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UniProtKB - Q8IXL7 (MSRB3_HUMAN)

Entry version 150 (07 Apr 2021)
Sequence version 2 (05 Apr 2011)
Previous versions | rss
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Protein

Methionine-R-sulfoxide reductase B3

Gene

MSRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi86ZincPROSITE-ProRule annotation1
Metal bindingi89ZincPROSITE-ProRule annotation1
Metal bindingi135ZincPROSITE-ProRule annotation1
Metal bindingi138ZincPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei158NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.8.4.12, 2681
1.8.4.B3, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IXL7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5676934, Protein repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B3 (EC:1.8.4.12By similarity, EC:1.8.4.14By similarity)
Short name:
MsrB3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSRB3
ORF Names:UNQ1965/PRO4487
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27375, MSRB3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613719, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IXL7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000174099.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 74 (DFNB74)1 Publication
The disease is caused by variants affecting the gene represented in this entry. A nonsense mutation affecting exclusively mitochondrial isoform 2 is sufficient to produce hearing loss.
Disease descriptionA form of non-syndromic sensorineural deafness characterized by prelingual, bilateral, profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06490489C → G in DFNB74; abolishes zinc-binding and enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs387907088Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi141H → G: 30-fold reduction in activity. 1 Publication1
Mutagenesisi160N → F: 7000-fold reduction in activity. 1 Publication1
Mutagenesisi160N → Y: 500-fold reduction in activity. 1 Publication1

Keywords - Diseasei

Deafness, Disease variant, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		253827

MalaCards human disease database

More...MalaCardsi		MSRB3
MIMi613718, phenotype

Open Targets

More...OpenTargetsi		ENSG00000174099

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134991350

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IXL7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3509604

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MSRB3

Domain mapping of disease mutations (DMDM)

More...DMDMi		327478523

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032724033 – 192Methionine-R-sulfoxide reductase B3Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42N6-acetyllysineBy similarity1
Modified residuei183PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IXL7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IXL7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IXL7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IXL7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IXL7

PeptideAtlas

More...PeptideAtlasi		Q8IXL7

PRoteomics IDEntifications database

More...PRIDEi		Q8IXL7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		71024 [Q8IXL7-1]
71025 [Q8IXL7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IXL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IXL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174099, Expressed in myometrium and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IXL7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IXL7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174099, Tissue enhanced (smooth)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8IXL7
With#Exp.IntAct
GOLGA2 [Q08379]3EBI-8634060,EBI-618309
PRDM4 [Q9UKN5]3EBI-8634060,EBI-2803427
TCF4 [P15884]3EBI-8634060,EBI-533224
TRIP6 [Q15654]3EBI-8634060,EBI-742327
Isoform 2 [Q8IXL7-2]
With#Exp.IntAct
ASB13 - isoform 2 [Q8WXK3-2]3EBI-10699187,EBI-12015080
BANP - isoform 2 [Q8N9N5-2]3EBI-10699187,EBI-11524452
CTBP2 - isoform 3 [P56545-3]5EBI-10699187,EBI-10171902
EEF1AKMT3 [Q96AZ1]3EBI-10699187,EBI-12108304
EFEMP1 [Q12805]3EBI-10699187,EBI-536772
EIF6 [P56537]3EBI-10699187,EBI-372243
FAM168B - isoform 2 [A1KXE4-2]3EBI-10699187,EBI-12193763
FHL3 [Q13643]3EBI-10699187,EBI-741101
GOLGA2 [Q08379]3EBI-10699187,EBI-618309
GPR37 [O15354]3EBI-10699187,EBI-15639515
GRN [P28799]3EBI-10699187,EBI-747754
GRN - isoform 2 [P28799-2]3EBI-10699187,EBI-25860013
KIF1B - isoform 2 [O60333-2]3EBI-10699187,EBI-10975473
KRT31 [Q15323]3EBI-10699187,EBI-948001
KRT34 [O76011]3EBI-10699187,EBI-1047093
KRT40 [Q6A162]3EBI-10699187,EBI-10171697
LCN2 [P80188]3EBI-10699187,EBI-11911016
MED12L [Q86YW9]3EBI-10699187,EBI-3957138
METTL15 - isoform 4 [A6NJ78-4]3EBI-10699187,EBI-10174029
METTL21A [Q8WXB1]3EBI-10699187,EBI-8652459
MGLL [A0A0C4DFN3]3EBI-10699187,EBI-12866138
NEFL [P07196]3EBI-10699187,EBI-475646
PICK1 [Q9NRD5]3EBI-10699187,EBI-79165
PLEKHG4 [Q58EX7]3EBI-10699187,EBI-949255
POU6F2 [P78424]3EBI-10699187,EBI-12029004
REL - isoform 2 [Q04864-2]3EBI-10699187,EBI-10829018
RNF11 [Q9Y3C5]3EBI-10699187,EBI-396669
SPRED1 [Q7Z699]3EBI-10699187,EBI-5235340
TRIM23 [P36406]3EBI-10699187,EBI-740098
UFSP1 [Q6NVU6]3EBI-10699187,EBI-12068150
WDR61 [Q9GZS3]3EBI-10699187,EBI-358545
WFS1 [O76024]3EBI-10699187,EBI-720609
ZMYND12 [Q9H0C1]3EBI-10699187,EBI-12030590

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128990, 74 interactors

Protein interaction database and analysis system

More...IntActi		Q8IXL7, 46 interactors

Molecular INTeraction database

More...MINTi		Q8IXL7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347324

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IXL7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IXL7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 169MsrBPROSITE-ProRule annotationAdd BLAST123

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi189 – 192Endoplasmic reticulum retention signalBy similarity4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0856, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155240

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IXL7

Identification of Orthologs from Complete Genome Data

More...OMAi		DEQWRAE

Database of Orthologous Groups

More...OrthoDBi		1549489at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IXL7

TreeFam database of animal gene trees

More...TreeFami		TF329147

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_01400, MsrB, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028427, Met_Sox_Rdtase
IPR002579, Met_Sox_Rdtase_MsrB
IPR011057, Mss4-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR10173, PTHR10173, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01641, SelR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51316, SSF51316, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00357, TIGR00357, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51790, MSRB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IXL7-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSPRRTLPRP LSLCLSLCLC LCLAAALGSA QSGSCRDKKN CKVVFSQQEL 
        60         70         80         90        100
RKRLTPLQYH VTQEKGTESA FEGEYTHHKD PGIYKCVVCG TPLFKSETKF 
       110        120        130        140        150
DSGSGWPSFH DVINSEAITF TDDFSYGMHR VETSCSQCGA HLGHIFDDGP 
       160        170        180        190 
RPTGKRYCIN SAALSFTPAD SSGTAEGGSG VASPAQADKA EL
Length:192
Mass (Da):20,702
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3326F6103369083
GO
Isoform 2 (identifier: Q8IXL7-2) [UniParc]FASTAAdd to basket
Also known as: B, C, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MSPRRTLPRPLSLCLSLCLCLCLAAALGSAQ → MSAFNLLHLVTKSQPVALRACGLP

Note: Has a transit peptide.Curated
Show »
Length:185
Mass (Da):20,010
Checksum:i37576AFCF88CE227
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YFW5H0YFW5_HUMAN
Peptide-methionine (R)-S-oxide redu...
MSRB3
174Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6G9F5H6G9_HUMAN
Peptide-methionine (R)-S-oxide redu...
MSRB3
160Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H199F5H199_HUMAN
Peptide-methionine (R)-S-oxide redu...
MSRB3
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2B7H7C2B7_HUMAN
Peptide-methionine (R)-S-oxide redu...
MSRB3
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7C4F5H7C4_HUMAN
L-methionine (R)-S-oxide reductase
MSRB3
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7J8A0A2R8Y7J8_HUMAN
L-methionine (R)-S-oxide reductase
MSRB3
84Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4C9F5H4C9_HUMAN
Methionine-R-sulfoxide reductase B3
MSRB3
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49E → G in BAH14736 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06490489C → G in DFNB74; abolishes zinc-binding and enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs387907088Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0408831 – 31MSPRR…LGSAQ → MSAFNLLHLVTKSQPVALRA CGLP in isoform 2. 3 PublicationsAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY358229 mRNA Translation: AAQ88596.1
AK293084 mRNA Translation: BAF85773.1
AK299065 mRNA Translation: BAG61131.1
AK316365 mRNA Translation: BAH14736.1
BX648776 mRNA Translation: CAI46018.1
BC040053 mRNA Translation: AAH40053.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31853.1 [Q8IXL7-2]
CCDS8973.1 [Q8IXL7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001026849.1, NM_001031679.2 [Q8IXL7-2]
NP_001180389.1, NM_001193460.1 [Q8IXL7-2]
NP_001180390.1, NM_001193461.1 [Q8IXL7-2]
NP_932346.1, NM_198080.3 [Q8IXL7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000308259; ENSP00000312274; ENSG00000174099 [Q8IXL7-2]
ENST00000355192; ENSP00000347324; ENSG00000174099 [Q8IXL7-1]
ENST00000535664; ENSP00000441650; ENSG00000174099 [Q8IXL7-2]
ENST00000614640; ENSP00000481483; ENSG00000174099 [Q8IXL7-2]
ENST00000642404; ENSP00000496008; ENSG00000174099 [Q8IXL7-2]
ENST00000642411; ENSP00000494265; ENSG00000174099 [Q8IXL7-2]
ENST00000646299; ENSP00000494941; ENSG00000174099 [Q8IXL7-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		253827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:253827

UCSC genome browser

More...UCSCi		uc001ssm.3, human [Q8IXL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358229 mRNA Translation: AAQ88596.1
AK293084 mRNA Translation: BAF85773.1
AK299065 mRNA Translation: BAG61131.1
AK316365 mRNA Translation: BAH14736.1
BX648776 mRNA Translation: CAI46018.1
BC040053 mRNA Translation: AAH40053.1
CCDSiCCDS31853.1 [Q8IXL7-2]
CCDS8973.1 [Q8IXL7-1]
RefSeqiNP_001026849.1, NM_001031679.2 [Q8IXL7-2]
NP_001180389.1, NM_001193460.1 [Q8IXL7-2]
NP_001180390.1, NM_001193461.1 [Q8IXL7-2]
NP_932346.1, NM_198080.3 [Q8IXL7-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6QA0X-ray1.71A/B31-169[»]
SMRiQ8IXL7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128990, 74 interactors
IntActiQ8IXL7, 46 interactors
MINTiQ8IXL7
STRINGi9606.ENSP00000347324

Chemistry databases

ChEMBLiCHEMBL3509604

PTM databases

iPTMnetiQ8IXL7
PhosphoSitePlusiQ8IXL7

Genetic variation databases

BioMutaiMSRB3
DMDMi327478523

Proteomic databases

EPDiQ8IXL7
jPOSTiQ8IXL7
MassIVEiQ8IXL7
MaxQBiQ8IXL7
PaxDbiQ8IXL7
PeptideAtlasiQ8IXL7
PRIDEiQ8IXL7
ProteomicsDBi71024 [Q8IXL7-1]
71025 [Q8IXL7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2870, 119 antibodies

The DNASU plasmid repository

More...DNASUi		253827

Genome annotation databases

EnsembliENST00000308259; ENSP00000312274; ENSG00000174099 [Q8IXL7-2]
ENST00000355192; ENSP00000347324; ENSG00000174099 [Q8IXL7-1]
ENST00000535664; ENSP00000441650; ENSG00000174099 [Q8IXL7-2]
ENST00000614640; ENSP00000481483; ENSG00000174099 [Q8IXL7-2]
ENST00000642404; ENSP00000496008; ENSG00000174099 [Q8IXL7-2]
ENST00000642411; ENSP00000494265; ENSG00000174099 [Q8IXL7-2]
ENST00000646299; ENSP00000494941; ENSG00000174099 [Q8IXL7-2]
GeneIDi253827
KEGGihsa:253827
UCSCiuc001ssm.3, human [Q8IXL7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		253827
DisGeNETi253827

GeneCards: human genes, protein and diseases

More...GeneCardsi		MSRB3
HGNCiHGNC:27375, MSRB3
HPAiENSG00000174099, Tissue enhanced (smooth)
MalaCardsiMSRB3
MIMi613718, phenotype
613719, gene
neXtProtiNX_Q8IXL7
OpenTargetsiENSG00000174099
Orphaneti90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA134991350
VEuPathDBiHostDB:ENSG00000174099.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0856, Eukaryota
GeneTreeiENSGT00940000155240
InParanoidiQ8IXL7
OMAiDEQWRAE
OrthoDBi1549489at2759
PhylomeDBiQ8IXL7
TreeFamiTF329147

Enzyme and pathway databases

BRENDAi1.8.4.12, 2681
1.8.4.B3, 2681
PathwayCommonsiQ8IXL7
ReactomeiR-HSA-5676934, Protein repair

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		253827, 5 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MSRB3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		253827
PharosiQ8IXL7, Tbio

Protein Ontology

More...PROi		PR:Q8IXL7
RNActiQ8IXL7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174099, Expressed in myometrium and 215 other tissues
ExpressionAtlasiQ8IXL7, baseline and differential
GenevisibleiQ8IXL7, HS

Family and domain databases

HAMAPiMF_01400, MsrB, 1 hit
InterProiView protein in InterPro
IPR028427, Met_Sox_Rdtase
IPR002579, Met_Sox_Rdtase_MsrB
IPR011057, Mss4-like_sf
PANTHERiPTHR10173, PTHR10173, 1 hit
PfamiView protein in Pfam
PF01641, SelR, 1 hit
SUPFAMiSSF51316, SSF51316, 1 hit
TIGRFAMsiTIGR00357, TIGR00357, 1 hit
PROSITEiView protein in PROSITE
PS51790, MSRB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSRB3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXL7
Secondary accession number(s): B4DR19, B7ZAQ0, Q6UXS2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 5, 2011
Last modified: April 7, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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