UniProtKB - Q8IXK2 (GLT12_HUMAN)
Protein
Polypeptide N-acetylgalactosaminyltransferase 12
Gene
GALNT12
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Catalytic activityi
- L-seryl-[protein] + UDP-N-acetyl-α-D-galactosamine = 3-O-[N-acetyl-α-D-galactosaminyl]-L-seryl-[protein] + H+ + UDP1 PublicationEC:2.4.1.411 Publication
- L-threonyl-[protein] + UDP-N-acetyl-α-D-galactosamine = 3-O-[N-acetyl-α-D-galactosaminyl]-L-threonyl-[protein] + H+ + UDP1 PublicationEC:2.4.1.411 Publication
Cofactori
Mn2+By similarity
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 176 | SubstrateBy similarity | 1 | |
Binding sitei | 205 | SubstrateBy similarity | 1 | |
Metal bindingi | 228 | ManganeseBy similarity | 1 | |
Metal bindingi | 230 | ManganeseBy similarity | 1 | |
Binding sitei | 335 | SubstrateBy similarity | 1 | |
Metal bindingi | 363 | ManganeseBy similarity | 1 | |
Binding sitei | 371 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- polypeptide N-acetylgalactosaminyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- O-glycan processing Source: Reactome
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Ligand | Lectin, Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 2.4.1.41, 2681 |
PathwayCommonsi | Q8IXK2 |
Reactomei | R-HSA-5083636, Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-913709, O-linked glycosylation of mucins |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | CBM13, Carbohydrate-Binding Module Family 13 GT27, Glycosyltransferase Family 27 |
Names & Taxonomyi
Protein namesi | Recommended name: Polypeptide N-acetylgalactosaminyltransferase 12 (EC:2.4.1.41)Alternative name(s): Polypeptide GalNAc transferase 12 Short name: GalNAc-T12 Short name: pp-GaNTase 12 Protein-UDP acetylgalactosaminyltransferase 12 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12 |
Gene namesi | Name:GALNT12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19877, GALNT12 |
MIMi | 610290, gene |
neXtProti | NX_Q8IXK2 |
VEuPathDBi | HostDB:ENSG00000119514.6 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Single-pass type II membrane protein By similarity
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 19 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 20 – 37 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 18 | |
Topological domaini | 38 – 581 | LumenalSequence analysisAdd BLAST | 544 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Colorectal cancer 1 (CRCS1)3 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry. The role of GALNT12 in colon cancer susceptibility is however subject to discussion: studies on 103 probants with colorectal cancer 1 (CRCS1) suggest that it does not act as a major contributor of CRCS1 (PubMed:24115450).1 Publication
Disease descriptionA complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064357 | 297 | R → W in CRCS1; germline mutation; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs149726976EnsemblClinVar. | 1 | |
Natural variantiVAR_064358 | 303 | D → N in CRCS1; germline mutation; reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs145236923EnsemblClinVar. | 1 | |
Natural variantiVAR_064359 | 341 | E → D in CRCS1; somatic mutation; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_064360 | 373 | R → H in CRCS1; germline mutation; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs920049418EnsemblClinVar. | 1 | |
Natural variantiVAR_064361 | 382 | R → H in CRCS1; germline mutation; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs868590153EnsemblClinVar. | 1 | |
Natural variantiVAR_068509 | 396 | Y → C in CRCS1. 1 PublicationCorresponds to variant dbSNP:rs1272530441Ensembl. | 1 | |
Natural variantiVAR_064362 | 479 | C → F in CRCS1; somatic mutation; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_064363 | 491 | T → M in CRCS1; germline mutation; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs267606840EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 79695 |
MalaCardsi | GALNT12 |
MIMi | 608812, phenotype |
OpenTargetsi | ENSG00000119514 |
PharmGKBi | PA134929192 |
Miscellaneous databases
Pharosi | Q8IXK2, Tbio |
Genetic variation databases
BioMutai | GALNT12 |
DMDMi | 84028209 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059128 | 1 – 581 | Polypeptide N-acetylgalactosaminyltransferase 12Add BLAST | 581 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 125 ↔ 358 | PROSITE-ProRule annotation | ||
Disulfide bondi | 349 ↔ 422 | PROSITE-ProRule annotation | ||
Disulfide bondi | 458 ↔ 479 | PROSITE-ProRule annotation | ||
Disulfide bondi | 506 ↔ 521 | PROSITE-ProRule annotation | ||
Disulfide bondi | 547 ↔ 566 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | Q8IXK2 |
jPOSTi | Q8IXK2 |
MassIVEi | Q8IXK2 |
MaxQBi | Q8IXK2 |
PaxDbi | Q8IXK2 |
PeptideAtlasi | Q8IXK2 |
PRIDEi | Q8IXK2 |
ProteomicsDBi | 71019 [Q8IXK2-1] 71020 [Q8IXK2-2] |
PTM databases
iPTMneti | Q8IXK2 |
PhosphoSitePlusi | Q8IXK2 |
SwissPalmi | Q8IXK2 |
Expressioni
Tissue specificityi
Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate.1 Publication
Gene expression databases
Bgeei | ENSG00000119514, Expressed in palpebral conjunctiva and 188 other tissues |
ExpressionAtlasi | Q8IXK2, baseline and differential |
Genevisiblei | Q8IXK2, HS |
Organism-specific databases
HPAi | ENSG00000119514, Tissue enhanced (epididymis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122816, 35 interactors |
IntActi | Q8IXK2, 33 interactors |
MINTi | Q8IXK2 |
STRINGi | 9606.ENSP00000364150 |
Miscellaneous databases
RNActi | Q8IXK2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IXK2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 445 – 577 | Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 244 | Catalytic subdomain AAdd BLAST | 110 | |
Regioni | 304 – 366 | Catalytic subdomain BAdd BLAST | 63 |
Domaini
There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.By similarity
The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity.By similarity
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3736, Eukaryota |
GeneTreei | ENSGT00940000157173 |
HOGENOMi | CLU_013477_0_3_1 |
InParanoidi | Q8IXK2 |
OMAi | QKWFFEE |
OrthoDBi | 606683at2759 |
PhylomeDBi | Q8IXK2 |
TreeFami | TF352660 |
Family and domain databases
CDDi | cd00161, RICIN, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR001173, Glyco_trans_2-like IPR029044, Nucleotide-diphossugar_trans IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit PF00652, Ricin_B_lectin, 1 hit |
SMARTi | View protein in SMART SM00458, RICIN, 1 hit |
SUPFAMi | SSF50370, SSF50370, 1 hit SSF53448, SSF53448, 1 hit |
PROSITEi | View protein in PROSITE PS50231, RICIN_B_LECTIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IXK2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWGRTARRRC PRELRRGREA LLVLLALLAL AGLGSVLRAQ RGAGAGAAEP
60 70 80 90 100
GPPRTPRPGR REPVMPRPPV PANALGARGE AVRLQLQGEE LRLQEESVRL
110 120 130 140 150
HQINIYLSDR ISLHRRLPER WNPLCKEKKY DYDNLPRTSV IIAFYNEAWS
160 170 180 190 200
TLLRTVYSVL ETSPDILLEE VILVDDYSDR EHLKERLANE LSGLPKVRLI
210 220 230 240 250
RANKREGLVR ARLLGASAAR GDVLTFLDCH CECHEGWLEP LLQRIHEEES
260 270 280 290 300
AVVCPVIDVI DWNTFEYLGN SGEPQIGGFD WRLVFTWHTV PERERIRMQS
310 320 330 340 350
PVDVIRSPTM AGGLFAVSKK YFEYLGSYDT GMEVWGGENL EFSFRIWQCG
360 370 380 390 400
GVLETHPCSH VGHVFPKQAP YSRNKALANS VRAAEVWMDE FKELYYHRNP
410 420 430 440 450
RARLEPFGDV TERKQLRDKL QCKDFKWFLE TVYPELHVPE DRPGFFGMLQ
460 470 480 490 500
NKGLTDYCFD YNPPDENQIV GHQVILYLCH GMGQNQFFEY TSQKEIRYNT
510 520 530 540 550
HQPEGCIAVE AGMDTLIMHL CEETAPENQK FILQEDGSLF HEQSKKCVQA
560 570 580
ARKESSDSFV PLLRDCTNSD HQKWFFKERM L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WT76 | A0A087WT76_HUMAN | Polypeptide N-acetylgalactosaminylt... | GALNT12 | 31 | Annotation score: |
Sequence cautioni
The sequence BAB15027 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064352 | 3 | G → E1 PublicationCorresponds to variant dbSNP:rs1356894484Ensembl. | 1 | |
Natural variantiVAR_064353 | 46 | G → R1 PublicationCorresponds to variant dbSNP:rs10987768EnsemblClinVar. | 1 | |
Natural variantiVAR_064354 | 119 | E → V2 PublicationsCorresponds to variant dbSNP:rs1137654EnsemblClinVar. | 1 | |
Natural variantiVAR_064355 | 261 | D → N1 PublicationCorresponds to variant dbSNP:rs41306504EnsemblClinVar. | 1 | |
Natural variantiVAR_064356 | 272 | G → R1 PublicationCorresponds to variant dbSNP:rs367645298EnsemblClinVar. | 1 | |
Natural variantiVAR_064357 | 297 | R → W in CRCS1; germline mutation; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs149726976EnsemblClinVar. | 1 | |
Natural variantiVAR_064358 | 303 | D → N in CRCS1; germline mutation; reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs145236923EnsemblClinVar. | 1 | |
Natural variantiVAR_064359 | 341 | E → D in CRCS1; somatic mutation; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_064360 | 373 | R → H in CRCS1; germline mutation; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs920049418EnsemblClinVar. | 1 | |
Natural variantiVAR_064361 | 382 | R → H in CRCS1; germline mutation; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs868590153EnsemblClinVar. | 1 | |
Natural variantiVAR_068509 | 396 | Y → C in CRCS1. 1 PublicationCorresponds to variant dbSNP:rs1272530441Ensembl. | 1 | |
Natural variantiVAR_064362 | 479 | C → F in CRCS1; somatic mutation; loss of activity. 1 Publication | 1 | |
Natural variantiVAR_064363 | 491 | T → M in CRCS1; germline mutation; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs267606840EnsemblClinVar. | 1 | |
Natural variantiVAR_064364 | 552 | R → K1 PublicationCorresponds to variant dbSNP:rs1285871027EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011217 | 1 – 309 | Missing in isoform 2. 1 PublicationAdd BLAST | 309 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB078146 mRNA Translation: BAC07181.1 AJ132365 mRNA Translation: CAC80100.2 AL136084 Genomic DNA No translation available. BC013945 mRNA Translation: AAH13945.1 AK024865 mRNA Translation: BAB15027.1 Different initiation. |
CCDSi | CCDS6737.1 [Q8IXK2-1] |
RefSeqi | NP_078918.3, NM_024642.4 [Q8IXK2-1] XP_006717350.1, XM_006717287.1 |
Genome annotation databases
Ensembli | ENST00000375011; ENSP00000364150; ENSG00000119514 [Q8IXK2-1] |
GeneIDi | 79695 |
KEGGi | hsa:79695 |
UCSCi | uc004ayz.3, human [Q8IXK2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - GTase Polypeptide N-acetylgalactosaminyltransferase 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB078146 mRNA Translation: BAC07181.1 AJ132365 mRNA Translation: CAC80100.2 AL136084 Genomic DNA No translation available. BC013945 mRNA Translation: AAH13945.1 AK024865 mRNA Translation: BAB15027.1 Different initiation. |
CCDSi | CCDS6737.1 [Q8IXK2-1] |
RefSeqi | NP_078918.3, NM_024642.4 [Q8IXK2-1] XP_006717350.1, XM_006717287.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6PXU | X-ray | 2.01 | A/B | 39-581 | [»] | |
SMRi | Q8IXK2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122816, 35 interactors |
IntActi | Q8IXK2, 33 interactors |
MINTi | Q8IXK2 |
STRINGi | 9606.ENSP00000364150 |
Protein family/group databases
CAZyi | CBM13, Carbohydrate-Binding Module Family 13 GT27, Glycosyltransferase Family 27 |
PTM databases
iPTMneti | Q8IXK2 |
PhosphoSitePlusi | Q8IXK2 |
SwissPalmi | Q8IXK2 |
Genetic variation databases
BioMutai | GALNT12 |
DMDMi | 84028209 |
Proteomic databases
EPDi | Q8IXK2 |
jPOSTi | Q8IXK2 |
MassIVEi | Q8IXK2 |
MaxQBi | Q8IXK2 |
PaxDbi | Q8IXK2 |
PeptideAtlasi | Q8IXK2 |
PRIDEi | Q8IXK2 |
ProteomicsDBi | 71019 [Q8IXK2-1] 71020 [Q8IXK2-2] |
Protocols and materials databases
Antibodypediai | 29005, 83 antibodies |
DNASUi | 79695 |
Genome annotation databases
Ensembli | ENST00000375011; ENSP00000364150; ENSG00000119514 [Q8IXK2-1] |
GeneIDi | 79695 |
KEGGi | hsa:79695 |
UCSCi | uc004ayz.3, human [Q8IXK2-1] |
Organism-specific databases
CTDi | 79695 |
DisGeNETi | 79695 |
GeneCardsi | GALNT12 |
HGNCi | HGNC:19877, GALNT12 |
HPAi | ENSG00000119514, Tissue enhanced (epididymis) |
MalaCardsi | GALNT12 |
MIMi | 608812, phenotype 610290, gene |
neXtProti | NX_Q8IXK2 |
OpenTargetsi | ENSG00000119514 |
PharmGKBi | PA134929192 |
VEuPathDBi | HostDB:ENSG00000119514.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3736, Eukaryota |
GeneTreei | ENSGT00940000157173 |
HOGENOMi | CLU_013477_0_3_1 |
InParanoidi | Q8IXK2 |
OMAi | QKWFFEE |
OrthoDBi | 606683at2759 |
PhylomeDBi | Q8IXK2 |
TreeFami | TF352660 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
BRENDAi | 2.4.1.41, 2681 |
PathwayCommonsi | Q8IXK2 |
Reactomei | R-HSA-5083636, Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-913709, O-linked glycosylation of mucins |
Miscellaneous databases
BioGRID-ORCSi | 79695, 3 hits in 872 CRISPR screens |
ChiTaRSi | GALNT12, human |
GenomeRNAii | 79695 |
Pharosi | Q8IXK2, Tbio |
PROi | PR:Q8IXK2 |
RNActi | Q8IXK2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119514, Expressed in palpebral conjunctiva and 188 other tissues |
ExpressionAtlasi | Q8IXK2, baseline and differential |
Genevisiblei | Q8IXK2, HS |
Family and domain databases
CDDi | cd00161, RICIN, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR001173, Glyco_trans_2-like IPR029044, Nucleotide-diphossugar_trans IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin |
Pfami | View protein in Pfam PF00535, Glycos_transf_2, 1 hit PF00652, Ricin_B_lectin, 1 hit |
SMARTi | View protein in SMART SM00458, RICIN, 1 hit |
SUPFAMi | SSF50370, SSF50370, 1 hit SSF53448, SSF53448, 1 hit |
PROSITEi | View protein in PROSITE PS50231, RICIN_B_LECTIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLT12_HUMAN | |
Accessioni | Q8IXK2Primary (citable) accession number: Q8IXK2 Secondary accession number(s): Q5TCF7 Q9H771 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2004 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants