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Entry version 118 (29 Sep 2021)
Sequence version 1 (01 Mar 2003)
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Protein

Uncharacterized protein C4orf19

Gene

C4orf19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IY42

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C4orf19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C4orf19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25618, C4orf19

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY42

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000154274

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55286

Open Targets

More...
OpenTargetsi
ENSG00000154274

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596500

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IY42, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C4orf19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728286

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002865611 – 314Uncharacterized protein C4orf19Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineCombined sources1
Modified residuei106PhosphothreonineBy similarity1
Modified residuei238PhosphoserineCombined sources1
Modified residuei241PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IY42

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY42

PeptideAtlas

More...
PeptideAtlasi
Q8IY42

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY42

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71104

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY42

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY42

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154274, Expressed in amniotic fluid and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IY42, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY42, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000154274, Tissue enhanced (pancreas, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120574, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY42, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284437

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IY42, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IY42

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 142DisorderedSequence analysisAdd BLAST107
Regioni267 – 291DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi50 – 71Polar residuesSequence analysisAdd BLAST22
Compositional biasi105 – 135Polar residuesSequence analysisAdd BLAST31

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S5D9, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013778

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_076375_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY42

Identification of Orthologs from Complete Genome Data

More...
OMAi
GNYVEKD

Database of Orthologous Groups

More...
OrthoDBi
1420708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY42

TreeFam database of animal gene trees

More...
TreeFami
TF337421

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031528, DUF4699

The PANTHER Classification System

More...
PANTHERi
PTHR16106, PTHR16106, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15770, DUF4699, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IY42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRCCKIIQ SYLFDPVQVP SPGYVNEVNS CKLDEDDTDK LKGKWSSEVL
60 70 80 90 100
VQKNDPQRQG SKKTESSSRT ADPWEPCWPH QGPLPQGDAG GEHHACGVNG
110 120 130 140 150
IGPAATPQPT GNSSPTQDDR GSWASTANTV PPTQPFLEGG GTRKQDCVLL
160 170 180 190 200
ASEGTQVMRN GDSRAPSEAE SFALEVQDHV FQIPAPDYLQ HWGPAGDNVD
210 220 230 240 250
HNEKDCVFKN HTEDESLEGI QPPVGEHGLN TPFSVRRSWD SLNEDVETEV
260 270 280 290 300
LSICFNEKGP VHAMPVVDSG NRQEDTHGSD GDGDGEIVDE DAAVAEALAA
310
LEAATAGEDL DETD
Length:314
Mass (Da):33,742
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65A8FEBD0F1B08EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFF1D6RFF1_HUMAN
Uncharacterized protein C4orf19
C4orf19
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05077039D → E. Corresponds to variant dbSNP:rs6852908Ensembl.1
Natural variantiVAR_032118151A → T. Corresponds to variant dbSNP:rs2973275Ensembl.1
Natural variantiVAR_032119274E → G1 PublicationCorresponds to variant dbSNP:rs3733500Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001879 mRNA Translation: BAA91958.1
BC037906 mRNA Translation: AAH37906.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3442.1

NCBI Reference Sequences

More...
RefSeqi
NP_001098099.1, NM_001104629.1
NP_060772.2, NM_018302.2
XP_011512014.1, XM_011513712.2
XP_011512015.1, XM_011513713.2
XP_016863850.1, XM_017008361.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284437; ENSP00000284437; ENSG00000154274
ENST00000381980; ENSP00000371408; ENSG00000154274

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55286

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55286

UCSC genome browser

More...
UCSCi
uc003gsw.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001879 mRNA Translation: BAA91958.1
BC037906 mRNA Translation: AAH37906.1
CCDSiCCDS3442.1
RefSeqiNP_001098099.1, NM_001104629.1
NP_060772.2, NM_018302.2
XP_011512014.1, XM_011513712.2
XP_011512015.1, XM_011513713.2
XP_016863850.1, XM_017008361.1

3D structure databases

SMRiQ8IY42
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120574, 9 interactors
IntActiQ8IY42, 9 interactors
STRINGi9606.ENSP00000284437

PTM databases

iPTMnetiQ8IY42
PhosphoSitePlusiQ8IY42

Genetic variation databases

BioMutaiC4orf19
DMDMi74728286

Proteomic databases

MassIVEiQ8IY42
PaxDbiQ8IY42
PeptideAtlasiQ8IY42
PRIDEiQ8IY42
ProteomicsDBi71104

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
43802, 72 antibodies

The DNASU plasmid repository

More...
DNASUi
55286

Genome annotation databases

EnsembliENST00000284437; ENSP00000284437; ENSG00000154274
ENST00000381980; ENSP00000371408; ENSG00000154274
GeneIDi55286
KEGGihsa:55286
UCSCiuc003gsw.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55286
DisGeNETi55286

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C4orf19
HGNCiHGNC:25618, C4orf19
HPAiENSG00000154274, Tissue enhanced (pancreas, placenta)
neXtProtiNX_Q8IY42
OpenTargetsiENSG00000154274
PharmGKBiPA144596500
VEuPathDBiHostDB:ENSG00000154274

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S5D9, Eukaryota
GeneTreeiENSGT00390000013778
HOGENOMiCLU_076375_0_0_1
InParanoidiQ8IY42
OMAiGNYVEKD
OrthoDBi1420708at2759
PhylomeDBiQ8IY42
TreeFamiTF337421

Enzyme and pathway databases

PathwayCommonsiQ8IY42

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55286, 10 hits in 981 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C4orf19, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55286
PharosiQ8IY42, Tdark

Protein Ontology

More...
PROi
PR:Q8IY42
RNActiQ8IY42, protein

Gene expression databases

BgeeiENSG00000154274, Expressed in amniotic fluid and 168 other tissues
ExpressionAtlasiQ8IY42, baseline and differential
GenevisibleiQ8IY42, HS

Family and domain databases

InterProiView protein in InterPro
IPR031528, DUF4699
PANTHERiPTHR16106, PTHR16106, 1 hit
PfamiView protein in Pfam
PF15770, DUF4699, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD019_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY42
Secondary accession number(s): Q9NV03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: September 29, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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