Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GPALPP motifs-containing protein 1

Gene

GPALPP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GPALPP motifs-containing protein 1
Alternative name(s):
Lipopolysaccharide-specific response protein 7
Gene namesi
Name:GPALPP1
Synonyms:KIAA1704, LSR7
ORF Names:AD029
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000133114.17
HGNCiHGNC:20298 GPALPP1
neXtProtiNX_Q8IXQ4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133114
PharmGKBiPA134943194

Polymorphism and mutation databases

BioMutaiGPALPP1
DMDMi74728222

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002937142 – 340GPALPP motifs-containing protein 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei140PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Cross-linki271Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki308Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IXQ4
MaxQBiQ8IXQ4
PaxDbiQ8IXQ4
PeptideAtlasiQ8IXQ4
PRIDEiQ8IXQ4
ProteomicsDBi71037
71038 [Q8IXQ4-2]
71039 [Q8IXQ4-3]
71040 [Q8IXQ4-4]

PTM databases

iPTMnetiQ8IXQ4
PhosphoSitePlusiQ8IXQ4

Expressioni

Gene expression databases

BgeeiENSG00000133114 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_KIAA1704
ExpressionAtlasiQ8IXQ4 baseline and differential
GenevisibleiQ8IXQ4 HS

Organism-specific databases

HPAiHPA038966
HPA058739

Interactioni

Protein-protein interaction databases

BioGridi120665, 26 interactors
IntActiQ8IXQ4, 10 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8IXQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi7 – 12GPALPP motif 16
Motifi32 – 37GPALPP motif 26
Motifi92 – 97GPALPP motif 36
Motifi112 – 117GPALPP motif 46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 49Poly-Ser9
Compositional biasi81 – 88Poly-Asp8

Phylogenomic databases

eggNOGiKOG4188 Eukaryota
ENOG4111F1D LUCA
GeneTreeiENSGT00390000008389
HOVERGENiHBG057200
InParanoidiQ8IXQ4
OMAiWMLVPPS
OrthoDBiEOG091G0INW
PhylomeDBiQ8IXQ4
TreeFamiTF314389

Family and domain databases

InterProiView protein in InterPro
IPR022226 DUF3752
PfamiView protein in Pfam
PF12572 DUF3752, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IXQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARDLIGPAL PPGFKARGTA EDEERDPSPV AGPALPPNYK SSSSDSSDSD
60 70 80 90 100
EDSSSLYEEG NQESEEDDSG PTARKQRKNQ DDDDDDDDGF FGPALPPGFK
110 120 130 140 150
KQDDSPPRPI IGPALPPGFI KSTQKSDKGR DDPGQQETDS SEDEDIIGPM
160 170 180 190 200
PAKGPVNYNV TTEFEKRAQR MKEKLTKGDD DSSKPIVRES WMTELPPEMK
210 220 230 240 250
DFGLGPRTFK RRADDTSGDR SIWTDTPADR ERKAKETQEA RKSSSKKDEE
260 270 280 290 300
HILSGRDKRL AEQVSSYNES KRSESLMDIH HKKLKSKAAE DKNKPQERIP
310 320 330 340
FDRDKDLKVN RFDEAQKKAL IKKSRELNTR FSHGKGNMFL
Length:340
Mass (Da):38,142
Last modified:March 1, 2003 - v1
Checksum:iF752A6A2917132E6
GO
Isoform 2 (identifier: Q8IXQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):22,226
Checksum:iF398D2648B8C9B52
GO
Isoform 3 (identifier: Q8IXQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):19,807
Checksum:iB181167EB8421D96
GO
Isoform 4 (identifier: Q8IXQ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-175: ETDSSEDEDI...KRAQRMKEKL → VSSSHFNSKV...CSYYNHWTQL
     176-340: Missing.

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):19,237
Checksum:i0606892D4AFD3B66
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRI1A0A0A0MRI1_HUMAN
GPALPP motifs-containing protein 1
GPALPP1 KIAA1704, hCG_32794
338Annotation score:
A0A087WW86A0A087WW86_HUMAN
GPALPP motifs-containing protein 1
GPALPP1
100Annotation score:

Sequence cautioni

The sequence AAH17776 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB21795 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126S → I in AAH32333 (PubMed:15489334).Curated1
Sequence conflicti194E → K in AAF70548 (Ref. 1) Curated1
Sequence conflicti212R → G in AAF70548 (Ref. 1) Curated1
Sequence conflicti242K → E in AAF70548 (Ref. 1) Curated1
Sequence conflicti280H → Q in AAH17776 (PubMed:15489334).Curated1
Sequence conflicti295P → L in AAH39586 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0265671 – 170Missing in isoform 3. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_0265681 – 149Missing in isoform 2. 1 PublicationAdd BLAST149
Alternative sequenceiVSP_026569137 – 175ETDSS…MKEKL → VSSSHFNSKVWKVFIERIRC IVTNSKLYACSYYNHWTQL in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_026570176 – 340Missing in isoform 4. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145122 mRNA Translation: AAF70548.1
AB051491 mRNA Translation: BAB21795.1 Different initiation.
AF245045 mRNA Translation: AAG44482.1
AK292493 mRNA Translation: BAF85182.1
AL359706 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08720.1
BC017776 mRNA Translation: AAH17776.1 Sequence problems.
BC032333 mRNA Translation: AAH32333.1
BC039586 mRNA Translation: AAH39586.1
CCDSiCCDS9394.1 [Q8IXQ4-1]
RefSeqiNP_001303880.1, NM_001316951.1 [Q8IXQ4-1]
NP_001303881.1, NM_001316952.1
NP_061029.2, NM_018559.3 [Q8IXQ4-1]
XP_005266501.1, XM_005266444.3 [Q8IXQ4-1]
UniGeneiHs.731811
Hs.744143

Genome annotation databases

EnsembliENST00000357537; ENSP00000350145; ENSG00000133114 [Q8IXQ4-3]
ENST00000379151; ENSP00000368447; ENSG00000133114 [Q8IXQ4-1]
ENST00000497558; ENSP00000432500; ENSG00000133114 [Q8IXQ4-1]
GeneIDi55425
KEGGihsa:55425
UCSCiuc001uzq.4 human [Q8IXQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145122 mRNA Translation: AAF70548.1
AB051491 mRNA Translation: BAB21795.1 Different initiation.
AF245045 mRNA Translation: AAG44482.1
AK292493 mRNA Translation: BAF85182.1
AL359706 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08720.1
BC017776 mRNA Translation: AAH17776.1 Sequence problems.
BC032333 mRNA Translation: AAH32333.1
BC039586 mRNA Translation: AAH39586.1
CCDSiCCDS9394.1 [Q8IXQ4-1]
RefSeqiNP_001303880.1, NM_001316951.1 [Q8IXQ4-1]
NP_001303881.1, NM_001316952.1
NP_061029.2, NM_018559.3 [Q8IXQ4-1]
XP_005266501.1, XM_005266444.3 [Q8IXQ4-1]
UniGeneiHs.731811
Hs.744143

3D structure databases

ProteinModelPortaliQ8IXQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120665, 26 interactors
IntActiQ8IXQ4, 10 interactors

PTM databases

iPTMnetiQ8IXQ4
PhosphoSitePlusiQ8IXQ4

Polymorphism and mutation databases

BioMutaiGPALPP1
DMDMi74728222

Proteomic databases

EPDiQ8IXQ4
MaxQBiQ8IXQ4
PaxDbiQ8IXQ4
PeptideAtlasiQ8IXQ4
PRIDEiQ8IXQ4
ProteomicsDBi71037
71038 [Q8IXQ4-2]
71039 [Q8IXQ4-3]
71040 [Q8IXQ4-4]

Protocols and materials databases

DNASUi55425
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357537; ENSP00000350145; ENSG00000133114 [Q8IXQ4-3]
ENST00000379151; ENSP00000368447; ENSG00000133114 [Q8IXQ4-1]
ENST00000497558; ENSP00000432500; ENSG00000133114 [Q8IXQ4-1]
GeneIDi55425
KEGGihsa:55425
UCSCiuc001uzq.4 human [Q8IXQ4-1]

Organism-specific databases

CTDi55425
EuPathDBiHostDB:ENSG00000133114.17
GeneCardsiGPALPP1
HGNCiHGNC:20298 GPALPP1
HPAiHPA038966
HPA058739
neXtProtiNX_Q8IXQ4
OpenTargetsiENSG00000133114
PharmGKBiPA134943194
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4188 Eukaryota
ENOG4111F1D LUCA
GeneTreeiENSGT00390000008389
HOVERGENiHBG057200
InParanoidiQ8IXQ4
OMAiWMLVPPS
OrthoDBiEOG091G0INW
PhylomeDBiQ8IXQ4
TreeFamiTF314389

Miscellaneous databases

ChiTaRSiGPALPP1 human
GeneWikiiKIAA1704
GenomeRNAii55425
PROiPR:Q8IXQ4

Gene expression databases

BgeeiENSG00000133114 Expressed in 209 organ(s), highest expression level in corpus callosum
CleanExiHS_KIAA1704
ExpressionAtlasiQ8IXQ4 baseline and differential
GenevisibleiQ8IXQ4 HS

Family and domain databases

InterProiView protein in InterPro
IPR022226 DUF3752
PfamiView protein in Pfam
PF12572 DUF3752, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPAM1_HUMAN
AccessioniPrimary (citable) accession number: Q8IXQ4
Secondary accession number(s): A8K8X8
, Q05BX8, Q05D87, Q5T3Z3, Q5T3Z5, Q9C0F9, Q9H2R0, Q9P0W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again