UniProtKB - Q8IXM3 (RM41_HUMAN)
39S ribosomal protein L41, mitochondrial
MRPL41
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
- translation Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Biological process | Apoptosis, Cell cycle |
Enzyme and pathway databases
PathwayCommonsi | Q8IXM3 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L41, mitochondrialShort name: L41mt Short name: MRP-L41 Alternative name(s): 39S ribosomal protein L27 homolog Bcl-2-interacting mitochondrial ribosomal protein L41 Cell proliferation-inducing gene 3 protein MRP-L27 homolog Mitochondrial large ribosomal subunit protein mL411 Publication |
Gene namesi | Name:MRPL41 Synonyms:BMRP, MRPL27, RPML27 ORF Names:PIG3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14492, MRPL41 |
MIMi | 611846, gene |
neXtProti | NX_Q8IXM3 |
VEuPathDBi | HostDB:ENSG00000182154.7 |
Subcellular locationi
Mitochondrion
- Mitochondrion 4 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Other locations
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 64975 |
OpenTargetsi | ENSG00000182154 |
PharmGKBi | PA30973 |
Miscellaneous databases
Pharosi | Q8IXM3, Tbio |
Genetic variation databases
BioMutai | MRPL41 |
DMDMi | 74750734 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 13 | MitochondrionBy similarityAdd BLAST | 13 | |
ChainiPRO_0000273228 | 14 – 137 | 39S ribosomal protein L41, mitochondrialAdd BLAST | 124 |
Proteomic databases
EPDi | Q8IXM3 |
jPOSTi | Q8IXM3 |
MassIVEi | Q8IXM3 |
MaxQBi | Q8IXM3 |
PaxDbi | Q8IXM3 |
PeptideAtlasi | Q8IXM3 |
PRIDEi | Q8IXM3 |
ProteomicsDBi | 71029 |
TopDownProteomicsi | Q8IXM3 |
PTM databases
iPTMneti | Q8IXM3 |
PhosphoSitePlusi | Q8IXM3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000182154, Expressed in quadriceps femoris and 212 other tissues |
Genevisiblei | Q8IXM3, HS |
Organism-specific databases
HPAi | ENSG00000182154, Tissue enhanced (blood, skeletal muscle) |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379).
Interacts with BCL2 (PubMed:15547950).
1 Publication3 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 122363, 101 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q8IXM3 |
IntActi | Q8IXM3, 69 interactors |
MINTi | Q8IXM3 |
STRINGi | 9606.ENSP00000360498 |
Miscellaneous databases
RNActi | Q8IXM3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q8IXM3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG4756, Eukaryota |
GeneTreei | ENSGT00390000013158 |
HOGENOMi | CLU_155983_0_0_1 |
InParanoidi | Q8IXM3 |
OMAi | HNKGRGA |
OrthoDBi | 1294210at2759 |
PhylomeDBi | Q8IXM3 |
TreeFami | TF325007 |
Family and domain databases
InterProi | View protein in InterPro IPR019189, Ribosomal_L27/L41_mit |
PANTHERi | PTHR21338, PTHR21338, 1 hit |
Pfami | View protein in Pfam PF09809, MRP-L27, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGVLAAAARC LVRGADRMSK WTSKRGPRSF RGRKGRGAKG IGFLTSGWRF
60 70 80 90 100
VQIKEMVPEF VVPDLTGFKL KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI
110 120 130
EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY232291 mRNA Translation: AAP69986.1 AL365502 Genomic DNA No translation available. BC040035 mRNA Translation: AAH40035.1 AB051625 Genomic DNA Translation: BAB54952.1 |
CCDSi | CCDS7046.1 |
RefSeqi | NP_115866.1, NM_032477.2 |
Genome annotation databases
Ensembli | ENST00000371443; ENSP00000360498; ENSG00000182154 |
GeneIDi | 64975 |
KEGGi | hsa:64975 |
UCSCi | uc004cnh.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY232291 mRNA Translation: AAP69986.1 AL365502 Genomic DNA No translation available. BC040035 mRNA Translation: AAH40035.1 AB051625 Genomic DNA Translation: BAB54952.1 |
CCDSi | CCDS7046.1 |
RefSeqi | NP_115866.1, NM_032477.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | 9 | 1-137 | [»] | |
3J9M | electron microscopy | 3.50 | 9 | 1-137 | [»] | |
5OOL | electron microscopy | 3.06 | 9 | 1-137 | [»] | |
5OOM | electron microscopy | 3.03 | 9 | 1-137 | [»] | |
6I9R | electron microscopy | 3.90 | 9 | 1-137 | [»] | |
6NU2 | electron microscopy | 3.90 | 9 | 15-137 | [»] | |
6NU3 | electron microscopy | 4.40 | 9 | 1-137 | [»] | |
6VLZ | electron microscopy | 2.97 | 9 | 1-137 | [»] | |
6VMI | electron microscopy | 2.96 | 9 | 1-137 | [»] | |
6ZS9 | electron microscopy | 4.00 | 9 | 1-137 | [»] | |
6ZSA | electron microscopy | 4.00 | 9 | 1-137 | [»] | |
6ZSB | electron microscopy | 4.50 | 9 | 1-137 | [»] | |
6ZSC | electron microscopy | 3.50 | 9 | 1-137 | [»] | |
6ZSD | electron microscopy | 3.70 | 9 | 1-137 | [»] | |
6ZSE | electron microscopy | 5.00 | 9 | 1-137 | [»] | |
6ZSG | electron microscopy | 4.00 | 9 | 1-137 | [»] | |
SMRi | Q8IXM3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122363, 101 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q8IXM3 |
IntActi | Q8IXM3, 69 interactors |
MINTi | Q8IXM3 |
STRINGi | 9606.ENSP00000360498 |
PTM databases
iPTMneti | Q8IXM3 |
PhosphoSitePlusi | Q8IXM3 |
Genetic variation databases
BioMutai | MRPL41 |
DMDMi | 74750734 |
Proteomic databases
EPDi | Q8IXM3 |
jPOSTi | Q8IXM3 |
MassIVEi | Q8IXM3 |
MaxQBi | Q8IXM3 |
PaxDbi | Q8IXM3 |
PeptideAtlasi | Q8IXM3 |
PRIDEi | Q8IXM3 |
ProteomicsDBi | 71029 |
TopDownProteomicsi | Q8IXM3 |
Protocols and materials databases
Antibodypediai | 19072, 151 antibodies |
DNASUi | 64975 |
Genome annotation databases
Ensembli | ENST00000371443; ENSP00000360498; ENSG00000182154 |
GeneIDi | 64975 |
KEGGi | hsa:64975 |
UCSCi | uc004cnh.5, human |
Organism-specific databases
CTDi | 64975 |
DisGeNETi | 64975 |
GeneCardsi | MRPL41 |
HGNCi | HGNC:14492, MRPL41 |
HPAi | ENSG00000182154, Tissue enhanced (blood, skeletal muscle) |
MIMi | 611846, gene |
neXtProti | NX_Q8IXM3 |
OpenTargetsi | ENSG00000182154 |
PharmGKBi | PA30973 |
VEuPathDBi | HostDB:ENSG00000182154.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4756, Eukaryota |
GeneTreei | ENSGT00390000013158 |
HOGENOMi | CLU_155983_0_0_1 |
InParanoidi | Q8IXM3 |
OMAi | HNKGRGA |
OrthoDBi | 1294210at2759 |
PhylomeDBi | Q8IXM3 |
TreeFami | TF325007 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXM3 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
Miscellaneous databases
BioGRID-ORCSi | 64975, 479 hits in 882 CRISPR screens |
ChiTaRSi | MRPL41, human |
GeneWikii | Mitochondrial_ribosomal_protein_L41 |
GenomeRNAii | 64975 |
Pharosi | Q8IXM3, Tbio |
PROi | PR:Q8IXM3 |
RNActi | Q8IXM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182154, Expressed in quadriceps femoris and 212 other tissues |
Genevisiblei | Q8IXM3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019189, Ribosomal_L27/L41_mit |
PANTHERi | PTHR21338, PTHR21338, 1 hit |
Pfami | View protein in Pfam PF09809, MRP-L27, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM41_HUMAN | |
Accessioni | Q8IXM3Primary (citable) accession number: Q8IXM3 Secondary accession number(s): Q96Q49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries