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Protein

Transcription factor Sp8

Gene

SP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri314 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri344 – 368C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri374 – 396C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp8
Alternative name(s):
Specificity protein 8
Gene namesi
Name:SP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000164651.16
HGNCiHGNC:19196 SP8
MIMi608306 gene
neXtProtiNX_Q8IXZ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221833
OpenTargetsiENSG00000164651
PharmGKBiPA134893390

Polymorphism and mutation databases

BioMutaiSP8
DMDMi300669678

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471521 – 490Transcription factor Sp8Add BLAST490

Proteomic databases

EPDiQ8IXZ3
PaxDbiQ8IXZ3
PeptideAtlasiQ8IXZ3
PRIDEiQ8IXZ3
ProteomicsDBi71080
71081 [Q8IXZ3-1]
71082 [Q8IXZ3-2]

PTM databases

iPTMnetiQ8IXZ3
PhosphoSitePlusiQ8IXZ3

Expressioni

Gene expression databases

BgeeiENSG00000164651 Expressed in 58 organ(s), highest expression level in forebrain
CleanExiHS_SP8
ExpressionAtlasiQ8IXZ3 baseline and differential
GenevisibleiQ8IXZ3 HS

Organism-specific databases

HPAiHPA054006

Interactioni

Protein-protein interaction databases

BioGridi128760, 3 interactors
IntActiQ8IXZ3, 1 interactor
MINTiQ8IXZ3
STRINGi9606.ENSP00000408792

Structurei

3D structure databases

ProteinModelPortaliQ8IXZ3
SMRiQ8IXZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 114Ser-richAdd BLAST104
Compositional biasi68 – 81Ala-richAdd BLAST14

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri314 – 338C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri344 – 368C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri374 – 396C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG036899
InParanoidiQ8IXZ3
KOiK09198
OMAiSYPDTSP
OrthoDBiEOG091G0HX6
PhylomeDBiQ8IXZ3
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: Q8IXZ3-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAATCNKIG SPSPSPSSLS DSSSSFGKGF HPWKRSSSSS SASCNVVGSS
60 70 80 90 100
LSSFGVSGAS RNGGSSSAAA AAAAAAAAAA ALVSDSFSCG GSPGSSAFSL
110 120 130 140 150
TSSSAAAAAA AAAAAASSSP FANDYSVFQA PGVSGGSGGG GGGGGGGSSA
160 170 180 190 200
HSQDGSHQPV FISKVHTSVD GLQGIYPRVG MAHPYESWFK PSHPGLGAAG
210 220 230 240 250
EVGSAGASSW WDVGAGWIDV QNPNSAAALP GSLHPAAGGL QTSLHSPLGG
260 270 280 290 300
YNSDYSGLSH SAFSSGASSH LLSPAGQHLM DGFKPVLPGS YPDSAPSPLA
310 320 330 340 350
GAGGSMLSAG PSAPLGGSPR SSARRYSGRA TCDCPNCQEA ERLGPAGASL
360 370 380 390 400
RRKGLHSCHI PGCGKVYGKT SHLKAHLRWH TGERPFVCNW LFCGKRFTRS
410 420 430 440 450
DELQRHLRTH TGEKRFACPV CNKRFMRSDH LSKHVKTHSG GGGGGGSAGS
460 470 480 490
GSGGKKGSDT DSEHSAAGSP PCHSPELLQP PEPGHRNGLE
Length:490
Mass (Da):48,674
Last modified:July 13, 2010 - v3
Checksum:i8FB659057C6F8E58
GO
Isoform 1 (identifier: Q8IXZ3-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-145: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):45,235
Checksum:i23D3E1CE4DBBE0AE
GO
Isoform 2 (identifier: Q8IXZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-147: Missing.

Note: No experimental confirmation available.
Show »
Length:434
Mass (Da):44,012
Checksum:i8D1AC12A65A89605
GO
Isoform 4 (identifier: Q8IXZ3-4) [UniParc]FASTAAdd to basket
Also known as: Sp8L

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MATSLLGEEPRLGSTPLAM

Show »
Length:508
Mass (Da):50,500
Checksum:i99C8728AA08D139F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Q6A0A087X0Q6_HUMAN
Sp8 transcription factor, isoform C...
SP8 hCG_38927
466Annotation score:

Sequence cautioni

The sequence BAB71297 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti430H → R in BC038669 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0440941M → MATSLLGEEPRLGSTPLAM in isoform 4. 1 Publication1
Alternative sequenceiVSP_00744192 – 147Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_011036104 – 145Missing in isoform 1. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167047 mRNA Translation: AAO38028.1
AY167048 mRNA Translation: AAO38029.1
AK056857 mRNA Translation: BAB71297.1 Different initiation.
CH471073 Genomic DNA Translation: EAW93731.1
BC038669 mRNA No translation available.
CCDSiCCDS43555.1 [Q8IXZ3-4]
CCDS5372.1 [Q8IXZ3-3]
RefSeqiNP_874359.2, NM_182700.5 [Q8IXZ3-4]
NP_945194.1, NM_198956.3 [Q8IXZ3-3]
UniGeneiHs.195922

Genome annotation databases

EnsembliENST00000361443; ENSP00000354482; ENSG00000164651 [Q8IXZ3-3]
ENST00000418710; ENSP00000408792; ENSG00000164651 [Q8IXZ3-4]
GeneIDi221833
KEGGihsa:221833
UCSCiuc022aak.3 human [Q8IXZ3-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167047 mRNA Translation: AAO38028.1
AY167048 mRNA Translation: AAO38029.1
AK056857 mRNA Translation: BAB71297.1 Different initiation.
CH471073 Genomic DNA Translation: EAW93731.1
BC038669 mRNA No translation available.
CCDSiCCDS43555.1 [Q8IXZ3-4]
CCDS5372.1 [Q8IXZ3-3]
RefSeqiNP_874359.2, NM_182700.5 [Q8IXZ3-4]
NP_945194.1, NM_198956.3 [Q8IXZ3-3]
UniGeneiHs.195922

3D structure databases

ProteinModelPortaliQ8IXZ3
SMRiQ8IXZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128760, 3 interactors
IntActiQ8IXZ3, 1 interactor
MINTiQ8IXZ3
STRINGi9606.ENSP00000408792

PTM databases

iPTMnetiQ8IXZ3
PhosphoSitePlusiQ8IXZ3

Polymorphism and mutation databases

BioMutaiSP8
DMDMi300669678

Proteomic databases

EPDiQ8IXZ3
PaxDbiQ8IXZ3
PeptideAtlasiQ8IXZ3
PRIDEiQ8IXZ3
ProteomicsDBi71080
71081 [Q8IXZ3-1]
71082 [Q8IXZ3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361443; ENSP00000354482; ENSG00000164651 [Q8IXZ3-3]
ENST00000418710; ENSP00000408792; ENSG00000164651 [Q8IXZ3-4]
GeneIDi221833
KEGGihsa:221833
UCSCiuc022aak.3 human [Q8IXZ3-3]

Organism-specific databases

CTDi221833
DisGeNETi221833
EuPathDBiHostDB:ENSG00000164651.16
GeneCardsiSP8
HGNCiHGNC:19196 SP8
HPAiHPA054006
MIMi608306 gene
neXtProtiNX_Q8IXZ3
OpenTargetsiENSG00000164651
PharmGKBiPA134893390
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG036899
InParanoidiQ8IXZ3
KOiK09198
OMAiSYPDTSP
OrthoDBiEOG091G0HX6
PhylomeDBiQ8IXZ3
TreeFamiTF350150

Miscellaneous databases

GeneWikiiSp8_transcription_factor
GenomeRNAii221833
PROiPR:Q8IXZ3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164651 Expressed in 58 organ(s), highest expression level in forebrain
CleanExiHS_SP8
ExpressionAtlasiQ8IXZ3 baseline and differential
GenevisibleiQ8IXZ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP8_HUMAN
AccessioniPrimary (citable) accession number: Q8IXZ3
Secondary accession number(s): Q7Z615, Q7Z616, Q96MJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: July 13, 2010
Last modified: November 7, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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