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UniProtKB - Q8IX15 (HOMEZ_HUMAN)

Protein

Homeobox and leucine zipper protein Homez

Gene

HOMEZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcriptional regulator.

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi55 – 114Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi355 – 415Homeobox 2PROSITE-ProRule annotationAdd BLAST61
DNA bindingi451 – 510Homeobox 3PROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox and leucine zipper protein Homez
Alternative name(s):
Homeodomain leucine zipper-containing factor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOMEZ
Synonyms:KIAA1443
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000215271.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:20164 HOMEZ

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608119 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IX15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57594

Open Targets

More...OpenTargetsi		ENSG00000215271

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162391555

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HOMEZ

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373364

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000491351 – 550Homeobox and leucine zipper protein HomezAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki200Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei351PhosphoserineCombined sources1
Modified residuei451PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IX15

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IX15

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IX15

PeptideAtlas

More...PeptideAtlasi		Q8IX15

PRoteomics IDEntifications database

More...PRIDEi		Q8IX15

ProteomicsDB human proteome resource

More...ProteomicsDBi		70963

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IX15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IX15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000215271 Expressed in 96 organ(s), highest expression level in left testis

CleanEx database of gene expression profiles

More...CleanExi		HS_HOMEZ

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IX15 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IX15 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA036316
HPA036317

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer (Potential). Interacts with HOXC8.Curated1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		121645, 37 interactors

Protein interaction database and analysis system

More...IntActi		Q8IX15, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000350049

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1550
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q8IX15

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IX15

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8IX15

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi358 – 363Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi160 – 195Pro-richAdd BLAST36
Compositional biasi284 – 291Poly-Ser8
Compositional biasi425 – 465Pro-richAdd BLAST41
Compositional biasi515 – 536Glu-richAdd BLAST22
Compositional biasi537 – 544Poly-Asp8

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFGX Eukaryota
ENOG410YKZF LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154145

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000136732

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051919

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IX15

Identification of Orthologs from Complete Genome Data

More...OMAi		MVRGWEP

Database of Orthologous Groups

More...OrthoDBi		EOG091G02WT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IX15

TreeFam database of animal gene trees

More...TreeFami		TF333363

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086 homeodomain, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR024578 Homez_homeobox_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF11569 Homez, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389 HOX, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50071 HOMEOBOX_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRGWEPPPG LDCAISEGHK SEGTMPPNKE ASGLSSSPAG LICLPPISEE 
        60         70         80         90        100
LQLVWTQAAQ TSELDSNEHL LKTFSYFPYP SLADIALLCL RYGLQMEKVK 
       110        120        130        140        150
TWFMAQRLRC GISWSSEEIE ETRARVVYRR DQLHFKSLLS FTHHAGRPPE 
       160        170        180        190        200
EVPPPPVPAP EQVGIGIGPP TLSKPTQTKG LKVEPEEPSQ MPPLPQSHQK 
       210        220        230        240        250
LKESLMTPGS GAFPYQSDFW QHLQSSGLSK EQAGRGPNQS HGIGTASWNH 
       260        270        280        290        300
STTVPQPQAR DKPPPIALIA SSCKEESASS VTPSSSSTSS SFQVLANGAT 
       310        320        330        340        350
AASKPLQPLG CVPQSVSPSE QALPPHLEPA WPQGLRHNSV PGRVGPTEYL 
       360        370        380        390        400
SPDMQRQRKT KRKTKEQLAI LKSFFLQCQW ARREDYQKLE QITGLPRPEI 
       410        420        430        440        450
IQWFGDTRYA LKHGQLKWFR DNAVPGAPSF QDPAIPTPPP STRSLNERAE 
       460        470        480        490        500
TPPLPIPPPP PDIQPLERYW AAHQQLRETD IPQLSQASRL STQQVLDWFD 
       510        520        530        540        550
SRLPQPAEVV VCLDEEEEEE EEELPEDDEE EEEEEEEDDD DDDDDVIIQD
Length:550
Mass (Da):61,240
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7DDF6DD56D8BDF0
GO
Isoform 2 (identifier: Q8IX15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MVRGWEPPPGLDC → MLKSRISMRSRHPRR

Note: No experimental confirmation available.
Show »
Length:552
Mass (Da):61,695
Checksum:i2079A7F5CE2B97D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPW8U3KPW8_HUMAN
Homeobox and leucine zipper protein...
HOMEZ
324Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN76991 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92681 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti302A → T in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti529Missing in AAN76991 (PubMed:12925734).Curated1
Sequence conflicti529Missing in BAA92681 (PubMed:10718198).Curated1
Sequence conflicti529Missing in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti538D → E in AAI30393 (PubMed:15489334).Curated1
Sequence conflicti538Missing in BAG63992 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055956278A → T. Corresponds to variant dbSNP:rs10131813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0543031 – 13MVRGW…PGLDC → MLKSRISMRSRHPRR in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF463523 mRNA Translation: AAN76991.1 Different initiation.
AB037864 mRNA Translation: BAA92681.1 Different initiation.
AK302788 mRNA Translation: BAG63992.1
AL049829 Genomic DNA No translation available.
BC130392 mRNA Translation: AAI30393.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45085.1 [Q8IX15-1]

NCBI Reference Sequences

More...RefSeqi		NP_065885.2, NM_020834.2 [Q8IX15-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.632332

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000357460; ENSP00000350049; ENSG00000215271 [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271 [Q8IX15-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57594

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57594

UCSC genome browser

More...UCSCi		uc001wja.3 human [Q8IX15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF463523 mRNA Translation: AAN76991.1 Different initiation.
AB037864 mRNA Translation: BAA92681.1 Different initiation.
AK302788 mRNA Translation: BAG63992.1
AL049829 Genomic DNA No translation available.
BC130392 mRNA Translation: AAI30393.1
CCDSiCCDS45085.1 [Q8IX15-1]
RefSeqiNP_065885.2, NM_020834.2 [Q8IX15-1]
UniGeneiHs.632332

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ECCNMR-A361-423[»]
2YS9NMR-A453-509[»]
ProteinModelPortaliQ8IX15
SMRiQ8IX15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121645, 37 interactors
IntActiQ8IX15, 35 interactors
STRINGi9606.ENSP00000350049

PTM databases

iPTMnetiQ8IX15
PhosphoSitePlusiQ8IX15

Polymorphism and mutation databases

BioMutaiHOMEZ
DMDMi317373364

Proteomic databases

EPDiQ8IX15
MaxQBiQ8IX15
PaxDbiQ8IX15
PeptideAtlasiQ8IX15
PRIDEiQ8IX15
ProteomicsDBi70963

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357460; ENSP00000350049; ENSG00000215271 [Q8IX15-1]
ENST00000561013; ENSP00000453979; ENSG00000215271 [Q8IX15-3]
GeneIDi57594
KEGGihsa:57594
UCSCiuc001wja.3 human [Q8IX15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57594
DisGeNETi57594
EuPathDBiHostDB:ENSG00000215271.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		HOMEZ

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0011535
HGNCiHGNC:20164 HOMEZ
HPAiHPA036316
HPA036317
MIMi608119 gene
neXtProtiNX_Q8IX15
OpenTargetsiENSG00000215271
PharmGKBiPA162391555

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFGX Eukaryota
ENOG410YKZF LUCA
GeneTreeiENSGT00940000154145
HOGENOMiHOG000136732
HOVERGENiHBG051919
InParanoidiQ8IX15
OMAiMVRGWEP
OrthoDBiEOG091G02WT
PhylomeDBiQ8IX15
TreeFamiTF333363

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HOMEZ human
EvolutionaryTraceiQ8IX15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57594

Protein Ontology

More...PROi		PR:Q8IX15

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000215271 Expressed in 96 organ(s), highest expression level in left testis
CleanExiHS_HOMEZ
ExpressionAtlasiQ8IX15 baseline and differential
GenevisibleiQ8IX15 HS

Family and domain databases

CDDicd00086 homeodomain, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR024578 Homez_homeobox_dom
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF11569 Homez, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHOMEZ_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX15
Secondary accession number(s): A1L445
, B4DZ80, F8WCA3, Q6P049, Q86XB6, Q9P2A5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 11, 2011
Last modified: December 5, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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