UniProtKB - Q8IXQ9 (ETKMT_HUMAN)
Electron transfer flavoprotein beta subunit lysine methyltransferase
ETFBKMT
Functioni
Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781).
Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781).
2 PublicationsGO - Molecular functioni
- heat shock protein binding Source: UniProtKB
- protein-lysine N-methyltransferase activity Source: UniProtKB
- protein methyltransferase activity Source: GO_Central
GO - Biological processi
- negative regulation of electron transfer activity Source: UniProtKB
- negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: UniProtKB
- peptidyl-lysine methylation Source: UniProtKB
- peptidyl-lysine trimethylation Source: UniProtKB
- protein methylation Source: Reactome
Keywordsi
Molecular function | Methyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q8IXQ9 |
Reactomei | R-HSA-8876725, Protein methylation |
SignaLinki | Q8IXQ9 |
Names & Taxonomyi
Protein namesi | Recommended name: Electron transfer flavoprotein beta subunit lysine methyltransferase1 Publication (EC:2.1.1.-2 Publications)Alternative name(s): ETFB lysine methyltransferase1 Publication Short name: ETFB-KMT1 Publication Protein N-lysine methyltransferase METTL20 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28739, ETFBKMT |
MIMi | 615256, gene |
neXtProti | NX_Q8IXQ9 |
VEuPathDBi | HostDB:ENSG00000139160 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Mitochondrion
- Mitochondrion matrix 1 Publication1 Publication
Note: Concentrated in cytoplasmic granular foci.1 Publication
Mitochondrion
- mitochondrial matrix Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 121 | D → A: Loss of lysine methyltransferase activity. 1 Publication | 1 |
Organism-specific databases
OpenTargetsi | ENSG00000139160 |
PharmGKBi | PA164716777 |
Miscellaneous databases
Pharosi | Q8IXQ9, Tbio |
Genetic variation databases
BioMutai | ETFBKMT |
DMDMi | 74759679 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 38 | MitochondrionSequence analysisAdd BLAST | 38 | |
ChainiPRO_0000318709 | 39 – 262 | Electron transfer flavoprotein beta subunit lysine methyltransferaseAdd BLAST | 224 |
Proteomic databases
EPDi | Q8IXQ9 |
MassIVEi | Q8IXQ9 |
PaxDbi | Q8IXQ9 |
PeptideAtlasi | Q8IXQ9 |
PRIDEi | Q8IXQ9 |
ProteomicsDBi | 71049 |
PTM databases
iPTMneti | Q8IXQ9 |
PhosphoSitePlusi | Q8IXQ9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000139160, Expressed in buccal mucosa cell and 146 other tissues |
ExpressionAtlasi | Q8IXQ9, baseline and differential |
Genevisiblei | Q8IXQ9, HS |
Organism-specific databases
HPAi | ENSG00000139160, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with HSPD1; this protein may possibly be a methylation substrate.
1 PublicationGO - Molecular functioni
- heat shock protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 129005, 34 interactors |
IntActi | Q8IXQ9, 3 interactors |
STRINGi | 9606.ENSP00000350353 |
Miscellaneous databases
RNActi | Q8IXQ9, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502QUSY, Eukaryota |
GeneTreei | ENSGT00940000162982 |
HOGENOMi | CLU_074455_2_1_1 |
InParanoidi | Q8IXQ9 |
OMAi | ILNCELN |
OrthoDBi | 1585716at2759 |
PhylomeDBi | Q8IXQ9 |
TreeFami | TF314934 |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases |
SUPFAMi | SSF53335, SSF53335, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MALSLGWKAH RNHCGLLLQA LRSSGLLLFP CGQCPWRGAG SFLDPEIKAF
60 70 80 90 100
LEENTEVTSS GSLTPEIQLR LLTPRCKFWW ERADLWPHSD PYWAIYWPGG
110 120 130 140 150
QALSRYLLDN PDVVRGKSVL DLGSGCGATA IAAKMSGASR ILANDIDPIA
160 170 180 190 200
GMAITLNCEL NRLNPFPILI QNILNLEQDK WDLVVLGDMF YDEDLADSLH
210 220 230 240 250
QWLKKCFWTY RTRVLIGDPG RPQFSGHSIQ HHLHKVVEYS LLESTRQENS
260
GLTTSTVWGF QP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5EA40 | G5EA40_HUMAN | Electron transfer flavoprotein beta... | ETFBKMT MGC50559, hCG_39178 | 114 | Annotation score: | ||
F5H481 | F5H481_HUMAN | Electron transfer flavoprotein beta... | ETFBKMT | 72 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290248 mRNA Translation: BAF82937.1 CH471116 Genomic DNA Translation: EAW88545.1 CH471116 Genomic DNA Translation: EAW88547.1 CH471116 Genomic DNA Translation: EAW88548.1 BC039107 mRNA Translation: AAH39107.1 BC039535 mRNA Translation: AAH39535.1 |
CCDSi | CCDS8724.1 |
RefSeqi | NP_001129335.1, NM_001135863.1 NP_001129336.1, NM_001135864.1 NP_776163.1, NM_173802.3 |
Genome annotation databases
Ensembli | ENST00000357721.3; ENSP00000350353.3; ENSG00000139160.13 ENST00000395763.7; ENSP00000379112.3; ENSG00000139160.13 ENST00000412352.6; ENSP00000396123.2; ENSG00000139160.13 ENST00000538463.5; ENSP00000441421.1; ENSG00000139160.13 |
GeneIDi | 254013 |
KEGGi | hsa:254013 |
MANE-Selecti | ENST00000357721.3; ENSP00000350353.3; NM_001135863.2; NP_001129335.1 |
UCSCi | uc001rkl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290248 mRNA Translation: BAF82937.1 CH471116 Genomic DNA Translation: EAW88545.1 CH471116 Genomic DNA Translation: EAW88547.1 CH471116 Genomic DNA Translation: EAW88548.1 BC039107 mRNA Translation: AAH39107.1 BC039535 mRNA Translation: AAH39535.1 |
CCDSi | CCDS8724.1 |
RefSeqi | NP_001129335.1, NM_001135863.1 NP_001129336.1, NM_001135864.1 NP_776163.1, NM_173802.3 |
3D structure databases
AlphaFoldDBi | Q8IXQ9 |
SMRi | Q8IXQ9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129005, 34 interactors |
IntActi | Q8IXQ9, 3 interactors |
STRINGi | 9606.ENSP00000350353 |
PTM databases
iPTMneti | Q8IXQ9 |
PhosphoSitePlusi | Q8IXQ9 |
Genetic variation databases
BioMutai | ETFBKMT |
DMDMi | 74759679 |
Proteomic databases
EPDi | Q8IXQ9 |
MassIVEi | Q8IXQ9 |
PaxDbi | Q8IXQ9 |
PeptideAtlasi | Q8IXQ9 |
PRIDEi | Q8IXQ9 |
ProteomicsDBi | 71049 |
Protocols and materials databases
Antibodypediai | 24685, 34 antibodies from 14 providers |
DNASUi | 254013 |
Genome annotation databases
Ensembli | ENST00000357721.3; ENSP00000350353.3; ENSG00000139160.13 ENST00000395763.7; ENSP00000379112.3; ENSG00000139160.13 ENST00000412352.6; ENSP00000396123.2; ENSG00000139160.13 ENST00000538463.5; ENSP00000441421.1; ENSG00000139160.13 |
GeneIDi | 254013 |
KEGGi | hsa:254013 |
MANE-Selecti | ENST00000357721.3; ENSP00000350353.3; NM_001135863.2; NP_001129335.1 |
UCSCi | uc001rkl.4, human |
Organism-specific databases
CTDi | 254013 |
GeneCardsi | ETFBKMT |
HGNCi | HGNC:28739, ETFBKMT |
HPAi | ENSG00000139160, Low tissue specificity |
MIMi | 615256, gene |
neXtProti | NX_Q8IXQ9 |
OpenTargetsi | ENSG00000139160 |
PharmGKBi | PA164716777 |
VEuPathDBi | HostDB:ENSG00000139160 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUSY, Eukaryota |
GeneTreei | ENSGT00940000162982 |
HOGENOMi | CLU_074455_2_1_1 |
InParanoidi | Q8IXQ9 |
OMAi | ILNCELN |
OrthoDBi | 1585716at2759 |
PhylomeDBi | Q8IXQ9 |
TreeFami | TF314934 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXQ9 |
Reactomei | R-HSA-8876725, Protein methylation |
SignaLinki | Q8IXQ9 |
Miscellaneous databases
BioGRID-ORCSi | 254013, 8 hits in 1065 CRISPR screens |
ChiTaRSi | ETFBKMT, human |
GenomeRNAii | 254013 |
Pharosi | Q8IXQ9, Tbio |
PROi | PR:Q8IXQ9 |
RNActi | Q8IXQ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139160, Expressed in buccal mucosa cell and 146 other tissues |
ExpressionAtlasi | Q8IXQ9, baseline and differential |
Genevisiblei | Q8IXQ9, HS |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR029063, SAM-dependent_MTases |
SUPFAMi | SSF53335, SSF53335, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ETKMT_HUMAN | |
Accessioni | Q8IXQ9Primary (citable) accession number: Q8IXQ9 Secondary accession number(s): D3DUW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families