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Entry version 117 (08 May 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Uncharacterized protein C9orf40

Gene

C9orf40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C9orf40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C9orf40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:23433 C9orf40

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IXQ3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000135045

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870430

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C9orf40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73620021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000896821 – 194Uncharacterized protein C9orf40Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei69PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IXQ3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IXQ3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IXQ3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IXQ3

PeptideAtlas

More...
PeptideAtlasi
Q8IXQ3

PRoteomics IDEntifications database

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PRIDEi
Q8IXQ3

ProteomicsDB human proteome resource

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ProteomicsDBi
71036

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q8IXQ3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IXQ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IXQ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135045 Expressed in 209 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IXQ3 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA042167

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120388, 15 interactors

Protein interaction database and analysis system

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IntActi
Q8IXQ3, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000366050

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 32Poly-Pro5
Compositional biasi97 – 103Poly-Pro7
Compositional biasi119 – 122Poly-Gly4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWV7 Eukaryota
ENOG41116VB LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000001325

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111638

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IXQ3

Identification of Orthologs from Complete Genome Data

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OMAi
TFHVPWK

Database of Orthologous Groups

More...
OrthoDBi
1435359at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IXQ3

TreeFam database of animal gene trees

More...
TreeFami
TF338442

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020521 Uncharacterised_C9orf40
IPR033461 WRNPLPNID

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15017 WRNPLPNID, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD309264 C9orf40, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8IXQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKRRAAEPV TFHVPWKRLL LCDFAEQPPP PPLWIRPPGV AHAGQLLGVP
60 70 80 90 100
EQHRKRKIDA GTMAEPSASP SKRRDSGDNS APSGQEREDH GLETGDPPLP
110 120 130 140 150
PPPVLPGPGE ELPGARLPGG GGDDGAGRAG PPRGDWGVAS RQHNEEFWQY
160 170 180 190
NTFQYWRNPL PPIDLADIED LSEDTLTEAT LQGRNEGAEV DMES
Length:194
Mass (Da):21,063
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE7DE67DA59393731
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141R → C in BAA91449 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK000972 mRNA Translation: BAA91449.1
AL158825 Genomic DNA No translation available.
BC039588 mRNA Translation: AAH39588.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6648.1

NCBI Reference Sequences

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RefSeqi
NP_060468.2, NM_017998.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000376854; ENSP00000366050; ENSG00000135045

Database of genes from NCBI RefSeq genomes

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GeneIDi
55071

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55071

UCSC genome browser

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UCSCi
uc004ajo.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000972 mRNA Translation: BAA91449.1
AL158825 Genomic DNA No translation available.
BC039588 mRNA Translation: AAH39588.1
CCDSiCCDS6648.1
RefSeqiNP_060468.2, NM_017998.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120388, 15 interactors
IntActiQ8IXQ3, 1 interactor
STRINGi9606.ENSP00000366050

PTM databases

iPTMnetiQ8IXQ3
PhosphoSitePlusiQ8IXQ3

Polymorphism and mutation databases

BioMutaiC9orf40
DMDMi73620021

Proteomic databases

EPDiQ8IXQ3
jPOSTiQ8IXQ3
MaxQBiQ8IXQ3
PaxDbiQ8IXQ3
PeptideAtlasiQ8IXQ3
PRIDEiQ8IXQ3
ProteomicsDBi71036
TopDownProteomicsiQ8IXQ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376854; ENSP00000366050; ENSG00000135045
GeneIDi55071
KEGGihsa:55071
UCSCiuc004ajo.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55071

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C9orf40

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008103
HGNCiHGNC:23433 C9orf40
HPAiHPA042167
neXtProtiNX_Q8IXQ3
OpenTargetsiENSG00000135045
PharmGKBiPA134870430

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWV7 Eukaryota
ENOG41116VB LUCA
GeneTreeiENSGT00390000001325
HOGENOMiHOG000111638
InParanoidiQ8IXQ3
OMAiTFHVPWK
OrthoDBi1435359at2759
PhylomeDBiQ8IXQ3
TreeFamiTF338442

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55071

Protein Ontology

More...
PROi
PR:Q8IXQ3

Gene expression databases

BgeeiENSG00000135045 Expressed in 209 organ(s), highest expression level in secondary oocyte
GenevisibleiQ8IXQ3 HS

Family and domain databases

InterProiView protein in InterPro
IPR020521 Uncharacterised_C9orf40
IPR033461 WRNPLPNID
PfamiView protein in Pfam
PF15017 WRNPLPNID, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD309264 C9orf40, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCI040_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXQ3
Secondary accession number(s): Q9NWD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: May 8, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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