

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00940000156069
InParanoidiQ8IY47
KOiK10470
OMAiKPSLVYC
OrthoDBi249821at2759
PhylomeDBiQ8IY47
TreeFamiTF332672

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
25948 49 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KBTBD2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25948
PharosiQ8IY47 Tdark

Protein Ontology

More...
PROi
PR:Q8IY47
RNActiQ8IY47 protein

Gene expression databases

BgeeiENSG00000170852 Expressed in amniotic fluid and 228 other tissues
ExpressionAtlasiQ8IY47 baseline and differential
GenevisibleiQ8IY47 HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 1 hit
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 4 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKBTB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY47
Secondary accession number(s): A8K9T7
, Q86Y62, Q9P239, Q9UFM7, Q9Y382
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: July 25, 2003
Last modified: June 17, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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