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Protein

Protein FAM178B

Gene

FAM178B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM178B
Gene namesi
Name:FAM178B
ORF Names:HSPC234
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168754.14
HGNCiHGNC:28036 FAM178B
neXtProtiNX_Q8IXR5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168754
PharmGKBiPA162387456

Polymorphism and mutation databases

BioMutaiFAM178B
DMDMi172045738

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201931 – 827Protein FAM178BAdd BLAST827

Proteomic databases

PaxDbiQ8IXR5
PRIDEiQ8IXR5
ProteomicsDBi71050
71051 [Q8IXR5-2]

PTM databases

iPTMnetiQ8IXR5
PhosphoSitePlusiQ8IXR5

Expressioni

Gene expression databases

BgeeiENSG00000168754 Expressed in 131 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_FAM178B
GenevisibleiQ8IXR5 HS

Organism-specific databases

HPAiHPA042516
HPA062110

Interactioni

Protein-protein interaction databases

BioGridi119409, 1 interactor
IntActiQ8IXR5, 2 interactors
STRINGi9606.ENSP00000429896

Structurei

3D structure databases

ProteinModelPortaliQ8IXR5
SMRiQ8IXR5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM178 family.Curated

Phylogenomic databases

eggNOGiENOG410IIBY Eukaryota
ENOG410YMV9 LUCA
GeneTreeiENSGT00530000064017
HOGENOMiHOG000050235
HOVERGENiHBG107879
InParanoidiQ8IXR5
OMAiPQAMHRT
OrthoDBiEOG091G01IC
PhylomeDBiQ8IXR5
TreeFamiTF332216

Family and domain databases

InterProiView protein in InterPro
IPR026161 FAM178
PANTHERiPTHR16046 PTHR16046, 1 hit
PfamiView protein in Pfam
PF14816 FAM178, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IXR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHEREILKG MYEELKEKSH KPDVELIQHR AWRIDMVSTE LESFRKASYI
60 70 80 90 100
ESGPEEFYQR FKKCFSATHI FISIKGKDSQ NTAHGYLILN RTLHQQLKIK
110 120 130 140 150
NPFLAPSSEA VRIPATLPHP GALPFPPYVA KASSDELLNL QKPLQSALGF
160 170 180 190 200
VILRSSQNWN SKNRQRWSRT KAGQMSHGLQ MAGPQETVLA LPLREGVQAA
210 220 230 240 250
ATVPILLYNL EDGLSDHPLD QGPRCPARRP CSPASAPAPT SPKKPKIQAP
260 270 280 290 300
GETFPTDWSP PPVEFLNPRV LQASREAPAQ RWVGVVGPQG LRRLAGELPE
310 320 330 340 350
ELEQEHLDLD PKRGLALPEK LFWNTSGLSQ QAAAPEFSWG GSGSYFNNLD
360 370 380 390 400
YLLQEKREQA LEQERERLLL QECLNLNSLD LDEEEVPLTP EHRMLVEKYS
410 420 430 440 450
VSLQTIPPVH PGETVFLPRC HPLPCILDSS LLKPRSHLEG LFLSSPPAQQ
460 470 480 490 500
LSFLRSGLLN ILYLHMPDCP VSLLQWLFQL LTWPPETSLG AFGLLWDLIV
510 520 530 540 550
DGIFLQPDED KHLWCPSLQE VREAFHSLGA HSPALYPLGP FWHGGRVLPG
560 570 580 590 600
EAGLNENEEQ DAPQEIALDI SLGHIYKFLA LCAQAQPGAY TDENLMGLIE
610 620 630 640 650
LLCRTSLDVG LRLLPKVDLQ QLLLLLLENI REWPGKLQEL CCTLSWVSDH
660 670 680 690 700
HHNLLALVQF FPDMTSRSRR LRSQLSLVVI ARMLGQQEML PLWQEKTQLS
710 720 730 740 750
SLSRLLGLMR PSSLRQYLDS VPLPPCQEQQ PKASAELDHK ACYLCHSLLM
760 770 780 790 800
LAGVVVSCQD ITPDQWGELQ LLCMQLDRHI STQIRESPQA MHRTMLKDLA
810 820
TQTYIRWQEL LTHCQPQAQY FSPWKDI
Length:827
Mass (Da):93,514
Last modified:February 26, 2008 - v2
Checksum:iE2C6664FB9D42A3F
GO
Isoform 2 (identifier: Q8IXR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-708: Missing.

Show »
Length:119
Mass (Da):13,809
Checksum:i5E7010D9805BE57B
GO
Isoform 3 (identifier: Q8IXR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MAHEREILKG...NRQRWSRTKA → MWPRLPGAGLAPQLRRQDQRLHFT

Note: Gene prediction based on EST data.
Show »
Length:679
Mass (Da):76,515
Checksum:i8140A458F9026C22
GO

Sequence cautioni

The sequence AAF36154 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence AAF36154 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039172793R → C. Corresponds to variant dbSNP:rs34013660Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0316361 – 708Missing in isoform 2. 2 PublicationsAdd BLAST708
Alternative sequenceiVSP_0471621 – 172MAHER…SRTKA → MWPRLPGAGLAPQLRRQDQR LHFT in isoform 3. CuratedAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151068 mRNA Translation: AAF36154.1 Sequence problems.
AC079395 Genomic DNA No translation available.
AC092636 Genomic DNA Translation: AAY14968.1
BC038583 mRNA Translation: AAH38583.3
BC039488 mRNA Translation: AAH39488.1
BC051379 mRNA Translation: AAH51379.1
CCDSiCCDS33252.1 [Q8IXR5-2]
CCDS46366.2 [Q8IXR5-3]
RefSeqiNP_001116118.2, NM_001122646.2 [Q8IXR5-3]
NP_001166138.1, NM_001172667.1
NP_057574.2, NM_016490.4 [Q8IXR5-2]
XP_016859757.1, XM_017004268.1 [Q8IXR5-2]
UniGeneiHs.107922

Genome annotation databases

EnsembliENST00000393526; ENSP00000377160; ENSG00000168754 [Q8IXR5-2]
ENST00000490605; ENSP00000429896; ENSG00000168754 [Q8IXR5-3]
GeneIDi51252
KEGGihsa:51252
UCSCiuc002sxj.4 human [Q8IXR5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151068 mRNA Translation: AAF36154.1 Sequence problems.
AC079395 Genomic DNA No translation available.
AC092636 Genomic DNA Translation: AAY14968.1
BC038583 mRNA Translation: AAH38583.3
BC039488 mRNA Translation: AAH39488.1
BC051379 mRNA Translation: AAH51379.1
CCDSiCCDS33252.1 [Q8IXR5-2]
CCDS46366.2 [Q8IXR5-3]
RefSeqiNP_001116118.2, NM_001122646.2 [Q8IXR5-3]
NP_001166138.1, NM_001172667.1
NP_057574.2, NM_016490.4 [Q8IXR5-2]
XP_016859757.1, XM_017004268.1 [Q8IXR5-2]
UniGeneiHs.107922

3D structure databases

ProteinModelPortaliQ8IXR5
SMRiQ8IXR5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119409, 1 interactor
IntActiQ8IXR5, 2 interactors
STRINGi9606.ENSP00000429896

PTM databases

iPTMnetiQ8IXR5
PhosphoSitePlusiQ8IXR5

Polymorphism and mutation databases

BioMutaiFAM178B
DMDMi172045738

Proteomic databases

PaxDbiQ8IXR5
PRIDEiQ8IXR5
ProteomicsDBi71050
71051 [Q8IXR5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393526; ENSP00000377160; ENSG00000168754 [Q8IXR5-2]
ENST00000490605; ENSP00000429896; ENSG00000168754 [Q8IXR5-3]
GeneIDi51252
KEGGihsa:51252
UCSCiuc002sxj.4 human [Q8IXR5-1]

Organism-specific databases

CTDi51252
EuPathDBiHostDB:ENSG00000168754.14
GeneCardsiFAM178B
H-InvDBiHIX0002285
HGNCiHGNC:28036 FAM178B
HPAiHPA042516
HPA062110
neXtProtiNX_Q8IXR5
OpenTargetsiENSG00000168754
PharmGKBiPA162387456
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBY Eukaryota
ENOG410YMV9 LUCA
GeneTreeiENSGT00530000064017
HOGENOMiHOG000050235
HOVERGENiHBG107879
InParanoidiQ8IXR5
OMAiPQAMHRT
OrthoDBiEOG091G01IC
PhylomeDBiQ8IXR5
TreeFamiTF332216

Miscellaneous databases

ChiTaRSiFAM178B human
GenomeRNAii51252
PROiPR:Q8IXR5

Gene expression databases

BgeeiENSG00000168754 Expressed in 131 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_FAM178B
GenevisibleiQ8IXR5 HS

Family and domain databases

InterProiView protein in InterPro
IPR026161 FAM178
PANTHERiPTHR16046 PTHR16046, 1 hit
PfamiView protein in Pfam
PF14816 FAM178, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF178B_HUMAN
AccessioniPrimary (citable) accession number: Q8IXR5
Secondary accession number(s): A8MXN2
, E9PD86, Q8IUY0, Q9P0P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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