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UniProtKB - Q8IY21 (DDX60_HUMAN)

Entry version 146 (02 Dec 2020)
Sequence version 3 (18 May 2010)
Previous versions | rss
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Protein

Probable ATP-dependent RNA helicase DDX60

Gene

DDX60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi785 – 792ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processAntiviral defense, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IY21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX60 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000137628.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:25942, DDX60

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613974, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IY21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55601

Open Targets

More...OpenTargetsi		ENSG00000137628

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162383444

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IY21, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DDX60

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439377

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003181541 – 1712Probable ATP-dependent RNA helicase DDX60Add BLAST1712

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IY21

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IY21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IY21

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IY21

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IY21

PeptideAtlas

More...PeptideAtlasi		Q8IY21

PRoteomics IDEntifications database

More...PRIDEi		Q8IY21

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IY21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IY21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By interferon (IFN). Up-regulated during vesicular stomatitis virus (VSV), or poliovirus (PV) infection.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137628, Expressed in colon and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IY21, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IY21, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137628, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EXOSC1, EXOSC4, DDX58/RIG-I, IFIH1/MDA5 and DHX58/LGP2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120742, 76 interactors

Protein interaction database and analysis system

More...IntActi		Q8IY21, 75 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377344

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IY21, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IY21

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini772 – 939Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini1226 – 1370Helicase C-terminalPROSITE-ProRule annotationAdd BLAST145

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi889 – 892DEVH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0949, Eukaryota
KOG0950, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157188

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IY21

Identification of Orthologs from Complete Genome Data

More...OMAi		FEFYQSK

Database of Orthologous Groups

More...OrthoDBi		546283at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IY21

TreeFam database of animal gene trees

More...TreeFami		TF314846

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8IY21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERNVLTTFS QEMSQLILNE MPKAEYSSLF NDFVESEFFL IDGDSLLITC 
        60         70         80         90        100
ICEISFKPGQ NLHFFYLVER YLVDLISKGG QFTIVFFKDA EYAYFNFPEL 
       110        120        130        140        150
LSLRTALILH LQKNTTIDVR TTFSRCLSKE WGSFLEESYP YFLIVADEGL 
       160        170        180        190        200
NDLQTQLFNF LIIHSWARKV NVVLSSGQES DVLCLYAYLL PSMYRHQIFS 
       210        220        230        240        250
WKNKQNIKDA YTTLLNQLER FKLSALAPLF GSLKWNNITE EAHKTVSLLT 
       260        270        280        290        300
QVWPEGSDIR RVFCVTSCSL SLRMYHRFLG NREPSSGQET EIQQVNSNCL 
       310        320        330        340        350
TLQEMEDLCK LHCLTVVFLL HLPLSQRACA RVITSHWAED MKPLLQMKKW 
       360        370        380        390        400
CEYFILRNIH TFEFWNLNLI HLSDLNDELL LKNIAFYYEN ENVKGLHLNL 
       410        420        430        440        450
GDTIMKDYEY LWNTVSKLVR DFEVGQPFPL RTTKVCFLEK KPSPIKDSSN 
       460        470        480        490        500
EMVPNLGFIP TSSFVVDKFA GDILKDLPFL KSDDPIVTSL VKQKEFDELV 
       510        520        530        540        550
HWHSHKPLSD DYDRSRCQFD EKSRDPRVLR SVQKYHVFQR FYGNSLETVS 
       560        570        580        590        600
SKIIVTQTIK SKKDFSGPKS KKAHETKAEI IARENKKRLF AREEQKEEQK 
       610        620        630        640        650
WNALSFSIEE QLKENLHSGI KSLEDFLKSC KSSCVKLQVE MVGLTACLKA 
       660        670        680        690        700
WKEHCRSEEG KTTKDLSIAV QVMKRIHSLM EKYSELLQED DRQLIARCLK 
       710        720        730        740        750
YLGFDELASS LHPAQDAEND VKVKKRNKYS VGIGPARFQL QYMGHYLIRD 
       760        770        780        790        800
ERKDPDPRVQ DFIPDTWQRE LLDVVDKNES AVIVAPTSSG KTYASYYCME 
       810        820        830        840        850
KVLKESDDGV VVYVAPTKAL VNQVAATVQN RFTKNLPSGE VLCGVFTREY 
       860        870        880        890        900
RHDALNCQVL ITVPACFEIL LLAPHRQNWV KKIRYVIFDE VHCLGGEIGA 
       910        920        930        940        950
EIWEHLLVMI RCPFLALSAT ISNPEHLTEW LQSVKWYWKQ EDKIIENNTA 
       960        970        980        990       1000
SKRHVGRQAG FPKDYLQVKQ SYKVRLVLYG ERYNDLEKHV CSIKHGDIHF 
      1010       1020       1030       1040       1050
DHFHPCAALT TDHIERYGFP PDLTLSPRES IQLYDAMFQI WKSWPRAQEL 
      1060       1070       1080       1090       1100
CPENFIHFNN KLVIKKMDAR KYEESLKAEL TSWIKNGNVE QARMVLQNLS 
      1110       1120       1130       1140       1150
PEADLSPENM ITMFPLLVEK LRKMEKLPAL FFLFKLGAVE NAAESVSTFL 
      1160       1170       1180       1190       1200
KKKQETKRPP KADKEAHVMA NKLRKVKKSI EKQKIIDEKS QKKTRNVDQS 
      1210       1220       1230       1240       1250
LIHEAEHDNL VKCLEKNLEI PQDCTYADQK AVDTETLQKV FGRVKFERKG 
      1260       1270       1280       1290       1300
EELKALAERG IGYHHSAMSF KEKQLVEILF RKGYLRVVTA TGTLALGVNM 
      1310       1320       1330       1340       1350
PCKSVVFAQN SVYLDALNYR QMSGRAGRRG QDLMGDVYFF DIPFPKIGKL 
      1360       1370       1380       1390       1400
IKSNVPELRG HFPLSITLVL RLMLLASKGD DPEDAKAKVL SVLKHSLLSF 
      1410       1420       1430       1440       1450
KQPRVMDMLK LYFLFSLQFL VKEGYLDQEG NPMGFAGLVS HLHYHEPSNL 
      1460       1470       1480       1490       1500
VFVSFLVNGL FHDLCQPTRK GSKHFSQDVM EKLVLVLAHL FGRRYFPPKF 
      1510       1520       1530       1540       1550
QDAHFEFYQS KVFLDDLPED FSDALDEYNM KIMEDFTTFL RIVSKLADMN 
      1560       1570       1580       1590       1600
QEYQLPLSKI KFTGKECEDS QLVSHLMSCK EGRVAISPFV CLSGNFDDDL 
      1610       1620       1630       1640       1650
LRLETPNHVT LGTIGVNRSQ APVLLSQKFD NRGRKMSLNA YALDFYKHGS 
      1660       1670       1680       1690       1700
LIGLVQDNRM NEGDAYYLLK DFALTIKSIS VSLRELCENE DDNVVLAFEQ 
      1710 
LSTTFWEKLN KV
Length:1,712
Mass (Da):197,853
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F71D8E5A06D3EB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8Z7H0Y8Z7_HUMAN
Probable ATP-dependent RNA helicase...
DDX60
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R944D6R944_HUMAN
Probable ATP-dependent RNA helicase...
DDX60
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9B2H0Y9B2_HUMAN
Probable ATP-dependent RNA helicase...
DDX60
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti415V → I in BAA91809 (PubMed:14702039).Curated1
Sequence conflicti439E → G in AAH38115 (PubMed:15489334).Curated1
Sequence conflicti731V → I in AAH38115 (PubMed:15489334).Curated1
Sequence conflicti1385A → T in AAH38115 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055895672V → M. Corresponds to variant dbSNP:rs550625Ensembl.1
Natural variantiVAR_055896998I → V. Corresponds to variant dbSNP:rs576619Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC068989 Genomic DNA No translation available.
BC007820 mRNA Translation: AAH07820.1
BC038115 mRNA Translation: AAH38115.1
AK001649 mRNA Translation: BAA91809.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34097.1

NCBI Reference Sequences

More...RefSeqi		NP_060101.3, NM_017631.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000393743; ENSP00000377344; ENSG00000137628

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55601

UCSC genome browser

More...UCSCi		uc003irp.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068989 Genomic DNA No translation available.
BC007820 mRNA Translation: AAH07820.1
BC038115 mRNA Translation: AAH38115.1
AK001649 mRNA Translation: BAA91809.1
CCDSiCCDS34097.1
RefSeqiNP_060101.3, NM_017631.5

3D structure databases

SMRiQ8IY21
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120742, 76 interactors
IntActiQ8IY21, 75 interactors
STRINGi9606.ENSP00000377344

PTM databases

iPTMnetiQ8IY21
PhosphoSitePlusiQ8IY21

Polymorphism and mutation databases

BioMutaiDDX60
DMDMi296439377

Proteomic databases

EPDiQ8IY21
jPOSTiQ8IY21
MassIVEiQ8IY21
MaxQBiQ8IY21
PaxDbiQ8IY21
PeptideAtlasiQ8IY21
PRIDEiQ8IY21
ProteomicsDBi71088

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49250, 36 antibodies

Genome annotation databases

EnsembliENST00000393743; ENSP00000377344; ENSG00000137628
GeneIDi55601
KEGGihsa:55601
UCSCiuc003irp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55601
DisGeNETi55601
EuPathDBiHostDB:ENSG00000137628.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		DDX60
HGNCiHGNC:25942, DDX60
HPAiENSG00000137628, Low tissue specificity
MIMi613974, gene
neXtProtiNX_Q8IY21
OpenTargetsiENSG00000137628
PharmGKBiPA162383444

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0949, Eukaryota
KOG0950, Eukaryota
GeneTreeiENSGT00940000157188
HOGENOMiCLU_002305_0_0_1
InParanoidiQ8IY21
OMAiFEFYQSK
OrthoDBi546283at2759
PhylomeDBiQ8IY21
TreeFamiTF314846

Enzyme and pathway databases

PathwayCommonsiQ8IY21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55601, 6 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DDX60, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55601
PharosiQ8IY21, Tbio

Protein Ontology

More...PROi		PR:Q8IY21
RNActiQ8IY21, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137628, Expressed in colon and 222 other tissues
ExpressionAtlasiQ8IY21, baseline and differential
GenevisibleiQ8IY21, HS

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX60_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY21
Secondary accession number(s): Q6PK35, Q9NVE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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