UniProtKB - Q8IXM2 (BAP18_HUMAN)
Chromatin complexes subunit BAP18
BAP18
Functioni
Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator, DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IXM2 |
SignaLinki | Q8IXM2 |
Names & Taxonomyi
Protein namesi | Recommended name: Chromatin complexes subunit BAP18Alternative name(s): BPTF-associated protein of 18 kDa |
Gene namesi | Name:BAP18 Synonyms:C17orf49 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28737, C17orf49 |
neXtProti | NX_Q8IXM2 |
VEuPathDBi | HostDB:ENSG00000258315 |
Subcellular locationi
Nucleus
- Nucleus Curated
Cytosol
- cytosol Source: HPA
Nucleus
- MLL1 complex Source: UniProtKB
- nucleoplasm Source: HPA
- NURF complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 124944 |
OpenTargetsi | ENSG00000258315 |
PharmGKBi | PA142672232 |
Miscellaneous databases
Pharosi | Q8IXM2, Tbio |
Genetic variation databases
BioMutai | C17orf49 |
DMDMi | 74759674 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000264251 | 1 – 172 | Chromatin complexes subunit BAP18Add BLAST | 172 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 96 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q8IXM2 |
jPOSTi | Q8IXM2 |
MassIVEi | Q8IXM2 |
MaxQBi | Q8IXM2 |
PaxDbi | Q8IXM2 |
PeptideAtlasi | Q8IXM2 |
PRIDEi | Q8IXM2 |
ProteomicsDBi | 71027 [Q8IXM2-1] 71028 [Q8IXM2-2] 8467 |
TopDownProteomicsi | Q8IXM2-1 [Q8IXM2-1] |
PTM databases
GlyGeni | Q8IXM2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8IXM2 |
MetOSitei | Q8IXM2 |
PhosphoSitePlusi | Q8IXM2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000258315, Expressed in testis and 118 other tissues |
ExpressionAtlasi | Q8IXM2, baseline and differential |
Genevisiblei | Q8IXM2, HS |
Organism-specific databases
HPAi | ENSG00000258315, Low tissue specificity |
Interactioni
Subunit structurei
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Component of the nucleosome-remodeling factor (NURF) complex.
2 PublicationsBinary interactionsi
Q8IXM2
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 125903, 96 interactors |
CORUMi | Q8IXM2 |
DIPi | DIP-60552N |
IntActi | Q8IXM2, 21 interactors |
MINTi | Q8IXM2 |
STRINGi | 9606.ENSP00000448598 |
Miscellaneous databases
RNActi | Q8IXM2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 86 | SANTAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 172 | DisorderedSequence analysisAdd BLAST | 86 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 110 – 124 | Pro residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG4834, Eukaryota |
GeneTreei | ENSGT00390000014721 |
HOGENOMi | CLU_104449_0_0_1 |
InParanoidi | Q8IXM2 |
OMAi | PEECQVK |
OrthoDBi | 1590112at2759 |
PhylomeDBi | Q8IXM2 |
TreeFami | TF324877 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR037931, BAP18 IPR009057, Homeobox-like_sf IPR001005, SANT/Myb |
PANTHERi | PTHR21397:SF2, PTHR21397:SF2, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVADSSPAGA KWTETEIEML
60 70 80 90 100
RAAVKRFGDD LNHISCVIKE RTVAQIKATV KRKVYEDSGI PLPAESPKKG
110 120 130 140 150
PKKVASGVLS PPPAAPPPSS SSVPEAGGPP IKKQKADVTL SALNDSDANS
160 170
DVVDIEGLGE TPPAKKLNFD QA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W038 | F8W038_HUMAN | Chromosome 17 open reading frame 49 | C17orf49 | 157 | Annotation score: | ||
F8W1H0 | F8W1H0_HUMAN | Chromosome 17 open reading frame 49 | C17orf49 | 166 | Annotation score: | ||
K7ES76 | K7ES76_HUMAN | Chromosome 17 open reading frame 49 | C17orf49 | 23 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043754 | 40 – 73 | Missing in isoform 2. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_047095 | 172 | A → DSLTLDSGLLMTSADPPLLS C in isoform 3. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CN280697 mRNA No translation available. AK295795 mRNA Translation: BAG58615.1 AC040977 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90278.1 BC040036 mRNA Translation: AAH40036.1 BC040148 mRNA Translation: AAH40148.1 |
CCDSi | CCDS32542.1 [Q8IXM2-1] CCDS45595.1 [Q8IXM2-3] CCDS45596.1 [Q8IXM2-2] |
RefSeqi | NP_001136270.1, NM_001142798.2 [Q8IXM2-3] NP_001136271.1, NM_001142799.2 [Q8IXM2-2] NP_777553.1, NM_174893.3 [Q8IXM2-1] |
Genome annotation databases
Ensembli | ENST00000439424.6; ENSP00000411851.2; ENSG00000258315.5 ENST00000546495.5; ENSP00000448598.1; ENSG00000258315.5 [Q8IXM2-3] ENST00000552402.5; ENSP00000448746.1; ENSG00000258315.5 [Q8IXM2-2] |
GeneIDi | 124944 |
KEGGi | hsa:124944 |
MANE-Selecti | ENST00000439424.6; ENSP00000411851.2; NM_174893.4; NP_777553.1 |
UCSCi | uc002ged.4, human [Q8IXM2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CN280697 mRNA No translation available. AK295795 mRNA Translation: BAG58615.1 AC040977 Genomic DNA No translation available. CH471108 Genomic DNA Translation: EAW90278.1 BC040036 mRNA Translation: AAH40036.1 BC040148 mRNA Translation: AAH40148.1 |
CCDSi | CCDS32542.1 [Q8IXM2-1] CCDS45595.1 [Q8IXM2-3] CCDS45596.1 [Q8IXM2-2] |
RefSeqi | NP_001136270.1, NM_001142798.2 [Q8IXM2-3] NP_001136271.1, NM_001142799.2 [Q8IXM2-2] NP_777553.1, NM_174893.3 [Q8IXM2-1] |
3D structure databases
AlphaFoldDBi | Q8IXM2 |
SMRi | Q8IXM2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125903, 96 interactors |
CORUMi | Q8IXM2 |
DIPi | DIP-60552N |
IntActi | Q8IXM2, 21 interactors |
MINTi | Q8IXM2 |
STRINGi | 9606.ENSP00000448598 |
PTM databases
GlyGeni | Q8IXM2, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q8IXM2 |
MetOSitei | Q8IXM2 |
PhosphoSitePlusi | Q8IXM2 |
Genetic variation databases
BioMutai | C17orf49 |
DMDMi | 74759674 |
Proteomic databases
EPDi | Q8IXM2 |
jPOSTi | Q8IXM2 |
MassIVEi | Q8IXM2 |
MaxQBi | Q8IXM2 |
PaxDbi | Q8IXM2 |
PeptideAtlasi | Q8IXM2 |
PRIDEi | Q8IXM2 |
ProteomicsDBi | 71027 [Q8IXM2-1] 71028 [Q8IXM2-2] 8467 |
TopDownProteomicsi | Q8IXM2-1 [Q8IXM2-1] |
Protocols and materials databases
Antibodypediai | 61837, 102 antibodies from 20 providers |
DNASUi | 124944 |
Genome annotation databases
Ensembli | ENST00000439424.6; ENSP00000411851.2; ENSG00000258315.5 ENST00000546495.5; ENSP00000448598.1; ENSG00000258315.5 [Q8IXM2-3] ENST00000552402.5; ENSP00000448746.1; ENSG00000258315.5 [Q8IXM2-2] |
GeneIDi | 124944 |
KEGGi | hsa:124944 |
MANE-Selecti | ENST00000439424.6; ENSP00000411851.2; NM_174893.4; NP_777553.1 |
UCSCi | uc002ged.4, human [Q8IXM2-1] |
Organism-specific databases
CTDi | 124944 |
DisGeNETi | 124944 |
GeneCardsi | C17orf49 |
HGNCi | HGNC:28737, C17orf49 |
HPAi | ENSG00000258315, Low tissue specificity |
neXtProti | NX_Q8IXM2 |
OpenTargetsi | ENSG00000258315 |
PharmGKBi | PA142672232 |
VEuPathDBi | HostDB:ENSG00000258315 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4834, Eukaryota |
GeneTreei | ENSGT00390000014721 |
HOGENOMi | CLU_104449_0_0_1 |
InParanoidi | Q8IXM2 |
OMAi | PEECQVK |
OrthoDBi | 1590112at2759 |
PhylomeDBi | Q8IXM2 |
TreeFami | TF324877 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXM2 |
SignaLinki | Q8IXM2 |
Miscellaneous databases
BioGRID-ORCSi | 124944, 194 hits in 1019 CRISPR screens |
GenomeRNAii | 124944 |
Pharosi | Q8IXM2, Tbio |
PROi | PR:Q8IXM2 |
RNActi | Q8IXM2, protein |
Gene expression databases
Bgeei | ENSG00000258315, Expressed in testis and 118 other tissues |
ExpressionAtlasi | Q8IXM2, baseline and differential |
Genevisiblei | Q8IXM2, HS |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
InterProi | View protein in InterPro IPR037931, BAP18 IPR009057, Homeobox-like_sf IPR001005, SANT/Myb |
PANTHERi | PTHR21397:SF2, PTHR21397:SF2, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BAP18_HUMAN | |
Accessioni | Q8IXM2Primary (citable) accession number: Q8IXM2 Secondary accession number(s): B4DIV3, C9J4G0, E9PB29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM