Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 4N5

Gene

OR4N5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4N5
Alternative name(s):
Olfactory receptor OR14-33
Gene namesi
Name:OR4N5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000184394.1
HGNCiHGNC:15358 OR4N5
neXtProtiNX_Q8IXE1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 308CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32333

Polymorphism and mutation databases

BioMutaiOR4N5
DMDMi37081339

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505651 – 308Olfactory receptor 4N5Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IXE1
PeptideAtlasiQ8IXE1
PRIDEiQ8IXE1
ProteomicsDBi70983

PTM databases

iPTMnetiQ8IXE1
PhosphoSitePlusiQ8IXE1

Expressioni

Gene expression databases

BgeeiENSG00000184394 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR4N5
ExpressionAtlasiQ8IXE1 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332110

Structurei

3D structure databases

ProteinModelPortaliQ8IXE1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKKT Eukaryota
ENOG41117FS LUCA
GeneTreeiENSGT00920000148987
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8IXE1
KOiK04257
OMAiHVKGHSS
OrthoDBiEOG091G0FBN
PhylomeDBiQ8IXE1
TreeFamiTF338273

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IXE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METQNLTVVT EFILLGLTQS QDAQLLVFVL VLIFYLIILP GNFLIIFTIK
60 70 80 90 100
SDPGLTAPLY FFLGNLALLD ASYSFIVVPR MLVDFLSEKK VISYRSCITQ
110 120 130 140 150
LFFLHFLGAG EMFLLVVMAF DRYIAICRPL HYSTIMNPRA CYALSLVLWL
160 170 180 190 200
GGFIHSIVQV ALILHLPFCG PNQLDNFFCD VPQVIKLACT NTFVVELLMV
210 220 230 240 250
SNSGLLSLLC FLGLLASYAV ILCRIREHSS EGKSKAISTC TTHIIIIFLM
260 270 280 290 300
FGPAIFIYTC PFQAFPADKV VSLFHTVIFP LMNPVIYTLR NQEVKASMRK

LLSQHMFC
Length:308
Mass (Da):34,696
Last modified:March 1, 2003 - v1
Checksum:i4A123FBB723822BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024095191N → D. Corresponds to variant dbSNP:rs10131326Ensembl.1
Natural variantiVAR_034208234S → T. Corresponds to variant dbSNP:rs10140908Ensembl.1
Natural variantiVAR_034209260C → R. Corresponds to variant dbSNP:rs10134472Ensembl.1
Natural variantiVAR_053175290R → H. Corresponds to variant dbSNP:rs10141025Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065890 Genomic DNA Translation: BAC45262.1
BK004451 Genomic DNA Translation: DAA04849.1
CCDSiCCDS32031.1
RefSeqiNP_001004724.1, NM_001004724.1
UniGeneiHs.553766

Genome annotation databases

EnsembliENST00000333629; ENSP00000332110; ENSG00000184394
ENST00000641086; ENSP00000493307; ENSG00000184394
GeneIDi390437
KEGGihsa:390437
UCSCiuc010tla.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065890 Genomic DNA Translation: BAC45262.1
BK004451 Genomic DNA Translation: DAA04849.1
CCDSiCCDS32031.1
RefSeqiNP_001004724.1, NM_001004724.1
UniGeneiHs.553766

3D structure databases

ProteinModelPortaliQ8IXE1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332110

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8IXE1
PhosphoSitePlusiQ8IXE1

Polymorphism and mutation databases

BioMutaiOR4N5
DMDMi37081339

Proteomic databases

PaxDbiQ8IXE1
PeptideAtlasiQ8IXE1
PRIDEiQ8IXE1
ProteomicsDBi70983

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333629; ENSP00000332110; ENSG00000184394
ENST00000641086; ENSP00000493307; ENSG00000184394
GeneIDi390437
KEGGihsa:390437
UCSCiuc010tla.2 human

Organism-specific databases

CTDi390437
EuPathDBiHostDB:ENSG00000184394.1
GeneCardsiOR4N5
H-InvDBiHIX0211293
HGNCiHGNC:15358 OR4N5
neXtProtiNX_Q8IXE1
PharmGKBiPA32333
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKT Eukaryota
ENOG41117FS LUCA
GeneTreeiENSGT00920000148987
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8IXE1
KOiK04257
OMAiHVKGHSS
OrthoDBiEOG091G0FBN
PhylomeDBiQ8IXE1
TreeFamiTF338273

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Miscellaneous databases

GeneWikiiOR4N5
GenomeRNAii390437
PROiPR:Q8IXE1

Gene expression databases

BgeeiENSG00000184394 Expressed in 1 organ(s), highest expression level in blood
CleanExiHS_OR4N5
ExpressionAtlasiQ8IXE1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOR4N5_HUMAN
AccessioniPrimary (citable) accession number: Q8IXE1
Secondary accession number(s): Q6IF11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again