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UniProtKB - Q8IXL1 (Q8IXL1_HUMAN)
Protein
Submitted name:
ELK4, ETS-domain protein (SRF accessory protein 1)
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: ELK4, ETS-domain protein (SRF accessory protein 1)Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 95 – 175 | ETSInterPro annotationAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 59 – 80 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 204 – 229 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 264 – 286 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 341 – 372 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 384 – 413 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 501 – 521 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 79 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 347 – 362 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 393 – 409 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 981551at2759 |
PhylomeDBi | Q8IXL1 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR046328, ETS_fam IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849, PTHR11849, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q8IXL1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
RPQDPRRRCR VRGRGGRGAR SRGGGRCGRL RAPGGLGLAA AAFYGSAAGV
60 70 80 90 100
AAAAAPSSSF QREEEAEGGE AHRVRGGDRG GAPRAASLIA MDSAITLWQF
110 120 130 140 150
LLQLLQKPQN KHMICWTSND GQFKLLQAEE VARLWGIRKN KPNMNYDKLS
160 170 180 190 200
RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LNMDPMTVGR IEGDCESLNF
210 220 230 240 250
SEVSSSSKDV ENGGKDKPPQ PGAKTSSRND YIHSGLYSSF TLNSLNSSNV
260 270 280 290 300
KLFKLIKTEN PAEKLAEKKS PQEPTPSVIK FVTTPSKKPP VEPVAATISI
310 320 330 340 350
GPSISPSSEE TIQALETLVS PKLPSLEAPT SASNVMTAFA TTPPISSIPP
360 370 380 390 400
LQEPPRTPSP PLSSHPDIDT DIDSVASQPM ELPENLSLEP KDQDSVLLEK
410 420 430 440 450
DKVNNSSRSK KPKGLELAPT LVITSSDPSP LGILSPSLPT ASLTPAFFSQ
460 470 480 490 500
TPIILTPSPL LSSIHFWSTL SPVAPLSPAR LQGANTLFQF PSVLNSHGPF
510 520
TLSGLDGPST PGPFSPDLQK T
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC040145 mRNA Translation: AAH40145.1 |
RefSeqi | NP_001964.2, NM_001973.3 NP_068567.1, NM_021795.2 |
Genome annotation databases
GeneIDi | 2005 |
KEGGi | hsa:2005 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC040145 mRNA Translation: AAH40145.1 |
RefSeqi | NP_001964.2, NM_001973.3 NP_068567.1, NM_021795.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q8IXL1 |
ProteomicsDBi | 71021 |
Protocols and materials databases
DNASUi | 2005 |
Genome annotation databases
GeneIDi | 2005 |
KEGGi | hsa:2005 |
Organism-specific databases
CTDi | 2005 |
PharmGKBi | PA27753 |
Phylogenomic databases
OrthoDBi | 981551at2759 |
PhylomeDBi | Q8IXL1 |
Miscellaneous databases
BioGRID-ORCSi | 2005, 8 hits in 1098 CRISPR screens |
GenomeRNAii | 2005 |
Gene expression databases
Genevisiblei | Q8IXL1, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR046328, ETS_fam IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849, PTHR11849, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8IXL1_HUMAN | |
Accessioni | Q8IXL1Primary (citable) accession number: Q8IXL1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |