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Protein

Polyhomeotic-like protein 2

Gene

PHC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Miscellaneous

The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri633 – 667FCS-typePROSITE-ProRule annotationAdd BLAST35

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q8IXK0 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyhomeotic-like protein 2
Short name:
hPH2
Alternative name(s):
Early development regulatory protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHC2
Synonyms:EDR2, PH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000134686.16

Human Gene Nomenclature Database

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HGNCi
HGNC:3183 PHC2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602979 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IXK0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
1912

Open Targets

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OpenTargetsi
ENSG00000134686

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27620

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PHC2

Domain mapping of disease mutations (DMDM)

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DMDMi
74750731

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762861 – 858Polyhomeotic-like protein 2Add BLAST858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki598Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki600Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei619PhosphothreonineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Cross-linki632Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki702Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei751PhosphoserineCombined sources1
Cross-linki847Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8IXK0

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8IXK0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IXK0

PeptideAtlas

More...
PeptideAtlasi
Q8IXK0

PRoteomics IDEntifications database

More...
PRIDEi
Q8IXK0

ProteomicsDB human proteome resource

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ProteomicsDBi
71014
71015 [Q8IXK0-2]
71016 [Q8IXK0-3]
71017 [Q8IXK0-4]
71018 [Q8IXK0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IXK0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8IXK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134686 Expressed in 222 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IXK0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IXK0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047403

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a PRC1-like complex (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530). Interacts with CBX4 (PubMed:21282530). Interacts with BMI1, PCGF2, PHC1 and RNF2 (PubMed:9121482, PubMed:9199346, PubMed:12167701). Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2 (PubMed:10976766, PubMed:15094067).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-713786,EBI-713786
AENQ8WTP83EBI-713786,EBI-8637627
AP1M1Q9BXS53EBI-713786,EBI-541426
BMI1P352267EBI-713786,EBI-2341576
Bmi1P259162EBI-713786,EBI-927401From Mus musculus.
BYSLQ138956EBI-713786,EBI-358049
C1orf109Q9NX043EBI-713786,EBI-8643161
CARD9Q9H2573EBI-713786,EBI-751319
CBX8Q9HC527EBI-713786,EBI-712912
DRG1Q9Y2954EBI-713786,EBI-719554
ENKD1Q9H0I24EBI-713786,EBI-744099
FAM124AQ86V423EBI-713786,EBI-744506
FAM13CQ8NE313EBI-713786,EBI-751248
FAM161AQ3B8203EBI-713786,EBI-719941
FAM74A1Q5RGS33EBI-713786,EBI-10244822
FAM74A6Q5TZK33EBI-713786,EBI-10247271
KAT5Q929933EBI-713786,EBI-399080
KBTBD7Q8WVZ93EBI-713786,EBI-473695
KIFC3Q9BVG83EBI-713786,EBI-2125614
L3MBTL3Q96JM76EBI-713786,EBI-2686809
LMO1P258003EBI-713786,EBI-8639312
LMO2P257914EBI-713786,EBI-739696
MAB21L3Q8N8X93EBI-713786,EBI-10268010
MAGEB6Q8N7X43EBI-713786,EBI-6447163
MCRS1Q96EZ82EBI-713786,EBI-348259
MFAP1P550813EBI-713786,EBI-1048159
MORF4L2Q150143EBI-713786,EBI-399257
PCGF2P352278EBI-713786,EBI-2129767
PCGF3Q3KNV83EBI-713786,EBI-2339807
PCGF5Q86SE93EBI-713786,EBI-2827999
PLK1P533502EBI-713786,EBI-476768
POLR2LP628753EBI-713786,EBI-359527
PPP1R16BQ96T493EBI-713786,EBI-10293968
PRKAA1Q131313EBI-713786,EBI-1181405
PRPF3O433953EBI-11527347,EBI-744322
PRPF31Q8WWY33EBI-11527347,EBI-1567797
RBM39Q144983EBI-713786,EBI-395290
RBM39Q14498-33EBI-713786,EBI-6654703
RWDD2BP570603EBI-713786,EBI-724442
SDCBPO005603EBI-713786,EBI-727004
SFMBT1Q9UHJ34EBI-713786,EBI-747398
SIAH1Q8IUQ45EBI-713786,EBI-747107
SMAD3P840223EBI-713786,EBI-347161
SP1P080472EBI-713786,EBI-298336
SPATC1LQ9H0A93EBI-10304199,EBI-372911
SSX2IPQ9Y2D83EBI-713786,EBI-2212028
SYT16Q17RD73EBI-713786,EBI-10238936
THAP7Q9BT493EBI-713786,EBI-741350
TRIM41Q8WV443EBI-713786,EBI-725997
ZBTB24O431673EBI-713786,EBI-744471
ZGPATQ8N5A53EBI-713786,EBI-3439227
ZGPATQ8N5A5-23EBI-713786,EBI-10183064
ZMAT2Q96NC03EBI-713786,EBI-2682299
ZNF417Q8TAU33EBI-713786,EBI-740727

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108234, 100 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IXK0

Database of interacting proteins

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DIPi
DIP-34464N

Protein interaction database and analysis system

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IntActi
Q8IXK0, 92 interactors

Molecular INTeraction database

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MINTi
Q8IXK0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257118

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8IXK0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IXK0

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini794 – 858SAMPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 76Intrinsically disorderedBy similarityAdd BLAST76
Regioni33 – 53Interaction with BMI1By similarityAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi558 – 587HD1Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 37Ser-richAdd BLAST27
Compositional biasi55 – 111Gln-richAdd BLAST57
Compositional biasi329 – 377Gln-richAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

HD1 motif interacts with SAM domain of PHC1.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri633 – 667FCS-typePROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IDZN Eukaryota
ENOG4111F0Y LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160840

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000236275

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG039325

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8IXK0

KEGG Orthology (KO)

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KOi
K11457

Identification of Orthologs from Complete Genome Data

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OMAi
PQQCAPD

Database of Orthologous Groups

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OrthoDBi
EOG091G02VS

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IXK0

TreeFam database of animal gene trees

More...
TreeFami
TF331299

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.60.160, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00536 SAM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00454 SAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS51024 ZF_FCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IXK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENELPVPHT SSSACATSST SGASSSSGCN NSSSGGSGRP TGPQISVYSG
60 70 80 90 100
IPDRQTVQVI QQALHRQPST AAQYLQQMYA AQQQHLMLQT AALQQQHLSS
110 120 130 140 150
AQLQSLAAVQ QASLVSNRQG STSGSNVSAQ APAQSSSINL AASPAAAQLL
160 170 180 190 200
NRAQSVNSAA ASGIAQQAVL LGNTSSPALT ASQAQMYLRA QMLIFTPTAT
210 220 230 240 250
VATVQPELGT GSPARPPTPA QVQNLTLRTQ QTPAAAASGP TPTQPVLPSL
260 270 280 290 300
ALKPTPGGSQ PLPTPAQSRN TAQASPAGAK PGIADSVMEP HKKGDGNSSV
310 320 330 340 350
PGSMEGRAGL SRTVPAVAAH PLIAPAYAQL QPHQLLPQPS SKHLQPQFVI
360 370 380 390 400
QQQPQPQQQQ PPPQQSRPVL QAEPHPQLAS VSPSVALQPS SEAHAMPLGP
410 420 430 440 450
VTPALPLQCP TANLHKPGGS QQCHPPTPDT GPQNGHPEGV PHTPQRRFQH
460 470 480 490 500
TSAVILQLQP ASPPQQCVPD DWKEVAPGEK SVPETRSGPS PHQQAIVTAM
510 520 530 540 550
PGGLPVPTSP NIQPSPAHET GQGIVHALTD LSSPGMTSGN GNSASSIAGT
560 570 580 590 600
APQNGENKPP QAIVKPQILT HVIEGFVIQE GAEPFPVGRS SLLVGNLKKK
610 620 630 640 650
YAQGFLPEKL PQQDHTTTTD SEMEEPYLQE SKEEGAPLKL KCELCGRVDF
660 670 680 690 700
AYKFKRSKRF CSMACAKRYN VGCTKRVGLF HSDRSKLQKA GAATHNRRRA
710 720 730 740 750
SKASLPPLTK DTKKQPTGTV PLSVTAALQL THSQEDSSRC SDNSSYEEPL
760 770 780 790 800
SPISASSSTS RRRQGQRDLE LPDMHMRDLV GMGHHFLPSE PTKWNVEDVY
810 820 830 840 850
EFIRSLPGCQ EIAEEFRAQE IDGQALLLLK EDHLMSAMNI KLGPALKIYA

RISMLKDS
Length:858
Mass (Da):90,713
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E3FD3898CFD702B
GO
Isoform 2 (identifier: Q8IXK0-2) [UniParc]FASTAAdd to basket
Also known as: isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     1-535: Missing.

Show »
Length:323
Mass (Da):35,760
Checksum:i3D469465CA2C39AD
GO
Isoform 3 (identifier: Q8IXK0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-585: Missing.
     586-586: P → M
     809-852: CQEIAEEFRA...GPALKIYARI → LPSSFPKGHE...WPVLRPRPHL
     853-858: Missing.

Show »
Length:267
Mass (Da):30,053
Checksum:i2E784C87AA459AD0
GO
Isoform 4 (identifier: Q8IXK0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-221: Missing.

Note: No experimental confirmation available.
Show »
Length:829
Mass (Da):87,812
Checksum:iFFAF6D7224ADBD72
GO
Isoform 5 (identifier: Q8IXK0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     463-463: P → PV

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):90,812
Checksum:i7F6C839B758194DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSI2A0A0A0MSI2_HUMAN
Polyhomeotic-like protein 2
PHC2
830Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KPJ4B3KPJ4_HUMAN
cDNA FLJ31867 fis, clone NT2RP70018...
PHC2
464Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH68573 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH92492 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti745S → N in BAC87622 (PubMed:14702039).Curated1
Sequence conflicti778D → E in BAC87622 (PubMed:14702039).Curated1
Sequence conflicti813A → E in AAH28396 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051276254P → S. Corresponds to variant dbSNP:rs10914692Ensembl.1
Natural variantiVAR_051277475V → M1 PublicationCorresponds to variant dbSNP:rs12026290Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0169141 – 585Missing in isoform 3. 1 PublicationAdd BLAST585
Alternative sequenceiVSP_0169151 – 535Missing in isoform 2. 1 PublicationAdd BLAST535
Alternative sequenceiVSP_027217193 – 221Missing in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_039755463P → PV in isoform 5. 2 Publications1
Alternative sequenceiVSP_016916586P → M in isoform 3. 1 Publication1
Alternative sequenceiVSP_016917809 – 852CQEIA…IYARI → LPSSFPKGHETSIYSLSKHL RHSRFPQSPSGSCLWPVLRP RPHL in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_016918853 – 858Missing in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ419231 mRNA Translation: CAD11673.1
AK128821 mRNA Translation: BAC87622.1
AK292905 mRNA Translation: BAF85594.1
AL513327 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07457.1
CH471059 Genomic DNA Translation: EAX07458.1
CH471059 Genomic DNA Translation: EAX07459.1
BC015450 mRNA Translation: AAH15450.1
BC028396 mRNA Translation: AAH28396.3
BC029269 mRNA Translation: AAH29269.1
BC068573 mRNA Translation: AAH68573.1 Different initiation.
BC092492 mRNA Translation: AAH92492.1 Different initiation.
BC110863 mRNA Translation: AAI10864.2
BC130630 mRNA Translation: AAI30631.1
AJ242730 mRNA Translation: CAB44779.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS378.1 [Q8IXK0-1]
CCDS379.1 [Q8IXK0-2]

NCBI Reference Sequences

More...
RefSeqi
NP_004418.2, NM_004427.3 [Q8IXK0-2]
NP_932157.1, NM_198040.2 [Q8IXK0-1]
XP_005270627.1, XM_005270570.1
XP_016856005.1, XM_017000516.1
XP_016856006.1, XM_017000517.1
XP_016856007.1, XM_017000518.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.524271
Hs.674410

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257118; ENSP00000257118; ENSG00000134686 [Q8IXK0-1]
ENST00000373418; ENSP00000362517; ENSG00000134686 [Q8IXK0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1912

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1912

UCSC genome browser

More...
UCSCi
uc001bxe.2 human [Q8IXK0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ419231 mRNA Translation: CAD11673.1
AK128821 mRNA Translation: BAC87622.1
AK292905 mRNA Translation: BAF85594.1
AL513327 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07457.1
CH471059 Genomic DNA Translation: EAX07458.1
CH471059 Genomic DNA Translation: EAX07459.1
BC015450 mRNA Translation: AAH15450.1
BC028396 mRNA Translation: AAH28396.3
BC029269 mRNA Translation: AAH29269.1
BC068573 mRNA Translation: AAH68573.1 Different initiation.
BC092492 mRNA Translation: AAH92492.1 Different initiation.
BC110863 mRNA Translation: AAI10864.2
BC130630 mRNA Translation: AAI30631.1
AJ242730 mRNA Translation: CAB44779.1
CCDSiCCDS378.1 [Q8IXK0-1]
CCDS379.1 [Q8IXK0-2]
RefSeqiNP_004418.2, NM_004427.3 [Q8IXK0-2]
NP_932157.1, NM_198040.2 [Q8IXK0-1]
XP_005270627.1, XM_005270570.1
XP_016856005.1, XM_017000516.1
XP_016856006.1, XM_017000517.1
XP_016856007.1, XM_017000518.1
UniGeneiHs.524271
Hs.674410

3D structure databases

ProteinModelPortaliQ8IXK0
SMRiQ8IXK0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108234, 100 interactors
CORUMiQ8IXK0
DIPiDIP-34464N
IntActiQ8IXK0, 92 interactors
MINTiQ8IXK0
STRINGi9606.ENSP00000257118

Protein family/group databases

MoonDBiQ8IXK0 Predicted

PTM databases

iPTMnetiQ8IXK0
PhosphoSitePlusiQ8IXK0

Polymorphism and mutation databases

BioMutaiPHC2
DMDMi74750731

Proteomic databases

EPDiQ8IXK0
MaxQBiQ8IXK0
PaxDbiQ8IXK0
PeptideAtlasiQ8IXK0
PRIDEiQ8IXK0
ProteomicsDBi71014
71015 [Q8IXK0-2]
71016 [Q8IXK0-3]
71017 [Q8IXK0-4]
71018 [Q8IXK0-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257118; ENSP00000257118; ENSG00000134686 [Q8IXK0-1]
ENST00000373418; ENSP00000362517; ENSG00000134686 [Q8IXK0-2]
GeneIDi1912
KEGGihsa:1912
UCSCiuc001bxe.2 human [Q8IXK0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1912
DisGeNETi1912
EuPathDBiHostDB:ENSG00000134686.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PHC2
HGNCiHGNC:3183 PHC2
HPAiHPA047403
MIMi602979 gene
neXtProtiNX_Q8IXK0
OpenTargetsiENSG00000134686
PharmGKBiPA27620

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IDZN Eukaryota
ENOG4111F0Y LUCA
GeneTreeiENSGT00940000160840
HOGENOMiHOG000236275
HOVERGENiHBG039325
InParanoidiQ8IXK0
KOiK11457
OMAiPQQCAPD
OrthoDBiEOG091G02VS
PhylomeDBiQ8IXK0
TreeFamiTF331299

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4655427 SUMOylation of DNA methylation proteins
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-HSA-8943724 Regulation of PTEN gene transcription

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PHC2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PHC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1912

Protein Ontology

More...
PROi
PR:Q8IXK0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134686 Expressed in 222 organ(s), highest expression level in left coronary artery
ExpressionAtlasiQ8IXK0 baseline and differential
GenevisibleiQ8IXK0 HS

Family and domain databases

Gene3Di3.30.60.160, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR012313 Znf_FCS
IPR038603 Znf_FCS_sf
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS51024 ZF_FCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXK0
Secondary accession number(s): A1L4Q1
, A8KA40, D3DPR2, Q2TAL3, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 1, 2003
Last modified: December 5, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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