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Protein

Solute carrier family 35 member F2

Gene

SLC35F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative solute transporter.Curated

GO - Molecular functioni

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.24.10 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F2
Gene namesi
Name:SLC35F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110660.14
HGNCiHGNC:23615 SLC35F2
neXtProtiNX_Q8IXU6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei108 – 126HelicalSequence analysisAdd BLAST19
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54733
OpenTargetsiENSG00000110660
PharmGKBiPA134945023

Polymorphism and mutation databases

BioMutaiSLC35F2
DMDMi74728243

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073091 – 374Solute carrier family 35 member F2Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IXU6
MaxQBiQ8IXU6
PaxDbiQ8IXU6
PeptideAtlasiQ8IXU6
PRIDEiQ8IXU6
ProteomicsDBi71065
71066 [Q8IXU6-2]
71067 [Q8IXU6-3]

PTM databases

iPTMnetiQ8IXU6
PhosphoSitePlusiQ8IXU6

Expressioni

Gene expression databases

BgeeiENSG00000110660
CleanExiHS_SLC35F2
ExpressionAtlasiQ8IXU6 baseline and differential
GenevisibleiQ8IXU6 HS

Organism-specific databases

HPAiHPA048185
HPA050695

Interactioni

Protein-protein interaction databases

BioGridi120116, 23 interactors
IntActiQ8IXU6, 1 interactor
STRINGi9606.ENSP00000393571

Structurei

3D structure databases

ProteinModelPortaliQ8IXU6
SMRiQ8IXU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2766 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00390000015655
HOGENOMiHOG000241333
HOVERGENiHBG058983
InParanoidiQ8IXU6
KOiK15287
OMAiWKYIILA
OrthoDBiEOG091G0O0G
PhylomeDBiQ8IXU6
TreeFamiTF313645

Family and domain databases

InterProiView protein in InterPro
IPR009262 SLC35_F1/F2/F6
PfamiView protein in Pfam
PF06027 SLC35F, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEADSPAGPG APEPLAEGAA AEFSSLLRRI KGKLFTWNIL KTIALGQMLS
60 70 80 90 100
LCICGTAITS QYLAERYKVN TPMLQSFINY CLLFLIYTVM LAFRSGSDNL
110 120 130 140 150
LVILKRKWWK YILLGLADVE ANYVIVRAYQ YTTLTSVQLL DCFGIPVLMA
160 170 180 190 200
LSWFILHARY RVIHFIAVAV CLLGVGTMVG ADILAGREDN SGSDVLIGDI
210 220 230 240 250
LVLLGASLYA ISNVCEEYIV KKLSRQEFLG MVGLFGTIIS GIQLLIVEYK
260 270 280 290 300
DIASIHWDWK IALLFVAFAL CMFCLYSFMP LVIKVTSATS VNLGILTADL
310 320 330 340 350
YSLFVGLFLF GYKFSGLYIL SFTVIMVGFI LYCSTPTRTA EPAESSVPPV
360 370
TSIGIDNLGL KLEENLQETH SAVL
Length:374
Mass (Da):41,212
Last modified:March 1, 2003 - v1
Checksum:iADBF0F42F2DC7998
GO
Isoform 2 (identifier: Q8IXU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-358: FSGLYILSFT...PVTSIGIDNL → DSTSCPSLSS...QSPALGLTTW
     360-374: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):39,229
Checksum:i5C31F073D3E2E7C7
GO
Isoform 3 (identifier: Q8IXU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):36,305
Checksum:iD0737B61B9E583F8
GO

Sequence cautioni

The sequence CAA68226 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48M → T in BAB14394 (PubMed:14702039).Curated1
Sequence conflicti133T → A in CAA68226 (PubMed:9119394).Curated1
Sequence conflicti191S → SG in CAI46204 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0286991 – 47Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_028700314 – 358FSGLY…GIDNL → DSTSCPSLSSWWGLSCTAPP LLARPSRLKAACLQSPALGL TTW in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_028701360 – 374Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023080 mRNA Translation: BAB14394.1
AK128062 mRNA Translation: BAC87256.1
BC039195 mRNA Translation: AAH39195.1
BC048302 mRNA Translation: AAH48302.1
AL833969 Transcribed RNA Translation: CAI46204.1
X99961 mRNA Translation: CAA68226.1 Different initiation.
CCDSiCCDS41709.1 [Q8IXU6-1]
RefSeqiNP_059985.2, NM_017515.4 [Q8IXU6-1]
UniGeneiHs.524014

Genome annotation databases

EnsembliENST00000375682; ENSP00000364834; ENSG00000110660 [Q8IXU6-3]
ENST00000525071; ENSP00000434307; ENSG00000110660 [Q8IXU6-2]
ENST00000525815; ENSP00000436785; ENSG00000110660 [Q8IXU6-1]
GeneIDi54733
KEGGihsa:54733
UCSCiuc001pjq.3 human [Q8IXU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35F2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXU6
Secondary accession number(s): Q14963
, Q5JPA8, Q6ZRQ3, Q9H947
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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