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Protein

Dynein regulatory complex subunit 2

Gene

CCDC65

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • axonemal dynein complex assembly Source: GO_Central
  • cilium assembly Source: UniProtKB
  • cilium-dependent cell motility Source: GO_Central
  • regulation of cilium movement Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein regulatory complex subunit 21 Publication
Alternative name(s):
Coiled-coil domain-containing protein 65
Testis development protein NYD-SP28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC65
Synonyms:DRC21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139537.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29937 CCDC65

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611088 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IXS2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 27 (CILD27)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Cilia ultrastructure show normal outer dynein arms, radial spokes and central pairs, but a reduction in inner dynein arms and nexin links. In 5%-15% of cilia, microtubules are disorganized. Nasal epithelial cilia reveal a stiff, dyskinetic cilia waveform.
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
See also OMIM:615504

Keywords - Diseasei

Ciliopathy, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
85478

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CCDC65

MalaCards human disease database

More...
MalaCardsi
CCDC65
MIMi615504 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000139537

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
244 Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485417

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC65

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74728229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002847781 – 484Dynein regulatory complex subunit 2Add BLAST484

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IXS2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IXS2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IXS2

PeptideAtlas

More...
PeptideAtlasi
Q8IXS2

PRoteomics IDEntifications database

More...
PRIDEi
Q8IXS2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
71055
71056 [Q8IXS2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IXS2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IXS2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult testis, in spermatocytes and spermatids. Also observed in spermatogonia. Not detected in Leydig cells, nor in fetal testis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139537 Expressed in 121 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCDC65

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IXS2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IXS2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038520
HPA057573

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC).By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124553, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312706

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IXS2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IXS2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili92 – 160Sequence analysisAdd BLAST69
Coiled coili374 – 403Sequence analysisAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DRC2 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE4Y Eukaryota
ENOG410XQTS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153804

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059628

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG103693

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IXS2

Identification of Orthologs from Complete Genome Data

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OMAi
QMKKIQR

Database of Orthologous Groups

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OrthoDBi
EOG091G0BMS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IXS2

TreeFam database of animal gene trees

More...
TreeFami
TF326074

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039505 DRC1/2_N
IPR039750 DRC1/DRC2

The PANTHER Classification System

More...
PANTHERi
PTHR21625 PTHR21625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14772 NYD-SP28, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IXS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKKEKMAKT PLSDEKQLLL FQQKLLAEEE MAKKKERLLS QFLKDKLAKE
60 70 80 90 100
EHNSALNLNK INTQWRTVLR EVKTRELHKD IEILSQTFER VVDCKDNVIK
110 120 130 140 150
SLAKDLSEAE EQYAHALRSH LHNVDQLLAL QRHRLSLLEE SYNMELEALT
160 170 180 190 200
KEFETERKTI IDQHEKEIHY LQDIFMAMEQ NYIDSEYESK LEFQSMWNDL
210 220 230 240 250
KNMNLEEKHF LRLHLENRVE DLWRKFQDVL KNYTDATEDR KAAFETLQVK
260 270 280 290 300
DEKSSKEIEV QMKKIQKLQD AITISKGKIM IHSRESEDEN RYIRNDKELV
310 320 330 340 350
LVQLRKLKAQ RTQARAASQK NLVRLTLESN ATLKALRKIV DKGEKILKLA
360 370 380 390 400
EICRKFETEE EKVLPFYSSV LTPKEQEGIQ KNNLEELTEE LTKVMVDYIG
410 420 430 440 450
MENFWKRYNK VKLEQLSLQH RRAQLLDING KLREMLKQYL DGISVSDEVL
460 470 480
SQLNPLFIVN YQSNLLQPLS IRIAHPGDKQ HPTT
Length:484
Mass (Da):57,297
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B3E8E676512AAF2
GO
Isoform 2 (identifier: Q8IXS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     478-484: DKQHPTT → STSPSAPWRDQRRSFFLGSS

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):58,740
Checksum:i8FC23EA8D83AA456
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VR42F8VR42_HUMAN
Dynein regulatory complex subunit 2
CCDC65
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W0R6F8W0R6_HUMAN
Dynein regulatory complex subunit 2
CCDC65
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05324 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti164H → R in BAC04035 (PubMed:14702039).Curated1
Sequence conflicti202N → D in AAK60542 (PubMed:17089017).Curated1
Sequence conflicti242A → T in AAK60542 (PubMed:17089017).Curated1
Sequence conflicti308K → E in BAC05324 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056780133H → R. Corresponds to variant dbSNP:rs10747556EnsemblClinVar.1
Natural variantiVAR_056781408Y → C. Corresponds to variant dbSNP:rs4760600EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024644478 – 484DKQHPTT → STSPSAPWRDQRRSFFLGSS in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF382188 mRNA Translation: AAK60542.1
AK093051 mRNA Translation: BAC04035.1
AK098529 mRNA Translation: BAC05324.1 Different initiation.
AK314623 mRNA Translation: BAG37189.1
AC073610 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58020.1
CH471111 Genomic DNA Translation: EAW58021.1
BC039317 mRNA Translation: AAH39317.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS8772.1 [Q8IXS2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_149115.2, NM_033124.4 [Q8IXS2-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.512805

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266984; ENSP00000266984; ENSG00000139537 [Q8IXS2-2]
ENST00000320516; ENSP00000312706; ENSG00000139537 [Q8IXS2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85478

UCSC genome browser

More...
UCSCi
uc001rso.4 human [Q8IXS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF382188 mRNA Translation: AAK60542.1
AK093051 mRNA Translation: BAC04035.1
AK098529 mRNA Translation: BAC05324.1 Different initiation.
AK314623 mRNA Translation: BAG37189.1
AC073610 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58020.1
CH471111 Genomic DNA Translation: EAW58021.1
BC039317 mRNA Translation: AAH39317.2
CCDSiCCDS8772.1 [Q8IXS2-1]
RefSeqiNP_149115.2, NM_033124.4 [Q8IXS2-1]
UniGeneiHs.512805

3D structure databases

ProteinModelPortaliQ8IXS2
SMRiQ8IXS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124553, 5 interactors
STRINGi9606.ENSP00000312706

PTM databases

iPTMnetiQ8IXS2
PhosphoSitePlusiQ8IXS2

Polymorphism and mutation databases

BioMutaiCCDC65
DMDMi74728229

Proteomic databases

EPDiQ8IXS2
MaxQBiQ8IXS2
PaxDbiQ8IXS2
PeptideAtlasiQ8IXS2
PRIDEiQ8IXS2
ProteomicsDBi71055
71056 [Q8IXS2-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
85478
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266984; ENSP00000266984; ENSG00000139537 [Q8IXS2-2]
ENST00000320516; ENSP00000312706; ENSG00000139537 [Q8IXS2-1]
GeneIDi85478
KEGGihsa:85478
UCSCiuc001rso.4 human [Q8IXS2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85478
DisGeNETi85478
EuPathDBiHostDB:ENSG00000139537.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC65
GeneReviewsiCCDC65
HGNCiHGNC:29937 CCDC65
HPAiHPA038520
HPA057573
MalaCardsiCCDC65
MIMi611088 gene
615504 phenotype
neXtProtiNX_Q8IXS2
OpenTargetsiENSG00000139537
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA143485417

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE4Y Eukaryota
ENOG410XQTS LUCA
GeneTreeiENSGT00940000153804
HOGENOMiHOG000059628
HOVERGENiHBG103693
InParanoidiQ8IXS2
OMAiQMKKIQR
OrthoDBiEOG091G0BMS
PhylomeDBiQ8IXS2
TreeFamiTF326074

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85478

Protein Ontology

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PROi
PR:Q8IXS2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000139537 Expressed in 121 organ(s), highest expression level in testis
CleanExiHS_CCDC65
ExpressionAtlasiQ8IXS2 baseline and differential
GenevisibleiQ8IXS2 HS

Family and domain databases

InterProiView protein in InterPro
IPR039505 DRC1/2_N
IPR039750 DRC1/DRC2
PANTHERiPTHR21625 PTHR21625, 1 hit
PfamiView protein in Pfam
PF14772 NYD-SP28, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXS2
Secondary accession number(s): A6NJG5
, B2RBE2, Q8N7G4, Q8NA91, Q96JA0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2004
Last modified: December 5, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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