UniProtKB - Q8IX15 (HOMEZ_HUMAN)
Protein
Homeobox and leucine zipper protein Homez
Gene
HOMEZ
Organism
Homo sapiens (Human)
Status
Functioni
May function as a transcriptional regulator.
Caution
It is uncertain whether Met-1 or Met-25 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 55 – 114 | Homeobox 1PROSITE-ProRule annotationAdd BLAST | 60 | |
DNA bindingi | 355 – 415 | Homeobox 2PROSITE-ProRule annotationAdd BLAST | 61 | |
DNA bindingi | 451 – 510 | Homeobox 3PROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8IX15 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox and leucine zipper protein HomezAlternative name(s): Homeodomain leucine zipper-containing factor |
Gene namesi | Name:HOMEZ Synonyms:KIAA1443 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000215271.7 |
HGNCi | HGNC:20164, HOMEZ |
MIMi | 608119, gene |
neXtProti | NX_Q8IX15 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57594 |
OpenTargetsi | ENSG00000215271 |
PharmGKBi | PA162391555 |
Miscellaneous databases
Pharosi | Q8IX15, Tbio |
Polymorphism and mutation databases
BioMutai | HOMEZ |
DMDMi | 317373364 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049135 | 1 – 550 | Homeobox and leucine zipper protein HomezAdd BLAST | 550 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 200 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 351 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IX15 |
jPOSTi | Q8IX15 |
MassIVEi | Q8IX15 |
MaxQBi | Q8IX15 |
PaxDbi | Q8IX15 |
PeptideAtlasi | Q8IX15 |
PRIDEi | Q8IX15 |
ProteomicsDBi | 31083 70963 [Q8IX15-1] |
PTM databases
iPTMneti | Q8IX15 |
PhosphoSitePlusi | Q8IX15 |
Expressioni
Tissue specificityi
Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000215271, Expressed in left testis and 121 other tissues |
ExpressionAtlasi | Q8IX15, baseline and differential |
Genevisiblei | Q8IX15, HS |
Organism-specific databases
HPAi | ENSG00000215271, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer or heterodimer (Potential).
Interacts with HOXC8.
Curated1 PublicationBinary interactionsi
Hide detailsIsoform 2 [Q8IX15-3]
Protein-protein interaction databases
BioGRIDi | 121645, 120 interactors |
IntActi | Q8IX15, 42 interactors |
STRINGi | 9606.ENSP00000350049 |
Miscellaneous databases
RNActi | Q8IX15, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q8IX15 |
SMRi | Q8IX15 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IX15 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 358 – 363 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 160 – 195 | Pro-richAdd BLAST | 36 | |
Compositional biasi | 284 – 291 | Poly-Ser | 8 | |
Compositional biasi | 425 – 465 | Pro-richAdd BLAST | 41 | |
Compositional biasi | 515 – 536 | Glu-richAdd BLAST | 22 | |
Compositional biasi | 537 – 544 | Poly-Asp | 8 |
Keywords - Domaini
Homeobox, RepeatPhylogenomic databases
eggNOGi | KOG3986, Eukaryota |
GeneTreei | ENSGT00950000182893 |
HOGENOMi | CLU_032878_0_0_1 |
InParanoidi | Q8IX15 |
OMAi | RNSHFFQ |
OrthoDBi | 518562at2759 |
PhylomeDBi | Q8IX15 |
TreeFami | TF333363 |
Family and domain databases
CDDi | cd00086, homeodomain, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR024578, Homez_homeobox_dom |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit PF11569, Homez, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IX15-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE
60 70 80 90 100
LQLVWTQAAQ TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK
110 120 130 140 150
TWFMAQRLRC GISWSSEEIE ETRARVVYRR DQLHFKSLLS FTHHAGRPPE
160 170 180 190 200
EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG LKVEPEEPSQ MPPLPQSHQK
210 220 230 240 250
LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS HGIGTASWNH
260 270 280 290 300
STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
310 320 330 340 350
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL
360 370 380 390 400
SPDMQRQRKT KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI
410 420 430 440 450
IQWFGDTRYA LKHGQLKWFR DNAVPGAPSF QDPAIPTPPP STRSLNERAE
460 470 480 490 500
TPPLPIPPPP PDIQPLERYW AAHQQLRETD IPQLSQASRL STQQVLDWFD
510 520 530 540 550
SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD DDDDDVIIQD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3KPW8 | U3KPW8_HUMAN | Homeobox and leucine zipper protein... | HOMEZ | 324 | Annotation score: | ||
A0A669KB72 | A0A669KB72_HUMAN | Homeobox and leucine zipper protein... | HOMEZ | 439 | Annotation score: |
Sequence cautioni
The sequence AAN76991 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA92681 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 302 | A → T in AAI30393 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 529 | Missing in AAN76991 (PubMed:12925734).Curated | 1 | |
Sequence conflicti | 529 | Missing in BAA92681 (PubMed:10718198).Curated | 1 | |
Sequence conflicti | 529 | Missing in AAI30393 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 538 | D → E in AAI30393 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 538 | Missing in BAG63992 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055956 | 278 | A → T. Corresponds to variant dbSNP:rs10131813Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054303 | 1 – 13 | MVRGW…PGLDC → MLKSRISMRSRHPRR in isoform 2. 1 PublicationAdd BLAST | 13 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF463523 mRNA Translation: AAN76991.1 Different initiation. AB037864 mRNA Translation: BAA92681.1 Different initiation. AK302788 mRNA Translation: BAG63992.1 AL049829 Genomic DNA No translation available. BC130392 mRNA Translation: AAI30393.1 |
CCDSi | CCDS45085.1 [Q8IX15-1] |
RefSeqi | NP_065885.2, NM_020834.2 [Q8IX15-1] |
Genome annotation databases
Ensembli | ENST00000357460; ENSP00000350049; ENSG00000215271 [Q8IX15-1] ENST00000561013; ENSP00000453979; ENSG00000215271 [Q8IX15-3] |
GeneIDi | 57594 |
KEGGi | hsa:57594 |
UCSCi | uc001wja.3, human [Q8IX15-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF463523 mRNA Translation: AAN76991.1 Different initiation. AB037864 mRNA Translation: BAA92681.1 Different initiation. AK302788 mRNA Translation: BAG63992.1 AL049829 Genomic DNA No translation available. BC130392 mRNA Translation: AAI30393.1 |
CCDSi | CCDS45085.1 [Q8IX15-1] |
RefSeqi | NP_065885.2, NM_020834.2 [Q8IX15-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2ECC | NMR | - | A | 361-423 | [»] | |
2YS9 | NMR | - | A | 453-509 | [»] | |
BMRBi | Q8IX15 | |||||
SMRi | Q8IX15 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121645, 120 interactors |
IntActi | Q8IX15, 42 interactors |
STRINGi | 9606.ENSP00000350049 |
PTM databases
iPTMneti | Q8IX15 |
PhosphoSitePlusi | Q8IX15 |
Polymorphism and mutation databases
BioMutai | HOMEZ |
DMDMi | 317373364 |
Proteomic databases
EPDi | Q8IX15 |
jPOSTi | Q8IX15 |
MassIVEi | Q8IX15 |
MaxQBi | Q8IX15 |
PaxDbi | Q8IX15 |
PeptideAtlasi | Q8IX15 |
PRIDEi | Q8IX15 |
ProteomicsDBi | 31083 70963 [Q8IX15-1] |
Protocols and materials databases
Antibodypediai | 22427, 138 antibodies |
Genome annotation databases
Ensembli | ENST00000357460; ENSP00000350049; ENSG00000215271 [Q8IX15-1] ENST00000561013; ENSP00000453979; ENSG00000215271 [Q8IX15-3] |
GeneIDi | 57594 |
KEGGi | hsa:57594 |
UCSCi | uc001wja.3, human [Q8IX15-1] |
Organism-specific databases
CTDi | 57594 |
DisGeNETi | 57594 |
EuPathDBi | HostDB:ENSG00000215271.7 |
GeneCardsi | HOMEZ |
HGNCi | HGNC:20164, HOMEZ |
HPAi | ENSG00000215271, Low tissue specificity |
MIMi | 608119, gene |
neXtProti | NX_Q8IX15 |
OpenTargetsi | ENSG00000215271 |
PharmGKBi | PA162391555 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3986, Eukaryota |
GeneTreei | ENSGT00950000182893 |
HOGENOMi | CLU_032878_0_0_1 |
InParanoidi | Q8IX15 |
OMAi | RNSHFFQ |
OrthoDBi | 518562at2759 |
PhylomeDBi | Q8IX15 |
TreeFami | TF333363 |
Enzyme and pathway databases
PathwayCommonsi | Q8IX15 |
Miscellaneous databases
BioGRID-ORCSi | 57594, 9 hits in 863 CRISPR screens |
ChiTaRSi | HOMEZ, human |
EvolutionaryTracei | Q8IX15 |
GenomeRNAii | 57594 |
Pharosi | Q8IX15, Tbio |
PROi | PR:Q8IX15 |
RNActi | Q8IX15, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000215271, Expressed in left testis and 121 other tissues |
ExpressionAtlasi | Q8IX15, baseline and differential |
Genevisiblei | Q8IX15, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR008422, Homeobox_KN_domain IPR024578, Homez_homeobox_dom |
Pfami | View protein in Pfam PF05920, Homeobox_KN, 1 hit PF11569, Homez, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS50071, HOMEOBOX_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HOMEZ_HUMAN | |
Accessioni | Q8IX15Primary (citable) accession number: Q8IX15 Secondary accession number(s): A1L445 Q9P2A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations