UniProtKB - Q8IXQ6 (PARP9_HUMAN)
Protein mono-ADP-ribosyltransferase PARP9
PARP9
Functioni
Catalytic activityi
- [protein]-C-terminal glycine + NAD+ = [protein]-C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide1 PublicationThis reaction proceeds in the forward1 Publication direction.
Activity regulationi
Kineticsi
- KM=196 µM for NAD+1 Publication
GO - Molecular functioni
- ADP-D-ribose binding Source: UniProtKB
- enzyme binding Source: UniProtKB
- enzyme inhibitor activity Source: UniProtKB
- histone binding Source: UniProtKB
- NAD+ ADP-ribosyltransferase activity Source: UniProtKB
- protein ADP-ribosylase activity Source: GO_Central
- STAT family protein binding Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
GO - Biological processi
- cell migration Source: UniProtKB
- defense response to virus Source: UniProtKB-KW
- double-strand break repair Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- NAD biosynthesis via nicotinamide riboside salvage pathway Source: Reactome
- negative regulation of catalytic activity Source: UniProtKB
- negative regulation of gene expression Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of chromatin binding Source: UniProtKB
- positive regulation of defense response to virus by host Source: UniProtKB
- positive regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
- positive regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
- positive regulation of protein localization to nucleus Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- posttranscriptional regulation of gene expression Source: UniProtKB
- protein ADP-ribosylation Source: UniProtKB
- protein mono-ADP-ribosylation Source: GO_Central
- regulation of response to interferon-gamma Source: UniProtKB
- viral protein processing Source: Reactome
Keywordsi
Molecular function | Transferase |
Biological process | Antiviral defense, DNA damage, DNA repair, Immunity, Innate immunity |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | Q8IXQ6 |
Reactomei | R-HSA-197264, Nicotinamide salvaging R-HSA-9683610, Maturation of nucleoprotein R-HSA-9694631, Maturation of nucleoprotein |
Names & Taxonomyi
Protein namesi | Recommended name: Protein mono-ADP-ribosyltransferase PARP9Curated (EC:2.4.2.-1 Publication)Alternative name(s): ADP-ribosyltransferase diphtheria toxin-like 9 Short name: ARTD9 B aggressive lymphoma protein1 Publication Poly [ADP-ribose] polymerase 9 Short name: PARP-9 |
Gene namesi | Name:PARP9 Synonyms:BAL1 Publication, BAL11 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24118, PARP9 |
MIMi | 612065, gene |
neXtProti | NX_Q8IXQ6 |
VEuPathDBi | HostDB:ENSG00000138496.16 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 3 Publications
Nucleus
- Nucleus 5 Publications
Note: Shuttles between the nucleus and the cytosol (PubMed:16809771). Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Export to the cytosol depends on the interaction with DTX3L (PubMed:16809771). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742).4 Publications
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
- protein-containing complex Source: UniProtKB
- site of DNA damage Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 147 | G → E: Reduces the binding to poly(ADP-ribose) by 50 percent and prevents increase in DTX3L-mediated histone ubiquitination without affecting ubiquitin ADP ribosylation, interaction with DTX3L and STAT1 and DTX3L catalytic activity; when associated with E-346. 2 Publications | 1 | |
Mutagenesisi | 346 | G → E: Reduces the binding to poly(ADP-ribose) by 50 percent and prevents increase in DTX3L-mediated histone ubiquitination without affecting ubiquitin ADP ribosylation, interaction with DTX3L and STAT1 and DTX3L catalytic activity; when associated with E-147. 2 Publications | 1 | |
Mutagenesisi | 719 – 722 | Missing : Loss of ADP ribosylation activity and interaction with DTX3L. 1 Publication | 4 | |
Mutagenesisi | 737 | Y → A: No defect in ubiquitin ADP ribosylation and the interaction with DTX3L. 1 Publication | 1 | |
Mutagenesisi | 738 | F → K: Severe reduction in ubiquitin ADP ribosylation. No effect on the interaction with DTX3L and on DTX3L E3 ligase activity. Increases DNA repair. 1 Publication | 1 | |
Mutagenesisi | 766 – 769 | Missing : Loss of ADP ribosylation activity and interaction with DTX3L. 1 Publication | 4 | |
Mutagenesisi | 780 – 784 | Missing : Reduces ADP ribosylation activity and interaction with DTX3L. 1 Publication | 5 | |
Mutagenesisi | 802 – 803 | PE → AA: No defect in ADP ribosylation and interaction with DTX3L. 1 Publication | 2 | |
Mutagenesisi | 831 – 854 | Missing : No defect in ADP ribosylation and interaction with DTX3L. 1 PublicationAdd BLAST | 24 |
Organism-specific databases
DisGeNETi | 83666 |
OpenTargetsi | ENSG00000138496 |
PharmGKBi | PA134870403 |
Miscellaneous databases
Pharosi | Q8IXQ6, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295895 |
Genetic variation databases
BioMutai | PARP9 |
DMDMi | 48474734 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211339 | 1 – 854 | Protein mono-ADP-ribosyltransferase PARP9Add BLAST | 854 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylationProteomic databases
EPDi | Q8IXQ6 |
jPOSTi | Q8IXQ6 |
MassIVEi | Q8IXQ6 |
MaxQBi | Q8IXQ6 |
PaxDbi | Q8IXQ6 |
PeptideAtlasi | Q8IXQ6 |
PRIDEi | Q8IXQ6 |
ProteomicsDBi | 20136 71045 [Q8IXQ6-1] 71046 [Q8IXQ6-2] |
PTM databases
iPTMneti | Q8IXQ6 |
MetOSitei | Q8IXQ6 |
PhosphoSitePlusi | Q8IXQ6 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000138496, Expressed in ectocervix and 201 other tissues |
ExpressionAtlasi | Q8IXQ6, baseline and differential |
Genevisiblei | Q8IXQ6, HS |
Organism-specific databases
HPAi | ENSG00000138496, Low tissue specificity |
Interactioni
Subunit structurei
Forms a stable complex with E3 ligase DTX3L; the interaction is required for PARP9 mediated ADP-ribosylation of ubiquitin (PubMed:12670957, PubMed:28525742).
Interacts (via PARP catalytic domain) with DTX3L (via N-terminus) (PubMed:26479788).
Forms a complex with STAT1 and DTX3L independently of IFNB1 or IFNG-mediated STAT1 'Tyr-701' phosphorylation (PubMed:26479788).
Forms a complex with STAT1, DTX3L and histone H2B H2BC9/H2BJ; the interaction is likely to induce H2BC9/H2BJ ubiquitination (PubMed:26479788).
Interacts (via N-terminus) with STAT1 (PubMed:26479788).
Interacts with PARP14 in IFNG-stimulated macrophages; the interaction prevents PARP14-mediated STAT1 and STAT6 ADP-riboslylation (PubMed:27796300).
Interacts with PARP1 (when poly-ADP-ribosylated) (PubMed:23230272).
5 PublicationsGO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone binding Source: UniProtKB
- STAT family protein binding Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123723, 19 interactors |
CORUMi | Q8IXQ6 |
IntActi | Q8IXQ6, 2 interactors |
STRINGi | 9606.ENSP00000353512 |
Miscellaneous databases
RNActi | Q8IXQ6, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8IXQ6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 296 | Macro 1PROSITE-ProRule annotationAdd BLAST | 190 | |
Domaini | 306 – 487 | Macro 2PROSITE-ProRule annotationAdd BLAST | 182 | |
Domaini | 628 – 850 | PARP catalyticPROSITE-ProRule annotationAdd BLAST | 223 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2633, Eukaryota |
GeneTreei | ENSGT00940000158837 |
HOGENOMi | CLU_012160_0_0_1 |
InParanoidi | Q8IXQ6 |
OMAi | SEFPKPQ |
OrthoDBi | 681829at2759 |
PhylomeDBi | Q8IXQ6 |
TreeFami | TF328965 |
Family and domain databases
Gene3Di | 3.40.220.10, 2 hits |
InterProi | View protein in InterPro IPR002589, Macro_dom IPR043472, Macro_dom-like IPR012317, Poly(ADP-ribose)pol_cat_dom |
Pfami | View protein in Pfam PF01661, Macro, 2 hits |
SMARTi | View protein in SMART SM00506, A1pp, 2 hits |
SUPFAMi | SSF52949, SSF52949, 2 hits |
PROSITEi | View protein in PROSITE PS51154, MACRO, 2 hits PS51059, PARP_CATALYTIC, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFSMVAGAA AYNEKSGRIT SLSLLFQKVF AQIFPQWRKG NTEECLPYKC
60 70 80 90 100
SETGALGENY SWQIPINHND FKILKNNERQ LCEVLQNKFG CISTLVSPVQ
110 120 130 140 150
EGNSKSLQVF RKMLTPRIEL SVWKDDLTTH AVDAVVNAAN EDLLHGGGLA
160 170 180 190 200
LALVKAGGFE IQEESKQFVA RYGKVSAGEI AVTGAGRLPC KQIIHAVGPR
210 220 230 240 250
WMEWDKQGCT GKLQRAIVSI LNYVIYKNTH IKTVAIPALS SGIFQFPLNL
260 270 280 290 300
CTKTIVETIR VSLQGKPMMS NLKEIHLVSN EDPTVAAFKA ASEFILGKSE
310 320 330 340 350
LGQETTPSFN AMVVNNLTLQ IVQGHIEWQT ADVIVNSVNP HDITVGPVAK
360 370 380 390 400
SILQQAGVEM KSEFLATKAK QFQRSQLVLV TKGFNLFCKY IYHVLWHSEF
410 420 430 440 450
PKPQILKHAM KECLEKCIEQ NITSISFPAL GTGNMEIKKE TAAEILFDEV
460 470 480 490 500
LTFAKDHVKH QLTVKFVIFP TDLEIYKAFS SEMAKRSKML SLNNYSVPQS
510 520 530 540 550
TREEKRENGL EARSPAINLM GFNVEEMYEA HAWIQRILSL QNHHIIENNH
560 570 580 590 600
ILYLGRKEHD ILSQLQKTSS VSITEIISPG RTELEIEGAR ADLIEVVMNI
610 620 630 640 650
EDMLCKVQEE MARKKERGLW RSLGQWTIQQ QKTQDEMKEN IIFLKCPVPP
660 670 680 690 700
TQELLDQKKQ FEKCGLQVLK VEKIDNEVLM AAFQRKKKMM EEKLHRQPVS
710 720 730 740 750
HRLFQQVPYQ FCNVVCRVGF QRMYSTPCDP KYGAGIYFTK NLKNLAEKAK
760 770 780 790 800
KISAADKLIY VFEAEVLTGF FCQGHPLNIV PPPLSPGAID GHDSVVDNVS
810 820 830 840 850
SPETFVIFSG MQAIPQYLWT CTQEYVQSQD YSSGPMRPFA QHPWRGFASG
SPVD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9U8 | G5E9U8_HUMAN | Poly (ADP-ribose) polymerase family... | PARP9 hCG_17211 | 399 | Annotation score: | ||
C9K0E5 | C9K0E5_HUMAN | Protein mono-ADP-ribosyltransferase... | PARP9 | 115 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 487 | S → P in BAF85648 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 839 | F → S in BAG36276 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056654 | 21 | S → L. Corresponds to variant dbSNP:rs34006803Ensembl. | 1 | |
Natural variantiVAR_056655 | 517 | I → V1 PublicationCorresponds to variant dbSNP:rs28365795Ensembl. | 1 | |
Natural variantiVAR_056656 | 528 | Y → C3 PublicationsCorresponds to variant dbSNP:rs9851180Ensembl. | 1 | |
Natural variantiVAR_056657 | 651 | T → A. Corresponds to variant dbSNP:rs6780543EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008505 | 17 – 51 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 35 | |
Alternative sequenceiVSP_046086 | 729 – 745 | DPKYG…NLKNL → GRCQCLIIGATLWNLVS in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_046087 | 746 – 854 | Missing in isoform 3. 1 PublicationAdd BLAST | 109 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF307338 mRNA Translation: AAK07558.1 AF307339 mRNA Translation: AAK07559.1 AK292959 mRNA Translation: BAF85648.1 AK313494 mRNA Translation: BAG36276.1 AC092908 Genomic DNA No translation available. AC096861 Genomic DNA No translation available. BC017463 mRNA No translation available. BC039580 mRNA Translation: AAH39580.1 AL713679 mRNA Translation: CAD28483.1 |
CCDSi | CCDS3014.1 [Q8IXQ6-1] CCDS54633.1 [Q8IXQ6-3] CCDS54634.1 [Q8IXQ6-2] |
RefSeqi | NP_001139574.1, NM_001146102.1 [Q8IXQ6-1] NP_001139575.1, NM_001146103.1 [Q8IXQ6-2] NP_001139576.1, NM_001146104.1 [Q8IXQ6-2] NP_001139577.1, NM_001146105.1 [Q8IXQ6-2] NP_113646.2, NM_031458.2 [Q8IXQ6-1] XP_005247877.1, XM_005247820.2 [Q8IXQ6-1] XP_016862793.1, XM_017007304.1 [Q8IXQ6-1] XP_016862794.1, XM_017007305.1 [Q8IXQ6-2] XP_016862795.1, XM_017007306.1 [Q8IXQ6-2] |
Genome annotation databases
Ensembli | ENST00000360356; ENSP00000353512; ENSG00000138496 [Q8IXQ6-1] ENST00000462315; ENSP00000418894; ENSG00000138496 [Q8IXQ6-3] ENST00000471785; ENSP00000419001; ENSG00000138496 [Q8IXQ6-2] ENST00000477522; ENSP00000419506; ENSG00000138496 [Q8IXQ6-2] |
GeneIDi | 83666 |
KEGGi | hsa:83666 |
UCSCi | uc003efh.5, human [Q8IXQ6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF307338 mRNA Translation: AAK07558.1 AF307339 mRNA Translation: AAK07559.1 AK292959 mRNA Translation: BAF85648.1 AK313494 mRNA Translation: BAG36276.1 AC092908 Genomic DNA No translation available. AC096861 Genomic DNA No translation available. BC017463 mRNA No translation available. BC039580 mRNA Translation: AAH39580.1 AL713679 mRNA Translation: CAD28483.1 |
CCDSi | CCDS3014.1 [Q8IXQ6-1] CCDS54633.1 [Q8IXQ6-3] CCDS54634.1 [Q8IXQ6-2] |
RefSeqi | NP_001139574.1, NM_001146102.1 [Q8IXQ6-1] NP_001139575.1, NM_001146103.1 [Q8IXQ6-2] NP_001139576.1, NM_001146104.1 [Q8IXQ6-2] NP_001139577.1, NM_001146105.1 [Q8IXQ6-2] NP_113646.2, NM_031458.2 [Q8IXQ6-1] XP_005247877.1, XM_005247820.2 [Q8IXQ6-1] XP_016862793.1, XM_017007304.1 [Q8IXQ6-1] XP_016862794.1, XM_017007305.1 [Q8IXQ6-2] XP_016862795.1, XM_017007306.1 [Q8IXQ6-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5AIL | X-ray | 1.55 | A/B | 310-493 | [»] | |
SMRi | Q8IXQ6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123723, 19 interactors |
CORUMi | Q8IXQ6 |
IntActi | Q8IXQ6, 2 interactors |
STRINGi | 9606.ENSP00000353512 |
Chemistry databases
ChEMBLi | CHEMBL4295895 |
PTM databases
iPTMneti | Q8IXQ6 |
MetOSitei | Q8IXQ6 |
PhosphoSitePlusi | Q8IXQ6 |
Genetic variation databases
BioMutai | PARP9 |
DMDMi | 48474734 |
Proteomic databases
EPDi | Q8IXQ6 |
jPOSTi | Q8IXQ6 |
MassIVEi | Q8IXQ6 |
MaxQBi | Q8IXQ6 |
PaxDbi | Q8IXQ6 |
PeptideAtlasi | Q8IXQ6 |
PRIDEi | Q8IXQ6 |
ProteomicsDBi | 20136 71045 [Q8IXQ6-1] 71046 [Q8IXQ6-2] |
Protocols and materials databases
Antibodypediai | 32910, 96 antibodies |
Genome annotation databases
Ensembli | ENST00000360356; ENSP00000353512; ENSG00000138496 [Q8IXQ6-1] ENST00000462315; ENSP00000418894; ENSG00000138496 [Q8IXQ6-3] ENST00000471785; ENSP00000419001; ENSG00000138496 [Q8IXQ6-2] ENST00000477522; ENSP00000419506; ENSG00000138496 [Q8IXQ6-2] |
GeneIDi | 83666 |
KEGGi | hsa:83666 |
UCSCi | uc003efh.5, human [Q8IXQ6-1] |
Organism-specific databases
CTDi | 83666 |
DisGeNETi | 83666 |
GeneCardsi | PARP9 |
HGNCi | HGNC:24118, PARP9 |
HPAi | ENSG00000138496, Low tissue specificity |
MIMi | 612065, gene |
neXtProti | NX_Q8IXQ6 |
OpenTargetsi | ENSG00000138496 |
PharmGKBi | PA134870403 |
VEuPathDBi | HostDB:ENSG00000138496.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2633, Eukaryota |
GeneTreei | ENSGT00940000158837 |
HOGENOMi | CLU_012160_0_0_1 |
InParanoidi | Q8IXQ6 |
OMAi | SEFPKPQ |
OrthoDBi | 681829at2759 |
PhylomeDBi | Q8IXQ6 |
TreeFami | TF328965 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXQ6 |
Reactomei | R-HSA-197264, Nicotinamide salvaging R-HSA-9683610, Maturation of nucleoprotein R-HSA-9694631, Maturation of nucleoprotein |
Miscellaneous databases
BioGRID-ORCSi | 83666, 4 hits in 998 CRISPR screens |
ChiTaRSi | PARP9, human |
GenomeRNAii | 83666 |
Pharosi | Q8IXQ6, Tbio |
PROi | PR:Q8IXQ6 |
RNActi | Q8IXQ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138496, Expressed in ectocervix and 201 other tissues |
ExpressionAtlasi | Q8IXQ6, baseline and differential |
Genevisiblei | Q8IXQ6, HS |
Family and domain databases
Gene3Di | 3.40.220.10, 2 hits |
InterProi | View protein in InterPro IPR002589, Macro_dom IPR043472, Macro_dom-like IPR012317, Poly(ADP-ribose)pol_cat_dom |
Pfami | View protein in Pfam PF01661, Macro, 2 hits |
SMARTi | View protein in SMART SM00506, A1pp, 2 hits |
SUPFAMi | SSF52949, SSF52949, 2 hits |
PROSITEi | View protein in PROSITE PS51154, MACRO, 2 hits PS51059, PARP_CATALYTIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PARP9_HUMAN | |
Accessioni | Q8IXQ6Primary (citable) accession number: Q8IXQ6 Secondary accession number(s): A8KA94 Q9BZL9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | October 10, 2003 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references