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Protein

Solute carrier family 15 member 3

Gene

SLC15A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-427975 Proton/oligopeptide cotransporters

Protein family/group databases

TCDBi2.A.17.3.9 the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 3
Alternative name(s):
Osteoclast transporter
Peptide transporter 3
Peptide/histidine transporter 2
Gene namesi
Name:SLC15A3
Synonyms:OCTP, PHT2, PTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110446.9
HGNCiHGNC:18068 SLC15A3
MIMi610408 gene
neXtProtiNX_Q8IY34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51296
OpenTargetsiENSG00000110446
PharmGKBiPA134919658

Polymorphism and mutation databases

BioMutaiSLC15A3
DMDMi296452890

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959121 – 581Solute carrier family 15 member 3Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IY34
PaxDbiQ8IY34
PeptideAtlasiQ8IY34
PRIDEiQ8IY34
ProteomicsDBi71102

PTM databases

PhosphoSitePlusiQ8IY34

Expressioni

Gene expression databases

BgeeiENSG00000110446 Expressed in 149 organ(s), highest expression level in blood
CleanExiHS_SLC15A3
ExpressionAtlasiQ8IY34 baseline and differential
GenevisibleiQ8IY34 HS

Organism-specific databases

HPAiHPA047880
HPA057642

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi119447, 8 interactors
DIPiDIP-60838N
IntActiQ8IY34, 9 interactors
STRINGi9606.ENSP00000227880

Structurei

3D structure databases

ProteinModelPortaliQ8IY34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 170Poly-Leu6
Compositional biasi380 – 383Poly-Val4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961
HOGENOMiHOG000143436
HOVERGENiHBG108431
InParanoidiQ8IY34
KOiK14638
OMAiHHNETVS
OrthoDBiEOG091G0GF9
PhylomeDBiQ8IY34
TreeFamiTF330897

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000109 POT_fam
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8IY34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF
60 70 80 90 100
GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR
110 120 130 140 150
YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR
160 170 180 190 200
SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN
210 220 230 240 250
WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV
260 270 280 290 300
FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG
310 320 330 340 350
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF
360 370 380 390 400
PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR
410 420 430 440 450
CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL
460 470 480 490 500
YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF
510 520 530 540 550
CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA
560 570 580
VTALLFVWIA GRYERASQGP ASHSRFSRDR G
Length:581
Mass (Da):63,560
Last modified:May 18, 2010 - v2
Checksum:i56768D2963DB13D4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H251F5H251_HUMAN
Solute carrier family 15 member 3
SLC15A3
209Annotation score:
F5H1C8F5H1C8_HUMAN
Solute carrier family 15 member 3
SLC15A3 hCG_40399
456Annotation score:
H0YFC1H0YFC1_HUMAN
Solute carrier family 15 member 3
SLC15A3
247Annotation score:
F5GZ36F5GZ36_HUMAN
Solute carrier family 15 member 3
SLC15A3
149Annotation score:
H0YG40H0YG40_HUMAN
Solute carrier family 15 member 3
SLC15A3
43Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034592349I → F1 PublicationCorresponds to variant dbSNP:rs17855607Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020598 mRNA Translation: BAA93432.1
AF135600 mRNA Translation: AAQ13565.1
AP003721 Genomic DNA No translation available.
BC037974 mRNA Translation: AAH37974.1
CCDSiCCDS7998.1
RefSeqiNP_057666.1, NM_016582.2
UniGeneiHs.237856

Genome annotation databases

EnsembliENST00000227880; ENSP00000227880; ENSG00000110446
GeneIDi51296
KEGGihsa:51296
UCSCiuc001nqn.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020598 mRNA Translation: BAA93432.1
AF135600 mRNA Translation: AAQ13565.1
AP003721 Genomic DNA No translation available.
BC037974 mRNA Translation: AAH37974.1
CCDSiCCDS7998.1
RefSeqiNP_057666.1, NM_016582.2
UniGeneiHs.237856

3D structure databases

ProteinModelPortaliQ8IY34
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119447, 8 interactors
DIPiDIP-60838N
IntActiQ8IY34, 9 interactors
STRINGi9606.ENSP00000227880

Protein family/group databases

TCDBi2.A.17.3.9 the proton-dependent oligopeptide transporter (pot/ptr) family

PTM databases

PhosphoSitePlusiQ8IY34

Polymorphism and mutation databases

BioMutaiSLC15A3
DMDMi296452890

Proteomic databases

MaxQBiQ8IY34
PaxDbiQ8IY34
PeptideAtlasiQ8IY34
PRIDEiQ8IY34
ProteomicsDBi71102

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227880; ENSP00000227880; ENSG00000110446
GeneIDi51296
KEGGihsa:51296
UCSCiuc001nqn.3 human

Organism-specific databases

CTDi51296
DisGeNETi51296
EuPathDBiHostDB:ENSG00000110446.9
GeneCardsiSLC15A3
HGNCiHGNC:18068 SLC15A3
HPAiHPA047880
HPA057642
MIMi610408 gene
neXtProtiNX_Q8IY34
OpenTargetsiENSG00000110446
PharmGKBiPA134919658
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1237 Eukaryota
COG3104 LUCA
GeneTreeiENSGT00530000062961
HOGENOMiHOG000143436
HOVERGENiHBG108431
InParanoidiQ8IY34
KOiK14638
OMAiHHNETVS
OrthoDBiEOG091G0GF9
PhylomeDBiQ8IY34
TreeFamiTF330897

Enzyme and pathway databases

ReactomeiR-HSA-427975 Proton/oligopeptide cotransporters

Miscellaneous databases

GenomeRNAii51296
PROiPR:Q8IY34
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110446 Expressed in 149 organ(s), highest expression level in blood
CleanExiHS_SLC15A3
ExpressionAtlasiQ8IY34 baseline and differential
GenevisibleiQ8IY34 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR000109 POT_fam
PANTHERiPTHR11654 PTHR11654, 1 hit
PfamiView protein in Pfam
PF00854 PTR2, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS15A3_HUMAN
AccessioniPrimary (citable) accession number: Q8IY34
Secondary accession number(s): Q9P2X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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