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Protein

Intraflagellar transport protein 20 homolog

Gene

IFT20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).By similarity2 Publications

GO - Molecular functioni

  • opsin binding Source: Ensembl
  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 20 homolog
Short name:
hIFT20
Gene namesi
Name:IFT20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000109083.13
HGNCiHGNC:30989 IFT20
MIMi614394 gene
neXtProtiNX_Q8IY31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109083
PharmGKBiPA142671663

Polymorphism and mutation databases

BioMutaiIFT20
DMDMi74728279

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493031 – 132Intraflagellar transport protein 20 homologAdd BLAST132

Proteomic databases

EPDiQ8IY31
MaxQBiQ8IY31
PaxDbiQ8IY31
PeptideAtlasiQ8IY31
PRIDEiQ8IY31
ProteomicsDBi71093
71094 [Q8IY31-2]
71095 [Q8IY31-3]
TopDownProteomicsiQ8IY31-3 [Q8IY31-3]

PTM databases

iPTMnetiQ8IY31
PhosphoSitePlusiQ8IY31

Expressioni

Tissue specificityi

Expressed in almost all tissues.1 Publication

Gene expression databases

BgeeiENSG00000109083 Expressed in 235 organ(s), highest expression level in testis
CleanExiHS_IFT20
ExpressionAtlasiQ8IY31 baseline and differential
GenevisibleiQ8IY31 HS

Organism-specific databases

HPAiHPA021376

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts directly with IFT57 and KIF3B/Kinesin II subunit (By similarity). Interacts with IFT88 (By similarity). Interacts with CEP83 (PubMed:23530209). Interacts with SPEF2 (via C-terminus) (PubMed:19889948). Interacts with CBL and CBLB (PubMed:29237719).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124711, 107 interactors
CORUMiQ8IY31
IntActiQ8IY31, 67 interactors
MINTiQ8IY31
STRINGi9606.ENSP00000350570

Structurei

3D structure databases

ProteinModelPortaliQ8IY31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 132IFT57-bindingBy similarityAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 114Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KC8U Eukaryota
ENOG4110P7T LUCA
GeneTreeiENSGT00390000003413
HOGENOMiHOG000230527
HOVERGENiHBG081781
InParanoidiQ8IY31
KOiK16473
OMAiIEADQNE
OrthoDBiEOG091G0VSN
PhylomeDBiQ8IY31
TreeFamiTF319434

Family and domain databases

InterProiView protein in InterPro
IPR028172 FT20
PANTHERiPTHR31978 PTHR31978, 1 hit
PfamiView protein in Pfam
PF14931 IFT20, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IY31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKDILGEAG LHFDELNKLR VLDPEVTQQT IELKEECKDF VDKIGQFQKI
60 70 80 90 100
VGGLIELVDQ LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK
110 120 130
KMQLERYRVE YEALCKVEAE QNEFIDQFIF QK
Length:132
Mass (Da):15,281
Last modified:March 1, 2003 - v1
Checksum:i8C751DE18FEEB30F
GO
Isoform 2 (identifier: Q8IY31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTHLLLTATVTPSEQNSSREPGWETAM

Show »
Length:158
Mass (Da):18,120
Checksum:i8CB5C24AC62F22D1
GO
Isoform 3 (identifier: Q8IY31-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-132: AIGARNLLKS...EFIDQFIFQK → SLAVSPRLEC...KENAARKVSG

Show »
Length:148
Mass (Da):15,964
Checksum:iC19CC3F33BC56CA8
GO
Isoform 4 (identifier: Q8IY31-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-132: YRVEYEALCKVEAEQNEFIDQFIFQK → NELKISLL

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):12,969
Checksum:i80A74AE1A98303BA
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QR43J3QR43_HUMAN
Intraflagellar transport protein 20...
IFT20
132Annotation score:
J3QRC6J3QRC6_HUMAN
Intraflagellar transport protein 20...
IFT20
141Annotation score:
A0A087X2B4A0A087X2B4_HUMAN
Intraflagellar transport 20 homolog...
IFT20 hCG_31823
74Annotation score:
J3QRH2J3QRH2_HUMAN
Intraflagellar transport protein 20...
IFT20
71Annotation score:
J3KRU2J3KRU2_HUMAN
Intraflagellar transport protein 20...
IFT20
85Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0203901M → MTHLLLTATVTPSEQNSSRE PGWETAM in isoform 2. 1 Publication1
Alternative sequenceiVSP_02039172 – 132AIGAR…FIFQK → SLAVSPRLECTGAISAHCKL CLSDSSDSPTSPSRVGGTTG HRCSELAQIYSKAERSSTAA TSSPNSRKENAARKVSG in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_046026107 – 132YRVEY…FIFQK → NELKISLL in isoform 4. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY224601 mRNA Translation: AAP50265.1
BQ639919 mRNA No translation available.
AC002094 Genomic DNA No translation available.
BC002640 mRNA Translation: AAH02640.1
BC038094 mRNA Translation: AAH38094.1
CCDSiCCDS32593.1 [Q8IY31-3]
CCDS58533.1 [Q8IY31-4]
CCDS58534.1 [Q8IY31-1]
CCDS58535.1 [Q8IY31-2]
RefSeqiNP_001254703.1, NM_001267774.1 [Q8IY31-2]
NP_001254704.1, NM_001267775.1 [Q8IY31-1]
NP_001254705.1, NM_001267776.1 [Q8IY31-1]
NP_001254706.1, NM_001267777.1 [Q8IY31-4]
NP_001254707.1, NM_001267778.1
NP_777547.1, NM_174887.3 [Q8IY31-3]
UniGeneiHs.705431
Hs.744876

Genome annotation databases

EnsembliENST00000357896; ENSP00000350570; ENSG00000109083 [Q8IY31-3]
ENST00000395418; ENSP00000378809; ENSG00000109083 [Q8IY31-1]
ENST00000579419; ENSP00000463322; ENSG00000109083 [Q8IY31-4]
ENST00000585089; ENSP00000464443; ENSG00000109083 [Q8IY31-2]
ENST00000585313; ENSP00000463138; ENSG00000109083 [Q8IY31-1]
GeneIDi90410
KEGGihsa:90410
UCSCiuc002hau.3 human [Q8IY31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY224601 mRNA Translation: AAP50265.1
BQ639919 mRNA No translation available.
AC002094 Genomic DNA No translation available.
BC002640 mRNA Translation: AAH02640.1
BC038094 mRNA Translation: AAH38094.1
CCDSiCCDS32593.1 [Q8IY31-3]
CCDS58533.1 [Q8IY31-4]
CCDS58534.1 [Q8IY31-1]
CCDS58535.1 [Q8IY31-2]
RefSeqiNP_001254703.1, NM_001267774.1 [Q8IY31-2]
NP_001254704.1, NM_001267775.1 [Q8IY31-1]
NP_001254705.1, NM_001267776.1 [Q8IY31-1]
NP_001254706.1, NM_001267777.1 [Q8IY31-4]
NP_001254707.1, NM_001267778.1
NP_777547.1, NM_174887.3 [Q8IY31-3]
UniGeneiHs.705431
Hs.744876

3D structure databases

ProteinModelPortaliQ8IY31
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124711, 107 interactors
CORUMiQ8IY31
IntActiQ8IY31, 67 interactors
MINTiQ8IY31
STRINGi9606.ENSP00000350570

PTM databases

iPTMnetiQ8IY31
PhosphoSitePlusiQ8IY31

Polymorphism and mutation databases

BioMutaiIFT20
DMDMi74728279

Proteomic databases

EPDiQ8IY31
MaxQBiQ8IY31
PaxDbiQ8IY31
PeptideAtlasiQ8IY31
PRIDEiQ8IY31
ProteomicsDBi71093
71094 [Q8IY31-2]
71095 [Q8IY31-3]
TopDownProteomicsiQ8IY31-3 [Q8IY31-3]

Protocols and materials databases

DNASUi90410
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357896; ENSP00000350570; ENSG00000109083 [Q8IY31-3]
ENST00000395418; ENSP00000378809; ENSG00000109083 [Q8IY31-1]
ENST00000579419; ENSP00000463322; ENSG00000109083 [Q8IY31-4]
ENST00000585089; ENSP00000464443; ENSG00000109083 [Q8IY31-2]
ENST00000585313; ENSP00000463138; ENSG00000109083 [Q8IY31-1]
GeneIDi90410
KEGGihsa:90410
UCSCiuc002hau.3 human [Q8IY31-1]

Organism-specific databases

CTDi90410
EuPathDBiHostDB:ENSG00000109083.13
GeneCardsiIFT20
HGNCiHGNC:30989 IFT20
HPAiHPA021376
MIMi614394 gene
neXtProtiNX_Q8IY31
OpenTargetsiENSG00000109083
PharmGKBiPA142671663
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC8U Eukaryota
ENOG4110P7T LUCA
GeneTreeiENSGT00390000003413
HOGENOMiHOG000230527
HOVERGENiHBG081781
InParanoidiQ8IY31
KOiK16473
OMAiIEADQNE
OrthoDBiEOG091G0VSN
PhylomeDBiQ8IY31
TreeFamiTF319434

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRSiIFT20 human
GeneWikiiIFT20
GenomeRNAii90410
PROiPR:Q8IY31
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109083 Expressed in 235 organ(s), highest expression level in testis
CleanExiHS_IFT20
ExpressionAtlasiQ8IY31 baseline and differential
GenevisibleiQ8IY31 HS

Family and domain databases

InterProiView protein in InterPro
IPR028172 FT20
PANTHERiPTHR31978 PTHR31978, 1 hit
PfamiView protein in Pfam
PF14931 IFT20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFT20_HUMAN
AccessioniPrimary (citable) accession number: Q8IY31
Secondary accession number(s): J3QL09, Q5GLZ2, Q9BUG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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