Cell division cycle and apoptosis regulator protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ligand-dependent nuclear receptor transcription coactivator activity Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 18722177
• RNA binding Source: UniProtKBInferred from high throughput direct assayⁱ
  • 22658674
  • 22681889
• RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 24245781
• transcription coactivator activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 24245781
• transcription corepressor activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23887938

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• apoptotic process Source: UniProtKB-KW
• cell cycle Source: UniProtKB-KW
• mRNA splicing, via spliceosome Source: Reactome
• positive regulation of cell migration Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23887938
• positive regulation of cell proliferation Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 23887938
• regulation of transcription, DNA-templated Source: UniProtKB-KW
• transcription, DNA-templated Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA 
        60         70         80         90        100
AGLTTQTPAN YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ 
       110        120        130        140        150
PQQTLLTQPA VALPTSLSLS TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF 
       160        170        180        190        200
TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP QVGDRVLVEA TYNPNMPFKW 
       210        220        230        240        250
NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT QPQPQSLLQA 
       260        270        280        290        300
QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR 
       310        320        330        340        350
FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER 
       360        370        380        390        400
SPRRVRRVVP RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT 
       410        420        430        440        450
WVDAFPLSRP FQLGNYCNFY VMHREVESLE KNMAILDPPD ADHLYSAKVM 
       460        470        480        490        500
LMASPSMEDL YHKSCALAED PQELRDGFQH PARLVKFLVG MKGKDEAMAI 
       510        520        530        540        550
GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT QWYRFAEIRY 
       560        570        580        590        600
HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK 
       610        620        630        640        650
LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES 
       660        670        680        690        700
RALSSKGLKS QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD 
       710        720        730        740        750
KEEEERKRQE EIERQRRERR YILPDEPAII VHPNWAAKSG KFDCSIMSLS 
       760        770        780        790        800
VLLDYRLEDN KEHSFEVSLF AELFNEMLQR DFGVRIYKSL LSLPEKEDKK 
       810        820        830        840        850
EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE DRDERKKEDK 
       860        870        880        890        900
RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN 
       910        920        930        940        950
RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY 
       960        970        980        990       1000
TLGLHLSRAQ VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML 
      1010       1020       1030       1040       1050
GNRLLLPTPT VKQESKDVEE NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE 
      1060       1070       1080       1090       1100
VEQKLQLLEE KTDEDEKTIL NLENSNKSLS GELREVKKDL SQLQENLKIS 
      1110       1120       1130       1140       1150
ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD QKSKENGASV 

        10         20         30         40         50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA 
        60         70         80         90        100
AGLTTQTPAN YQLTQTAALQ QQAAAAAAAL QQLQQPQQTL LTQPAVALPT 
       110        120        130        140        150
SLSLSTPQPT AQITVSYPTP RSSQQQTQPQ KQRVFTGVVT KLHDTFGFVD 
       160        170        180        190        200
EDVFFQLSAV KGKTPQVGDR VLVEATYNPN MPFKWNAQRI QTLPNQNQSQ 
       210        220        230        240        250
TQPLLKTPPA VLQPIAPQTT FGVQTQPQPQ SLLQAQISAA SITPLLQTQP 
       260        270        280        290        300
QPLLQQPQQK AGLLQPPVRI VSQPQPARRL DPPSRFSGRN DRGDQVPNRK 
       310        320        330        340        350
DDRSRERERE RRRSRERSPQ RKRSRERSPR RERERSPRRV RRVVPRYTVQ 
       360        370        380        390        400
FSKFSLDCPS CDMMELRRRY QNLYIPSDFF DAQFTWVDAF PLSRPFQLGN 
       410        420        430        440        450
YCNFYVMHRE VESLEKNMAI LDPPDADHLY SAKVMLMASP SMEDLYHKSC 
       460        470        480        490        500
ALAEDPQELR DGFQHPARLV KFLVGMKGKD EAMAIGGHWS PSLDGPDPEK 
       510        520        530        540        550
DPSVLIKTAI RCCKALTGID LSVCTQWYRF AEIRYHRPEE THKGRTVPAH 
       560        570        580        590        600
VETVVLFFPD VWHCLPTRSE WETLSRGYKQ QLVEKLQGER KEADGEQDEE 
       610        620        630        640        650
EKDDGEAKEI STPTHWSKLD PKTMKVNDLR KELESRALSS KGLKSQLIAR 
       660        670        680        690        700
LTKQLKVEEQ KEEQKELEKS EKEEDEDDDR KSEDDKEEEE RKRQEEIERQ 
       710        720        730        740        750
RRERRYILPD EPAIIVHPNW AAKSGKFDCS IMSLSVLLDY RLEDNKEHSF 
       760        770        780        790        800
EVSLFAELFN EMLQRDFGVR IYKSLLSLPE KEDKKEKDKK SKKDERKDKK 
       810        820        830        840        850
EERDDETDEP KPKRRKSGDD KDKKEDRDER KKEDKRKDDS KDDDETEEDN 
       860        870        880        890        900
NQDEYDPMEA EEAEDEEDDR DEEEMTKRDD KRDINRYCKE RPSKDKEKEK 
       910        920        930        940        950
TQMITINRDL LMAFVYFDQS HCGYLLEKDL EEILYTLGLH LSRAQVKKLL 
       960        970        980        990       1000
NKVVLRESCF YRKLTDTSKD EENHEESESL QEDMLGNRLL LPTPTVKQES 
      1010       1020       1030       1040       1050
KDVEENVGLI VYNGAMVDVG SLLQKLEKSE KVRAEVEQKL QLLEEKTDED 
      1060       1070       1080       1090       1100
EKTILNLENS NKSLSGELRE VKKDLSQLQE NLKISENMNL QFENQMNKTI 
      1110       1120       1130 
RNLSTVMDEI HTVLKKDNVK NEDKDQKSKE NGASV                 

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 10
   Human chromosome 10: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot