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UniProtKB - Q8IXN4 (Q8IXN4_HUMAN)
Protein
Submitted name:
MAK protein
Gene
MAK
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine kinase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: MAK proteinImportedSubmitted name: Serine/threonine-protein kinase MAKImported |
Gene namesi | Name:MAKImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6816, MAK |
VEuPathDBi | HostDB:ENSG00000111837 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111837, Expressed in sperm and 133 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 284 | Protein kinaseInterPro annotationAdd BLAST | 281 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 328 – 392 | DisorderedSequence analysisAdd BLAST | 65 | |
Regioni | 416 – 436 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 333 – 392 | Polar residuesSequence analysisAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000156581 |
HOGENOMi | CLU_000288_181_25_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8IXN4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNRYTTMRQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE
60 70 80 90 100
VKSLKKLNHA NVIKLKEVIR ENDHLYFIFE YMKENLYQLM KDRNKLFPES
110 120 130 140 150
VIRNIMYQIL QGLAFIHKHG FFHRDMKPEN LLCMGPELVK IADFGLAREL
160 170 180 190 200
RSQPPYTDYV STRWYRAPEV LLRSSVYSSP IDVWAVGSIM AELYMLRPLF
210 220 230 240 250
PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ CVPINLKTLI
260 270 280 290 300
PNASNEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GPSSNHLESK
310 320 330 340 350
QSLNKQLQPL ESKPSLVEVE PKPLPDIIDQ VVGQPQPKTS QQPLQPIQPP
360 370 380 390 400
QNLSVQQPPK QQSQEKPPQT LFPSIVKNMP TKPNGTLSHK SGRRRWGQTI
410 420 430 440 450
FKSGDSWEEL EDYDFGASHS KKPSMGVFKE KRKKDSPFRQ QVKMAVISLS
AHQFPTL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP20794 | MAK_HUMAN | Serine/threonine-protein kinase MAK | MAK | 623 | Annotation score: | ||
A0A6Q8PH30 | A0A6Q8PH30_HUMAN | Serine/threonine-protein kinase MAK | MAK | 501 | Annotation score: | ||
A0A6Q8PG01 | A0A6Q8PG01_HUMAN | Serine/threonine-protein kinase MAK | MAK | 549 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL024498 Genomic DNA No translation available. BC039825 mRNA Translation: AAH39825.1 |
Genome annotation databases
Ensembli | ENST00000538030; ENSP00000442250; ENSG00000111837 |
UCSCi | uc063lvk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL024498 Genomic DNA No translation available. BC039825 mRNA Translation: AAH39825.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
DIPi | DIP-59495N |
IntActi | Q8IXN4, 3 interactors |
Proteomic databases
ProteomicsDBi | 71033 |
Protocols and materials databases
Antibodypediai | 24855, 432 antibodies from 30 providers |
Genome annotation databases
Ensembli | ENST00000538030; ENSP00000442250; ENSG00000111837 |
UCSCi | uc063lvk.1, human |
Organism-specific databases
HGNCi | HGNC:6816, MAK |
OpenTargetsi | ENSG00000111837 |
VEuPathDBi | HostDB:ENSG00000111837 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156581 |
HOGENOMi | CLU_000288_181_25_1 |
Miscellaneous databases
ChiTaRSi | MAK, human |
Gene expression databases
Bgeei | ENSG00000111837, Expressed in sperm and 133 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IXN4_HUMAN | |
Accessioni | Q8IXN4Primary (citable) accession number: Q8IXN4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | January 19, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |