BAP18

Functionⁱ

Component of chromatin complexes such as the MLL1/MLL and NURF complexes.

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin organization Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator, DNA-binding

Molecular function

Chromatin regulator, DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chromatin complexes subunit BAP18 Alternative name(s): BPTF-associated protein of 18 kDa
Gene namesⁱ	Name:BAP18 Synonyms:C17orf49
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000258315.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28737 C17orf49
neXtProtⁱ	NX_Q8IXM2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000258315
PharmGKBⁱ	PA142672232

Polymorphism and mutation databases

BioMutaⁱ	BAP18
DMDMⁱ	74759674

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000264251	1 – 172	Chromatin complexes subunit BAP18Add BLAST		172

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	96	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8IXM2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IXM2
PaxDbⁱ	Q8IXM2
PeptideAtlas More...PeptideAtlasⁱ	Q8IXM2
PRIDEⁱ	Q8IXM2
ProteomicsDBⁱ	71027 71028 [Q8IXM2-2]
TopDownProteomicsⁱ	Q8IXM2-1 [Q8IXM2-1]

PTM databases

iPTMnetⁱ	Q8IXM2
PhosphoSitePlusⁱ	Q8IXM2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000258315 Expressed in 92 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_C17orf49
ExpressionAtlasⁱ	Q8IXM2 baseline and differential
Genevisibleⁱ	Q8IXM2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA022961 HPA024457

HPAⁱ

HPA022961
HPA024457

Interactionⁱ

Subunit structureⁱ

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the nucleosome-remodeling factor (NURF) complex.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DPY30	Q9C005	3	EBI-4280811,EBI-744973

With

Entry

#Exp.

IntAct

Notes

DPY30

Q9C005

3

EBI-4280811,EBI-744973

Protein-protein interaction databases

BioGridⁱ	125903, 29 interactors
CORUMⁱ	Q8IXM2
Database of interacting proteins More...DIPⁱ	DIP-60552N
IntActⁱ	Q8IXM2, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q8IXM2
STRINGⁱ	9606.ENSP00000448598

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IXM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 86	SANTAdd BLAST		49

Phylogenomic databases

eggNOGⁱ	KOG4834 Eukaryota ENOG4111K4E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014721
HOGENOMⁱ	HOG000234357
HOVERGENⁱ	HBG056647
InParanoidⁱ	Q8IXM2
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZKS
PhylomeDBⁱ	Q8IXM2
TreeFamⁱ	TF324877

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00167 SANT, 1 hit
InterProⁱ	View protein in InterPro IPR037931 BAP18 IPR009057 Homeobox-like_sf IPR001005 SANT/Myb
PANTHERⁱ	PTHR21397:SF2 PTHR21397:SF2, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8IXM2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVADSSPAGA KWTETEIEML 
        60         70         80         90        100
RAAVKRFGDD LNHISCVIKE RTVAQIKATV KRKVYEDSGI PLPAESPKKG 
       110        120        130        140        150
PKKVASGVLS PPPAAPPPSS SSVPEAGGPP IKKQKADVTL SALNDSDANS 
       160        170 
DVVDIEGLGE TPPAKKLNFD QA

Length:172

Mass (Da):17,900

Last modified:March 1, 2003 - v1

Checksum:ⁱEED33FA9BD649F19

GO

Isoform 2 (identifier: Q8IXM2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
40-73: Missing.

« Hide

        10         20         30         40         50
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVADSSPAGA QIKATVKRKV 
        60         70         80         90        100
YEDSGIPLPA ESPKKGPKKV ASGVLSPPPA APPPSSSSVP EAGGPPIKKQ 
       110        120        130 
KADVTLSALN DSDANSDVVD IEGLGETPPA KKLNFDQA

Note: No experimental confirmation available.

Show »

Length:138

Mass (Da):13,958

Checksum:ⁱ30D3C4ECF6F6D97A

GO

Isoform 3 (identifier: Q8IXM2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
172-172: A → DSLTLDSGLLMTSADPPLLSC

« Hide

        10         20         30         40         50
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVADSSPAGA KWTETEIEML 
        60         70         80         90        100
RAAVKRFGDD LNHISCVIKE RTVAQIKATV KRKVYEDSGI PLPAESPKKG 
       110        120        130        140        150
PKKVASGVLS PPPAAPPPSS SSVPEAGGPP IKKQKADVTL SALNDSDANS 
       160        170        180        190 
DVVDIEGLGE TPPAKKLNFD QDSLTLDSGL LMTSADPPLL SC

Note: Gene prediction based on EST data.

Show »

Length:192

Mass (Da):19,961

Checksum:ⁱ764AC185E4B868A4

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W038	F8W038_HUMAN	Chromosome 17 open reading frame 49 Chromosome 17 open reading frame 49	C17orf49	157	Annotation score:
F8W1H0	F8W1H0_HUMAN	Chromosome 17 open reading frame 49 Chromosome 17 open reading frame 49	C17orf49	166	Annotation score:
K7ES76	K7ES76_HUMAN	Chromosome 17 open reading frame 49 Chromosome 17 open reading frame 49	C17orf49	23	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043754	40 – 73	Missing in isoform 2. 1 PublicationAdd BLAST		34
Alternative sequenceⁱVSP_047095	172	A → DSLTLDSGLLMTSADPPLLS C in isoform 3. Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CN280697 mRNA No translation available. AK295795 mRNA Translation: BAG58615.1 AC040977 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90278.1 BC040036 mRNA Translation: AAH40036.1 BC040148 mRNA Translation: AAH40148.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32542.1 [Q8IXM2-1] CCDS45595.1 [Q8IXM2-3] CCDS45596.1 [Q8IXM2-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001136270.1, NM_001142798.2 [Q8IXM2-3] NP_001136271.1, NM_001142799.2 [Q8IXM2-2] NP_777553.1, NM_174893.3 [Q8IXM2-1]
UniGeneⁱ	Hs.511801

Genome annotation databases

Ensemblⁱ	ENST00000439424; ENSP00000411851; ENSG00000258315 [Q8IXM2-1] ENST00000546495; ENSP00000448598; ENSG00000258315 [Q8IXM2-3] ENST00000552402; ENSP00000448746; ENSG00000258315 [Q8IXM2-2]
GeneIDⁱ	124944
KEGGⁱ	hsa:124944
UCSC genome browser More...UCSCⁱ	uc002ged.4 human [Q8IXM2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IXM2	Chromatin complexes subunit BAP18		BOVIN		172	UniRef90_Q8IXM2
Chromatin complexes subunit BAP18		MOUSE		171
Uncharacterized protein (Fragment)		HETGA		186
Chromatin complexes subunit BAP18 (Fragment)		MYOBR		174
Chromatin complexes subunit BAP18 isoform 2		MACMU		172
+68
Q8IXM2-2	chromatin complexes subunit BAP18 isoform X3		DELLE		158	UniRef90_Q8IXM2-2
chromatin complexes subunit BAP18 isoform X3		ERIEU		158
chromatin complexes subunit BAP18 isoform X3		PHYCD		158
chromatin complexes subunit BAP18 isoform X3		Yangtze finless porpoise		158
Chromatin complexes subunit BAP18 isoform 3		MACMU		138
+64
Q8IXM2-3	RIKEN cDNA 0610010K14 gene		MOUSE		191	UniRef90_D3Z687
Uncharacterized protein		PAPAN		201
Uncharacterized protein		MACFA		201
chromatin complexes subunit BAP18 isoform X1		DIPOR		193
Chromosome 17 C17orf49 homolog		PANTR		192
+96

Protein	Similar proteins		Species	Score	Length	Source
Q8IXM2	Chromatin complexes subunit BAP18		BOVIN		172	UniRef50_Q8IXM2
Chromatin complexes subunit BAP18		MOUSE		171
Uncharacterized protein (Fragment)		HETGA		186
Chromatin complexes subunit BAP18 (Fragment)		MYOBR		174
Uncharacterized protein		CAVPO		172
+119
Q8IXM2-2	chromatin complexes subunit BAP18 isoform X3		DELLE		158	UniRef50_Q8IXM2-2
chromatin complexes subunit BAP18 isoform X3		Yangtze finless porpoise		158
chromatin complexes subunit BAP18 isoform X3		ERIEU		158
chromatin complexes subunit BAP18 isoform X3		PHYCD		158
chromatin complexes subunit BAP18 isoform X3		TARSY		138
+110
Q8IXM2-3	RIKEN cDNA 0610010K14 gene		MOUSE		191	UniRef50_D3Z687
Uncharacterized protein		PAPAN		201
Uncharacterized protein		MACFA		201
chromatin complexes subunit BAP18 isoform X1		DIPOR		193
chromatin complexes subunit BAP18 isoform X1		TARSY		192
+103

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CN280697 mRNA No translation available. AK295795 mRNA Translation: BAG58615.1 AC040977 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90278.1 BC040036 mRNA Translation: AAH40036.1 BC040148 mRNA Translation: AAH40148.1
CCDSⁱ	CCDS32542.1 [Q8IXM2-1] CCDS45595.1 [Q8IXM2-3] CCDS45596.1 [Q8IXM2-2]
RefSeqⁱ	NP_001136270.1, NM_001142798.2 [Q8IXM2-3] NP_001136271.1, NM_001142799.2 [Q8IXM2-2] NP_777553.1, NM_174893.3 [Q8IXM2-1]
UniGeneⁱ	Hs.511801

3D structure databases

ProteinModelPortalⁱ	Q8IXM2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	125903, 29 interactors
CORUMⁱ	Q8IXM2
DIPⁱ	DIP-60552N
IntActⁱ	Q8IXM2, 10 interactors
MINTⁱ	Q8IXM2
STRINGⁱ	9606.ENSP00000448598

PTM databases

iPTMnetⁱ	Q8IXM2
PhosphoSitePlusⁱ	Q8IXM2

Polymorphism and mutation databases

BioMutaⁱ	BAP18
DMDMⁱ	74759674

Proteomic databases

EPDⁱ	Q8IXM2
MaxQBⁱ	Q8IXM2
PaxDbⁱ	Q8IXM2
PeptideAtlasⁱ	Q8IXM2
PRIDEⁱ	Q8IXM2
ProteomicsDBⁱ	71027 71028 [Q8IXM2-2]
TopDownProteomicsⁱ	Q8IXM2-1 [Q8IXM2-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	124944
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000439424; ENSP00000411851; ENSG00000258315 [Q8IXM2-1] ENST00000546495; ENSP00000448598; ENSG00000258315 [Q8IXM2-3] ENST00000552402; ENSP00000448746; ENSG00000258315 [Q8IXM2-2]
GeneIDⁱ	124944
KEGGⁱ	hsa:124944
UCSCⁱ	uc002ged.4 human [Q8IXM2-1]

Organism-specific databases

CTDⁱ	124944
EuPathDBⁱ	HostDB:ENSG00000258315.5
GeneCardsⁱ	C17orf49
H-InvDBⁱ	HIX0157195
HGNCⁱ	HGNC:28737 C17orf49
HPAⁱ	HPA022961 HPA024457
neXtProtⁱ	NX_Q8IXM2
OpenTargetsⁱ	ENSG00000258315
PharmGKBⁱ	PA142672232
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4834 Eukaryota ENOG4111K4E LUCA
GeneTreeⁱ	ENSGT00390000014721
HOGENOMⁱ	HOG000234357
HOVERGENⁱ	HBG056647
InParanoidⁱ	Q8IXM2
OrthoDBⁱ	EOG091G0ZKS
PhylomeDBⁱ	Q8IXM2
TreeFamⁱ	TF324877

Miscellaneous databases

ChiTaRSⁱ	C17orf49 human
GenomeRNAiⁱ	124944
Protein Ontology More...PROⁱ	PR:Q8IXM2

Gene expression databases

Bgeeⁱ	ENSG00000258315 Expressed in 92 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_C17orf49
ExpressionAtlasⁱ	Q8IXM2 baseline and differential
Genevisibleⁱ	Q8IXM2 HS

Family and domain databases

CDDⁱ	cd00167 SANT, 1 hit
InterProⁱ	View protein in InterPro IPR037931 BAP18 IPR009057 Homeobox-like_sf IPR001005 SANT/Myb
PANTHERⁱ	PTHR21397:SF2 PTHR21397:SF2, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BAP18_HUMAN
Accessionⁱ	Q8IXM2Primary (citable) accession number: Q8IXM2 Secondary accession number(s): B4DIV3, C9J4G0, E9PB29
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	March 1, 2003
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8IXM2 (BAP18_HUMAN)

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Chromatin complexes subunit BAP18

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ