UniProtKB - Q8IY34 (S15A3_HUMAN)
Protein
Solute carrier family 15 member 3
Gene
SLC15A3
Organism
Homo sapiens (Human)
Status
Functioni
Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).By similarity1 Publication
Catalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
- H+(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) = H+(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in)By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- dipeptide transmembrane transporter activity Source: UniProtKB
- peptidoglycan transmembrane transporter activity Source: UniProtKB
- symporter activity Source: UniProtKB-KW
GO - Biological processi
- dipeptide import across plasma membrane Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- ion transport Source: Reactome
- peptidoglycan transport Source: UniProtKB
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Immunity, Innate immunity, Peptide transport, Protein transport, Symport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q8IY34 |
Reactomei | R-HSA-427975, Proton/oligopeptide cotransporters |
Protein family/group databases
TCDBi | 2.A.17.3.9, the proton-dependent oligopeptide transporter (pot/ptr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 15 member 3CuratedAlternative name(s): Osteoclast transporter1 Publication Peptide transporter 31 Publication Peptide/histidine transporter 21 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000110446.9 |
HGNCi | HGNC:18068, SLC15A3 |
MIMi | 610408, gene |
neXtProti | NX_Q8IY34 |
Subcellular locationi
Endosome
- Endosome membrane By similarity; Multi-pass membrane protein Sequence analysis
Lysosome
- Lysosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Endosome
- endosome membrane Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 38 – 58 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 76 – 96 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 310 – 330 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 369 – 389 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 411 – 431 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 458 – 478 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 497 – 517 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 540 – 560 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endosome, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51296 |
OpenTargetsi | ENSG00000110446 |
PharmGKBi | PA134919658 |
Miscellaneous databases
Pharosi | Q8IY34, Tbio |
Polymorphism and mutation databases
BioMutai | SLC15A3 |
DMDMi | 296452890 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295912 | 1 – 581 | Solute carrier family 15 member 3Add BLAST | 581 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 223 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 356 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q8IY34 |
MassIVEi | Q8IY34 |
MaxQBi | Q8IY34 |
PaxDbi | Q8IY34 |
PeptideAtlasi | Q8IY34 |
PRIDEi | Q8IY34 |
ProteomicsDBi | 71102 |
PTM databases
GlyGeni | Q8IY34, 6 sites |
PhosphoSitePlusi | Q8IY34 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110446, Expressed in blood and 165 other tissues |
ExpressionAtlasi | Q8IY34, baseline and differential |
Genevisiblei | Q8IY34, HS |
Organism-specific databases
HPAi | ENSG00000110446, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8IY34
Protein-protein interaction databases
BioGRIDi | 119447, 231 interactors |
DIPi | DIP-60838N |
IntActi | Q8IY34, 8 interactors |
STRINGi | 9606.ENSP00000227880 |
Miscellaneous databases
RNActi | Q8IY34, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000161889 |
HOGENOMi | CLU_009313_6_1_1 |
InParanoidi | Q8IY34 |
OMAi | LQNCCPR |
OrthoDBi | 365203at2759 |
PhylomeDBi | Q8IY34 |
TreeFami | TF330897 |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR000109, POT_fam |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q8IY34-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF
60 70 80 90 100
GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR
110 120 130 140 150
YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR
160 170 180 190 200
SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN
210 220 230 240 250
WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV
260 270 280 290 300
FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG
310 320 330 340 350
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF
360 370 380 390 400
PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR
410 420 430 440 450
CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL
460 470 480 490 500
YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF
510 520 530 540 550
CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA
560 570 580
VTALLFVWIA GRYERASQGP ASHSRFSRDR G
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H251 | F5H251_HUMAN | Solute carrier family 15 member 3 | SLC15A3 | 209 | Annotation score: | ||
F5H1C8 | F5H1C8_HUMAN | Solute carrier family 15 member 3 | SLC15A3 hCG_40399 | 456 | Annotation score: | ||
H0YFC1 | H0YFC1_HUMAN | Solute carrier family 15 member 3 | SLC15A3 | 247 | Annotation score: | ||
F5GZ36 | F5GZ36_HUMAN | Solute carrier family 15 member 3 | SLC15A3 | 149 | Annotation score: | ||
H0YG40 | H0YG40_HUMAN | Solute carrier family 15 member 3 | SLC15A3 | 43 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034592 | 349 | I → F1 PublicationCorresponds to variant dbSNP:rs17855607Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020598 mRNA Translation: BAA93432.1 AF135600 mRNA Translation: AAQ13565.1 AP003721 Genomic DNA No translation available. BC037974 mRNA Translation: AAH37974.1 |
CCDSi | CCDS7998.1 |
RefSeqi | NP_057666.1, NM_016582.2 |
Genome annotation databases
Ensembli | ENST00000227880; ENSP00000227880; ENSG00000110446 |
GeneIDi | 51296 |
KEGGi | hsa:51296 |
UCSCi | uc001nqn.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020598 mRNA Translation: BAA93432.1 AF135600 mRNA Translation: AAQ13565.1 AP003721 Genomic DNA No translation available. BC037974 mRNA Translation: AAH37974.1 |
CCDSi | CCDS7998.1 |
RefSeqi | NP_057666.1, NM_016582.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119447, 231 interactors |
DIPi | DIP-60838N |
IntActi | Q8IY34, 8 interactors |
STRINGi | 9606.ENSP00000227880 |
Protein family/group databases
TCDBi | 2.A.17.3.9, the proton-dependent oligopeptide transporter (pot/ptr) family |
PTM databases
GlyGeni | Q8IY34, 6 sites |
PhosphoSitePlusi | Q8IY34 |
Polymorphism and mutation databases
BioMutai | SLC15A3 |
DMDMi | 296452890 |
Proteomic databases
jPOSTi | Q8IY34 |
MassIVEi | Q8IY34 |
MaxQBi | Q8IY34 |
PaxDbi | Q8IY34 |
PeptideAtlasi | Q8IY34 |
PRIDEi | Q8IY34 |
ProteomicsDBi | 71102 |
Protocols and materials databases
Antibodypediai | 50766, 98 antibodies |
Genome annotation databases
Ensembli | ENST00000227880; ENSP00000227880; ENSG00000110446 |
GeneIDi | 51296 |
KEGGi | hsa:51296 |
UCSCi | uc001nqn.3, human |
Organism-specific databases
CTDi | 51296 |
DisGeNETi | 51296 |
EuPathDBi | HostDB:ENSG00000110446.9 |
GeneCardsi | SLC15A3 |
HGNCi | HGNC:18068, SLC15A3 |
HPAi | ENSG00000110446, Low tissue specificity |
MIMi | 610408, gene |
neXtProti | NX_Q8IY34 |
OpenTargetsi | ENSG00000110446 |
PharmGKBi | PA134919658 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1237, Eukaryota |
GeneTreei | ENSGT00940000161889 |
HOGENOMi | CLU_009313_6_1_1 |
InParanoidi | Q8IY34 |
OMAi | LQNCCPR |
OrthoDBi | 365203at2759 |
PhylomeDBi | Q8IY34 |
TreeFami | TF330897 |
Enzyme and pathway databases
PathwayCommonsi | Q8IY34 |
Reactomei | R-HSA-427975, Proton/oligopeptide cotransporters |
Miscellaneous databases
BioGRID-ORCSi | 51296, 6 hits in 843 CRISPR screens |
ChiTaRSi | SLC15A3, human |
GenomeRNAii | 51296 |
Pharosi | Q8IY34, Tbio |
PROi | PR:Q8IY34 |
RNActi | Q8IY34, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110446, Expressed in blood and 165 other tissues |
ExpressionAtlasi | Q8IY34, baseline and differential |
Genevisiblei | Q8IY34, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf IPR000109, POT_fam |
PANTHERi | PTHR11654, PTHR11654, 1 hit |
Pfami | View protein in Pfam PF00854, PTR2, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S15A3_HUMAN | |
Accessioni | Q8IY34Primary (citable) accession number: Q8IY34 Secondary accession number(s): Q9P2X9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations