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Entry version 140 (10 Feb 2021)
Sequence version 3 (13 Jun 2006)
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Protein

Phospholipid phosphatase 6

Gene

PLPP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7-8.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8IY26

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-191273, Cholesterol biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid phosphatase 6Imported (EC:3.1.3.-)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 2
Short name:
PPAP2 domain-containing protein 2
Presqualene diphosphate phosphatase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLPP6Imported
Synonyms:PPAPDC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23682, PLPP6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611666, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY26

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000205808.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
403313

Open Targets

More...
OpenTargetsi
ENSG00000205808

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671155

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IY26, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLPP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
108860900

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002393961 – 295Phospholipid phosphatase 6Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei26PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei70PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IY26

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IY26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IY26

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IY26

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY26

PeptideAtlas

More...
PeptideAtlasi
Q8IY26

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY26

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71092

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
PLPP6

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205808, Expressed in amniotic fluid and 191 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY26, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205808, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IY26
With#Exp.IntAct
AMIGO1 [Q86WK6]3EBI-11721828,EBI-19125216
AQP6 [Q13520]3EBI-11721828,EBI-13059134
AQP8 [O94778]3EBI-11721828,EBI-19124986
BTN2A1 - isoform 4 [Q7KYR7-4]3EBI-11721828,EBI-17841208
BTNL9 - isoform 3 [Q6UXG8-3]3EBI-11721828,EBI-17953245
CD79A [P11912]3EBI-11721828,EBI-7797864
CIAO2A [Q9H5X1]3EBI-11721828,EBI-752069
CLDN15 [Q96FX9]3EBI-11721828,EBI-12867518
CLDN9 [O95484]3EBI-11721828,EBI-18341636
CLEC4M [Q9H2X3]3EBI-11721828,EBI-1391211
CLN5 [A0A024R644]3EBI-11721828,EBI-12838990
COMT [P21964]3EBI-11721828,EBI-372265
CREB3L1 [Q96BA8]5EBI-11721828,EBI-6942903
EBP [Q15125]3EBI-11721828,EBI-3915253
FAM174A [Q8TBP5]3EBI-11721828,EBI-18636064
FAM209A [Q5JX71]3EBI-11721828,EBI-18304435
FAM210B [Q96KR6]3EBI-11721828,EBI-18938272
FIMP [Q96LL3]3EBI-11721828,EBI-12887376
FKBP7 [Q9Y680]3EBI-11721828,EBI-3918971
FNDC9 [Q8TBE3]3EBI-11721828,EBI-12142257
FXYD3 - isoform 3 [Q14802-3]3EBI-11721828,EBI-12175685
GJB5 [O95377]3EBI-11721828,EBI-3909454
GKN1 [Q9NS71]3EBI-11721828,EBI-3933251
GORAB [Q5T7V8]3EBI-11721828,EBI-3917143
GPX8 [Q8TED1]3EBI-11721828,EBI-11721746
IL10RA [Q13651]3EBI-11721828,EBI-1031656
IL13RA2 [Q14627]3EBI-11721828,EBI-4320063
KASH5 [Q8N6L0]3EBI-11721828,EBI-749265
LAYN - isoform 2 [Q6UX15-2]3EBI-11721828,EBI-19944128
LDLRAD1 [Q5T700]3EBI-11721828,EBI-10173166
MMGT1 [Q8N4V1]3EBI-11721828,EBI-6163737
MS4A3 [Q96HJ5]3EBI-11721828,EBI-12806656
MUC1 - isoform Y-LSP [P15941-11]3EBI-11721828,EBI-17263240
NCR3LG1 [Q68D85]3EBI-11721828,EBI-14061804
PDGFRA - isoform 2 [P16234-2]3EBI-11721828,EBI-13380852
PDZK1IP1 [Q13113]3EBI-11721828,EBI-716063
PHACTR3 [Q96KR7]3EBI-11721828,EBI-717068
PRLR [P16471]3EBI-11721828,EBI-476182
PVR [P15151]3EBI-11721828,EBI-3919694
RETREG3 [Q86VR2]3EBI-11721828,EBI-10192441
RNF170 - isoform 5 [Q96K19-5]3EBI-11721828,EBI-12055631
RNF5 [Q99942]3EBI-11721828,EBI-348482
SEC11C [Q9BY50]3EBI-11721828,EBI-2855401
SHISAL1 [Q3SXP7]3EBI-11721828,EBI-18037857
SIGLEC12 [Q96PQ1]3EBI-11721828,EBI-17640454
SLC7A14 [Q8TBB6]3EBI-11721828,EBI-5235586
SMAGP [Q0VAQ4]3EBI-11721828,EBI-10226799
SSMEM1 [Q8WWF3]3EBI-11721828,EBI-17280858
STX1A [Q16623]3EBI-11721828,EBI-712466
SYNE4 - isoform 2 [Q8N205-2]3EBI-11721828,EBI-12099160
SYNPR [Q8TBG9]3EBI-11721828,EBI-10273251
TMEM106C [Q9BVX2]3EBI-11721828,EBI-2821497
TNFRSF10D [Q9UBN6]3EBI-11721828,EBI-1044859
VSIR [Q9H7M9]3EBI-11721828,EBI-744988

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
135624, 60 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY26, 63 interactors

Molecular INTeraction database

More...
MINTi
Q8IY26

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371307

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IY26, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4268, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160907

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072573_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY26

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVCAGEN

Database of Orthologous Groups

More...
OrthoDBi
1356295at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY26

TreeFam database of animal gene trees

More...
TreeFami
TF323272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01569, PAP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00014, acidPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48317, SSF48317, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IY26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSPRRSMEG RPLGVSASSS SSSPGSPAHG GGGGGSRFEF QSLLSSRATA
60 70 80 90 100
VDPTCARLRA SESPVHRRGS FPLAAAGPSQ SPAPPLPEED RMDLNPSFLG
110 120 130 140 150
IALRSLLAID LWLSKKLGVC AGESSSWGSV RPLMKLLEIS GHGIPWLLGT
160 170 180 190 200
LYCLCRSDSW AGREVLMNLL FALLLDLLLV ALIKGLVRRR RPAHNQMDMF
210 220 230 240 250
VTLSVDKYSF PSGHATRAAL MSRFILNHLV LAIPLRVLVV LWAFVLGLSR
260 270 280 290
VMLGRHNVTD VAFGFFLGYM QYSIVDYCWL SPHNAPVLFL LWSQR
Length:295
Mass (Da):32,194
Last modified:June 13, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92024580CE727AED
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK074672 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0506167S → G. Corresponds to variant dbSNP:rs34250374Ensembl.1
Natural variantiVAR_0506178M → T. Corresponds to variant dbSNP:rs35791393Ensembl.1
Natural variantiVAR_026645140S → W1 PublicationCorresponds to variant dbSNP:rs17857157Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK074672 mRNA No translation available.
AK128369 mRNA Translation: BAG54667.1
AL136231 Genomic DNA No translation available.
BC038108 mRNA Translation: AAH38108.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34981.1

NCBI Reference Sequences

More...
RefSeqi
NP_982278.3, NM_203453.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000381883; ENSP00000371307; ENSG00000205808

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
403313

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:403313

UCSC genome browser

More...
UCSCi
uc003zin.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074672 mRNA No translation available.
AK128369 mRNA Translation: BAG54667.1
AL136231 Genomic DNA No translation available.
BC038108 mRNA Translation: AAH38108.2
CCDSiCCDS34981.1
RefSeqiNP_982278.3, NM_203453.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi135624, 60 interactors
IntActiQ8IY26, 63 interactors
MINTiQ8IY26
STRINGi9606.ENSP00000371307

PTM databases

DEPODiPLPP6
iPTMnetiQ8IY26
PhosphoSitePlusiQ8IY26

Genetic variation databases

BioMutaiPLPP6
DMDMi108860900

Proteomic databases

EPDiQ8IY26
jPOSTiQ8IY26
MassIVEiQ8IY26
MaxQBiQ8IY26
PaxDbiQ8IY26
PeptideAtlasiQ8IY26
PRIDEiQ8IY26
ProteomicsDBi71092

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3112, 130 antibodies

Genome annotation databases

EnsembliENST00000381883; ENSP00000371307; ENSG00000205808
GeneIDi403313
KEGGihsa:403313
UCSCiuc003zin.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
403313
DisGeNETi403313

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLPP6
HGNCiHGNC:23682, PLPP6
HPAiENSG00000205808, Low tissue specificity
MIMi611666, gene
neXtProtiNX_Q8IY26
OpenTargetsiENSG00000205808
PharmGKBiPA142671155
VEuPathDBiHostDB:ENSG00000205808.5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4268, Eukaryota
GeneTreeiENSGT00940000160907
HOGENOMiCLU_072573_4_0_1
InParanoidiQ8IY26
OMAiGVCAGEN
OrthoDBi1356295at2759
PhylomeDBiQ8IY26
TreeFamiTF323272

Enzyme and pathway databases

PathwayCommonsiQ8IY26
ReactomeiR-HSA-191273, Cholesterol biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
403313, 5 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLPP6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
403313
PharosiQ8IY26, Tbio

Protein Ontology

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PROi
PR:Q8IY26
RNActiQ8IY26, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000205808, Expressed in amniotic fluid and 191 other tissues
GenevisibleiQ8IY26, HS

Family and domain databases

InterProiView protein in InterPro
IPR036938, P_Acid_Pase_2/haloperoxi_sf
IPR000326, P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569, PAP2, 1 hit
SMARTiView protein in SMART
SM00014, acidPPc, 1 hit
SUPFAMiSSF48317, SSF48317, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLPP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY26
Secondary accession number(s): B3KY05, Q5JVJ6, Q8NCK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: February 10, 2021
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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