UniProtKB - Q8IXR5 (F178B_HUMAN)
Protein
Protein FAM178B
Gene
FAM178B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM178BCurated |
Gene namesi | Name:FAM178BImported ORF Names:HSPC234 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28036, FAM178B |
neXtProti | NX_Q8IXR5 |
VEuPathDBi | HostDB:ENSG00000168754.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51252 |
OpenTargetsi | ENSG00000168754 |
PharmGKBi | PA162387456 |
Miscellaneous databases
Pharosi | Q8IXR5, Tdark |
Genetic variation databases
BioMutai | FAM178B |
DMDMi | 172045738 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320193 | 1 – 679 | Protein FAM178BAdd BLAST | 679 |
Proteomic databases
MassIVEi | Q8IXR5 |
PaxDbi | Q8IXR5 |
PeptideAtlasi | Q8IXR5 |
PRIDEi | Q8IXR5 |
ProteomicsDBi | 19608 71051 [Q8IXR5-2] |
PTM databases
PhosphoSitePlusi | Q8IXR5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000168754, Expressed in bone marrow and 153 other tissues |
Genevisiblei | Q8IXR5, HS |
Organism-specific databases
HPAi | ENSG00000168754, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119409, 1 interactor |
IntActi | Q8IXR5, 2 interactors |
STRINGi | 9606.ENSP00000429896 |
Miscellaneous databases
RNActi | Q8IXR5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM178 family.Curated
Phylogenomic databases
eggNOGi | ENOG502RXJ9, Eukaryota |
GeneTreei | ENSGT00530000064017 |
HOGENOMi | CLU_166950_0_0_1 |
InParanoidi | Q8IXR5 |
OMAi | EVREAFH |
OrthoDBi | 713086at2759 |
PhylomeDBi | Q8IXR5 |
TreeFami | TF332216 |
Family and domain databases
InterProi | View protein in InterPro IPR026161, FAM178 |
PANTHERi | PTHR16046, PTHR16046, 1 hit |
Pfami | View protein in Pfam PF14816, FAM178, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 3 (identifier: Q8IXR5-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWPRLPGAGL APQLRRQDQR LHFTGQMSHG LQMAGPQETV LALPLREGVQ
60 70 80 90 100
AAATVPILLY NLEDGLSDHP LDQGPRCPAR RPCSPASAPA PTSPKKPKIQ
110 120 130 140 150
APGETFPTDW SPPPVEFLNP RVLQASREAP AQRWVGVVGP QGLRRLAGEL
160 170 180 190 200
PEELEQEHLD LDPKRGLALP EKLFWNTSGL SQQAAAPEFS WGGSGSYFNN
210 220 230 240 250
LDYLLQEKRE QALEQERERL LLQECLNLNS LDLDEEEVPL TPEHRMLVEK
260 270 280 290 300
YSVSLQTIPP VHPGETVFLP RCHPLPCILD SSLLKPRSHL EGLFLSSPPA
310 320 330 340 350
QQLSFLRSGL LNILYLHMPD CPVSLLQWLF QLLTWPPETS LGAFGLLWDL
360 370 380 390 400
IVDGIFLQPD EDKHLWCPSL QEVREAFHSL GAHSPALYPL GPFWHGGRVL
410 420 430 440 450
PGEAGLNENE EQDAPQEIAL DISLGHIYKF LALCAQAQPG AYTDENLMGL
460 470 480 490 500
IELLCRTSLD VGLRLLPKVD LQQLLLLLLE NIREWPGKLQ ELCCTLSWVS
510 520 530 540 550
DHHHNLLALV QFFPDMTSRS RRLRSQLSLV VIARMLGQQE MLPLWQEKTQ
560 570 580 590 600
LSSLSRLLGL MRPSSLRQYL DSVPLPPCQE QQPKASAELD HKACYLCHSL
610 620 630 640 650
LMLAGVVVSC QDITPDQWGE LQLLCMQLDR HISTQIRESP QAMHRTMLKD
660 670
LATQTYIRWQ ELLTHCQPQA QYFSPWKDI
Sequence cautioni
The sequence AAF36154 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 563 | P → H in AAF36154 (PubMed:11042152).Curated | 1 | |
Sequence conflicti | 646 | T → P in AAF36154 (PubMed:11042152).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039172 | 645 | R → C. Corresponds to variant dbSNP:rs34013660Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060401 | 1 – 560 | Missing in isoform 2. Add BLAST | 560 | |
Alternative sequenceiVSP_060402 | 1 – 541 | Missing in isoform 4. Add BLAST | 541 | |
Alternative sequenceiVSP_060403 | 542 – 550 | LPLWQEKTQ → MKMMVVLLM in isoform 4. | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151068 mRNA Translation: AAF36154.1 Frameshift. AC079395 Genomic DNA No translation available. AC092636 Genomic DNA Translation: AAY14968.1 BC038583 mRNA Translation: AAH38583.3 BC039488 mRNA Translation: AAH39488.1 BC051379 mRNA Translation: AAH51379.1 |
CCDSi | CCDS33252.1 [Q8IXR5-2] CCDS46366.2 [Q8IXR5-3] |
RefSeqi | NP_001116118.2, NM_001122646.2 [Q8IXR5-3] NP_001166138.1, NM_001172667.1 [Q8IXR5-4] NP_057574.2, NM_016490.4 [Q8IXR5-2] XP_016859757.1, XM_017004268.1 [Q8IXR5-2] |
Genome annotation databases
Ensembli | ENST00000393526; ENSP00000377160; ENSG00000168754 [Q8IXR5-2] ENST00000490605; ENSP00000429896; ENSG00000168754 [Q8IXR5-3] |
GeneIDi | 51252 |
KEGGi | hsa:51252 |
UCSCi | uc002sxj.4, human [Q8IXR5-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151068 mRNA Translation: AAF36154.1 Frameshift. AC079395 Genomic DNA No translation available. AC092636 Genomic DNA Translation: AAY14968.1 BC038583 mRNA Translation: AAH38583.3 BC039488 mRNA Translation: AAH39488.1 BC051379 mRNA Translation: AAH51379.1 |
CCDSi | CCDS33252.1 [Q8IXR5-2] CCDS46366.2 [Q8IXR5-3] |
RefSeqi | NP_001116118.2, NM_001122646.2 [Q8IXR5-3] NP_001166138.1, NM_001172667.1 [Q8IXR5-4] NP_057574.2, NM_016490.4 [Q8IXR5-2] XP_016859757.1, XM_017004268.1 [Q8IXR5-2] |
3D structure databases
SMRi | Q8IXR5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119409, 1 interactor |
IntActi | Q8IXR5, 2 interactors |
STRINGi | 9606.ENSP00000429896 |
PTM databases
PhosphoSitePlusi | Q8IXR5 |
Genetic variation databases
BioMutai | FAM178B |
DMDMi | 172045738 |
Proteomic databases
MassIVEi | Q8IXR5 |
PaxDbi | Q8IXR5 |
PeptideAtlasi | Q8IXR5 |
PRIDEi | Q8IXR5 |
ProteomicsDBi | 19608 71051 [Q8IXR5-2] |
Protocols and materials databases
Antibodypediai | 47509, 24 antibodies |
Genome annotation databases
Ensembli | ENST00000393526; ENSP00000377160; ENSG00000168754 [Q8IXR5-2] ENST00000490605; ENSP00000429896; ENSG00000168754 [Q8IXR5-3] |
GeneIDi | 51252 |
KEGGi | hsa:51252 |
UCSCi | uc002sxj.4, human [Q8IXR5-3] |
Organism-specific databases
CTDi | 51252 |
DisGeNETi | 51252 |
GeneCardsi | FAM178B |
HGNCi | HGNC:28036, FAM178B |
HPAi | ENSG00000168754, Tissue enhanced (bone marrow, lymphoid tissue, testis) |
neXtProti | NX_Q8IXR5 |
OpenTargetsi | ENSG00000168754 |
PharmGKBi | PA162387456 |
VEuPathDBi | HostDB:ENSG00000168754.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RXJ9, Eukaryota |
GeneTreei | ENSGT00530000064017 |
HOGENOMi | CLU_166950_0_0_1 |
InParanoidi | Q8IXR5 |
OMAi | EVREAFH |
OrthoDBi | 713086at2759 |
PhylomeDBi | Q8IXR5 |
TreeFami | TF332216 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXR5 |
Miscellaneous databases
BioGRID-ORCSi | 51252, 6 hits in 880 CRISPR screens |
ChiTaRSi | FAM178B, human |
GenomeRNAii | 51252 |
Pharosi | Q8IXR5, Tdark |
PROi | PR:Q8IXR5 |
RNActi | Q8IXR5, protein |
Gene expression databases
Bgeei | ENSG00000168754, Expressed in bone marrow and 153 other tissues |
Genevisiblei | Q8IXR5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026161, FAM178 |
PANTHERi | PTHR16046, PTHR16046, 1 hit |
Pfami | View protein in Pfam PF14816, FAM178, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F178B_HUMAN | |
Accessioni | Q8IXR5Primary (citable) accession number: Q8IXR5 Secondary accession number(s): A8MXN2 Q9P0P4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | November 13, 2019 | |
Last modified: | February 10, 2021 | |
This is version 115 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants