Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Problable inactive peptidyl-prolyl cis-trans isomerase-like 6

Gene

PPIL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.1 Publication

Caution

Despite the fact that it belongs to the cyclophilin-type PPIase family, a report has shown that it has probably no peptidyl-prolyl cis-trans isomerase activity.1 Publication

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Problable inactive peptidyl-prolyl cis-trans isomerase-like 61 Publication
Short name:
PPIase1 Publication
Alternative name(s):
Cyclophilin-like protein PPIL6Imported
Rotamase PPIL6
Gene namesi
Name:PPIL6Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000185250.15
HGNCiHGNC:21557 PPIL6
neXtProtiNX_Q8IXY8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185250
PharmGKBiPA134939571

Polymorphism and mutation databases

BioMutaiPPIL6
DMDMi74762491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637551 – 311Problable inactive peptidyl-prolyl cis-trans isomerase-like 6Add BLAST311

Proteomic databases

PeptideAtlasiQ8IXY8
PRIDEiQ8IXY8
ProteomicsDBi71076
71077 [Q8IXY8-2]

PTM databases

iPTMnetiQ8IXY8
PhosphoSitePlusiQ8IXY8

Expressioni

Gene expression databases

BgeeiENSG00000185250
CleanExiHS_PPIL6
ExpressionAtlasiQ8IXY8 baseline and differential
GenevisibleiQ8IXY8 HS

Organism-specific databases

HPAiHPA036717

Interactioni

Protein-protein interaction databases

IntActiQ8IXY8, 4 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8IXY8
SMRiQ8IXY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 308PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Phylogenomic databases

GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG056776
InParanoidiQ8IXY8
KOiK12739
OMAiKGRHSNG
OrthoDBiEOG091G0BGL
PhylomeDBiQ8IXY8
TreeFamiTF351326

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN
60 70 80 90 100
HPSKFEDPIL VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG
110 120 130 140 150
DALDLQKWAH EVWDIVDIKP SALYDALTED FSAKFLRDTK HDFVFLDICI
160 170 180 190 200
DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG KAGFSQRGIR LHYKNSIFHR
210 220 230 240 250
IVQNGWIQGG DIVYGKGDNG ESIYGPTFED ENFSVPHNKR GVLGMANKGR
260 270 280 290 300
HSNGSQFYIT LQATPYLDRK FVAFGQLIEG TEVLKQLELV PTQNERPIHM
310
CRITDSGDPY A
Length:311
Mass (Da):35,228
Last modified:March 1, 2003 - v1
Checksum:i034E81BD5D077148
GO
Isoform 2 (identifier: Q8IXY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: E → EELYGSLKRSVKRQKESRGVGKIEKYR

Note: No experimental confirmation available.
Show »
Length:337
Mass (Da):38,306
Checksum:i367792C3788259C5
GO
Isoform 3 (identifier: Q8IXY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-77: Missing.

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:279
Mass (Da):31,298
Checksum:i990B706D9590BE4E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029620110H → R. Corresponds to variant dbSNP:rs9398200Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05565846 – 77Missing in isoform 3. CuratedAdd BLAST32
Alternative sequenceiVSP_043036229E → EELYGSLKRSVKRQKESRGV GKIEKYR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ363562 mRNA Translation: ABC88651.1
DQ423529 mRNA Translation: ABD83948.1
AL109947 Genomic DNA No translation available.
AL359711 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48347.1
BC038716 mRNA Translation: AAH38716.1
CCDSiCCDS47466.2 [Q8IXY8-2]
CCDS5074.1 [Q8IXY8-1]
CCDS69169.1 [Q8IXY8-3]
RefSeqiNP_001104768.2, NM_001111298.2 [Q8IXY8-2]
NP_001273289.1, NM_001286360.1 [Q8IXY8-3]
NP_001273290.1, NM_001286361.1
NP_775943.1, NM_173672.4 [Q8IXY8-1]
UniGeneiHs.32234

Genome annotation databases

EnsembliENST00000424445; ENSP00000407731; ENSG00000185250 [Q8IXY8-3]
ENST00000440797; ENSP00000392257; ENSG00000185250 [Q8IXY8-2]
ENST00000521072; ENSP00000427929; ENSG00000185250 [Q8IXY8-1]
GeneIDi285755
KEGGihsa:285755
UCSCiuc003ptg.4 human [Q8IXY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPPIL6_HUMAN
AccessioniPrimary (citable) accession number: Q8IXY8
Secondary accession number(s): A9NIU0, A9NIU9, E7EX15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health