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Protein

Phospholipid phosphatase 6

Gene

PLPP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.1 Publication

pH dependencei

Optimum pH is 7-8.1 Publication

GO - Molecular functioni

  • hydrolase activity Source: Reactome
  • lipid phosphatase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 6Imported (EC:3.1.3.-)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 2
Short name:
PPAP2 domain-containing protein 2
Presqualene diphosphate phosphatase
Gene namesi
Name:PLPP6Imported
Synonyms:PPAPDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000205808.5
HGNCiHGNC:23682 PLPP6
MIMi611666 gene
neXtProtiNX_Q8IY26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205808
PharmGKBiPA142671155

Polymorphism and mutation databases

BioMutaiPPAPDC2
DMDMi108860900

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393961 – 295Phospholipid phosphatase 6Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei70PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY26
MaxQBiQ8IY26
PaxDbiQ8IY26
PeptideAtlasiQ8IY26
PRIDEiQ8IY26
ProteomicsDBi71092

PTM databases

DEPODiQ8IY26
iPTMnetiQ8IY26
PhosphoSitePlusiQ8IY26

Expressioni

Tissue specificityi

Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.1 Publication

Gene expression databases

BgeeiENSG00000205808 Expressed in 174 organ(s), highest expression level in amniotic fluid
CleanExiHS_PPAPDC2
GenevisibleiQ8IY26 HS

Organism-specific databases

HPAiHPA018096

Interactioni

Protein-protein interaction databases

BioGridi135624, 4 interactors
IntActiQ8IY26, 52 interactors
MINTiQ8IY26
STRINGi9606.ENSP00000371307

Structurei

3D structure databases

ProteinModelPortaliQ8IY26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4268 Eukaryota
ENOG410ZVFK LUCA
GeneTreeiENSGT00390000012789
HOGENOMiHOG000231931
HOVERGENiHBG054746
InParanoidiQ8IY26
OMAiLGYMQYS
OrthoDBiEOG091G0STF
PhylomeDBiQ8IY26
TreeFamiTF323272

Family and domain databases

InterProiView protein in InterPro
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IY26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSPRRSMEG RPLGVSASSS SSSPGSPAHG GGGGGSRFEF QSLLSSRATA
60 70 80 90 100
VDPTCARLRA SESPVHRRGS FPLAAAGPSQ SPAPPLPEED RMDLNPSFLG
110 120 130 140 150
IALRSLLAID LWLSKKLGVC AGESSSWGSV RPLMKLLEIS GHGIPWLLGT
160 170 180 190 200
LYCLCRSDSW AGREVLMNLL FALLLDLLLV ALIKGLVRRR RPAHNQMDMF
210 220 230 240 250
VTLSVDKYSF PSGHATRAAL MSRFILNHLV LAIPLRVLVV LWAFVLGLSR
260 270 280 290
VMLGRHNVTD VAFGFFLGYM QYSIVDYCWL SPHNAPVLFL LWSQR
Length:295
Mass (Da):32,194
Last modified:June 13, 2006 - v3
Checksum:i92024580CE727AED
GO

Sequence cautioni

The sequence AK074672 differs from that shown. Reason: Frameshift at position 267.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0506167S → G. Corresponds to variant dbSNP:rs34250374Ensembl.1
Natural variantiVAR_0506178M → T. Corresponds to variant dbSNP:rs35791393Ensembl.1
Natural variantiVAR_026645140S → W1 PublicationCorresponds to variant dbSNP:rs17857157Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074672 mRNA No translation available.
AK128369 mRNA Translation: BAG54667.1
AL136231 Genomic DNA No translation available.
BC038108 mRNA Translation: AAH38108.2
CCDSiCCDS34981.1
RefSeqiNP_982278.3, NM_203453.3
UniGeneiHs.107510
Hs.741406

Genome annotation databases

EnsembliENST00000381883; ENSP00000371307; ENSG00000205808
GeneIDi403313
KEGGihsa:403313
UCSCiuc003zin.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074672 mRNA No translation available.
AK128369 mRNA Translation: BAG54667.1
AL136231 Genomic DNA No translation available.
BC038108 mRNA Translation: AAH38108.2
CCDSiCCDS34981.1
RefSeqiNP_982278.3, NM_203453.3
UniGeneiHs.107510
Hs.741406

3D structure databases

ProteinModelPortaliQ8IY26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135624, 4 interactors
IntActiQ8IY26, 52 interactors
MINTiQ8IY26
STRINGi9606.ENSP00000371307

PTM databases

DEPODiQ8IY26
iPTMnetiQ8IY26
PhosphoSitePlusiQ8IY26

Polymorphism and mutation databases

BioMutaiPPAPDC2
DMDMi108860900

Proteomic databases

EPDiQ8IY26
MaxQBiQ8IY26
PaxDbiQ8IY26
PeptideAtlasiQ8IY26
PRIDEiQ8IY26
ProteomicsDBi71092

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381883; ENSP00000371307; ENSG00000205808
GeneIDi403313
KEGGihsa:403313
UCSCiuc003zin.5 human

Organism-specific databases

CTDi403313
EuPathDBiHostDB:ENSG00000205808.5
GeneCardsiPLPP6
HGNCiHGNC:23682 PLPP6
HPAiHPA018096
MIMi611666 gene
neXtProtiNX_Q8IY26
OpenTargetsiENSG00000205808
PharmGKBiPA142671155
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4268 Eukaryota
ENOG410ZVFK LUCA
GeneTreeiENSGT00390000012789
HOGENOMiHOG000231931
HOVERGENiHBG054746
InParanoidiQ8IY26
OMAiLGYMQYS
OrthoDBiEOG091G0STF
PhylomeDBiQ8IY26
TreeFamiTF323272

Enzyme and pathway databases

ReactomeiR-HSA-191273 Cholesterol biosynthesis

Miscellaneous databases

GenomeRNAii403313
PROiPR:Q8IY26
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205808 Expressed in 174 organ(s), highest expression level in amniotic fluid
CleanExiHS_PPAPDC2
GenevisibleiQ8IY26 HS

Family and domain databases

InterProiView protein in InterPro
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLPP6_HUMAN
AccessioniPrimary (citable) accession number: Q8IY26
Secondary accession number(s): B3KY05, Q5JVJ6, Q8NCK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 12, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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