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Protein

Nurim

Gene

NRM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Nurim
Alternative name(s):
Nuclear envelope membrane protein
Nuclear rim protein
Gene namesi
Name:NRM
Synonyms:NRM29
ORF Names:UNQ555/PRO1112
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137404.14
HGNCiHGNC:8003 NRM
neXtProtiNX_Q8IXM6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4NuclearSequence analysis4
Transmembranei5 – 28HelicalSequence analysisAdd BLAST24
Topological domaini29 – 58Perinuclear spaceSequence analysisAdd BLAST30
Transmembranei59 – 80HelicalSequence analysisAdd BLAST22
Topological domaini81 – 97NuclearSequence analysisAdd BLAST17
Transmembranei98 – 114HelicalSequence analysisAdd BLAST17
Topological domaini115 – 133Perinuclear spaceSequence analysisAdd BLAST19
Transmembranei134 – 164HelicalSequence analysisAdd BLAST31
Topological domaini165 – 191NuclearSequence analysisAdd BLAST27
Transmembranei192 – 210HelicalSequence analysisAdd BLAST19
Topological domaini211 – 216Perinuclear spaceSequence analysis6
Transmembranei217 – 234HelicalSequence analysisAdd BLAST18
Topological domaini235 – 262NuclearSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11270
OpenTargetsiENSG00000137404
PharmGKBiPA31782

Polymorphism and mutation databases

DMDMi74750736

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993951 – 262NurimAdd BLAST262

Proteomic databases

EPDiQ8IXM6
MaxQBiQ8IXM6
PaxDbiQ8IXM6
PeptideAtlasiQ8IXM6
PRIDEiQ8IXM6
ProteomicsDBi71030
71031 [Q8IXM6-2]

PTM databases

iPTMnetiQ8IXM6
PhosphoSitePlusiQ8IXM6
SwissPalmiQ8IXM6

Expressioni

Gene expression databases

BgeeiENSG00000137404
CleanExiHS_NRM
ExpressionAtlasiQ8IXM6 baseline and differential
GenevisibleiQ8IXM6 HS

Organism-specific databases

HPAiHPA072545
HPA073982

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116427, 10 interactors
IntActiQ8IXM6, 46 interactors
STRINGi9606.ENSP00000259953

Structurei

3D structure databases

ProteinModelPortaliQ8IXM6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 72Poly-Leu6
Compositional biasi139 – 253Leu-richAdd BLAST115

Sequence similaritiesi

Belongs to the nurim family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVGT Eukaryota
ENOG4111VYI LUCA
GeneTreeiENSGT00390000008146
HOVERGENiHBG102998
InParanoidiQ8IXM6
OMAiHPLMLGF
OrthoDBiEOG09370BU7
PhylomeDBiQ8IXM6
TreeFamiTF324853

Family and domain databases

InterProiView protein in InterPro
IPR033580 Nurim-like
PANTHERiPTHR31040 PTHR31040, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXM6-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPALLLIPA ALASFILAFG TGVEFVRFTS LRPLLGGIPE SGGPDARQGW
60 70 80 90 100
LAALQDRSIL APLAWDLGLL LLFVGQHSLM AAERVKAWTS RYFGVLQRSL
110 120 130 140 150
YVACTALALQ LVMRYWEPIP KGPVLWEARA EPWATWVPLL CFVLHVISWL
160 170 180 190 200
LIFSILLVFD YAELMGLKQV YYHVLGLGEP LALKSPRALR LFSHLRHPVC
210 220 230 240 250
VELLTVLWVV PTLGTDRLLL AFLLTLYLGL AHGLDQQDLR YLRAQLQRKL
260
HLLSRPQDGE AE
Length:262
Mass (Da):29,379
Last modified:March 1, 2003 - v1
Checksum:i47ED52384BE6C299
GO
Isoform 2 (identifier: Q8IXM6-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     110-168: Missing.

Show »
Length:203
Mass (Da):22,397
Checksum:i1BCA26472F9A84BA
GO
Isoform 3 (identifier: Q8IXM6-6) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     45-109: DARQGWLAAL...LYVACTALAL → GILPCAGAGR...YPLPGPGSRA
     110-262: Missing.

Show »
Length:109
Mass (Da):10,526
Checksum:iAF1B4FB1FDB23157
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05431145 – 109DARQG…TALAL → GILPCAGAGRASGPEVSPGS QTLLPPAPPSVCGAADSAVG GAYPGHGPSPPCFPPYPLPG PGSRA in isoform 3. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_054312110 – 262Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_027627110 – 168Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ798186 mRNA Translation: AFL55648.1
JQ798187 mRNA Translation: AFL55649.1
AY358411 mRNA Translation: AAQ88777.1
AK315190 mRNA Translation: BAG37630.1
AB110935 Genomic DNA Translation: BAD13701.1
AB110936 Genomic DNA Translation: BAD13702.1
AB202096 Genomic DNA Translation: BAE78616.1
AL662797 Genomic DNA No translation available.
AL732442 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX908728 Genomic DNA No translation available.
CR759873 Genomic DNA No translation available.
CR788240 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03320.1
BC004509 mRNA Translation: AAH04509.2
BC021260 mRNA Translation: AAH21260.1
BC039865 mRNA Translation: AAH39865.1
AF143676 mRNA Translation: AAD45885.1
CCDSiCCDS4686.1 [Q8IXM6-1]
CCDS59498.1 [Q8IXM6-2]
RefSeqiNP_001257636.1, NM_001270707.1
NP_001257637.1, NM_001270708.1
NP_001257638.1, NM_001270709.1 [Q8IXM6-2]
NP_001257639.1, NM_001270710.1 [Q8IXM6-6]
NP_009174.1, NM_007243.2 [Q8IXM6-1]
UniGeneiHs.519993

Genome annotation databases

EnsembliENST00000259953; ENSP00000259953; ENSG00000137404 [Q8IXM6-1]
ENST00000376420; ENSP00000365602; ENSG00000137404 [Q8IXM6-2]
ENST00000376421; ENSP00000365603; ENSG00000137404 [Q8IXM6-1]
ENST00000383570; ENSP00000373064; ENSG00000206484 [Q8IXM6-2]
ENST00000383571; ENSP00000373065; ENSG00000206484 [Q8IXM6-1]
ENST00000422181; ENSP00000409285; ENSG00000234809 [Q8IXM6-1]
ENST00000422664; ENSP00000394788; ENSG00000228854 [Q8IXM6-2]
ENST00000422747; ENSP00000414927; ENSG00000236843 [Q8IXM6-1]
ENST00000427944; ENSP00000405789; ENSG00000228854 [Q8IXM6-1]
ENST00000431322; ENSP00000398752; ENSG00000228867 [Q8IXM6-1]
ENST00000438502; ENSP00000397755; ENSG00000235773 [Q8IXM6-1]
ENST00000445058; ENSP00000389958; ENSG00000236843 [Q8IXM6-2]
ENST00000449041; ENSP00000399560; ENSG00000228867 [Q8IXM6-2]
ENST00000450138; ENSP00000407111; ENSG00000234809 [Q8IXM6-2]
ENST00000456720; ENSP00000392502; ENSG00000235773 [Q8IXM6-2]
ENST00000610775; ENSP00000481407; ENSG00000228867 [Q8IXM6-1]
ENST00000612190; ENSP00000482593; ENSG00000234809 [Q8IXM6-1]
ENST00000613827; ENSP00000481406; ENSG00000228854 [Q8IXM6-1]
ENST00000617159; ENSP00000478812; ENSG00000236843 [Q8IXM6-1]
ENST00000617220; ENSP00000483875; ENSG00000206484 [Q8IXM6-1]
ENST00000620249; ENSP00000482740; ENSG00000235773 [Q8IXM6-1]
GeneIDi11270
KEGGihsa:11270
UCSCiuc003nrc.4 human [Q8IXM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNRM_HUMAN
AccessioniPrimary (citable) accession number: Q8IXM6
Secondary accession number(s): B0S7R0
, B0S7R1, I3XIE2, I3XIE3, Q5JP57, Q5JP58, Q5JP59, Q5JP60, Q8WU45, Q9BSX3, Q9UN92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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