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UniProtKB - Q8IX12 (CCAR1_HUMAN)

Entry version 159 (23 Feb 2022)
Sequence version 2 (02 May 2006)
Previous versions | rss
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Protein

Cell division cycle and apoptosis regulator protein 1

Gene

CCAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity).

May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952).

In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).

Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IX12

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-72163, mRNA Splicing - Major Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IX12

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle and apoptosis regulator protein 1
Alternative name(s):
Cell cycle and apoptosis regulatory protein 1
Short name:
CARP-1
Death inducer with SAP domain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCAR1
Synonyms:CARP1, DIS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24236, CCAR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612569, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IX12

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000060339

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55749

Open Targets

More...OpenTargetsi		ENSG00000060339

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134920227

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IX12, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCAR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		94707499

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331481 – 1150Cell division cycle and apoptosis regulator protein 1Add BLAST1150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei456PhosphoserineCombined sources1
Modified residuei627PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki637Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei667PhosphothreonineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei861PhosphothreonineCombined sources1
Cross-linki1012Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki1012Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki1067Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IX12

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IX12

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IX12

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IX12

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IX12

PeptideAtlas

More...PeptideAtlasi		Q8IX12

PRoteomics IDEntifications database

More...PRIDEi		Q8IX12

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70961 [Q8IX12-1]
70962 [Q8IX12-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8IX12, 25 sites, 2 O-linked glycans (25 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IX12

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q8IX12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IX12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000060339, Expressed in testis and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IX12, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IX12, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000060339, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Directly interacts with ESR1, NR3C1 and p53/TP53 (By similarity).

Interacts (via N-terminus) with CALCOCO1.

Interacts with MED1 (By similarity).

Interacts with GATA1.

Interacts with AR and GATA2.

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120867, 107 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8IX12

Database of interacting proteins

More...DIPi		DIP-27607N

Protein interaction database and analysis system

More...IntActi		Q8IX12, 56 interactors

Molecular INTeraction database

More...MINTi		Q8IX12

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265872

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IX12, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IX12

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini636 – 670SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 249Interaction with AR1 PublicationAdd BLAST249
Regioni124 – 146DisorderedSequence analysisAdd BLAST23
Regioni203 – 660Interaction with GATA21 PublicationAdd BLAST458
Regioni285 – 354DisorderedSequence analysisAdd BLAST70
Regioni600 – 638DisorderedSequence analysisAdd BLAST39
Regioni643 – 1150Interaction with GATA11 PublicationAdd BLAST508
Regioni673 – 713DisorderedSequence analysisAdd BLAST41
Regioni796 – 915DisorderedSequence analysisAdd BLAST120

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili594 – 618Sequence analysisAdd BLAST25
Coiled coili1033 – 1114Sequence analysisAdd BLAST82

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi299 – 354Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi621 – 638Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi684 – 699Acidic residuesSequence analysisAdd BLAST16
Compositional biasi796 – 857Basic and acidic residuesSequence analysisAdd BLAST62
Compositional biasi858 – 888Acidic residuesSequence analysisAdd BLAST31
Compositional biasi889 – 915Basic and acidic residuesSequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4246, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063672

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IX12

Identification of Orthologs from Complete Genome Data

More...OMAi		LRYSDMH

Database of Orthologous Groups

More...OrthoDBi		614048at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IX12

TreeFam database of animal gene trees

More...TreeFami		TF316387

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045354, BURAN
IPR025224, CCAR1/CCAR2
IPR025954, DBC1/CARP1_inactive_NUDIX_dom
IPR011992, EF-hand-dom_pair
IPR045353, LAIKA
IPR012340, NA-bd_OB-fold
IPR025223, S1-like_RNA-bd_dom
IPR003034, SAP_dom
IPR036361, SAP_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR14304, PTHR14304, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF19257, BURAN, 1 hit
PF14443, DBC1, 1 hit
PF19256, LAIKA, 1 hit
PF14444, S1-like, 1 hit
PF02037, SAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01122, DBC1, 1 hit
SM00513, SAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF50249, SSF50249, 1 hit
SSF68906, SSF68906, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50800, SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA 
        60         70         80         90        100
AGLTTQTPAN YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ 
       110        120        130        140        150
PQQTLLTQPA VALPTSLSLS TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF 
       160        170        180        190        200
TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP QVGDRVLVEA TYNPNMPFKW 
       210        220        230        240        250
NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT QPQPQSLLQA 
       260        270        280        290        300
QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR 
       310        320        330        340        350
FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER 
       360        370        380        390        400
SPRRVRRVVP RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT 
       410        420        430        440        450
WVDAFPLSRP FQLGNYCNFY VMHREVESLE KNMAILDPPD ADHLYSAKVM 
       460        470        480        490        500
LMASPSMEDL YHKSCALAED PQELRDGFQH PARLVKFLVG MKGKDEAMAI 
       510        520        530        540        550
GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT QWYRFAEIRY 
       560        570        580        590        600
HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK 
       610        620        630        640        650
LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES 
       660        670        680        690        700
RALSSKGLKS QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD 
       710        720        730        740        750
KEEEERKRQE EIERQRRERR YILPDEPAII VHPNWAAKSG KFDCSIMSLS 
       760        770        780        790        800
VLLDYRLEDN KEHSFEVSLF AELFNEMLQR DFGVRIYKSL LSLPEKEDKK 
       810        820        830        840        850
EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE DRDERKKEDK 
       860        870        880        890        900
RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN 
       910        920        930        940        950
RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY 
       960        970        980        990       1000
TLGLHLSRAQ VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML 
      1010       1020       1030       1040       1050
GNRLLLPTPT VKQESKDVEE NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE 
      1060       1070       1080       1090       1100
VEQKLQLLEE KTDEDEKTIL NLENSNKSLS GELREVKKDL SQLQENLKIS 
      1110       1120       1130       1140       1150
ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD QKSKENGASV
Length:1,150
Mass (Da):132,821
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30618DCC8097F552
GO
Isoform 2 (identifier: Q8IX12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-97: Missing.

Show »
Length:1,135
Mass (Da):131,043
Checksum:i1F36D655EC82941E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGG8A0A0C4DGG8_HUMAN
Cell division cycle and apoptosis r...
CCAR1
1,043Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2E6F5H2E6_HUMAN
Cell division cycle and apoptosis r...
CCAR1
772Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3E1F5H3E1_HUMAN
Cell division cycle and apoptosis r...
CCAR1
568Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1H2F5H1H2_HUMAN
Cell division cycle and apoptosis r...
CCAR1
646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFJ7H0YFJ7_HUMAN
Cell division cycle and apoptosis r...
CCAR1
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7M9F5H7M9_HUMAN
Cell division cycle and apoptosis r...
CCAR1
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H3I8F5H3I8_HUMAN
Cell division cycle and apoptosis r...
CCAR1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1L3F5H1L3_HUMAN
Cell division cycle and apoptosis r...
CCAR1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H808F5H808_HUMAN
Cell division cycle and apoptosis r...
CCAR1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFT7H0YFT7_HUMAN
Cell division cycle and apoptosis r...
CCAR1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26036 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI08683 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91354 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti296D → Y in BAA91354 (PubMed:14702039).Curated1
Sequence conflicti305N → S in BAG60310 (PubMed:14702039).Curated1
Sequence conflicti492K → E in BAA91847 (PubMed:14702039).Curated1
Sequence conflicti618D → Y in AAH15475 (PubMed:15489334).Curated1
Sequence conflicti650S → G in AAO17319 (Ref. 2) Curated1
Sequence conflicti650S → G in BAA91700 (PubMed:14702039).Curated1
Sequence conflicti723L → S in BAF85338 (PubMed:14702039).Curated1
Sequence conflicti801 – 803EKD → KKK in AAH89420 (PubMed:15489334).Curated3
Sequence conflicti816 – 818EER → KKK in AAH15475 (PubMed:15489334).Curated3
Sequence conflicti853D → G (PubMed:12816952).Curated1
Sequence conflicti853D → G (Ref. 2) Curated1
Sequence conflicti853D → G in BAA91700 (PubMed:14702039).Curated1
Sequence conflicti1104N → S (PubMed:12816952).Curated1
Sequence conflicti1104N → S (Ref. 2) Curated1
Sequence conflicti1104N → S in BAA91700 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058330588T → I. Corresponds to variant dbSNP:rs1782338Ensembl.1
Natural variantiVAR_035497607E → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_058331681E → G. Corresponds to variant dbSNP:rs1060145Ensembl.1
Natural variantiVAR_058332747M → V. Corresponds to variant dbSNP:rs11542602Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03773683 – 97Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY249140 mRNA Translation: AAP82002.1
AF465616 mRNA Translation: AAO17319.1
AK000741 mRNA Translation: BAA91354.1 Different initiation.
AK001452 mRNA Translation: BAA91700.1
AK001701 mRNA Translation: BAA91847.1
AK023438 mRNA Translation: BAB14574.1
AK298004 mRNA Translation: BAG60310.1
AK299307 mRNA Translation: BAG61320.1
AK292649 mRNA Translation: BAF85338.1
AL513534 Genomic DNA No translation available.
AL391539 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54302.1
BC015475 mRNA Translation: AAH15475.1
BC026036 mRNA Translation: AAH26036.1 Sequence problems.
BC089420 mRNA Translation: AAH89420.1
BC130626 mRNA Translation: AAI30627.1
BC132725 mRNA Translation: AAI32726.1
BC108682 mRNA Translation: AAI08683.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS60547.1 [Q8IX12-2]
CCDS7282.1 [Q8IX12-1]

NCBI Reference Sequences

More...RefSeqi		NP_001269888.1, NM_001282959.1 [Q8IX12-2]
NP_001269889.1, NM_001282960.1 [Q8IX12-2]
NP_060707.2, NM_018237.3 [Q8IX12-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265872; ENSP00000265872; ENSG00000060339
ENST00000543719; ENSP00000445254; ENSG00000060339 [Q8IX12-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55749

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000265872.11; ENSP00000265872.6; NM_018237.4; NP_060707.2

UCSC genome browser

More...UCSCi		uc001joo.5, human [Q8IX12-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY249140 mRNA Translation: AAP82002.1
AF465616 mRNA Translation: AAO17319.1
AK000741 mRNA Translation: BAA91354.1 Different initiation.
AK001452 mRNA Translation: BAA91700.1
AK001701 mRNA Translation: BAA91847.1
AK023438 mRNA Translation: BAB14574.1
AK298004 mRNA Translation: BAG60310.1
AK299307 mRNA Translation: BAG61320.1
AK292649 mRNA Translation: BAF85338.1
AL513534 Genomic DNA No translation available.
AL391539 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54302.1
BC015475 mRNA Translation: AAH15475.1
BC026036 mRNA Translation: AAH26036.1 Sequence problems.
BC089420 mRNA Translation: AAH89420.1
BC130626 mRNA Translation: AAI30627.1
BC132725 mRNA Translation: AAI32726.1
BC108682 mRNA Translation: AAI08683.1 Sequence problems.
CCDSiCCDS60547.1 [Q8IX12-2]
CCDS7282.1 [Q8IX12-1]
RefSeqiNP_001269888.1, NM_001282959.1 [Q8IX12-2]
NP_001269889.1, NM_001282960.1 [Q8IX12-2]
NP_060707.2, NM_018237.3 [Q8IX12-1]

3D structure databases

SMRiQ8IX12
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120867, 107 interactors
CORUMiQ8IX12
DIPiDIP-27607N
IntActiQ8IX12, 56 interactors
MINTiQ8IX12
STRINGi9606.ENSP00000265872

PTM databases

GlyGeniQ8IX12, 25 sites, 2 O-linked glycans (25 sites)
iPTMnetiQ8IX12
MetOSiteiQ8IX12
PhosphoSitePlusiQ8IX12

Genetic variation databases

BioMutaiCCAR1
DMDMi94707499

Proteomic databases

EPDiQ8IX12
jPOSTiQ8IX12
MassIVEiQ8IX12
MaxQBiQ8IX12
PaxDbiQ8IX12
PeptideAtlasiQ8IX12
PRIDEiQ8IX12
ProteomicsDBi70961 [Q8IX12-1]
70962 [Q8IX12-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2118, 202 antibodies from 31 providers

The DNASU plasmid repository

More...DNASUi		55749

Genome annotation databases

EnsembliENST00000265872; ENSP00000265872; ENSG00000060339
ENST00000543719; ENSP00000445254; ENSG00000060339 [Q8IX12-2]
GeneIDi55749
KEGGihsa:55749
MANE-SelectiENST00000265872.11; ENSP00000265872.6; NM_018237.4; NP_060707.2
UCSCiuc001joo.5, human [Q8IX12-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55749
DisGeNETi55749

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCAR1
HGNCiHGNC:24236, CCAR1
HPAiENSG00000060339, Low tissue specificity
MIMi612569, gene
neXtProtiNX_Q8IX12
OpenTargetsiENSG00000060339
PharmGKBiPA134920227
VEuPathDBiHostDB:ENSG00000060339

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4246, Eukaryota
GeneTreeiENSGT00530000063672
InParanoidiQ8IX12
OMAiLRYSDMH
OrthoDBi614048at2759
PhylomeDBiQ8IX12
TreeFamiTF316387

Enzyme and pathway databases

PathwayCommonsiQ8IX12
ReactomeiR-HSA-72163, mRNA Splicing - Major Pathway
SignaLinkiQ8IX12

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55749, 506 hits in 1052 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCAR1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CCAR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55749
PharosiQ8IX12, Tbio

Protein Ontology

More...PROi		PR:Q8IX12
RNActiQ8IX12, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000060339, Expressed in testis and 217 other tissues
ExpressionAtlasiQ8IX12, baseline and differential
GenevisibleiQ8IX12, HS

Family and domain databases

Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR045354, BURAN
IPR025224, CCAR1/CCAR2
IPR025954, DBC1/CARP1_inactive_NUDIX_dom
IPR011992, EF-hand-dom_pair
IPR045353, LAIKA
IPR012340, NA-bd_OB-fold
IPR025223, S1-like_RNA-bd_dom
IPR003034, SAP_dom
IPR036361, SAP_dom_sf
PANTHERiPTHR14304, PTHR14304, 1 hit
PfamiView protein in Pfam
PF19257, BURAN, 1 hit
PF14443, DBC1, 1 hit
PF19256, LAIKA, 1 hit
PF14444, S1-like, 1 hit
PF02037, SAP, 1 hit
SMARTiView protein in SMART
SM01122, DBC1, 1 hit
SM00513, SAP, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF50249, SSF50249, 1 hit
SSF68906, SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50800, SAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCAR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX12
Secondary accession number(s): A0JLT7
, A1L4P7, A8K9D4, B4DNP8, B4DRK8, Q32NE3, Q5EBM3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: February 23, 2022
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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