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Protein

Trafficking regulator of GLUT4 1

Gene

TRARG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking regulator of GLUT4 1Imported
Alternative name(s):
Dispanin subfamily B member 1
Short name:
DSPB1
Interferon-induced transmembrane domain-containing protein D3
Protein located at seventeen-p-thirteen point three 1
Tumor suppressor candidate 5
Gene namesi
Name:TRARG1Imported
Synonyms:IFITMD3, LOST1, TUSC5Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000184811.3
HGNCiHGNC:29592 TRARG1
MIMi612211 gene
neXtProtiNX_Q8IXB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 105ExtracellularSequence analysisAdd BLAST105
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 153CytoplasmicSequence analysisAdd BLAST27
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 177ExtracellularSequence analysis3

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi286753
OpenTargetsiENSG00000184811
PharmGKBiPA134868023

Polymorphism and mutation databases

BioMutaiTUSC5
DMDMi229462764

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636391 – 177Trafficking regulator of GLUT4 1Add BLAST177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei88PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IXB3
PeptideAtlasiQ8IXB3
PRIDEiQ8IXB3
ProteomicsDBi70982

PTM databases

iPTMnetiQ8IXB3
PhosphoSitePlusiQ8IXB3

Expressioni

Tissue specificityi

Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404).2 Publications

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000184811 Expressed in 112 organ(s), highest expression level in adipose tissue of abdominal region
CleanExiHS_TUSC5
GenevisibleiQ8IXB3 HS

Organism-specific databases

HPAiHPA050825

Interactioni

Subunit structurei

Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation.By similarity

Protein-protein interaction databases

BioGridi130417, 8 interactors
STRINGi9606.ENSP00000329548

Structurei

3D structure databases

ProteinModelPortaliQ8IXB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYHE Eukaryota
ENOG4111PC3 LUCA
GeneTreeiENSGT00530000063980
HOGENOMiHOG000261613
HOVERGENiHBG094099
InParanoidiQ8IXB3
OMAiMSRSSMQ
OrthoDBiEOG091G0JH3
PhylomeDBiQ8IXB3
TreeFamiTF333012

Family and domain databases

InterProiView protein in InterPro
IPR007593 CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505 CD225, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IXB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHPVQSEFP SAQEPGSAAF LDLPEMEILL TKAENKDDKT LNLSKTLSGP
60 70 80 90 100
LDLEQNSQGL PFKAISEGHL EAPLPRSPSR ASSRRASSIA TTSYAQDQEA
110 120 130 140 150
PRDYLILAVV ACFCPVWPLN LIPLIISIMS RSSMQQGNVD GARRLGRLAR
160 170
LLSITLIIMG IVIIMVAVTV NFTVQKK
Length:177
Mass (Da):19,254
Last modified:May 5, 2009 - v2
Checksum:iFCF701E12EDA70A5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0295893H → Y1 PublicationCorresponds to variant dbSNP:rs75616699Ensembl.1
Natural variantiVAR_02959015P → S1 PublicationCorresponds to variant dbSNP:rs111587833Ensembl.1
Natural variantiVAR_02959118A → T1 PublicationCorresponds to variant dbSNP:rs111701043Ensembl.1
Natural variantiVAR_02959220F → S1 PublicationCorresponds to variant dbSNP:rs6502774Ensembl.1
Natural variantiVAR_02959334E → D1 PublicationCorresponds to variant dbSNP:rs75025906Ensembl.1
Natural variantiVAR_02959457S → G1 PublicationCorresponds to variant dbSNP:rs6502776Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090231 mRNA Translation: BAC43751.1
AC032044 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90630.1
CCDSiCCDS42225.1
RefSeqiNP_758955.2, NM_172367.2
UniGeneiHs.146059

Genome annotation databases

EnsembliENST00000333813; ENSP00000329548; ENSG00000184811
GeneIDi286753
KEGGihsa:286753
UCSCiuc002fsi.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090231 mRNA Translation: BAC43751.1
AC032044 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90630.1
CCDSiCCDS42225.1
RefSeqiNP_758955.2, NM_172367.2
UniGeneiHs.146059

3D structure databases

ProteinModelPortaliQ8IXB3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130417, 8 interactors
STRINGi9606.ENSP00000329548

PTM databases

iPTMnetiQ8IXB3
PhosphoSitePlusiQ8IXB3

Polymorphism and mutation databases

BioMutaiTUSC5
DMDMi229462764

Proteomic databases

PaxDbiQ8IXB3
PeptideAtlasiQ8IXB3
PRIDEiQ8IXB3
ProteomicsDBi70982

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333813; ENSP00000329548; ENSG00000184811
GeneIDi286753
KEGGihsa:286753
UCSCiuc002fsi.1 human

Organism-specific databases

CTDi286753
DisGeNETi286753
EuPathDBiHostDB:ENSG00000184811.3
GeneCardsiTRARG1
H-InvDBiHIX0013398
HGNCiHGNC:29592 TRARG1
HPAiHPA050825
MIMi612211 gene
neXtProtiNX_Q8IXB3
OpenTargetsiENSG00000184811
PharmGKBiPA134868023
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYHE Eukaryota
ENOG4111PC3 LUCA
GeneTreeiENSGT00530000063980
HOGENOMiHOG000261613
HOVERGENiHBG094099
InParanoidiQ8IXB3
OMAiMSRSSMQ
OrthoDBiEOG091G0JH3
PhylomeDBiQ8IXB3
TreeFamiTF333012

Miscellaneous databases

ChiTaRSiTUSC5 human
GenomeRNAii286753
PROiPR:Q8IXB3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184811 Expressed in 112 organ(s), highest expression level in adipose tissue of abdominal region
CleanExiHS_TUSC5
GenevisibleiQ8IXB3 HS

Family and domain databases

InterProiView protein in InterPro
IPR007593 CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505 CD225, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTARG1_HUMAN
AccessioniPrimary (citable) accession number: Q8IXB3
Secondary accession number(s): A6NMK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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