FAM178B

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM178B
Gene namesⁱ	Name:FAM178B ORF Names:HSPC234
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168754.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28036 FAM178B
neXtProtⁱ	NX_Q8IXR5

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000168754
PharmGKBⁱ	PA162387456

Polymorphism and mutation databases

BioMutaⁱ	FAM178B
DMDMⁱ	172045738

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000320193	1 – 827	Protein FAM178BAdd BLAST		827

Proteomic databases

PaxDbⁱ	Q8IXR5
PRIDEⁱ	Q8IXR5
ProteomicsDBⁱ	71050 71051 [Q8IXR5-2]

PTM databases

iPTMnetⁱ	Q8IXR5
PhosphoSitePlusⁱ	Q8IXR5

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168754 Expressed in 131 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_FAM178B
Genevisibleⁱ	Q8IXR5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042516 HPA062110

HPAⁱ

HPA042516
HPA062110

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119409, 1 interactor
IntActⁱ	Q8IXR5, 2 interactors
STRINGⁱ	9606.ENSP00000429896

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IXR5
SMRⁱ	Q8IXR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FAM178 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IIBY Eukaryota ENOG410YMV9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000064017
HOGENOMⁱ	HOG000050235
HOVERGENⁱ	HBG107879
InParanoidⁱ	Q8IXR5
OMAⁱ	PQAMHRT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01IC
PhylomeDBⁱ	Q8IXR5
TreeFamⁱ	TF332216

Family and domain databases

InterProⁱ	View protein in InterPro IPR026161 FAM178
PANTHERⁱ	PTHR16046 PTHR16046, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14816 FAM178, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8IXR5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHEREILKG MYEELKEKSH KPDVELIQHR AWRIDMVSTE LESFRKASYI 
        60         70         80         90        100
ESGPEEFYQR FKKCFSATHI FISIKGKDSQ NTAHGYLILN RTLHQQLKIK 
       110        120        130        140        150
NPFLAPSSEA VRIPATLPHP GALPFPPYVA KASSDELLNL QKPLQSALGF 
       160        170        180        190        200
VILRSSQNWN SKNRQRWSRT KAGQMSHGLQ MAGPQETVLA LPLREGVQAA 
       210        220        230        240        250
ATVPILLYNL EDGLSDHPLD QGPRCPARRP CSPASAPAPT SPKKPKIQAP 
       260        270        280        290        300
GETFPTDWSP PPVEFLNPRV LQASREAPAQ RWVGVVGPQG LRRLAGELPE 
       310        320        330        340        350
ELEQEHLDLD PKRGLALPEK LFWNTSGLSQ QAAAPEFSWG GSGSYFNNLD 
       360        370        380        390        400
YLLQEKREQA LEQERERLLL QECLNLNSLD LDEEEVPLTP EHRMLVEKYS 
       410        420        430        440        450
VSLQTIPPVH PGETVFLPRC HPLPCILDSS LLKPRSHLEG LFLSSPPAQQ 
       460        470        480        490        500
LSFLRSGLLN ILYLHMPDCP VSLLQWLFQL LTWPPETSLG AFGLLWDLIV 
       510        520        530        540        550
DGIFLQPDED KHLWCPSLQE VREAFHSLGA HSPALYPLGP FWHGGRVLPG 
       560        570        580        590        600
EAGLNENEEQ DAPQEIALDI SLGHIYKFLA LCAQAQPGAY TDENLMGLIE 
       610        620        630        640        650
LLCRTSLDVG LRLLPKVDLQ QLLLLLLENI REWPGKLQEL CCTLSWVSDH 
       660        670        680        690        700
HHNLLALVQF FPDMTSRSRR LRSQLSLVVI ARMLGQQEML PLWQEKTQLS 
       710        720        730        740        750
SLSRLLGLMR PSSLRQYLDS VPLPPCQEQQ PKASAELDHK ACYLCHSLLM 
       760        770        780        790        800
LAGVVVSCQD ITPDQWGELQ LLCMQLDRHI STQIRESPQA MHRTMLKDLA 
       810        820 
TQTYIRWQEL LTHCQPQAQY FSPWKDI

Length:827

Mass (Da):93,514

Last modified:February 26, 2008 - v2

Checksum:ⁱE2C6664FB9D42A3F

GO

Isoform 2 (identifier: Q8IXR5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-708: Missing.

« Hide

        10         20         30         40         50
MRPSSLRQYL DSVPLPPCQE QQPKASAELD HKACYLCHSL LMLAGVVVSC 
        60         70         80         90        100
QDITPDQWGE LQLLCMQLDR HISTQIRESP QAMHRTMLKD LATQTYIRWQ 
       110 
ELLTHCQPQA QYFSPWKDI

Show »

Length:119

Mass (Da):13,809

Checksum:ⁱ5E7010D9805BE57B

GO

Isoform 3 (identifier: Q8IXR5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-172: MAHEREILKG...NRQRWSRTKA → MWPRLPGAGLAPQLRRQDQRLHFT

« Hide

        10         20         30         40         50
MWPRLPGAGL APQLRRQDQR LHFTGQMSHG LQMAGPQETV LALPLREGVQ 
        60         70         80         90        100
AAATVPILLY NLEDGLSDHP LDQGPRCPAR RPCSPASAPA PTSPKKPKIQ 
       110        120        130        140        150
APGETFPTDW SPPPVEFLNP RVLQASREAP AQRWVGVVGP QGLRRLAGEL 
       160        170        180        190        200
PEELEQEHLD LDPKRGLALP EKLFWNTSGL SQQAAAPEFS WGGSGSYFNN 
       210        220        230        240        250
LDYLLQEKRE QALEQERERL LLQECLNLNS LDLDEEEVPL TPEHRMLVEK 
       260        270        280        290        300
YSVSLQTIPP VHPGETVFLP RCHPLPCILD SSLLKPRSHL EGLFLSSPPA 
       310        320        330        340        350
QQLSFLRSGL LNILYLHMPD CPVSLLQWLF QLLTWPPETS LGAFGLLWDL 
       360        370        380        390        400
IVDGIFLQPD EDKHLWCPSL QEVREAFHSL GAHSPALYPL GPFWHGGRVL 
       410        420        430        440        450
PGEAGLNENE EQDAPQEIAL DISLGHIYKF LALCAQAQPG AYTDENLMGL 
       460        470        480        490        500
IELLCRTSLD VGLRLLPKVD LQQLLLLLLE NIREWPGKLQ ELCCTLSWVS 
       510        520        530        540        550
DHHHNLLALV QFFPDMTSRS RRLRSQLSLV VIARMLGQQE MLPLWQEKTQ 
       560        570        580        590        600
LSSLSRLLGL MRPSSLRQYL DSVPLPPCQE QQPKASAELD HKACYLCHSL 
       610        620        630        640        650
LMLAGVVVSC QDITPDQWGE LQLLCMQLDR HISTQIRESP QAMHRTMLKD 
       660        670 
LATQTYIRWQ ELLTHCQPQA QYFSPWKDI

Note: Gene prediction based on EST data.

Show »

Length:679

Mass (Da):76,515

Checksum:ⁱ8140A458F9026C22

GO

Sequence cautionⁱ

The sequence AAF36154 differs from that shown. Reason: Frameshift at several positions.Curated

The sequence AAF36154 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039172	793	R → C. Corresponds to variant dbSNP:rs34013660Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031636	1 – 708	Missing in isoform 2. 2 PublicationsAdd BLAST		708
Alternative sequenceⁱVSP_047162	1 – 172	MAHER…SRTKA → MWPRLPGAGLAPQLRRQDQR LHFT in isoform 3. CuratedAdd BLAST		172

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151068 mRNA Translation: AAF36154.1 Sequence problems. AC079395 Genomic DNA No translation available. AC092636 Genomic DNA Translation: AAY14968.1 BC038583 mRNA Translation: AAH38583.3 BC039488 mRNA Translation: AAH39488.1 BC051379 mRNA Translation: AAH51379.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33252.1 [Q8IXR5-2] CCDS46366.2 [Q8IXR5-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001116118.2, NM_001122646.2 [Q8IXR5-3] NP_001166138.1, NM_001172667.1 NP_057574.2, NM_016490.4 [Q8IXR5-2] XP_016859757.1, XM_017004268.1 [Q8IXR5-2]
UniGeneⁱ	Hs.107922

Genome annotation databases

Ensemblⁱ	ENST00000393526; ENSP00000377160; ENSG00000168754 [Q8IXR5-2] ENST00000490605; ENSP00000429896; ENSG00000168754 [Q8IXR5-3]
GeneIDⁱ	51252
KEGGⁱ	hsa:51252
UCSC genome browser More...UCSCⁱ	uc002sxj.4 human [Q8IXR5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q8IXR5	Isoform 2 of Protein FAM178B		HUMAN		119	UniRef100_Q8IXR5
cDNA FLJ16181 fis, clone BRSTN2002400		HUMAN		362
UPI0007DC57F5		HUMAN		145
UPI0001891C2B		HUMAN		232

Protein	Similar proteins		Species	Score	Length	Source
Q8IXR5	Isoform 2 of Protein FAM178B		HUMAN		119	UniRef90_Q8IXR5
Uncharacterized protein		GORGO		827
cDNA FLJ16181 fis, clone BRSTN2002400		HUMAN		362
Uncharacterized protein		GORGO		119
UPI0007DC57F5		HUMAN		145
+2
Q8IXR5-3	Uncharacterized protein (Fragment)		MACMU		696	UniRef90_Q8IXR5-3
Uncharacterized protein		COLAP		679
Uncharacterized protein		MACFA		679
Uncharacterized protein		GORGO		679
FAM178B isoform 1		PANTR		679
+34

Protein	Similar proteins		Species	Score	Length	Source
Q8IXR5	Isoform 2 of Protein FAM178B		HUMAN		119	UniRef50_Q8IXR5
Uncharacterized protein		GORGO		827
Family with sequence similarity 178 member B		CALJA		678
Uncharacterized protein		Cebus capucinus imitator		678
Family with sequence similarity 178 member B		MUSPF		654
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151068 mRNA Translation: AAF36154.1 Sequence problems. AC079395 Genomic DNA No translation available. AC092636 Genomic DNA Translation: AAY14968.1 BC038583 mRNA Translation: AAH38583.3 BC039488 mRNA Translation: AAH39488.1 BC051379 mRNA Translation: AAH51379.1
CCDSⁱ	CCDS33252.1 [Q8IXR5-2] CCDS46366.2 [Q8IXR5-3]
RefSeqⁱ	NP_001116118.2, NM_001122646.2 [Q8IXR5-3] NP_001166138.1, NM_001172667.1 NP_057574.2, NM_016490.4 [Q8IXR5-2] XP_016859757.1, XM_017004268.1 [Q8IXR5-2]
UniGeneⁱ	Hs.107922

3D structure databases

ProteinModelPortalⁱ	Q8IXR5
SMRⁱ	Q8IXR5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119409, 1 interactor
IntActⁱ	Q8IXR5, 2 interactors
STRINGⁱ	9606.ENSP00000429896

PTM databases

iPTMnetⁱ	Q8IXR5
PhosphoSitePlusⁱ	Q8IXR5

Polymorphism and mutation databases

BioMutaⁱ	FAM178B
DMDMⁱ	172045738

Proteomic databases

PaxDbⁱ	Q8IXR5
PRIDEⁱ	Q8IXR5
ProteomicsDBⁱ	71050 71051 [Q8IXR5-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000393526; ENSP00000377160; ENSG00000168754 [Q8IXR5-2] ENST00000490605; ENSP00000429896; ENSG00000168754 [Q8IXR5-3]
GeneIDⁱ	51252
KEGGⁱ	hsa:51252
UCSCⁱ	uc002sxj.4 human [Q8IXR5-1]

Organism-specific databases

CTDⁱ	51252
EuPathDBⁱ	HostDB:ENSG00000168754.14
GeneCardsⁱ	FAM178B
H-InvDBⁱ	HIX0002285
HGNCⁱ	HGNC:28036 FAM178B
HPAⁱ	HPA042516 HPA062110
neXtProtⁱ	NX_Q8IXR5
OpenTargetsⁱ	ENSG00000168754
PharmGKBⁱ	PA162387456
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIBY Eukaryota ENOG410YMV9 LUCA
GeneTreeⁱ	ENSGT00530000064017
HOGENOMⁱ	HOG000050235
HOVERGENⁱ	HBG107879
InParanoidⁱ	Q8IXR5
OMAⁱ	PQAMHRT
OrthoDBⁱ	EOG091G01IC
PhylomeDBⁱ	Q8IXR5
TreeFamⁱ	TF332216

Miscellaneous databases

ChiTaRSⁱ	FAM178B human
GenomeRNAiⁱ	51252
Protein Ontology More...PROⁱ	PR:Q8IXR5

Gene expression databases

Bgeeⁱ	ENSG00000168754 Expressed in 131 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_FAM178B
Genevisibleⁱ	Q8IXR5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026161 FAM178
PANTHERⁱ	PTHR16046 PTHR16046, 1 hit
Pfamⁱ	View protein in Pfam PF14816 FAM178, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F178B_HUMAN
Accessionⁱ	Q8IXR5Primary (citable) accession number: Q8IXR5 Secondary accession number(s): A8MXN2 , E9PD86, Q8IUY0, Q9P0P4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	September 12, 2018
	This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IXR5 (F178B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein FAM178B

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ