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Protein

Homeobox and leucine zipper protein Homez

Gene

HOMEZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcriptional regulator.

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi55 – 114Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi355 – 415Homeobox 2PROSITE-ProRule annotationAdd BLAST61
DNA bindingi451 – 510Homeobox 3PROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox and leucine zipper protein Homez
Alternative name(s):
Homeodomain leucine zipper-containing factor
Gene namesi
Name:HOMEZ
Synonyms:KIAA1443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000215271.7
HGNCiHGNC:20164 HOMEZ
MIMi608119 gene
neXtProtiNX_Q8IX15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57594
OpenTargetsiENSG00000215271
PharmGKBiPA162391555

Polymorphism and mutation databases

BioMutaiHOMEZ
DMDMi317373364

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000491351 – 550Homeobox and leucine zipper protein HomezAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei351PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IX15
MaxQBiQ8IX15
PaxDbiQ8IX15
PeptideAtlasiQ8IX15
PRIDEiQ8IX15
ProteomicsDBi70963

PTM databases

iPTMnetiQ8IX15
PhosphoSitePlusiQ8IX15

Expressioni

Tissue specificityi

Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000215271
CleanExiHS_HOMEZ
ExpressionAtlasiQ8IX15 baseline and differential
GenevisibleiQ8IX15 HS

Organism-specific databases

HPAiHPA036316
HPA036317

Interactioni

Subunit structurei

Homodimer or heterodimer (Potential). Interacts with HOXC8.Curated1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121645, 37 interactors
IntActiQ8IX15, 35 interactors
STRINGi9606.ENSP00000350049

Structurei

Secondary structure

1550
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi365 – 377Combined sources13
Helixi383 – 392Combined sources10
Helixi397 – 413Combined sources17
Helixi464 – 472Combined sources9
Helixi480 – 487Combined sources8
Helixi492 – 502Combined sources11

3D structure databases

ProteinModelPortaliQ8IX15
SMRiQ8IX15
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX15

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi358 – 363Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi160 – 195Pro-richAdd BLAST36
Compositional biasi284 – 291Poly-Ser8
Compositional biasi425 – 465Pro-richAdd BLAST41
Compositional biasi515 – 536Glu-richAdd BLAST22
Compositional biasi537 – 544Poly-Asp8

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiENOG410IFGX Eukaryota
ENOG410YKZF LUCA
GeneTreeiENSGT00530000063149
HOGENOMiHOG000136732
HOVERGENiHBG051919
InParanoidiQ8IX15
OMAiLEPAWPQ
OrthoDBiEOG091G02WT
PhylomeDBiQ8IX15
TreeFamiTF333363

Family and domain databases

CDDicd00086 homeodomain, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR024578 Homez_homeobox_dom
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IX15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE
60 70 80 90 100
LQLVWTQAAQ TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK
110 120 130 140 150
TWFMAQRLRC GISWSSEEIE ETRARVVYRR DQLHFKSLLS FTHHAGRPPE
160 170 180 190 200
EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG LKVEPEEPSQ MPPLPQSHQK
210 220 230 240 250
LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS HGIGTASWNH
260 270 280 290 300
STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT
310 320 330 340 350
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL
360 370 380 390 400
SPDMQRQRKT KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI
410 420 430 440 450
IQWFGDTRYA LKHGQLKWFR DNAVPGAPSF QDPAIPTPPP STRSLNERAE
460 470 480 490 500
TPPLPIPPPP PDIQPLERYW AAHQQLRETD IPQLSQASRL STQQVLDWFD
510 520 530 540 550
SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD DDDDDVIIQD
Length:550
Mass (Da):61,240
Last modified:January 11, 2011 - v2
Checksum:iA7DDF6DD56D8BDF0
GO
Isoform 2 (identifier: Q8IX15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVRGWEPPPGLDC → MLKSRISMRSRHPRR

Note: No experimental confirmation available.
Show »
Length:552
Mass (Da):61,695
Checksum:i2079A7F5CE2B97D5
GO

Sequence cautioni

The sequence AAN76991 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302A → T in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti529Missing in AAN76991 (PubMed:12925734).Curated1
Sequence conflicti529Missing in BAA92681 (PubMed:10718198).Curated1
Sequence conflicti529Missing in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti538D → E in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti538Missing in BAG63992 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055956278A → T. Corresponds to variant dbSNP:rs10131813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0543031 – 13MVRGW…PGLDC → MLKSRISMRSRHPRR in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463523 mRNA Translation: AAN76991.1 Different initiation.
AB037864 mRNA Translation: BAA92681.1 Different initiation.
AK302788 mRNA Translation: BAG63992.1
AL049829 Genomic DNA No translation available.
BC130392 mRNA Translation: AAI30393.1
CCDSiCCDS45085.1 [Q8IX15-1]
RefSeqiNP_065885.2, NM_020834.2 [Q8IX15-1]
UniGeneiHs.632332

Genome annotation databases

EnsembliENST00000357460; ENSP00000350049; ENSG00000215271 [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271 [Q8IX15-3]
GeneIDi57594
KEGGihsa:57594
UCSCiuc001wja.3 human [Q8IX15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHOMEZ_HUMAN
AccessioniPrimary (citable) accession number: Q8IX15
Secondary accession number(s): A1L445
, B4DZ80, F8WCA3, Q6P049, Q86XB6, Q9P2A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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