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Entry version 156 (13 Nov 2019)
Sequence version 2 (03 Apr 2007)
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Protein

DnaJ homolog subfamily C member 10

Gene

DNAJC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DnaJ homolog subfamily C member 10 (EC:1.8.4.-)
Alternative name(s):
Endoplasmic reticulum DNA J domain-containing protein 5
Short name:
ER-resident protein ERdj5
Short name:
ERdj5
Macrothioredoxin
Short name:
MTHr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAJC10
Synonyms:ERDJ5
ORF Names:UNQ495/PRO1012
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24637 DNAJC10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607987 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IXB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63H → Q: Prevents interaction with HSPA5, leading to prolonged interaction with substrate proteins. 1 Publication1
Mutagenesisi161C → A: Abolishes disulfide reductase activity; when associated with A-483; A-591 and A-703. 1 Publication1
Mutagenesisi483C → A: Abolishes disulfide reductase activity; when associated with A-161; A-591 and A-703. 1 Publication1
Mutagenesisi591C → A: Abolishes disulfide reductase activity; when associated with A-161; A-483 and A-703. 1 Publication1
Mutagenesisi703C → A: Abolishes disulfide reductase activity; when associated with A-161; A-483 and A-591. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54431

Open Targets

More...
OpenTargetsi
ENSG00000077232

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134917195

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IXB1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNAJC10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
142981524

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32Sequence analysisAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028148333 – 793DnaJ homolog subfamily C member 10Add BLAST761

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 161Redox-active
Disulfide bondi480 ↔ 483Redox-active
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi530N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi588 ↔ 591Redox-active
Disulfide bondi700 ↔ 703Redox-active

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IXB1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IXB1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IXB1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IXB1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IXB1

PeptideAtlas

More...
PeptideAtlasi
Q8IXB1

PRoteomics IDEntifications database

More...
PRIDEi
Q8IXB1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61664
70980 [Q8IXB1-1]
70981 [Q8IXB1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IXB1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IXB1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8IXB1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By endoplasmic reticulum stress.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000077232 Expressed in 221 organ(s), highest expression level in caput epididymis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IXB1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IXB1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031111

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EDEM1 (By similarity).

Interacts with HSPA5 (via its J domain).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119947, 73 interactors

Database of interacting proteins

More...
DIPi
DIP-48947N

Protein interaction database and analysis system

More...
IntActi
Q8IXB1, 42 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264065

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IXB1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 100JPROSITE-ProRule annotationAdd BLAST66
Domaini130 – 232Thioredoxin 1PROSITE-ProRule annotationAdd BLAST103
Domaini454 – 553Thioredoxin 2PROSITE-ProRule annotationAdd BLAST100
Domaini557 – 662Thioredoxin 3PROSITE-ProRule annotationAdd BLAST106
Domaini671 – 778Thioredoxin 4PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni235 – 350Trxb 1Add BLAST116
Regioni348 – 463Trxb 2Add BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi790 – 793Prevents secretion from ERPROSITE-ProRule annotation4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The thioredoxin-like regions Trxb 1 and 2 lack a redox-active CXXC motif.By similarity
Thioredoxin domains 3 and 4 are the primary reductase domains.By similarity

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IMZF Eukaryota
KOG0191 Eukaryota
COG0526 LUCA
COG2214 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155558

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IXB1

KEGG Orthology (KO)

More...
KOi
K09530

Identification of Orthologs from Complete Genome Data

More...
OMAi
APTWRKF

Database of Orthologous Groups

More...
OrthoDBi
522268at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IXB1

TreeFam database of animal gene trees

More...
TreeFami
TF105169

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257 DnaJ, 1 hit
cd03004 PDI_a_ERdj5_C, 3 hits
cd03003 PDI_a_ERdj5_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
3.40.30.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623 DnaJ_domain
IPR021170 ERdj5
IPR035674 ERdj5_TRX_C
IPR035673 ERdj5_TRX_N
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 4 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037293 DnaJ_homolog_subfam-C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00625 JDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00271 DnaJ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IXB1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVWLNKDDY IRDLKRIILC FLIVYMAILV GTDQDFYSLL GVSKTASSRE
60 70 80 90 100
IRQAFKKLAL KLHPDKNPNN PNAHGDFLKI NRAYEVLKDE DLRKKYDKYG
110 120 130 140 150
EKGLEDNQGG QYESWNYYRY DFGIYDDDPE IITLERREFD AAVNSGELWF
160 170 180 190 200
VNFYSPGCSH CHDLAPTWRD FAKEVDGLLR IGAVNCGDDR MLCRMKGVNS
210 220 230 240 250
YPSLFIFRSG MAPVKYHGDR SKESLVSFAM QHVRSTVTEL WTGNFVNSIQ
260 270 280 290 300
TAFAAGIGWL ITFCSKGGDC LTSQTRLRLS GMLDGLVNVG WMDCATQDNL
310 320 330 340 350
CKSLDITTST TAYFPPGATL NNKEKNSILF LNSLDAKEIY LEVIHNLPDF
360 370 380 390 400
ELLSANTLED RLAHHRWLLF FHFGKNENSN DPELKKLKTL LKNDHIQVGR
410 420 430 440 450
FDCSSAPDIC SNLYVFQPSL AVFKGQGTKE YEIHHGKKIL YDILAFAKES
460 470 480 490 500
VNSHVTTLGP QNFPANDKEP WLVDFFAPWC PPCRALLPEL RRASNLLYGQ
510 520 530 540 550
LKFGTLDCTV HEGLCNMYNI QAYPTTVVFN QSNIHEYEGH HSAEQILEFI
560 570 580 590 600
EDLMNPSVVS LTPTTFNELV TQRKHNEVWM VDFYSPWCHP CQVLMPEWKR
610 620 630 640 650
MARTLTGLIN VGSIDCQQYH SFCAQENVQR YPEIRFFPPK SNKAYHYHSY
660 670 680 690 700
NGWNRDAYSL RIWGLGFLPQ VSTDLTPQTF SEKVLQGKNH WVIDFYAPWC
710 720 730 740 750
GPCQNFAPEF ELLARMIKGK VKAGKVDCQA YAQTCQKAGI RAYPTVKFYF
760 770 780 790
YERAKRNFQE EQINTRDAKA IAALISEKLE TLRNQGKRNK DEL
Length:793
Mass (Da):91,080
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD39B64325432D5D
GO
Isoform 2 (identifier: Q8IXB1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-329: Missing.

Show »
Length:747
Mass (Da):86,136
Checksum:iD9F26A53E1B35455
GO
Isoform 3 (identifier: Q8IXB1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-332: FLN → LLH
     333-793: Missing.

Note: No experimental confirmation available.
Show »
Length:332
Mass (Da):37,682
Checksum:i256FEF2695B28BE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EP04E7EP04_HUMAN
DnaJ homolog subfamily C member 10
DNAJC10
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXH7A0A087WXH7_HUMAN
DnaJ homolog subfamily C member 10
DNAJC10
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q71S60Q71S60_HUMAN
DnaJ homolog subfamily C member 10
DNAJC10
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1G5A0A494C1G5_HUMAN
DnaJ homolog subfamily C member 10
DNAJC10
301Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1G0H7C1G0_HUMAN
DnaJ homolog subfamily C member 10
DNAJC10
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55121 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC11281 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5L → S in AAM09527 (PubMed:14587667).Curated1
Sequence conflicti5L → S in BAB55304 (PubMed:14702039).Curated1
Sequence conflicti213P → A in AAN73271 (PubMed:12411443).Curated1
Sequence conflicti356 – 359NTLE → KRVK in AAN73271 (PubMed:12411443).Curated4
Sequence conflicti446F → S in BAB55121 (PubMed:14702039).Curated1
Sequence conflicti565T → A in CAD89982 (PubMed:17974005).Curated1
Sequence conflicti633E → K in CAB70858 (PubMed:17974005).Curated1
Sequence conflicti755K → N in BAB55304 (PubMed:14702039).Curated1
Sequence conflicti771I → T in CAD89982 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03124776D → N2 PublicationsCorresponds to variant dbSNP:rs6729801Ensembl.1
Natural variantiVAR_048912347L → I. Corresponds to variant dbSNP:rs13414223Ensembl.1
Natural variantiVAR_031248414Y → C. Corresponds to variant dbSNP:rs11681366Ensembl.1
Natural variantiVAR_031249646H → Q3 PublicationsCorresponds to variant dbSNP:rs288334Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024011284 – 329Missing in isoform 2. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_054434330 – 332FLN → LLH in isoform 3. 1 Publication3
Alternative sequenceiVSP_054435333 – 793Missing in isoform 3. 1 PublicationAdd BLAST461

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF038503 mRNA Translation: AAN73271.1
AF490904 mRNA Translation: AAM09527.1
AY358577 mRNA Translation: AAQ88940.1
AK027450 mRNA Translation: BAB55121.1 Different initiation.
AK027647 mRNA Translation: BAB55263.1
AK027696 mRNA Translation: BAB55304.1
AC073951 Genomic DNA Translation: AAX88931.1
AC105396 Genomic DNA Translation: AAY24240.1
CH471058 Genomic DNA Translation: EAX10960.1
CH471058 Genomic DNA Translation: EAX10963.1
BC107425 mRNA Translation: AAI07426.1
BC117299 mRNA Translation: AAI17300.1
BC126168 mRNA Translation: AAI26169.1
AL137648 mRNA Translation: CAB70858.1
AL832646 mRNA Translation: CAD89982.1
AK074905 mRNA Translation: BAC11281.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS33345.1 [Q8IXB1-1]
CCDS74613.1 [Q8IXB1-2]

Protein sequence database of the Protein Information Resource

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PIRi
T46333

NCBI Reference Sequences

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RefSeqi
NP_001258510.1, NM_001271581.1 [Q8IXB1-2]
NP_061854.1, NM_018981.2 [Q8IXB1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264065; ENSP00000264065; ENSG00000077232 [Q8IXB1-1]
ENST00000537515; ENSP00000441560; ENSG00000077232 [Q8IXB1-3]
ENST00000616986; ENSP00000479930; ENSG00000077232 [Q8IXB1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54431

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54431

UCSC genome browser

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UCSCi
uc002uow.3 human [Q8IXB1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038503 mRNA Translation: AAN73271.1
AF490904 mRNA Translation: AAM09527.1
AY358577 mRNA Translation: AAQ88940.1
AK027450 mRNA Translation: BAB55121.1 Different initiation.
AK027647 mRNA Translation: BAB55263.1
AK027696 mRNA Translation: BAB55304.1
AC073951 Genomic DNA Translation: AAX88931.1
AC105396 Genomic DNA Translation: AAY24240.1
CH471058 Genomic DNA Translation: EAX10960.1
CH471058 Genomic DNA Translation: EAX10963.1
BC107425 mRNA Translation: AAI07426.1
BC117299 mRNA Translation: AAI17300.1
BC126168 mRNA Translation: AAI26169.1
AL137648 mRNA Translation: CAB70858.1
AL832646 mRNA Translation: CAD89982.1
AK074905 mRNA Translation: BAC11281.1 Different initiation.
CCDSiCCDS33345.1 [Q8IXB1-1]
CCDS74613.1 [Q8IXB1-2]
PIRiT46333
RefSeqiNP_001258510.1, NM_001271581.1 [Q8IXB1-2]
NP_061854.1, NM_018981.2 [Q8IXB1-1]

3D structure databases

SMRiQ8IXB1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119947, 73 interactors
DIPiDIP-48947N
IntActiQ8IXB1, 42 interactors
STRINGi9606.ENSP00000264065

PTM databases

iPTMnetiQ8IXB1
PhosphoSitePlusiQ8IXB1
SwissPalmiQ8IXB1

Polymorphism and mutation databases

BioMutaiDNAJC10
DMDMi142981524

Proteomic databases

EPDiQ8IXB1
jPOSTiQ8IXB1
MassIVEiQ8IXB1
MaxQBiQ8IXB1
PaxDbiQ8IXB1
PeptideAtlasiQ8IXB1
PRIDEiQ8IXB1
ProteomicsDBi61664
70980 [Q8IXB1-1]
70981 [Q8IXB1-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54431

Genome annotation databases

EnsembliENST00000264065; ENSP00000264065; ENSG00000077232 [Q8IXB1-1]
ENST00000537515; ENSP00000441560; ENSG00000077232 [Q8IXB1-3]
ENST00000616986; ENSP00000479930; ENSG00000077232 [Q8IXB1-2]
GeneIDi54431
KEGGihsa:54431
UCSCiuc002uow.3 human [Q8IXB1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54431
DisGeNETi54431

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNAJC10
HGNCiHGNC:24637 DNAJC10
HPAiHPA031111
MIMi607987 gene
neXtProtiNX_Q8IXB1
OpenTargetsiENSG00000077232
PharmGKBiPA134917195

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IMZF Eukaryota
KOG0191 Eukaryota
COG0526 LUCA
COG2214 LUCA
GeneTreeiENSGT00940000155558
InParanoidiQ8IXB1
KOiK09530
OMAiAPTWRKF
OrthoDBi522268at2759
PhylomeDBiQ8IXB1
TreeFamiTF105169

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAJC10 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DNAJC10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54431
PharosiQ8IXB1

Protein Ontology

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PROi
PR:Q8IXB1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077232 Expressed in 221 organ(s), highest expression level in caput epididymis
ExpressionAtlasiQ8IXB1 baseline and differential
GenevisibleiQ8IXB1 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
cd03004 PDI_a_ERdj5_C, 3 hits
cd03003 PDI_a_ERdj5_N, 1 hit
Gene3Di1.10.287.110, 1 hit
3.40.30.10, 6 hits
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR021170 ERdj5
IPR035674 ERdj5_TRX_C
IPR035673 ERdj5_TRX_N
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 4 hits
PIRSFiPIRSF037293 DnaJ_homolog_subfam-C, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 6 hits
PROSITEiView protein in PROSITE
PS50076 DNAJ_2, 1 hit
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 2 hits
PS51352 THIOREDOXIN_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDJC10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IXB1
Secondary accession number(s): Q17RJ6
, Q3B7W8, Q4ZG06, Q53QT7, Q6UWZ6, Q86T61, Q8NC82, Q8TD87, Q96K38, Q96K44, Q96K54, Q9NSY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 13, 2019
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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