UniProtKB - Q8IXS6 (PALM2_HUMAN)
Protein
Paralemmin-2
Gene
PALM2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- regulation of cell shape Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q8IXS6 |
Names & Taxonomyi
Protein namesi | Recommended name: Paralemmin-2 |
Gene namesi | Name:PALM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15845, PALM2 |
neXtProti | NX_Q8IXS6 |
VEuPathDBi | HostDB:ENSG00000243444.7 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 445815 |
OpenTargetsi | ENSG00000157654 |
PharmGKBi | PA32924 |
Miscellaneous databases
Pharosi | Q8IXS6, Tdark |
Genetic variation databases
BioMutai | PALM2 |
DMDMi | 124015203 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000273446 | 1 – 376 | Paralemmin-2Add BLAST | 376 | |
PropeptideiPRO_0000396693 | 377 – 379 | Removed in mature formSequence analysis | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 318 | PhosphoserineBy similarity | 1 | |
Modified residuei | 358 | PhosphoserineCombined sources | 1 | |
Lipidationi | 373 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 375 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 376 | Cysteine methyl esterSequence analysis | 1 | |
Lipidationi | 376 | S-farnesyl cysteineSequence analysis | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, Phosphoprotein, PrenylationProteomic databases
EPDi | Q8IXS6 |
jPOSTi | Q8IXS6 |
MassIVEi | Q8IXS6 |
MaxQBi | Q8IXS6 |
PeptideAtlasi | Q8IXS6 |
PRIDEi | Q8IXS6 |
ProteomicsDBi | 71057 [Q8IXS6-1] 71058 [Q8IXS6-2] |
PTM databases
iPTMneti | Q8IXS6 |
PhosphoSitePlusi | Q8IXS6 |
SwissPalmi | Q8IXS6 |
Expressioni
Tissue specificityi
Expressed in infantile heart and muscle, and fibroblasts.1 Publication
Gene expression databases
Bgeei | ENSG00000243444, Expressed in Brodmann (1909) area 46 and 154 other tissues |
ExpressionAtlasi | Q8IXS6, baseline and differential |
Genevisiblei | Q8IXS6, HS |
Organism-specific databases
HPAi | ENSG00000243444, Tissue enhanced (brain, liver) |
Interactioni
Binary interactionsi
Q8IXS6
With | #Exp. | IntAct |
---|---|---|
OPTN [Q96CV9] | 3 | EBI-12871462,EBI-748974 |
Protein-protein interaction databases
BioGRIDi | 125312, 24 interactors |
IntActi | Q8IXS6, 11 interactors |
STRINGi | 9606.ENSP00000323805 |
Miscellaneous databases
RNActi | Q8IXS6, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2 – 37 | Sequence analysisAdd BLAST | 36 | |
Coiled coili | 69 – 110 | Sequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the paralemmin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QSC7, Eukaryota |
GeneTreei | ENSGT00930000151059 |
InParanoidi | Q8IXS6 |
OrthoDBi | 275462at2759 |
PhylomeDBi | Q8IXS6 |
TreeFami | TF105402 |
Family and domain databases
InterProi | View protein in InterPro IPR004965, Paralemmin |
Pfami | View protein in Pfam PF03285, Paralemmin, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IXS6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE
60 70 80 90 100
KWLLQGIPAG TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE
110 120 130 140 150
SQISAKEQII LEKLKETEKS FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE
160 170 180 190 200
TKILSTSTIG PEGVHQKGVK VYDDGTKVVY EVRSGGTVVE NGVHKLSTKD
210 220 230 240 250
VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE AKLEMVHKSR
260 270 280 290 300
KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY
310 320 330 340 350
DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS
360 370
SPEGKEESLA TEPAPGTQKK KRCQCCVVM
Sequence cautioni
The sequence AAH39306 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 63 – 72 | Missing in BAC04472 (PubMed:14702039).Curated | 10 | |
Sequence conflicti | 102 | Q → R in AAH39306 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022566 | 1 – 2 | Missing in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_022567 | 133 | G → GDAVNYISSQLPDLPILCSR TAEPSPGQDGTSRAA in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ312216 mRNA Translation: CAC59693.1 AK095003 mRNA Translation: BAC04472.1 AL135789 Genomic DNA No translation available. AL158829 Genomic DNA No translation available. AL353806 Genomic DNA No translation available. AL627225 Genomic DNA No translation available. BC039306 mRNA Translation: AAH39306.2 Different initiation. |
CCDSi | CCDS35099.1 [Q8IXS6-1] CCDS48002.2 [Q8IXS6-2] |
RefSeqi | NP_001032370.1, NM_001037293.2 [Q8IXS6-1] NP_443749.5, NM_053016.5 [Q8IXS6-2] |
Genome annotation databases
GeneIDi | 445815 |
KEGGi | hsa:445815 |
UCSCi | uc004beg.4, human [Q8IXS6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ312216 mRNA Translation: CAC59693.1 AK095003 mRNA Translation: BAC04472.1 AL135789 Genomic DNA No translation available. AL158829 Genomic DNA No translation available. AL353806 Genomic DNA No translation available. AL627225 Genomic DNA No translation available. BC039306 mRNA Translation: AAH39306.2 Different initiation. |
CCDSi | CCDS35099.1 [Q8IXS6-1] CCDS48002.2 [Q8IXS6-2] |
RefSeqi | NP_001032370.1, NM_001037293.2 [Q8IXS6-1] NP_443749.5, NM_053016.5 [Q8IXS6-2] |
3D structure databases
SMRi | Q8IXS6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125312, 24 interactors |
IntActi | Q8IXS6, 11 interactors |
STRINGi | 9606.ENSP00000323805 |
PTM databases
iPTMneti | Q8IXS6 |
PhosphoSitePlusi | Q8IXS6 |
SwissPalmi | Q8IXS6 |
Genetic variation databases
BioMutai | PALM2 |
DMDMi | 124015203 |
Proteomic databases
EPDi | Q8IXS6 |
jPOSTi | Q8IXS6 |
MassIVEi | Q8IXS6 |
MaxQBi | Q8IXS6 |
PeptideAtlasi | Q8IXS6 |
PRIDEi | Q8IXS6 |
ProteomicsDBi | 71057 [Q8IXS6-1] 71058 [Q8IXS6-2] |
Protocols and materials databases
Antibodypediai | 56405, 43 antibodies |
Genome annotation databases
GeneIDi | 445815 |
KEGGi | hsa:445815 |
UCSCi | uc004beg.4, human [Q8IXS6-1] |
Organism-specific databases
CTDi | 445815 |
DisGeNETi | 445815 |
GeneCardsi | PALM2 PALM2AKAP2 |
HGNCi | HGNC:15845, PALM2 |
HPAi | ENSG00000243444, Tissue enhanced (brain, liver) |
neXtProti | NX_Q8IXS6 |
OpenTargetsi | ENSG00000157654 |
PharmGKBi | PA32924 |
VEuPathDBi | HostDB:ENSG00000243444.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSC7, Eukaryota |
GeneTreei | ENSGT00930000151059 |
InParanoidi | Q8IXS6 |
OrthoDBi | 275462at2759 |
PhylomeDBi | Q8IXS6 |
TreeFami | TF105402 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXS6 |
Miscellaneous databases
BioGRID-ORCSi | 114299, 7 hits in 869 CRISPR screens |
ChiTaRSi | PALM2, human |
GenomeRNAii | 114299 |
Pharosi | Q8IXS6, Tdark |
RNActi | Q8IXS6, protein |
Gene expression databases
Bgeei | ENSG00000243444, Expressed in Brodmann (1909) area 46 and 154 other tissues |
ExpressionAtlasi | Q8IXS6, baseline and differential |
Genevisiblei | Q8IXS6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004965, Paralemmin |
Pfami | View protein in Pfam PF03285, Paralemmin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PALM2_HUMAN | |
Accessioni | Q8IXS6Primary (citable) accession number: Q8IXS6 Secondary accession number(s): A9Z1X9, Q8N9D5, Q96DU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 125 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families