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Entry version 146 (02 Dec 2020)
Sequence version 3 (18 May 2010)
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Protein

Probable ATP-dependent RNA helicase DDX60

Gene

DDX60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi785 – 792ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processAntiviral defense, Immunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IY21

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX60 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDX60
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000137628.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25942, DDX60

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613974, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IY21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55601

Open Targets

More...
OpenTargetsi
ENSG00000137628

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162383444

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IY21, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDX60

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439377

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003181541 – 1712Probable ATP-dependent RNA helicase DDX60Add BLAST1712

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IY21

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IY21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IY21

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IY21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IY21

PeptideAtlas

More...
PeptideAtlasi
Q8IY21

PRoteomics IDEntifications database

More...
PRIDEi
Q8IY21

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71088

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IY21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IY21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, lymph node, prostate, stomach, thyroid, tongue, trachea, uterus, skeletal muscle, spleen, kidney, liver and small intestine.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By interferon (IFN). Up-regulated during vesicular stomatitis virus (VSV), or poliovirus (PV) infection.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137628, Expressed in colon and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IY21, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IY21, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137628, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EXOSC1, EXOSC4, DDX58/RIG-I, IFIH1/MDA5 and DHX58/LGP2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120742, 76 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IY21, 75 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377344

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IY21, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IY21

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini772 – 939Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini1226 – 1370Helicase C-terminalPROSITE-ProRule annotationAdd BLAST145

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi889 – 892DEVH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0949, Eukaryota
KOG0950, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157188

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IY21

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEFYQSK

Database of Orthologous Groups

More...
OrthoDBi
546283at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IY21

TreeFam database of animal gene trees

More...
TreeFami
TF314846

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8IY21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERNVLTTFS QEMSQLILNE MPKAEYSSLF NDFVESEFFL IDGDSLLITC
60 70 80 90 100
ICEISFKPGQ NLHFFYLVER YLVDLISKGG QFTIVFFKDA EYAYFNFPEL
110 120 130 140 150
LSLRTALILH LQKNTTIDVR TTFSRCLSKE WGSFLEESYP YFLIVADEGL
160 170 180 190 200
NDLQTQLFNF LIIHSWARKV NVVLSSGQES DVLCLYAYLL PSMYRHQIFS
210 220 230 240 250
WKNKQNIKDA YTTLLNQLER FKLSALAPLF GSLKWNNITE EAHKTVSLLT
260 270 280 290 300
QVWPEGSDIR RVFCVTSCSL SLRMYHRFLG NREPSSGQET EIQQVNSNCL
310 320 330 340 350
TLQEMEDLCK LHCLTVVFLL HLPLSQRACA RVITSHWAED MKPLLQMKKW
360 370 380 390 400
CEYFILRNIH TFEFWNLNLI HLSDLNDELL LKNIAFYYEN ENVKGLHLNL
410 420 430 440 450
GDTIMKDYEY LWNTVSKLVR DFEVGQPFPL RTTKVCFLEK KPSPIKDSSN
460 470 480 490 500
EMVPNLGFIP TSSFVVDKFA GDILKDLPFL KSDDPIVTSL VKQKEFDELV
510 520 530 540 550
HWHSHKPLSD DYDRSRCQFD EKSRDPRVLR SVQKYHVFQR FYGNSLETVS
560 570 580 590 600
SKIIVTQTIK SKKDFSGPKS KKAHETKAEI IARENKKRLF AREEQKEEQK
610 620 630 640 650
WNALSFSIEE QLKENLHSGI KSLEDFLKSC KSSCVKLQVE MVGLTACLKA
660 670 680 690 700
WKEHCRSEEG KTTKDLSIAV QVMKRIHSLM EKYSELLQED DRQLIARCLK
710 720 730 740 750
YLGFDELASS LHPAQDAEND VKVKKRNKYS VGIGPARFQL QYMGHYLIRD
760 770 780 790 800
ERKDPDPRVQ DFIPDTWQRE LLDVVDKNES AVIVAPTSSG KTYASYYCME
810 820 830 840 850
KVLKESDDGV VVYVAPTKAL VNQVAATVQN RFTKNLPSGE VLCGVFTREY
860 870 880 890 900
RHDALNCQVL ITVPACFEIL LLAPHRQNWV KKIRYVIFDE VHCLGGEIGA
910 920 930 940 950
EIWEHLLVMI RCPFLALSAT ISNPEHLTEW LQSVKWYWKQ EDKIIENNTA
960 970 980 990 1000
SKRHVGRQAG FPKDYLQVKQ SYKVRLVLYG ERYNDLEKHV CSIKHGDIHF
1010 1020 1030 1040 1050
DHFHPCAALT TDHIERYGFP PDLTLSPRES IQLYDAMFQI WKSWPRAQEL
1060 1070 1080 1090 1100
CPENFIHFNN KLVIKKMDAR KYEESLKAEL TSWIKNGNVE QARMVLQNLS
1110 1120 1130 1140 1150
PEADLSPENM ITMFPLLVEK LRKMEKLPAL FFLFKLGAVE NAAESVSTFL
1160 1170 1180 1190 1200
KKKQETKRPP KADKEAHVMA NKLRKVKKSI EKQKIIDEKS QKKTRNVDQS
1210 1220 1230 1240 1250
LIHEAEHDNL VKCLEKNLEI PQDCTYADQK AVDTETLQKV FGRVKFERKG
1260 1270 1280 1290 1300
EELKALAERG IGYHHSAMSF KEKQLVEILF RKGYLRVVTA TGTLALGVNM
1310 1320 1330 1340 1350
PCKSVVFAQN SVYLDALNYR QMSGRAGRRG QDLMGDVYFF DIPFPKIGKL
1360 1370 1380 1390 1400
IKSNVPELRG HFPLSITLVL RLMLLASKGD DPEDAKAKVL SVLKHSLLSF
1410 1420 1430 1440 1450
KQPRVMDMLK LYFLFSLQFL VKEGYLDQEG NPMGFAGLVS HLHYHEPSNL
1460 1470 1480 1490 1500
VFVSFLVNGL FHDLCQPTRK GSKHFSQDVM EKLVLVLAHL FGRRYFPPKF
1510 1520 1530 1540 1550
QDAHFEFYQS KVFLDDLPED FSDALDEYNM KIMEDFTTFL RIVSKLADMN
1560 1570 1580 1590 1600
QEYQLPLSKI KFTGKECEDS QLVSHLMSCK EGRVAISPFV CLSGNFDDDL
1610 1620 1630 1640 1650
LRLETPNHVT LGTIGVNRSQ APVLLSQKFD NRGRKMSLNA YALDFYKHGS
1660 1670 1680 1690 1700
LIGLVQDNRM NEGDAYYLLK DFALTIKSIS VSLRELCENE DDNVVLAFEQ
1710
LSTTFWEKLN KV
Length:1,712
Mass (Da):197,853
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F71D8E5A06D3EB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8Z7H0Y8Z7_HUMAN
Probable ATP-dependent RNA helicase...
DDX60
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R944D6R944_HUMAN
Probable ATP-dependent RNA helicase...
DDX60
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9B2H0Y9B2_HUMAN
Probable ATP-dependent RNA helicase...
DDX60
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti415V → I in BAA91809 (PubMed:14702039).Curated1
Sequence conflicti439E → G in AAH38115 (PubMed:15489334).Curated1
Sequence conflicti731V → I in AAH38115 (PubMed:15489334).Curated1
Sequence conflicti1385A → T in AAH38115 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055895672V → M. Corresponds to variant dbSNP:rs550625Ensembl.1
Natural variantiVAR_055896998I → V. Corresponds to variant dbSNP:rs576619Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC068989 Genomic DNA No translation available.
BC007820 mRNA Translation: AAH07820.1
BC038115 mRNA Translation: AAH38115.1
AK001649 mRNA Translation: BAA91809.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34097.1

NCBI Reference Sequences

More...
RefSeqi
NP_060101.3, NM_017631.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393743; ENSP00000377344; ENSG00000137628

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55601

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55601

UCSC genome browser

More...
UCSCi
uc003irp.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068989 Genomic DNA No translation available.
BC007820 mRNA Translation: AAH07820.1
BC038115 mRNA Translation: AAH38115.1
AK001649 mRNA Translation: BAA91809.1
CCDSiCCDS34097.1
RefSeqiNP_060101.3, NM_017631.5

3D structure databases

SMRiQ8IY21
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120742, 76 interactors
IntActiQ8IY21, 75 interactors
STRINGi9606.ENSP00000377344

PTM databases

iPTMnetiQ8IY21
PhosphoSitePlusiQ8IY21

Polymorphism and mutation databases

BioMutaiDDX60
DMDMi296439377

Proteomic databases

EPDiQ8IY21
jPOSTiQ8IY21
MassIVEiQ8IY21
MaxQBiQ8IY21
PaxDbiQ8IY21
PeptideAtlasiQ8IY21
PRIDEiQ8IY21
ProteomicsDBi71088

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49250, 36 antibodies

Genome annotation databases

EnsembliENST00000393743; ENSP00000377344; ENSG00000137628
GeneIDi55601
KEGGihsa:55601
UCSCiuc003irp.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55601
DisGeNETi55601
EuPathDBiHostDB:ENSG00000137628.16

GeneCards: human genes, protein and diseases

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GeneCardsi
DDX60
HGNCiHGNC:25942, DDX60
HPAiENSG00000137628, Low tissue specificity
MIMi613974, gene
neXtProtiNX_Q8IY21
OpenTargetsiENSG00000137628
PharmGKBiPA162383444

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0949, Eukaryota
KOG0950, Eukaryota
GeneTreeiENSGT00940000157188
HOGENOMiCLU_002305_0_0_1
InParanoidiQ8IY21
OMAiFEFYQSK
OrthoDBi546283at2759
PhylomeDBiQ8IY21
TreeFamiTF314846

Enzyme and pathway databases

PathwayCommonsiQ8IY21

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55601, 6 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DDX60, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55601
PharosiQ8IY21, Tbio

Protein Ontology

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PROi
PR:Q8IY21
RNActiQ8IY21, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137628, Expressed in colon and 222 other tissues
ExpressionAtlasiQ8IY21, baseline and differential
GenevisibleiQ8IY21, HS

Family and domain databases

InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF00271, Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX60_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IY21
Secondary accession number(s): Q6PK35, Q9NVE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: December 2, 2020
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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