MRPL41

Functionⁱ

Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).5 Publications

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
structural constituent of ribosome
Source: UniProtKB
Inferred from direct assayⁱ
- 16024796

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell cycle Source: UniProtKB-KW
mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome
translation
Source: UniProtKB
Inferred from direct assayⁱ
- 16024796

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein
Biological process	Apoptosis, Cell cycle

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 39S ribosomal protein L41, mitochondrial Short name: L41mt Short name: MRP-L41 Alternative name(s): 39S ribosomal protein L27 homolog Bcl-2-interacting mitochondrial ribosomal protein L41 Cell proliferation-inducing gene 3 protein MRP-L27 homolog Mitochondrial large ribosomal subunit protein mL411 Publication
Gene namesⁱ	Name:MRPL41 Synonyms:BMRP, MRPL27, RPML27 ORF Names:PIG3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182154.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14492 MRPL41
MIMⁱ	611846 gene
neXtProtⁱ	NX_Q8IXM3

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64975
Open Targets More...OpenTargetsⁱ	ENSG00000182154
PharmGKBⁱ	PA30973

Polymorphism and mutation databases

BioMutaⁱ	MRPL41
DMDMⁱ	74750734

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 13	MitochondrionBy similarityAdd BLAST		13
ChainⁱPRO_0000273228	14 – 137	39S ribosomal protein L41, mitochondrialAdd BLAST		124

Proteomic databases

EPDⁱ	Q8IXM3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IXM3
PaxDbⁱ	Q8IXM3
PeptideAtlas More...PeptideAtlasⁱ	Q8IXM3
PRIDEⁱ	Q8IXM3
ProteomicsDBⁱ	71029
TopDownProteomicsⁱ	Q8IXM3

PTM databases

PhosphoSitePlusⁱ	Q8IXM3

PhosphoSitePlusⁱ

Q8IXM3

Expressionⁱ

Tissue specificityⁱ

Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000182154 Expressed in 198 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MRPL27 HS_MRPL41
Genevisibleⁱ	Q8IXM3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024550 HPA027160

HPAⁱ

HPA024550
HPA027160

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). Interacts with BCL2 (PubMed:15547950).1 Publication3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TRIM63	Q969Q1	2	EBI-912501,EBI-5661333

With

Entry

#Exp.

IntAct

Notes

TRIM63

Q969Q1

2

EBI-912501,EBI-5661333

Protein-protein interaction databases

BioGridⁱ	122363, 76 interactors
CORUMⁱ	Q8IXM3
IntActⁱ	Q8IXM3, 20 interactors
Molecular INTeraction database More...MINTⁱ	Q8IXM3
STRINGⁱ	9606.ENSP00000360498

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	17 – 19	Combined sources	3
Turnⁱ	23 – 25	Combined sources	3
Helixⁱ	28 – 33	Combined sources	6
Beta strandⁱ	42 – 45	Combined sources	4
Turnⁱ	46 – 48	Combined sources	3
Beta strandⁱ	49 – 52	Combined sources	4
Turnⁱ	54 – 56	Combined sources	3
Beta strandⁱ	72 – 74	Combined sources	3
Helixⁱ	88 – 104	Combined sources	17
Helixⁱ	114 – 116	Combined sources	3
Turnⁱ	130 – 133	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q8IXM3
SMRⁱ	Q8IXM3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the mitochondrion-specific ribosomal protein mL41 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG4756 Eukaryota ENOG4111ND6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013158
HOGENOMⁱ	HOG000231555
HOVERGENⁱ	HBG080323
InParanoidⁱ	Q8IXM3
KEGG Orthology (KO) More...KOⁱ	K17422
OMAⁱ	HNKGRGA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UQ0
PhylomeDBⁱ	Q8IXM3
TreeFamⁱ	TF325007

Family and domain databases

InterProⁱ	View protein in InterPro IPR019189 Ribosomal_L27/L41_mit
PANTHERⁱ	PTHR21338 PTHR21338, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09809 MRP-L27, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q8IXM3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF 
        60         70         80         90        100
VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI 
       110        120        130 
EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR

Length:137

Mass (Da):15,383

Last modified:March 1, 2003 - v1

Checksum:ⁱ25A9F3105ABF1189

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY232291 mRNA Translation: AAP69986.1 AL365502 Genomic DNA No translation available. BC040035 mRNA Translation: AAH40035.1 AB051625 Genomic DNA Translation: BAB54952.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7046.1
NCBI Reference Sequences More...RefSeqⁱ	NP_115866.1, NM_032477.2
UniGeneⁱ	Hs.44017

Genome annotation databases

Ensemblⁱ	ENST00000371443; ENSP00000360498; ENSG00000182154
GeneIDⁱ	64975
KEGGⁱ	hsa:64975
UCSC genome browser More...UCSCⁱ	uc004cnh.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IXM3	Mitochondrial ribosomal protein L41		PANTR		137	UniRef100_Q8IXM3
MRPL41 isoform 1		PONAB		137
Mitochondrial ribosomal protein L41		GORGO		137

Protein	Similar proteins		Species	Score	Length	Source
Q8IXM3	Mitochondrial ribosomal protein L41		PANTR		137	UniRef90_Q8IXM3
MRPL41 isoform 1		PONAB		137
Mitochondrial ribosomal protein L41		GORGO		137
39S ribosomal protein L41, mitochondrial		MACMU		137
Uncharacterized protein (Fragment)		MACFA		80
+16

Protein	Similar proteins		Species	Score	Length	Source
Q8IXM3	39S ribosomal protein L41-A, mitochondrial		XENLA		135	UniRef50_Q8IXM3
39S ribosomal protein L41, mitochondrial		DANRE		135
Mitochondrial ribosomal protein L41		PANTR		137
MRPL41 isoform 1		PONAB		137
Mitochondrial ribosomal protein L41		GORGO		137
+196

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY232291 mRNA Translation: AAP69986.1 AL365502 Genomic DNA No translation available. BC040035 mRNA Translation: AAH40035.1 AB051625 Genomic DNA Translation: BAB54952.1
CCDSⁱ	CCDS7046.1
RefSeqⁱ	NP_115866.1, NM_032477.2
UniGeneⁱ	Hs.44017

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J7Y	electron microscopy	3.40	9	1-137	[»]
	3J9M	electron microscopy	3.50	9	1-137	[»]
	5OOL	electron microscopy	3.06	9	1-137	[»]
	5OOM	electron microscopy	3.03	9	1-137	[»]
ProteinModelPortalⁱ	Q8IXM3
SMRⁱ	Q8IXM3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122363, 76 interactors
CORUMⁱ	Q8IXM3
IntActⁱ	Q8IXM3, 20 interactors
MINTⁱ	Q8IXM3
STRINGⁱ	9606.ENSP00000360498

PTM databases

PhosphoSitePlusⁱ	Q8IXM3

PhosphoSitePlusⁱ

Q8IXM3

Polymorphism and mutation databases

BioMutaⁱ	MRPL41
DMDMⁱ	74750734

Proteomic databases

EPDⁱ	Q8IXM3
MaxQBⁱ	Q8IXM3
PaxDbⁱ	Q8IXM3
PeptideAtlasⁱ	Q8IXM3
PRIDEⁱ	Q8IXM3
ProteomicsDBⁱ	71029
TopDownProteomicsⁱ	Q8IXM3

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64975
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371443; ENSP00000360498; ENSG00000182154
GeneIDⁱ	64975
KEGGⁱ	hsa:64975
UCSCⁱ	uc004cnh.5 human

Organism-specific databases

CTDⁱ	64975
DisGeNETⁱ	64975
EuPathDBⁱ	HostDB:ENSG00000182154.7
GeneCardsⁱ	MRPL41
HGNCⁱ	HGNC:14492 MRPL41
HPAⁱ	HPA024550 HPA027160
MIMⁱ	611846 gene
neXtProtⁱ	NX_Q8IXM3
OpenTargetsⁱ	ENSG00000182154
PharmGKBⁱ	PA30973
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4756 Eukaryota ENOG4111ND6 LUCA
GeneTreeⁱ	ENSGT00390000013158
HOGENOMⁱ	HOG000231555
HOVERGENⁱ	HBG080323
InParanoidⁱ	Q8IXM3
KOⁱ	K17422
OMAⁱ	HNKGRGA
OrthoDBⁱ	EOG091G0UQ0
PhylomeDBⁱ	Q8IXM3
TreeFamⁱ	TF325007

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPL41 human
GeneWikiⁱ	Mitochondrial_ribosomal_protein_L41
GenomeRNAiⁱ	64975
Protein Ontology More...PROⁱ	PR:Q8IXM3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182154 Expressed in 198 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MRPL27 HS_MRPL41
Genevisibleⁱ	Q8IXM3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019189 Ribosomal_L27/L41_mit
PANTHERⁱ	PTHR21338 PTHR21338, 1 hit
Pfamⁱ	View protein in Pfam PF09809 MRP-L27, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM41_HUMAN
Accessionⁱ	Q8IXM3Primary (citable) accession number: Q8IXM3 Secondary accession number(s): Q96Q49
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
	Last sequence update:	March 1, 2003
	Last modified:	November 7, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Ribosomal proteins
Ribosomal proteins families and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IXM3 (RM41_HUMAN)

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39S ribosomal protein L41, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ