Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (17 Jun 2020)
Sequence version 2 (16 Aug 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

SMC5-SMC6 complex localization factor protein 2

Gene

SLF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions (PubMed:25931565).1 Publication

Miscellaneous

Localized in the locus associated with inherited infantile onset spinocerebellar ataxia (IOSCA). No mutation were found associated with IOSCA compared to control subjects. The expression level in the brain was not different between the 2 populations.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SMC5-SMC6 complex localization factor protein 2Imported
Alternative name(s):
Smc5/6 localization factor 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLF21 PublicationImported
Synonyms:C10orf6, FAM178A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000119906.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17814 SLF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610348 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IX21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi142Y → A in APIMmut; does not affect subcellular location. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55719

Open Targets

More...
OpenTargetsi
ENSG00000119906

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387411

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IX21 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73620064

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897781 – 1173SMC5-SMC6 complex localization factor protein 2Add BLAST1173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei481PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei607PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IX21

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IX21

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IX21

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IX21

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IX21

PeptideAtlas

More...
PeptideAtlasi
Q8IX21

PRoteomics IDEntifications database

More...
PRIDEi
Q8IX21

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3129
70968 [Q8IX21-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IX21

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IX21

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:12459258). Expressed at higher level in skeletal muscle and at slightly lower level in brain, liver and heart, than in lung, kidney, spleen and thymus (PubMed:12459258).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119906 Expressed in adrenal tissue and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IX21 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IX21 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000119906 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SLF1 (via N-terminus); this interaction links RAD18 to the SMC5-SMC6 complex (PubMed:25931565).

Interacts with RAD18; this interaction is increased in a SLF1-dependent manner (PubMed:25931565).

Interacts with SMC5 and SMC6 (PubMed:25931565).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120841, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IX21, 18 interactors

Molecular INTeraction database

More...
MINTi
Q8IX21

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359292

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IX21 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi137 – 149APIM motifAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi616 – 619Poly-Glu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM178 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGA2 Eukaryota
ENOG410YMV9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064017

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008361_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IX21

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYLVQMK

Database of Orthologous Groups

More...
OrthoDBi
713086at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IX21

TreeFam database of animal gene trees

More...
TreeFami
TF332216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026161 FAM178

The PANTHER Classification System

More...
PANTHERi
PTHR16046 PTHR16046, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14816 FAM178, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTRRCMPARP GFPSSPAPGS SPPRCHLRPG STAHAAAGKR TESPGDRKQS
60 70 80 90 100
IIDFFKPASK QDRHMLDSPQ KSNIKYGGSR LSITGTEQFE RKLSSPKESK
110 120 130 140 150
PKRVPPEKSP IIEAFMKGVK EHHEDHGIHE SRRPCLSLAS KYLAKGTNIY
160 170 180 190 200
VPSSYHLPKE MKSLKKKHRS PERRKSLFIH ENNEKNDRDR GKTNADSKKQ
210 220 230 240 250
TTVAEADIFN NSSRSLSSRS SLSRHHPEES PLGAKFQLSL ASYCRERELK
260 270 280 290 300
RLRKEQMEQR INSENSFSEA SSLSLKSSIE RKYKPRQEQR KQNDIIPGKN
310 320 330 340 350
NLSNVENGHL SRKRSSSDSW EPTSAGSKQN KFPEKRKRNS VDSDLKSTRE
360 370 380 390 400
SMIPKARESF LEKRPDGPHQ KEKFIKHIAL KTPGDVLRLE DISKEPSDET
410 420 430 440 450
DGSSAGLAPS NSGNSGHHST RNSDQIQVAG TKETKMQKPH LPLSQEKSAI
460 470 480 490 500
KKASNLQKNK TASSTTKEKE TKLPLLSRVP SAGSSLVPLN AKNCALPVSK
510 520 530 540 550
KDKERSSSKE CSGHSTESTK HKEHKAKTNK ADSNVSSGKI SGGPLRSEYG
560 570 580 590 600
TPTKSPPAAL EVVPCIPSPA APSDKAPSEG ESSGNSNAGS SALKRKLRGD
610 620 630 640 650
FDSDEESLGY NLDSDEEEET LKSLEEIMAL NFNQTPAATG KPPALSKGLR
660 670 680 690 700
SQSSDYTGHV HPGTYTNTLE RLVKEMEDTQ RLDELQKQLQ EDIRQGRGIK
710 720 730 740 750
SPIRIGEEDS TDDEDGLLEE HKEFLKKFSV TIDAIPDHHP GEEIFNFLNS
760 770 780 790 800
GKIFNQYTLD LRDSGFIGQS AVEKLILKSG KTDQIFLTTQ GFLTSAYHYV
810 820 830 840 850
QCPVPVLKWL FRMMSVHTDC IVSVQILSTL MEITIRNDTF SDSPVWPWIP
860 870 880 890 900
SLSDVAAVFF NMGIDFRSLF PLENLQPDFN EDYLVSETQT TSRGKESEDS
910 920 930 940 950
SYKPIFSTLP ETNILNVVKF LGLCTSIHPE GYQDREIMLL ILMLFKMSLE
960 970 980 990 1000
KQLKQIPLVD FQSLLINLMK NIRDWNTKVP ELCLGINELS SHPHNLLWLV
1010 1020 1030 1040 1050
QLVPNWTSRG RQLRQCLSLV IISKLLDEKH EDVPNASNLQ VSVLHRYLVQ
1060 1070 1080 1090 1100
MKPSDLLKKM VLKKKAEQPD GIIDDSLHLE LEKQAYYLTY ILLHLVGEVS
1110 1120 1130 1140 1150
CSHSFSSGQR KHFVLLCGAL EKHVKCDIRE DARLFYRTKV KDLVARIHGK
1160 1170
WQEIIQNCRP TQGQLHDFWV PDS
Length:1,173
Mass (Da):131,873
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A9FB5662185A633
GO
Isoform 2 (identifier: Q8IX21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1163-1173: GQLHDFWVPDS → VSFCYTISCILNSFAEWHSSYCLK

Show »
Length:1,186
Mass (Da):133,375
Checksum:i0D1127DB71F14835
GO
Isoform 3 (identifier: Q8IX21-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-63: KQSIIDFFKPASKQDR → YRAEGLRRGRVAGARV
     64-1173: Missing.

Show »
Length:63
Mass (Da):6,668
Checksum:i34461A1E4201A7BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AL16B1AL16_HUMAN
SMC5-SMC6 complex localization fact...
SLF2
758Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRS8A0A3B3IRS8_HUMAN
SMC5-SMC6 complex localization fact...
SLF2
681Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91657 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023112541S → Y1 PublicationCorresponds to variant dbSNP:rs10883563Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05491448 – 63KQSII…SKQDR → YRAEGLRRGRVAGARV in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_05491564 – 1173Missing in isoform 3. 1 PublicationAdd BLAST1110
Alternative sequenceiVSP_0456211163 – 1173GQLHDFWVPDS → VSFCYTISCILNSFAEWHSS YCLK in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF460991 mRNA Translation: AAN84475.1
AK001374 mRNA Translation: BAA91657.1 Different initiation.
AK292565 mRNA Translation: BAF85254.1
AL138762 Genomic DNA No translation available.
AL133215 Genomic DNA No translation available.
BC030565 mRNA No translation available.
BC073832 mRNA Translation: AAH73832.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44470.1 [Q8IX21-2]
CCDS65918.1 [Q8IX21-3]
CCDS7500.1 [Q8IX21-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001129595.1, NM_001136123.1 [Q8IX21-2]
NP_001230699.1, NM_001243770.1 [Q8IX21-3]
NP_060591.3, NM_018121.3 [Q8IX21-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238961; ENSP00000238961; ENSG00000119906 [Q8IX21-1]
ENST00000370269; ENSP00000359292; ENSG00000119906 [Q8IX21-2]
ENST00000609386; ENSP00000476379; ENSG00000119906 [Q8IX21-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55719

UCSC genome browser

More...
UCSCi
uc001krq.5 human [Q8IX21-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF460991 mRNA Translation: AAN84475.1
AK001374 mRNA Translation: BAA91657.1 Different initiation.
AK292565 mRNA Translation: BAF85254.1
AL138762 Genomic DNA No translation available.
AL133215 Genomic DNA No translation available.
BC030565 mRNA No translation available.
BC073832 mRNA Translation: AAH73832.1
CCDSiCCDS44470.1 [Q8IX21-2]
CCDS65918.1 [Q8IX21-3]
CCDS7500.1 [Q8IX21-1]
RefSeqiNP_001129595.1, NM_001136123.1 [Q8IX21-2]
NP_001230699.1, NM_001243770.1 [Q8IX21-3]
NP_060591.3, NM_018121.3 [Q8IX21-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120841, 12 interactors
IntActiQ8IX21, 18 interactors
MINTiQ8IX21
STRINGi9606.ENSP00000359292

PTM databases

iPTMnetiQ8IX21
PhosphoSitePlusiQ8IX21

Polymorphism and mutation databases

BioMutaiSLF2
DMDMi73620064

Proteomic databases

EPDiQ8IX21
jPOSTiQ8IX21
MassIVEiQ8IX21
MaxQBiQ8IX21
PaxDbiQ8IX21
PeptideAtlasiQ8IX21
PRIDEiQ8IX21
ProteomicsDBi3129
70968 [Q8IX21-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49598 18 antibodies

The DNASU plasmid repository

More...
DNASUi
55719

Genome annotation databases

EnsembliENST00000238961; ENSP00000238961; ENSG00000119906 [Q8IX21-1]
ENST00000370269; ENSP00000359292; ENSG00000119906 [Q8IX21-2]
ENST00000609386; ENSP00000476379; ENSG00000119906 [Q8IX21-3]
GeneIDi55719
KEGGihsa:55719
UCSCiuc001krq.5 human [Q8IX21-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55719
DisGeNETi55719
EuPathDBiHostDB:ENSG00000119906.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLF2
HGNCiHGNC:17814 SLF2
HPAiENSG00000119906 Low tissue specificity
MIMi610348 gene
neXtProtiNX_Q8IX21
OpenTargetsiENSG00000119906
PharmGKBiPA162387411

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGA2 Eukaryota
ENOG410YMV9 LUCA
GeneTreeiENSGT00530000064017
HOGENOMiCLU_008361_0_0_1
InParanoidiQ8IX21
OMAiHYLVQMK
OrthoDBi713086at2759
PhylomeDBiQ8IX21
TreeFamiTF332216

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55719 36 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLF2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55719
PharosiQ8IX21 Tbio

Protein Ontology

More...
PROi
PR:Q8IX21
RNActiQ8IX21 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119906 Expressed in adrenal tissue and 226 other tissues
ExpressionAtlasiQ8IX21 baseline and differential
GenevisibleiQ8IX21 HS

Family and domain databases

InterProiView protein in InterPro
IPR026161 FAM178
PANTHERiPTHR16046 PTHR16046, 1 hit
PfamiView protein in Pfam
PF14816 FAM178, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX21
Secondary accession number(s): A8K950
, B1AL17, Q5W0L8, Q6GMU6, Q9NPE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: June 17, 2020
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again