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Protein

RNA-binding protein 12B

Gene

RBM12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 12B
Alternative name(s):
RNA-binding motif protein 12B
Gene namesi
Name:RBM12B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000183808.11
HGNCiHGNC:32310 RBM12B
neXtProtiNX_Q8IXT5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183808
PharmGKBiPA142671098

Polymorphism and mutation databases

BioMutaiRBM12B
DMDMi215273872

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733661 – 1001RNA-binding protein 12BAdd BLAST1001

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98PhosphoserineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei250PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei276PhosphothreonineCombined sources1
Modified residuei278PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei319N6-acetyllysineCombined sources1
Cross-linki335Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei377PhosphoserineCombined sources1
Cross-linki514Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei575PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei640PhosphothreonineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Cross-linki895Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IXT5
MaxQBiQ8IXT5
PaxDbiQ8IXT5
PeptideAtlasiQ8IXT5
PRIDEiQ8IXT5
ProteomicsDBi71064

PTM databases

iPTMnetiQ8IXT5
PhosphoSitePlusiQ8IXT5

Expressioni

Gene expression databases

BgeeiENSG00000183808 Expressed in 215 organ(s), highest expression level in kidney
CleanExiHS_RBM12B
ExpressionAtlasiQ8IXT5 baseline and differential
GenevisibleiQ8IXT5 HS

Organism-specific databases

HPAiHPA024398
HPA053050

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CACNA1AO005552EBI-3044077,EBI-766279

Protein-protein interaction databases

BioGridi133227, 40 interactors
IntActiQ8IXT5, 17 interactors
STRINGi9606.ENSP00000382239

Structurei

3D structure databases

ProteinModelPortaliQ8IXT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 230RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini284 – 360RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini400 – 477RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini925 – 1001RRM 4PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4307 Eukaryota
ENOG4111WZ9 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000231575
HOVERGENiHBG057691
InParanoidiQ8IXT5
OMAiPFKANVN
OrthoDBiEOG091G05IT
PhylomeDBiQ8IXT5
TreeFamiTF331899

Family and domain databases

CDDicd12746 RRM2_RBM12B, 1 hit
cd12513 RRM3_RBM12B, 1 hit
Gene3Di3.30.70.330, 5 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034588 RBM12B_RRM2
IPR034858 RBM12B_RRM3
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 5 hits
SUPFAMiSSF54928 SSF54928, 4 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q8IXT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVVIRLLGL PFIAGPVDIR HFFTGLTIPD GGVHIIGGEI GEAFIIFATD
60 70 80 90 100
EDARRAISRS GGFIKDSSVE LFLSSKAEMQ KTIEMKRTDR VGRGRPGSGT
110 120 130 140 150
SGVDSLSNFI ESVKEEASNS GYGSSINQDA GFHTNGTGHG NLRPRKTRPL
160 170 180 190 200
KAENPYLFLR GLPYLVNEDD VRVFFSGLCV DGVIFLKHHD GRNNGDAIVK
210 220 230 240 250
FASCVDASGG LKCHRSFMGS RFIEVMQGSE QQWIEFGGNA VKEGDVLRRS
260 270 280 290 300
EEHSPPRGIN DRHFRKRSHS KSPRRTRSRS PLGFYVHLKN LSLSIDERDL
310 320 330 340 350
RNFFRGTDLT DEQIRFLYKD ENRTRYAFVM FKTLKDYNTA LSLHKTVLQY
360 370 380 390 400
RPVHIDPISR KQMLKFIARY EKKRSGSLER DRPGHVSQKY SQEGNSGQKL
410 420 430 440 450
CIYIRNFPFD VTKVEVQKFF ADFLLAEDDI YLLYDDKGVG LGEALVKFKS
460 470 480 490 500
EEQAMKAERL NRRRFLGTEV LLRLISEAQI QEFGVNFSVM SSEKMQARSQ
510 520 530 540 550
SRERGDHSHL FDSKDPPIYS VGAFENFRHQ LEDLRQLDNF KHPQRDFRQP
560 570 580 590 600
DRHPPEDFRH SSEDFRFPPE DFRHSPEDFR RPREEDFRRP SEEDFRRPWE
610 620 630 640 650
EDFRRPPEDD FRHPREEDWR RPLEEDWRRP LEEDFRRSPT EDFRQLPEED
660 670 680 690 700
FRQPPEEDLR WLPEEDFRRP PEEDWRRPPE EDFRRPLQGE WRRPPEDDFR
710 720 730 740 750
RPPEEDFRHS PEEDFRQSPQ EHFRRPPQEH FRRPPPEHFR RPPPEHFRRP
760 770 780 790 800
PPEHFRRPPP EHFRRPPPEH FRRPPPEHFR RPPQEHFRRP PQEHFRRSRE
810 820 830 840 850
EDFRHPPDED FRGPPDEDFR HPPDEDFRSP QEEDFRCPSD EDFRQLPEED
860 870 880 890 900
LREAPEEDPR LPDNFRPPGE DFRSPPDDFR SHRPFVNFGR PEGGKFDFGK
910 920 930 940 950
HNMGSFPEGR FMPDPKINCG SGRVTPIKIM NLPFKANVNE ILDFFHGYRI
960 970 980 990 1000
IPDSVSIQYN EQGLPTGEAI VAMINYNEAM AAIKDLNDRP VGPRKVKLTL

L
Length:1,001
Mass (Da):118,103
Last modified:November 25, 2008 - v2
Checksum:iA09C527B1A1EE845
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B9ZVT1B9ZVT1_HUMAN
RNA-binding protein 12B
RBM12B
881Annotation score:
E5RJV8E5RJV8_HUMAN
RNA-binding protein 12B
RBM12B
149Annotation score:
E5RHG1E5RHG1_HUMAN
RNA-binding protein 12B
RBM12B
122Annotation score:
E5RJW8E5RJW8_HUMAN
RNA-binding protein 12B
RBM12B
82Annotation score:
E5RJ83E5RJ83_HUMAN
RNA-binding protein 12B
RBM12B
143Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047291250S → F. Corresponds to variant dbSNP:rs17853906Ensembl.1
Natural variantiVAR_047292605R → C. Corresponds to variant dbSNP:rs17857188Ensembl.1
Natural variantiVAR_052219864N → H. Corresponds to variant dbSNP:rs16916188Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010834 Genomic DNA No translation available.
CCDSiCCDS43755.1
RefSeqiNP_976324.2, NM_203390.2
XP_005250972.1, XM_005250915.4
XP_011515329.1, XM_011517027.2
XP_011515330.1, XM_011517028.2
XP_011515331.1, XM_011517029.2
XP_016868895.1, XM_017013406.1
XP_016868896.1, XM_017013407.1
XP_016868897.1, XM_017013408.1
UniGeneiHs.606916

Genome annotation databases

EnsembliENST00000399300; ENSP00000382239; ENSG00000183808
GeneIDi389677
KEGGihsa:389677
UCSCiuc003yfz.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010834 Genomic DNA No translation available.
CCDSiCCDS43755.1
RefSeqiNP_976324.2, NM_203390.2
XP_005250972.1, XM_005250915.4
XP_011515329.1, XM_011517027.2
XP_011515330.1, XM_011517028.2
XP_011515331.1, XM_011517029.2
XP_016868895.1, XM_017013406.1
XP_016868896.1, XM_017013407.1
XP_016868897.1, XM_017013408.1
UniGeneiHs.606916

3D structure databases

ProteinModelPortaliQ8IXT5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133227, 40 interactors
IntActiQ8IXT5, 17 interactors
STRINGi9606.ENSP00000382239

PTM databases

iPTMnetiQ8IXT5
PhosphoSitePlusiQ8IXT5

Polymorphism and mutation databases

BioMutaiRBM12B
DMDMi215273872

Proteomic databases

EPDiQ8IXT5
MaxQBiQ8IXT5
PaxDbiQ8IXT5
PeptideAtlasiQ8IXT5
PRIDEiQ8IXT5
ProteomicsDBi71064

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399300; ENSP00000382239; ENSG00000183808
GeneIDi389677
KEGGihsa:389677
UCSCiuc003yfz.5 human

Organism-specific databases

CTDi389677
EuPathDBiHostDB:ENSG00000183808.11
GeneCardsiRBM12B
H-InvDBiHIX0025665
HGNCiHGNC:32310 RBM12B
HPAiHPA024398
HPA053050
neXtProtiNX_Q8IXT5
OpenTargetsiENSG00000183808
PharmGKBiPA142671098
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4307 Eukaryota
ENOG4111WZ9 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000231575
HOVERGENiHBG057691
InParanoidiQ8IXT5
OMAiPFKANVN
OrthoDBiEOG091G05IT
PhylomeDBiQ8IXT5
TreeFamiTF331899

Miscellaneous databases

ChiTaRSiRBM12B human
GenomeRNAii389677
PROiPR:Q8IXT5

Gene expression databases

BgeeiENSG00000183808 Expressed in 215 organ(s), highest expression level in kidney
CleanExiHS_RBM12B
ExpressionAtlasiQ8IXT5 baseline and differential
GenevisibleiQ8IXT5 HS

Family and domain databases

CDDicd12746 RRM2_RBM12B, 1 hit
cd12513 RRM3_RBM12B, 1 hit
Gene3Di3.30.70.330, 5 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034588 RBM12B_RRM2
IPR034858 RBM12B_RRM3
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 5 hits
SUPFAMiSSF54928 SSF54928, 4 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRB12B_HUMAN
AccessioniPrimary (citable) accession number: Q8IXT5
Secondary accession number(s): A8MYB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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