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Entry version 146 (31 Jul 2019)
Sequence version 1 (01 Mar 2003)
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Protein

Signal peptide, CUB and EGF-like domain-containing protein 3

Gene

SCUBE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal peptide, CUB and EGF-like domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCUBE3Imported
Synonyms:CEGF3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13655 SCUBE3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614708 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IX30

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
222663

Open Targets

More...
OpenTargetsi
ENSG00000146197

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134977856

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCUBE3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762488

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000025061621 – 993Signal peptide, CUB and EGF-like domain-containing protein 3Sequence analysisAdd BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 46Sequence analysis
Disulfide bondi40 ↔ 55Sequence analysis
Disulfide bondi57 ↔ 68Sequence analysis
Disulfide bondi74 ↔ 86Sequence analysis
Disulfide bondi82 ↔ 95Sequence analysis
Disulfide bondi97 ↔ 110Sequence analysis
Disulfide bondi116 ↔ 127Sequence analysis
Disulfide bondi123 ↔ 136Sequence analysis
Disulfide bondi161 ↔ 172Sequence analysis
Disulfide bondi168 ↔ 182Sequence analysis
Disulfide bondi184 ↔ 197Sequence analysis
Disulfide bondi201 ↔ 212Sequence analysis
Disulfide bondi208 ↔ 221Sequence analysis
Disulfide bondi223 ↔ 236Sequence analysis
Disulfide bondi240 ↔ 251Sequence analysis
Disulfide bondi247 ↔ 260Sequence analysis
Disulfide bondi262 ↔ 275Sequence analysis
Disulfide bondi281 ↔ 292Sequence analysis
Disulfide bondi288 ↔ 301Sequence analysis
Disulfide bondi303 ↔ 316Sequence analysis
Disulfide bondi322 ↔ 332Sequence analysis
Disulfide bondi328 ↔ 341Sequence analysis
Disulfide bondi343 ↔ 355Sequence analysis
Disulfide bondi361 ↔ 372Sequence analysis
Disulfide bondi368 ↔ 381Sequence analysis
Disulfide bondi383 ↔ 397Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi756N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi785N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi804 ↔ 830Sequence analysis
Disulfide bondi857 ↔ 878Sequence analysis

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IX30

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8IX30

PeptideAtlas

More...
PeptideAtlasi
Q8IX30

PRoteomics IDEntifications database

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PRIDEi
Q8IX30

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70970 [Q8IX30-1]
70971 [Q8IX30-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8IX30

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IX30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in osteoblasts. In normal lung, mainly expressed in bronchial epithelial cells. Tends to be up-regulated in lung cancer cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146197 Expressed in 127 organ(s), highest expression level in metanephros

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8IX30 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040606

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms homooligomers and heterooligomers with SCUBE1.

Interacts with TGFBR2 through the CUB domain; this interaction does not affect TGFB1-binding to TGFBR2.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q8IX30, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000274938

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IX30

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 69EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini70 – 111EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini112 – 148EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini157 – 198EGF-like 4PROSITE-ProRule annotationAdd BLAST42
Domaini199 – 237EGF-like 5PROSITE-ProRule annotationAdd BLAST39
Domaini238 – 276EGF-like 6PROSITE-ProRule annotationAdd BLAST39
Domaini277 – 317EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini318 – 356EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini357 – 398EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini804 – 916CUBPROSITE-ProRule annotationAdd BLAST113

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217 Eukaryota
ENOG410XP6K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230943

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IX30

Identification of Orthologs from Complete Genome Data

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OMAi
EPVKCQG

Database of Orthologous Groups

More...
OrthoDBi
73164at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8IX30

TreeFam database of animal gene trees

More...
TreeFami
TF351672

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026823 cEGF
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662 cEGF, 1 hit
PF00431 CUB, 1 hit
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042 CUB, 1 hit
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SM01411 Ephrin_rec_like, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 1 hit
SSF57184 SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 6 hits
PS01180 CUB, 1 hit
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 6 hits
PS01187 EGF_CA, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 13 Publications (identifier: Q8IX30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSGRVPGLC LLVLLVHARA AQYSKAAQDV DECVEGTDNC HIDAICQNTP
60 70 80 90 100
RSYKCICKSG YTGDGKHCKD VDECEREDNA GCVHDCVNIP GNYRCTCYDG
110 120 130 140 150
FHLAHDGHNC LDVDECAEGN GGCQQSCVNM MGSYECHCRE GFFLSDNQHT
160 170 180 190 200
CIQRPEEGMN CMNKNHGCAH ICRETPKGGI ACECRPGFEL TKNQRDCKLT
210 220 230 240 250
CNYGNGGCQH TCDDTEQGPR CGCHIKFVLH TDGKTCIETC AVNNGGCDSK
260 270 280 290 300
CHDAATGVHC TCPVGFMLQP DRKTCKDIDE CRLNNGGCDH ICRNTVGSFE
310 320 330 340 350
CSCKKGYKLL INERNCQDID ECSFDRTCDH ICVNTPGSFQ CLCHRGYLLY
360 370 380 390 400
GITHCGDVDE CSINRGGCRF GCINTPGSYQ CTCPAGQGRL HWNGKDCTEP
410 420 430 440 450
LKCQGSPGAS KAMLSCNRSG KKDTCALTCP SRARFLPESE NGFTVSCGTP
460 470 480 490 500
SPRAAPARAG HNGNSTNSNH CHEAAVLSIK QRASFKIKDA KCRLHLRNKG
510 520 530 540 550
KTEEAGRITG PGGAPCSECQ VTFIHLKCDS SRKGKGRRAR TPPGKEVTRL
560 570 580 590 600
TLELEAEVRA EETTASCGLP CLRQRMERRL KGSLKMLRKS INQDRFLLRL
610 620 630 640 650
AGLDYELAHK PGLVAGERAE PMESCRPGQH RAGTKCVSCP QGTYYHGQTE
660 670 680 690 700
QCVPCPAGTF QEREGQLSCD LCPGSDAHGP LGATNVTTCA GQCPPGQHSV
710 720 730 740 750
DGFKPCQPCP RGTYQPEAGR TLCFPCGGGL TTKHEGAISF QDCDTKVQCS
760 770 780 790 800
PGHYYNTSIH RCIRCAMGSY QPDFRQNFCS RCPGNTSTDF DGSTSVAQCK
810 820 830 840 850
NRQCGGELGE FTGYIESPNY PGNYPAGVEC IWNINPPPKR KILIVVPEIF
860 870 880 890 900
LPSEDECGDV LVMRKNSSPS SITTYETCQT YERPIAFTAR SRKLWINFKT
910 920 930 940 950
SEANSARGFQ IPYVTYDEDY EQLVEDIVRD GRLYASENHQ EILKDKKLIK
960 970 980 990
AFFEVLAHPQ NYFKYTEKHK EMLPKSFIKL LRSKVSSFLR PYK
Length:993
Mass (Da):109,282
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19BBE0E5627EEAF4
GO
Isoform 22 Publications (identifier: Q8IX30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-237: I → IGERRLEQHIPTQAVSN

Show »
Length:1,009
Mass (Da):111,099
Checksum:iECD68CB46B5094A9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03798 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157Missing in AAH52263 (PubMed:15489334).Curated1
Sequence conflicti256T → I in AAH52263 (PubMed:15489334).Curated1
Sequence conflicti483 – 484AS → SP in BAC03798 (PubMed:14702039).Curated2
Sequence conflicti635K → E in CAI56752 (PubMed:17974005).Curated1
Sequence conflicti856E → G in CAI56752 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048994410S → L. Corresponds to variant dbSNP:rs3800381Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052167237I → IGERRLEQHIPTQAVSN in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY639608 mRNA Translation: AAU08347.1
AF452494 mRNA Translation: AAN76808.1
AK092062 mRNA Translation: BAC03798.1 Different initiation.
AK291218 mRNA Translation: BAF83907.1
Z97832 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03812.1
BC052263 mRNA Translation: AAH52263.2
CR936607 mRNA Translation: CAI56752.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4800.1 [Q8IX30-1]

NCBI Reference Sequences

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RefSeqi
NP_001290065.1, NM_001303136.1
NP_689966.2, NM_152753.3 [Q8IX30-1]
XP_005249000.1, XM_005248943.1 [Q8IX30-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274938; ENSP00000274938; ENSG00000146197 [Q8IX30-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
222663

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:222663

UCSC genome browser

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UCSCi
uc003okf.2 human [Q8IX30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY639608 mRNA Translation: AAU08347.1
AF452494 mRNA Translation: AAN76808.1
AK092062 mRNA Translation: BAC03798.1 Different initiation.
AK291218 mRNA Translation: BAF83907.1
Z97832 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03812.1
BC052263 mRNA Translation: AAH52263.2
CR936607 mRNA Translation: CAI56752.1
CCDSiCCDS4800.1 [Q8IX30-1]
RefSeqiNP_001290065.1, NM_001303136.1
NP_689966.2, NM_152753.3 [Q8IX30-1]
XP_005249000.1, XM_005248943.1 [Q8IX30-2]

3D structure databases

SMRiQ8IX30
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ8IX30, 3 interactors
STRINGi9606.ENSP00000274938

PTM databases

iPTMnetiQ8IX30
PhosphoSitePlusiQ8IX30

Polymorphism and mutation databases

BioMutaiSCUBE3
DMDMi74762488

Proteomic databases

jPOSTiQ8IX30
PaxDbiQ8IX30
PeptideAtlasiQ8IX30
PRIDEiQ8IX30
ProteomicsDBi70970 [Q8IX30-1]
70971 [Q8IX30-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
222663
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274938; ENSP00000274938; ENSG00000146197 [Q8IX30-1]
GeneIDi222663
KEGGihsa:222663
UCSCiuc003okf.2 human [Q8IX30-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
222663
DisGeNETi222663

GeneCards: human genes, protein and diseases

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GeneCardsi
SCUBE3
HGNCiHGNC:13655 SCUBE3
HPAiHPA040606
MIMi614708 gene
neXtProtiNX_Q8IX30
OpenTargetsiENSG00000146197
PharmGKBiPA134977856

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
GeneTreeiENSGT00940000153185
HOGENOMiHOG000230943
InParanoidiQ8IX30
OMAiEPVKCQG
OrthoDBi73164at2759
PhylomeDBiQ8IX30
TreeFamiTF351672

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCUBE3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
222663

Protein Ontology

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PROi
PR:Q8IX30

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000146197 Expressed in 127 organ(s), highest expression level in metanephros
GenevisibleiQ8IX30 HS

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR026823 cEGF
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR035914 Sperma_CUB_dom_sf
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF00431 CUB, 1 hit
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 2 hits
PF07699 Ephrin_rec_like, 3 hits
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00181 EGF, 10 hits
SM00179 EGF_CA, 7 hits
SM01411 Ephrin_rec_like, 4 hits
SUPFAMiSSF49854 SSF49854, 1 hit
SSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 6 hits
PS01180 CUB, 1 hit
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 6 hits
PS01187 EGF_CA, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCUB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX30
Secondary accession number(s): A8K5A3
, Q5CZB3, Q86UZ9, Q8NAU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: July 31, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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