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Entry version 154 (07 Oct 2020)
Sequence version 2 (25 Nov 2008)
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Protein

RNA-binding protein 12B

Gene

RBM12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8IXT5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 12B
Alternative name(s):
RNA-binding motif protein 12B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM12B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183808.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32310, RBM12B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IXT5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
389677

Open Targets

More...
OpenTargetsi
ENSG00000183808

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IXT5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBM12B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273872

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002733661 – 1001RNA-binding protein 12BAdd BLAST1001

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei98PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei250PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei276PhosphothreonineCombined sources1
Modified residuei278PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei319N6-acetyllysineCombined sources1
Cross-linki335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei377PhosphoserineCombined sources1
Cross-linki514Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei575PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei640PhosphothreonineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Cross-linki895Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IXT5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IXT5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IXT5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IXT5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IXT5

PeptideAtlas

More...
PeptideAtlasi
Q8IXT5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IXT5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
71064

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IXT5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IXT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183808, Expressed in kidney and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IXT5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IXT5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183808, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
133227, 46 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IXT5, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382239

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IXT5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 230RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini284 – 360RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini400 – 477RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini925 – 1001RRM 4PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4307, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158322

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IXT5

Identification of Orthologs from Complete Genome Data

More...
OMAi
SENFRHQ

Database of Orthologous Groups

More...
OrthoDBi
249376at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IXT5

TreeFam database of animal gene trees

More...
TreeFami
TF331899

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12746, RRM2_RBM12B, 1 hit
cd12513, RRM3_RBM12B, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034588, RBM12B_RRM2
IPR034858, RBM12B_RRM3
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360, RRM, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8IXT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVVIRLLGL PFIAGPVDIR HFFTGLTIPD GGVHIIGGEI GEAFIIFATD
60 70 80 90 100
EDARRAISRS GGFIKDSSVE LFLSSKAEMQ KTIEMKRTDR VGRGRPGSGT
110 120 130 140 150
SGVDSLSNFI ESVKEEASNS GYGSSINQDA GFHTNGTGHG NLRPRKTRPL
160 170 180 190 200
KAENPYLFLR GLPYLVNEDD VRVFFSGLCV DGVIFLKHHD GRNNGDAIVK
210 220 230 240 250
FASCVDASGG LKCHRSFMGS RFIEVMQGSE QQWIEFGGNA VKEGDVLRRS
260 270 280 290 300
EEHSPPRGIN DRHFRKRSHS KSPRRTRSRS PLGFYVHLKN LSLSIDERDL
310 320 330 340 350
RNFFRGTDLT DEQIRFLYKD ENRTRYAFVM FKTLKDYNTA LSLHKTVLQY
360 370 380 390 400
RPVHIDPISR KQMLKFIARY EKKRSGSLER DRPGHVSQKY SQEGNSGQKL
410 420 430 440 450
CIYIRNFPFD VTKVEVQKFF ADFLLAEDDI YLLYDDKGVG LGEALVKFKS
460 470 480 490 500
EEQAMKAERL NRRRFLGTEV LLRLISEAQI QEFGVNFSVM SSEKMQARSQ
510 520 530 540 550
SRERGDHSHL FDSKDPPIYS VGAFENFRHQ LEDLRQLDNF KHPQRDFRQP
560 570 580 590 600
DRHPPEDFRH SSEDFRFPPE DFRHSPEDFR RPREEDFRRP SEEDFRRPWE
610 620 630 640 650
EDFRRPPEDD FRHPREEDWR RPLEEDWRRP LEEDFRRSPT EDFRQLPEED
660 670 680 690 700
FRQPPEEDLR WLPEEDFRRP PEEDWRRPPE EDFRRPLQGE WRRPPEDDFR
710 720 730 740 750
RPPEEDFRHS PEEDFRQSPQ EHFRRPPQEH FRRPPPEHFR RPPPEHFRRP
760 770 780 790 800
PPEHFRRPPP EHFRRPPPEH FRRPPPEHFR RPPQEHFRRP PQEHFRRSRE
810 820 830 840 850
EDFRHPPDED FRGPPDEDFR HPPDEDFRSP QEEDFRCPSD EDFRQLPEED
860 870 880 890 900
LREAPEEDPR LPDNFRPPGE DFRSPPDDFR SHRPFVNFGR PEGGKFDFGK
910 920 930 940 950
HNMGSFPEGR FMPDPKINCG SGRVTPIKIM NLPFKANVNE ILDFFHGYRI
960 970 980 990 1000
IPDSVSIQYN EQGLPTGEAI VAMINYNEAM AAIKDLNDRP VGPRKVKLTL

L
Length:1,001
Mass (Da):118,103
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA09C527B1A1EE845
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9ZVT1B9ZVT1_HUMAN
RNA-binding protein 12B
RBM12B
881Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJV8E5RJV8_HUMAN
RNA-binding protein 12B
RBM12B
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHG1E5RHG1_HUMAN
RNA-binding protein 12B
RBM12B
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ83E5RJ83_HUMAN
RNA-binding protein 12B
RBM12B
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJW8E5RJW8_HUMAN
RNA-binding protein 12B
RBM12B
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047291250S → F. Corresponds to variant dbSNP:rs17853906Ensembl.1
Natural variantiVAR_047292605R → C. Corresponds to variant dbSNP:rs17857188Ensembl.1
Natural variantiVAR_052219864N → H. Corresponds to variant dbSNP:rs16916188Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010834 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43755.1

NCBI Reference Sequences

More...
RefSeqi
NP_976324.2, NM_203390.2
XP_005250972.1, XM_005250915.4
XP_011515329.1, XM_011517027.2
XP_011515330.1, XM_011517028.2
XP_011515331.1, XM_011517029.2
XP_016868895.1, XM_017013406.1
XP_016868896.1, XM_017013407.1
XP_016868897.1, XM_017013408.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399300; ENSP00000382239; ENSG00000183808

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389677

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389677

UCSC genome browser

More...
UCSCi
uc003yfz.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010834 Genomic DNA No translation available.
CCDSiCCDS43755.1
RefSeqiNP_976324.2, NM_203390.2
XP_005250972.1, XM_005250915.4
XP_011515329.1, XM_011517027.2
XP_011515330.1, XM_011517028.2
XP_011515331.1, XM_011517029.2
XP_016868895.1, XM_017013406.1
XP_016868896.1, XM_017013407.1
XP_016868897.1, XM_017013408.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi133227, 46 interactors
IntActiQ8IXT5, 19 interactors
STRINGi9606.ENSP00000382239

PTM databases

iPTMnetiQ8IXT5
PhosphoSitePlusiQ8IXT5

Polymorphism and mutation databases

BioMutaiRBM12B
DMDMi215273872

Proteomic databases

EPDiQ8IXT5
jPOSTiQ8IXT5
MassIVEiQ8IXT5
MaxQBiQ8IXT5
PaxDbiQ8IXT5
PeptideAtlasiQ8IXT5
PRIDEiQ8IXT5
ProteomicsDBi71064

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
6688, 42 antibodies

Genome annotation databases

EnsembliENST00000399300; ENSP00000382239; ENSG00000183808
GeneIDi389677
KEGGihsa:389677
UCSCiuc003yfz.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389677
DisGeNETi389677
EuPathDBiHostDB:ENSG00000183808.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RBM12B
HGNCiHGNC:32310, RBM12B
HPAiENSG00000183808, Low tissue specificity
neXtProtiNX_Q8IXT5
OpenTargetsiENSG00000183808
PharmGKBiPA142671098

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4307, Eukaryota
GeneTreeiENSGT00940000158322
InParanoidiQ8IXT5
OMAiSENFRHQ
OrthoDBi249376at2759
PhylomeDBiQ8IXT5
TreeFamiTF331899

Enzyme and pathway databases

PathwayCommonsiQ8IXT5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
389677, 11 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBM12B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
389677
PharosiQ8IXT5, Tdark

Protein Ontology

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PROi
PR:Q8IXT5
RNActiQ8IXT5, protein

Gene expression databases

BgeeiENSG00000183808, Expressed in kidney and 228 other tissues
ExpressionAtlasiQ8IXT5, baseline and differential
GenevisibleiQ8IXT5, HS

Family and domain databases

CDDicd12746, RRM2_RBM12B, 1 hit
cd12513, RRM3_RBM12B, 1 hit
Gene3Di3.30.70.330, 5 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR034588, RBM12B_RRM2
IPR034858, RBM12B_RRM3
IPR000504, RRM_dom
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 5 hits
SUPFAMiSSF54928, SSF54928, 4 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRB12B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXT5
Secondary accession number(s): A8MYB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 25, 2008
Last modified: October 7, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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