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UniProtKB - Q8IXH8 (CAD26_HUMAN)

Entry version 153 (17 Jun 2020)
Sequence version 4 (12 Sep 2018)
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Protein

Cadherin-like protein 26

Gene

CDH26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4+ T cells activation (PubMed:28051089).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-like protein 26
Alternative name(s):
Cadherin-like protein VR20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDH26
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000124215.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:15902 CDH26

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617685 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IXH8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 614ExtracellularSequence analysisAdd BLAST587
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei615 – 635HelicalSequence analysisAdd BLAST21
Topological domaini636 – 832CytoplasmicSequence analysisAdd BLAST197

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000124215

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26298

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IXH8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDH26

Domain mapping of disease mutations (DMDM)

More...DMDMi		152031568

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000382928 – 832Cadherin-like protein 26Sequence analysisAdd BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IXH8

PeptideAtlas

More...PeptideAtlasi		Q8IXH8

PRoteomics IDEntifications database

More...PRIDEi		Q8IXH8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70996 [Q8IXH8-1]
70997 [Q8IXH8-2]
70998 [Q8IXH8-4]
70999 [Q8IXH8-5]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8IXH8

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IXH8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IXH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by epithelial cells of gastrointestinal tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124215 Expressed in bronchial epithelial cell and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IXH8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IXH8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124215 Tissue enhanced (lymphoid tissue, prostate)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:28051089).

Component of a cadherin:catenin adhesion complex composed of at least of CDH26, beta-catenin/CTNNB1, alpha-catenin/CTNNA1 and p120 catenin/CTNND1 (PubMed:28051089).

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121909, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339390

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IXH8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IXH8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 165Cadherin 1PROSITE-ProRule annotationAdd BLAST131
Domaini166 – 275Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini276 – 396Cadherin 3PROSITE-ProRule annotationAdd BLAST121
Domaini397 – 500Cadherin 4PROSITE-ProRule annotationAdd BLAST104

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161589

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005284_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IXH8

KEGG Orthology (KO)

More...KOi		K22658

Identification of Orthologs from Complete Genome Data

More...OMAi		WRAKFNI

Database of Orthologous Groups

More...OrthoDBi		158870at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IXH8

TreeFam database of animal gene trees

More...TreeFami		TF316817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS

The PANTHER Classification System

More...PANTHERi		PTHR24027 PTHR24027, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028 Cadherin, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112 CA, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313 SSF49313, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q8IXH8-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMRSGRHPS LLLLLVLLLW LLQVSIIDSV QQETDDLTKQ TKEKIYQPLR 
        60         70         80         90        100
RSKRRWVITT LELEEEDPGP FPKLIGELFN NMSYNMSLMY LISGPGVDEY 
       110        120        130        140        150
PEIGLFSLED HENGRIYVHR PVDREMTPSF TVYFDVVERS TGKIVDTSLI 
       160        170        180        190        200
FNIRISDVND HAPQFPEKEF NITVQENQSA GQPIFQMLAV DLDEENTPNS 
       210        220        230        240        250
QVLYFLISQT PLLKESGFRV DRLSGEIRLS GCLDYETAPQ FTLLIRARDC 
       260        270        280        290        300
GEPSLSSTTT VHVDVQEGNN HRPAFTQENY KVQIPEGRAS QGVLRLLVQD 
       310        320        330        340        350
RDSPFTSAWR AKFNILHGNE EGHFDISTDP ETNEGILNVI KPLDYETRPA 
       360        370        380        390        400
QSLIIVVENE ERLVFCERGK LQPPRKAAAS ATVSVQVTDA NDPPAFHPQS 
       410        420        430        440        450
FIVNKEEGAR PGTLLGTFNA MDPDSQIRYE LVHDPANWVS VDKNSGVVIT 
       460        470        480        490        500
VEPIDRESPH VNNSFYVIII HAVDDGFPPQ TATGTLMLFL SDINDNVPTL 
       510        520        530        540        550
RPRSRYMEVC ESAVHEPLHI EAEDPDLEPF SDPFTFELDN TWGNAEDTWK 
       560        570        580        590        600
LGRNWGQSVE LLTLRSLPRG NYLVPLFIGD KQGLSQKQTV HVRICPCASG 
       610        620        630        640        650
LTCVELADAE VGLHVGALFP VCAAFVALAV ALLFLLRCYF VLEPKRHGCS 
       660        670        680        690        700
VSNDEGHQTL VMYNAESKGT SAQTWSDVEG QRPALLICTA AAGPTQGVKD 
       710        720        730        740        750
LEEVPPSAAS QSAQARCALG SWGYGKPFEP RSVKNIHSTP AYPDATMHRQ 
       760        770        780        790        800
LLAPVEGRMA ETLNQKLHVA NVLEDDPGYL PHVYSEEGEC GGAPSLSSLA 
       810        820        830 
SLEQELQPDL LDSLGSKATP FEEIYSESGV PS
Length:832
Mass (Da):92,416
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CEF6129FE255BBB
GO
Isoform 1 (identifier: Q8IXH8-1) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     700-832: DLEEVPPSAA...EIYSESGVPS → AYPDATMHRQ...GGHNCRAVSG

Show »
Length:852
Mass (Da):95,278
Checksum:iA4AD1EF230FE2B11
GO
Isoform 2 (identifier: Q8IXH8-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-673: KGTSAQ → MKPLIW

Show »
Length:165
Mass (Da):17,672
Checksum:iB8C412AD6839D3A3
GO
Isoform 4 (identifier: Q8IXH8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-667: Missing.
     668-673: KGTSAQ → MKPLIW
     700-740: Missing.

Show »
Length:124
Mass (Da):13,320
Checksum:iEF11217150A3F3D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY79H7BY79_HUMAN
Cadherin-like protein 26
CDH26
444Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9NTY2Q9NTY2_HUMAN
Cadherin-like protein 26
CDH26
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055568144I → T. Corresponds to variant dbSNP:rs6015609Ensembl.1
Natural variantiVAR_055569301R → G. Corresponds to variant dbSNP:rs11086690Ensembl.1
Natural variantiVAR_055570448V → A. Corresponds to variant dbSNP:rs34866303Ensembl.1
Natural variantiVAR_055571479P → L. Corresponds to variant dbSNP:rs6071067Ensembl.1
Natural variantiVAR_055572615V → L. Corresponds to variant dbSNP:rs194998Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0083331 – 667Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST667
Alternative sequenceiVSP_008334668 – 673KGTSAQ → MKPLIW in isoform 2 and isoform 4. 2 Publications6
Alternative sequenceiVSP_059693700 – 832DLEEV…SGVPS → AYPDATMHRQLLAPVEGRMA ETLNQSKERNRFSLSRGCII PQGRATAGRGLPQDIYKEMM PRRLTQTGKRKHGALARTPS FKKVVYDHKEDEENKAGRKQ RSHLFKVMQLRNEQGGVRVQ SAHSPSPLNKKACFPGDYRG ESAGGHNCRAVSG in isoform 1. Add BLAST133
Alternative sequenceiVSP_059694700 – 740Missing in isoform 4. Add BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK055202 mRNA Translation: BAG51485.1
AK074477 mRNA Translation: BAB85093.1
AL109928 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75420.1
CH471077 Genomic DNA Translation: EAW75421.1
BC062570 mRNA Translation: AAH62570.1
AF169690 mRNA Translation: AAF89687.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13485.1 [Q8IXH8-4]
CCDS13486.1 [Q8IXH8-2]
CCDS86964.1 [Q8IXH8-5]

NCBI Reference Sequences

More...RefSeqi		NP_001335133.1, NM_001348204.1 [Q8IXH8-5]
NP_068582.2, NM_021810.5 [Q8IXH8-2]
NP_817089.1, NM_177980.3 [Q8IXH8-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000244049; ENSP00000244049; ENSG00000124215 [Q8IXH8-5]
ENST00000348616; ENSP00000339390; ENSG00000124215 [Q8IXH8-4]
ENST00000350849; ENSP00000310845; ENSG00000124215 [Q8IXH8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		60437

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:60437

UCSC genome browser

More...UCSCi		uc002ybe.4 human [Q8IXH8-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055202 mRNA Translation: BAG51485.1
AK074477 mRNA Translation: BAB85093.1
AL109928 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75420.1
CH471077 Genomic DNA Translation: EAW75421.1
BC062570 mRNA Translation: AAH62570.1
AF169690 mRNA Translation: AAF89687.1
CCDSiCCDS13485.1 [Q8IXH8-4]
CCDS13486.1 [Q8IXH8-2]
CCDS86964.1 [Q8IXH8-5]
RefSeqiNP_001335133.1, NM_001348204.1 [Q8IXH8-5]
NP_068582.2, NM_021810.5 [Q8IXH8-2]
NP_817089.1, NM_177980.3 [Q8IXH8-4]

3D structure databases

SMRiQ8IXH8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121909, 2 interactors
STRINGi9606.ENSP00000339390

PTM databases

CarbonylDBiQ8IXH8
iPTMnetiQ8IXH8
PhosphoSitePlusiQ8IXH8

Polymorphism and mutation databases

BioMutaiCDH26
DMDMi152031568

Proteomic databases

MassIVEiQ8IXH8
PeptideAtlasiQ8IXH8
PRIDEiQ8IXH8
ProteomicsDBi70996 [Q8IXH8-1]
70997 [Q8IXH8-2]
70998 [Q8IXH8-4]
70999 [Q8IXH8-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2400 142 antibodies

Genome annotation databases

EnsembliENST00000244049; ENSP00000244049; ENSG00000124215 [Q8IXH8-5]
ENST00000348616; ENSP00000339390; ENSG00000124215 [Q8IXH8-4]
ENST00000350849; ENSP00000310845; ENSG00000124215 [Q8IXH8-2]
GeneIDi60437
KEGGihsa:60437
UCSCiuc002ybe.4 human [Q8IXH8-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		60437
EuPathDBiHostDB:ENSG00000124215.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDH26
HGNCiHGNC:15902 CDH26
HPAiENSG00000124215 Tissue enhanced (lymphoid tissue, prostate)
MIMi617685 gene
neXtProtiNX_Q8IXH8
OpenTargetsiENSG00000124215
PharmGKBiPA26298

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000161589
HOGENOMiCLU_005284_5_0_1
InParanoidiQ8IXH8
KOiK22658
OMAiWRAKFNI
OrthoDBi158870at2759
PhylomeDBiQ8IXH8
TreeFamiTF316817

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		60437 6 hits in 787 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		60437
PharosiQ8IXH8 Tbio

Protein Ontology

More...PROi		PR:Q8IXH8
RNActiQ8IXH8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124215 Expressed in bronchial epithelial cell and 122 other tissues
ExpressionAtlasiQ8IXH8 baseline and differential
GenevisibleiQ8IXH8 HS

Family and domain databases

InterProiView protein in InterPro
IPR039808 Cadherin
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
PANTHERiPTHR24027 PTHR24027, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 3 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 4 hits
SUPFAMiSSF49313 SSF49313, 5 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 2 hits
PS50268 CADHERIN_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAD26_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXH8
Secondary accession number(s): A2A2M5
, B3KNX3, Q6P5Y6, Q8TCH3, Q9BQN4, Q9NRU1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 12, 2018
Last modified: June 17, 2020
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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