UniProtKB - Q8IXH8 (CAD26_HUMAN)
Protein
Cadherin-like protein 26
Gene
CDH26
Organism
Homo sapiens (Human)
Status
Functioni
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4+ T cells activation (PubMed:28051089).1 Publication
GO - Molecular functioni
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: GO_Central
- calcium ion binding Source: GO_Central
- delta-catenin binding Source: UniProtKB
- integrin binding Source: UniProtKB
GO - Biological processi
- CD4-positive, alpha-beta T cell activation Source: UniProtKB
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q8IXH8 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-like protein 26Alternative name(s): Cadherin-like protein VR20 |
Gene namesi | Name:CDH26 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15902, CDH26 |
MIMi | 617685, gene |
neXtProti | NX_Q8IXH8 |
VEuPathDBi | HostDB:ENSG00000124215.16 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Plasma Membrane
- catenin complex Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 614 | ExtracellularSequence analysisAdd BLAST | 587 | |
Transmembranei | 615 – 635 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 636 – 832 | CytoplasmicSequence analysisAdd BLAST | 197 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000124215 |
PharmGKBi | PA26298 |
Miscellaneous databases
Pharosi | Q8IXH8, Tbio |
Genetic variation databases
BioMutai | CDH26 |
DMDMi | 152031568 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000003829 | 28 – 832 | Cadherin-like protein 26Sequence analysisAdd BLAST | 805 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 171 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 462 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q8IXH8 |
PeptideAtlasi | Q8IXH8 |
PRIDEi | Q8IXH8 |
ProteomicsDBi | 70996 [Q8IXH8-1] 70997 [Q8IXH8-2] 70998 [Q8IXH8-4] 70999 [Q8IXH8-5] |
PTM databases
CarbonylDBi | Q8IXH8 |
GlyGeni | Q8IXH8, 5 sites |
iPTMneti | Q8IXH8 |
PhosphoSitePlusi | Q8IXH8 |
Expressioni
Tissue specificityi
Expressed by epithelial cells of gastrointestinal tissue.1 Publication
Gene expression databases
Bgeei | ENSG00000124215, Expressed in bronchial epithelial cell and 140 other tissues |
ExpressionAtlasi | Q8IXH8, baseline and differential |
Genevisiblei | Q8IXH8, HS |
Organism-specific databases
HPAi | ENSG00000124215, Tissue enhanced (lymphoid tissue, prostate) |
Interactioni
Subunit structurei
GO - Molecular functioni
- alpha-catenin binding Source: UniProtKB
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: GO_Central
- delta-catenin binding Source: UniProtKB
- integrin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121909, 2 interactors |
STRINGi | 9606.ENSP00000339390 |
Miscellaneous databases
RNActi | Q8IXH8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 165 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 131 | |
Domaini | 166 – 275 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 276 – 396 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 397 – 500 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 104 |
Domaini
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000161589 |
HOGENOMi | CLU_005284_5_0_1 |
InParanoidi | Q8IXH8 |
OMAi | WRAKFNI |
OrthoDBi | 158870at2759 |
PhylomeDBi | Q8IXH8 |
TreeFami | TF316817 |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: Q8IXH8-4) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAMRSGRHPS LLLLLVLLLW LLQVSIIDSV QQETDDLTKQ TKEKIYQPLR
60 70 80 90 100
RSKRRWVITT LELEEEDPGP FPKLIGELFN NMSYNMSLMY LISGPGVDEY
110 120 130 140 150
PEIGLFSLED HENGRIYVHR PVDREMTPSF TVYFDVVERS TGKIVDTSLI
160 170 180 190 200
FNIRISDVND HAPQFPEKEF NITVQENQSA GQPIFQMLAV DLDEENTPNS
210 220 230 240 250
QVLYFLISQT PLLKESGFRV DRLSGEIRLS GCLDYETAPQ FTLLIRARDC
260 270 280 290 300
GEPSLSSTTT VHVDVQEGNN HRPAFTQENY KVQIPEGRAS QGVLRLLVQD
310 320 330 340 350
RDSPFTSAWR AKFNILHGNE EGHFDISTDP ETNEGILNVI KPLDYETRPA
360 370 380 390 400
QSLIIVVENE ERLVFCERGK LQPPRKAAAS ATVSVQVTDA NDPPAFHPQS
410 420 430 440 450
FIVNKEEGAR PGTLLGTFNA MDPDSQIRYE LVHDPANWVS VDKNSGVVIT
460 470 480 490 500
VEPIDRESPH VNNSFYVIII HAVDDGFPPQ TATGTLMLFL SDINDNVPTL
510 520 530 540 550
RPRSRYMEVC ESAVHEPLHI EAEDPDLEPF SDPFTFELDN TWGNAEDTWK
560 570 580 590 600
LGRNWGQSVE LLTLRSLPRG NYLVPLFIGD KQGLSQKQTV HVRICPCASG
610 620 630 640 650
LTCVELADAE VGLHVGALFP VCAAFVALAV ALLFLLRCYF VLEPKRHGCS
660 670 680 690 700
VSNDEGHQTL VMYNAESKGT SAQTWSDVEG QRPALLICTA AAGPTQGVKD
710 720 730 740 750
LEEVPPSAAS QSAQARCALG SWGYGKPFEP RSVKNIHSTP AYPDATMHRQ
760 770 780 790 800
LLAPVEGRMA ETLNQKLHVA NVLEDDPGYL PHVYSEEGEC GGAPSLSSLA
810 820 830
SLEQELQPDL LDSLGSKATP FEEIYSESGV PS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BY79 | H7BY79_HUMAN | Cadherin-like protein 26 | CDH26 | 444 | Annotation score: | ||
Q9NTY2 | Q9NTY2_HUMAN | Cadherin-like protein 26 | CDH26 | 80 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055568 | 144 | I → T. Corresponds to variant dbSNP:rs6015609Ensembl. | 1 | |
Natural variantiVAR_055569 | 301 | R → G. Corresponds to variant dbSNP:rs11086690Ensembl. | 1 | |
Natural variantiVAR_055570 | 448 | V → A. Corresponds to variant dbSNP:rs34866303Ensembl. | 1 | |
Natural variantiVAR_055571 | 479 | P → L. Corresponds to variant dbSNP:rs6071067Ensembl. | 1 | |
Natural variantiVAR_055572 | 615 | V → L. Corresponds to variant dbSNP:rs194998Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008333 | 1 – 667 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 667 | |
Alternative sequenceiVSP_008334 | 668 – 673 | KGTSAQ → MKPLIW in isoform 2 and isoform 4. 2 Publications | 6 | |
Alternative sequenceiVSP_059693 | 700 – 832 | DLEEV…SGVPS → AYPDATMHRQLLAPVEGRMA ETLNQSKERNRFSLSRGCII PQGRATAGRGLPQDIYKEMM PRRLTQTGKRKHGALARTPS FKKVVYDHKEDEENKAGRKQ RSHLFKVMQLRNEQGGVRVQ SAHSPSPLNKKACFPGDYRG ESAGGHNCRAVSG in isoform 1. Add BLAST | 133 | |
Alternative sequenceiVSP_059694 | 700 – 740 | Missing in isoform 4. Add BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055202 mRNA Translation: BAG51485.1 AK074477 mRNA Translation: BAB85093.1 AL109928 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75420.1 CH471077 Genomic DNA Translation: EAW75421.1 BC062570 mRNA Translation: AAH62570.1 AF169690 mRNA Translation: AAF89687.1 |
CCDSi | CCDS13485.1 [Q8IXH8-4] CCDS13486.1 [Q8IXH8-2] CCDS86964.1 [Q8IXH8-5] |
RefSeqi | NP_001335133.1, NM_001348204.1 [Q8IXH8-5] NP_068582.2, NM_021810.5 [Q8IXH8-2] NP_817089.1, NM_177980.3 [Q8IXH8-4] |
Genome annotation databases
Ensembli | ENST00000244049; ENSP00000244049; ENSG00000124215 [Q8IXH8-5] ENST00000348616; ENSP00000339390; ENSG00000124215 [Q8IXH8-4] ENST00000350849; ENSP00000310845; ENSG00000124215 [Q8IXH8-2] |
GeneIDi | 60437 |
KEGGi | hsa:60437 |
UCSCi | uc002ybe.4, human [Q8IXH8-4] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK055202 mRNA Translation: BAG51485.1 AK074477 mRNA Translation: BAB85093.1 AL109928 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75420.1 CH471077 Genomic DNA Translation: EAW75421.1 BC062570 mRNA Translation: AAH62570.1 AF169690 mRNA Translation: AAF89687.1 |
CCDSi | CCDS13485.1 [Q8IXH8-4] CCDS13486.1 [Q8IXH8-2] CCDS86964.1 [Q8IXH8-5] |
RefSeqi | NP_001335133.1, NM_001348204.1 [Q8IXH8-5] NP_068582.2, NM_021810.5 [Q8IXH8-2] NP_817089.1, NM_177980.3 [Q8IXH8-4] |
3D structure databases
SMRi | Q8IXH8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121909, 2 interactors |
STRINGi | 9606.ENSP00000339390 |
PTM databases
CarbonylDBi | Q8IXH8 |
GlyGeni | Q8IXH8, 5 sites |
iPTMneti | Q8IXH8 |
PhosphoSitePlusi | Q8IXH8 |
Genetic variation databases
BioMutai | CDH26 |
DMDMi | 152031568 |
Proteomic databases
MassIVEi | Q8IXH8 |
PeptideAtlasi | Q8IXH8 |
PRIDEi | Q8IXH8 |
ProteomicsDBi | 70996 [Q8IXH8-1] 70997 [Q8IXH8-2] 70998 [Q8IXH8-4] 70999 [Q8IXH8-5] |
Protocols and materials databases
Antibodypediai | 2400, 148 antibodies |
Genome annotation databases
Ensembli | ENST00000244049; ENSP00000244049; ENSG00000124215 [Q8IXH8-5] ENST00000348616; ENSP00000339390; ENSG00000124215 [Q8IXH8-4] ENST00000350849; ENSP00000310845; ENSG00000124215 [Q8IXH8-2] |
GeneIDi | 60437 |
KEGGi | hsa:60437 |
UCSCi | uc002ybe.4, human [Q8IXH8-4] |
Organism-specific databases
CTDi | 60437 |
GeneCardsi | CDH26 |
HGNCi | HGNC:15902, CDH26 |
HPAi | ENSG00000124215, Tissue enhanced (lymphoid tissue, prostate) |
MIMi | 617685, gene |
neXtProti | NX_Q8IXH8 |
OpenTargetsi | ENSG00000124215 |
PharmGKBi | PA26298 |
VEuPathDBi | HostDB:ENSG00000124215.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000161589 |
HOGENOMi | CLU_005284_5_0_1 |
InParanoidi | Q8IXH8 |
OMAi | WRAKFNI |
OrthoDBi | 158870at2759 |
PhylomeDBi | Q8IXH8 |
TreeFami | TF316817 |
Enzyme and pathway databases
PathwayCommonsi | Q8IXH8 |
Miscellaneous databases
BioGRID-ORCSi | 60437, 9 hits in 987 CRISPR screens |
GenomeRNAii | 60437 |
Pharosi | Q8IXH8, Tbio |
PROi | PR:Q8IXH8 |
RNActi | Q8IXH8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124215, Expressed in bronchial epithelial cell and 140 other tissues |
ExpressionAtlasi | Q8IXH8, baseline and differential |
Genevisiblei | Q8IXH8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS |
PANTHERi | PTHR24027, PTHR24027, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 3 hits |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits |
SUPFAMi | SSF49313, SSF49313, 5 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 2 hits PS50268, CADHERIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAD26_HUMAN | |
Accessioni | Q8IXH8Primary (citable) accession number: Q8IXH8 Secondary accession number(s): A2A2M5 Q9NRU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2003 |
Last sequence update: | September 12, 2018 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot