UniProtKB - Q8IX12 (CCAR1_HUMAN)
Cell division cycle and apoptosis regulator protein 1
CCAR1
Functioni
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity).
May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (PubMed:12816952).
In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells (PubMed:23887938).
By similarity3 PublicationsGO - Molecular functioni
- nuclear receptor coactivator activity Source: MGI
- RNA binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription corepressor activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, Repressor |
Biological process | Apoptosis, Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q8IX12 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
SignaLinki | Q8IX12 |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division cycle and apoptosis regulator protein 1Alternative name(s): Cell cycle and apoptosis regulatory protein 1 Short name: CARP-1 Death inducer with SAP domain |
Gene namesi | Name:CCAR1 Synonyms:CARP1, DIS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24236, CCAR1 |
MIMi | 612569, gene |
neXtProti | NX_Q8IX12 |
VEuPathDBi | HostDB:ENSG00000060339 |
Subcellular locationi
Other locations
- perinuclear region 1 Publication
Nucleus
- nuclear envelope lumen Source: MGI
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55749 |
OpenTargetsi | ENSG00000060339 |
PharmGKBi | PA134920227 |
Miscellaneous databases
Pharosi | Q8IX12, Tbio |
Genetic variation databases
BioMutai | CCAR1 |
DMDMi | 94707499 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233148 | 1 – 1150 | Cell division cycle and apoptosis regulator protein 1Add BLAST | 1150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 456 | PhosphoserineCombined sources | 1 | |
Modified residuei | 627 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 637 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 667 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 685 | PhosphoserineCombined sources | 1 | |
Modified residuei | 697 | PhosphoserineCombined sources | 1 | |
Modified residuei | 861 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 1012 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 1012 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 1067 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1135 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IX12 |
jPOSTi | Q8IX12 |
MassIVEi | Q8IX12 |
MaxQBi | Q8IX12 |
PaxDbi | Q8IX12 |
PeptideAtlasi | Q8IX12 |
PRIDEi | Q8IX12 |
ProteomicsDBi | 70961 [Q8IX12-1] 70962 [Q8IX12-2] |
PTM databases
GlyGeni | Q8IX12, 25 sites, 2 O-linked glycans (25 sites) |
iPTMneti | Q8IX12 |
MetOSitei | Q8IX12 |
PhosphoSitePlusi | Q8IX12 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000060339, Expressed in testis and 217 other tissues |
ExpressionAtlasi | Q8IX12, baseline and differential |
Genevisiblei | Q8IX12, HS |
Organism-specific databases
HPAi | ENSG00000060339, Low tissue specificity |
Interactioni
Subunit structurei
Directly interacts with ESR1, NR3C1 and p53/TP53 (By similarity).
Interacts (via N-terminus) with CALCOCO1.
Interacts with MED1 (By similarity).
Interacts with GATA1.
Interacts with AR and GATA2.
By similarity3 PublicationsBinary interactionsi
Q8IX12
Protein-protein interaction databases
BioGRIDi | 120867, 107 interactors |
CORUMi | Q8IX12 |
DIPi | DIP-27607N |
IntActi | Q8IX12, 56 interactors |
MINTi | Q8IX12 |
STRINGi | 9606.ENSP00000265872 |
Miscellaneous databases
RNActi | Q8IX12, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 636 – 670 | SAPPROSITE-ProRule annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 249 | Interaction with AR1 PublicationAdd BLAST | 249 | |
Regioni | 124 – 146 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 203 – 660 | Interaction with GATA21 PublicationAdd BLAST | 458 | |
Regioni | 285 – 354 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 600 – 638 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 643 – 1150 | Interaction with GATA11 PublicationAdd BLAST | 508 | |
Regioni | 673 – 713 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 796 – 915 | DisorderedSequence analysisAdd BLAST | 120 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 594 – 618 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 1033 – 1114 | Sequence analysisAdd BLAST | 82 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 299 – 354 | Basic and acidic residuesSequence analysisAdd BLAST | 56 | |
Compositional biasi | 621 – 638 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 684 – 699 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 796 – 857 | Basic and acidic residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 858 – 888 | Acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 889 – 915 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4246, Eukaryota |
GeneTreei | ENSGT00530000063672 |
InParanoidi | Q8IX12 |
OMAi | LRYSDMH |
OrthoDBi | 614048at2759 |
PhylomeDBi | Q8IX12 |
TreeFami | TF316387 |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit |
InterProi | View protein in InterPro IPR045354, BURAN IPR025224, CCAR1/CCAR2 IPR025954, DBC1/CARP1_inactive_NUDIX_dom IPR011992, EF-hand-dom_pair IPR045353, LAIKA IPR012340, NA-bd_OB-fold IPR025223, S1-like_RNA-bd_dom IPR003034, SAP_dom IPR036361, SAP_dom_sf |
PANTHERi | PTHR14304, PTHR14304, 1 hit |
Pfami | View protein in Pfam PF19257, BURAN, 1 hit PF14443, DBC1, 1 hit PF19256, LAIKA, 1 hit PF14444, S1-like, 1 hit PF02037, SAP, 1 hit |
SMARTi | View protein in SMART SM01122, DBC1, 1 hit SM00513, SAP, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50249, SSF50249, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS50800, SAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA
60 70 80 90 100
AGLTTQTPAN YQLTQTAALQ QQAAAAAAAL QQQYSQPQQA LYSVQQQLQQ
110 120 130 140 150
PQQTLLTQPA VALPTSLSLS TPQPTAQITV SYPTPRSSQQ QTQPQKQRVF
160 170 180 190 200
TGVVTKLHDT FGFVDEDVFF QLSAVKGKTP QVGDRVLVEA TYNPNMPFKW
210 220 230 240 250
NAQRIQTLPN QNQSQTQPLL KTPPAVLQPI APQTTFGVQT QPQPQSLLQA
260 270 280 290 300
QISAASITPL LQTQPQPLLQ QPQQKAGLLQ PPVRIVSQPQ PARRLDPPSR
310 320 330 340 350
FSGRNDRGDQ VPNRKDDRSR ERERERRRSR ERSPQRKRSR ERSPRRERER
360 370 380 390 400
SPRRVRRVVP RYTVQFSKFS LDCPSCDMME LRRRYQNLYI PSDFFDAQFT
410 420 430 440 450
WVDAFPLSRP FQLGNYCNFY VMHREVESLE KNMAILDPPD ADHLYSAKVM
460 470 480 490 500
LMASPSMEDL YHKSCALAED PQELRDGFQH PARLVKFLVG MKGKDEAMAI
510 520 530 540 550
GGHWSPSLDG PDPEKDPSVL IKTAIRCCKA LTGIDLSVCT QWYRFAEIRY
560 570 580 590 600
HRPEETHKGR TVPAHVETVV LFFPDVWHCL PTRSEWETLS RGYKQQLVEK
610 620 630 640 650
LQGERKEADG EQDEEEKDDG EAKEISTPTH WSKLDPKTMK VNDLRKELES
660 670 680 690 700
RALSSKGLKS QLIARLTKQL KVEEQKEEQK ELEKSEKEED EDDDRKSEDD
710 720 730 740 750
KEEEERKRQE EIERQRRERR YILPDEPAII VHPNWAAKSG KFDCSIMSLS
760 770 780 790 800
VLLDYRLEDN KEHSFEVSLF AELFNEMLQR DFGVRIYKSL LSLPEKEDKK
810 820 830 840 850
EKDKKSKKDE RKDKKEERDD ETDEPKPKRR KSGDDKDKKE DRDERKKEDK
860 870 880 890 900
RKDDSKDDDE TEEDNNQDEY DPMEAEEAED EEDDRDEEEM TKRDDKRDIN
910 920 930 940 950
RYCKERPSKD KEKEKTQMIT INRDLLMAFV YFDQSHCGYL LEKDLEEILY
960 970 980 990 1000
TLGLHLSRAQ VKKLLNKVVL RESCFYRKLT DTSKDEENHE ESESLQEDML
1010 1020 1030 1040 1050
GNRLLLPTPT VKQESKDVEE NVGLIVYNGA MVDVGSLLQK LEKSEKVRAE
1060 1070 1080 1090 1100
VEQKLQLLEE KTDEDEKTIL NLENSNKSLS GELREVKKDL SQLQENLKIS
1110 1120 1130 1140 1150
ENMNLQFENQ MNKTIRNLST VMDEIHTVLK KDNVKNEDKD QKSKENGASV
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGG8 | A0A0C4DGG8_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 1,043 | Annotation score: | ||
F5H2E6 | F5H2E6_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 772 | Annotation score: | ||
F5H3E1 | F5H3E1_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 568 | Annotation score: | ||
F5H1H2 | F5H1H2_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 646 | Annotation score: | ||
H0YFJ7 | H0YFJ7_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 290 | Annotation score: | ||
F5H7M9 | F5H7M9_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 171 | Annotation score: | ||
F5H3I8 | F5H3I8_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 119 | Annotation score: | ||
F5H1L3 | F5H1L3_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 84 | Annotation score: | ||
F5H808 | F5H808_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 95 | Annotation score: | ||
H0YFT7 | H0YFT7_HUMAN | Cell division cycle and apoptosis r... | CCAR1 | 48 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 296 | D → Y in BAA91354 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 305 | N → S in BAG60310 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 492 | K → E in BAA91847 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 618 | D → Y in AAH15475 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 650 | S → G in AAO17319 (Ref. 2) Curated | 1 | |
Sequence conflicti | 650 | S → G in BAA91700 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 723 | L → S in BAF85338 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 801 – 803 | EKD → KKK in AAH89420 (PubMed:15489334).Curated | 3 | |
Sequence conflicti | 816 – 818 | EER → KKK in AAH15475 (PubMed:15489334).Curated | 3 | |
Sequence conflicti | 853 | D → G (PubMed:12816952).Curated | 1 | |
Sequence conflicti | 853 | D → G (Ref. 2) Curated | 1 | |
Sequence conflicti | 853 | D → G in BAA91700 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1104 | N → S (PubMed:12816952).Curated | 1 | |
Sequence conflicti | 1104 | N → S (Ref. 2) Curated | 1 | |
Sequence conflicti | 1104 | N → S in BAA91700 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058330 | 588 | T → I. Corresponds to variant dbSNP:rs1782338Ensembl. | 1 | |
Natural variantiVAR_035497 | 607 | E → K in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_058331 | 681 | E → G. Corresponds to variant dbSNP:rs1060145Ensembl. | 1 | |
Natural variantiVAR_058332 | 747 | M → V. Corresponds to variant dbSNP:rs11542602Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037736 | 83 – 97 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY249140 mRNA Translation: AAP82002.1 AF465616 mRNA Translation: AAO17319.1 AK000741 mRNA Translation: BAA91354.1 Different initiation. AK001452 mRNA Translation: BAA91700.1 AK001701 mRNA Translation: BAA91847.1 AK023438 mRNA Translation: BAB14574.1 AK298004 mRNA Translation: BAG60310.1 AK299307 mRNA Translation: BAG61320.1 AK292649 mRNA Translation: BAF85338.1 AL513534 Genomic DNA No translation available. AL391539 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54302.1 BC015475 mRNA Translation: AAH15475.1 BC026036 mRNA Translation: AAH26036.1 Sequence problems. BC089420 mRNA Translation: AAH89420.1 BC130626 mRNA Translation: AAI30627.1 BC132725 mRNA Translation: AAI32726.1 BC108682 mRNA Translation: AAI08683.1 Sequence problems. |
CCDSi | CCDS60547.1 [Q8IX12-2] CCDS7282.1 [Q8IX12-1] |
RefSeqi | NP_001269888.1, NM_001282959.1 [Q8IX12-2] NP_001269889.1, NM_001282960.1 [Q8IX12-2] NP_060707.2, NM_018237.3 [Q8IX12-1] |
Genome annotation databases
Ensembli | ENST00000265872; ENSP00000265872; ENSG00000060339 ENST00000543719; ENSP00000445254; ENSG00000060339 [Q8IX12-2] |
GeneIDi | 55749 |
KEGGi | hsa:55749 |
MANE-Selecti | ENST00000265872.11; ENSP00000265872.6; NM_018237.4; NP_060707.2 |
UCSCi | uc001joo.5, human [Q8IX12-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY249140 mRNA Translation: AAP82002.1 AF465616 mRNA Translation: AAO17319.1 AK000741 mRNA Translation: BAA91354.1 Different initiation. AK001452 mRNA Translation: BAA91700.1 AK001701 mRNA Translation: BAA91847.1 AK023438 mRNA Translation: BAB14574.1 AK298004 mRNA Translation: BAG60310.1 AK299307 mRNA Translation: BAG61320.1 AK292649 mRNA Translation: BAF85338.1 AL513534 Genomic DNA No translation available. AL391539 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54302.1 BC015475 mRNA Translation: AAH15475.1 BC026036 mRNA Translation: AAH26036.1 Sequence problems. BC089420 mRNA Translation: AAH89420.1 BC130626 mRNA Translation: AAI30627.1 BC132725 mRNA Translation: AAI32726.1 BC108682 mRNA Translation: AAI08683.1 Sequence problems. |
CCDSi | CCDS60547.1 [Q8IX12-2] CCDS7282.1 [Q8IX12-1] |
RefSeqi | NP_001269888.1, NM_001282959.1 [Q8IX12-2] NP_001269889.1, NM_001282960.1 [Q8IX12-2] NP_060707.2, NM_018237.3 [Q8IX12-1] |
3D structure databases
SMRi | Q8IX12 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120867, 107 interactors |
CORUMi | Q8IX12 |
DIPi | DIP-27607N |
IntActi | Q8IX12, 56 interactors |
MINTi | Q8IX12 |
STRINGi | 9606.ENSP00000265872 |
PTM databases
GlyGeni | Q8IX12, 25 sites, 2 O-linked glycans (25 sites) |
iPTMneti | Q8IX12 |
MetOSitei | Q8IX12 |
PhosphoSitePlusi | Q8IX12 |
Genetic variation databases
BioMutai | CCAR1 |
DMDMi | 94707499 |
Proteomic databases
EPDi | Q8IX12 |
jPOSTi | Q8IX12 |
MassIVEi | Q8IX12 |
MaxQBi | Q8IX12 |
PaxDbi | Q8IX12 |
PeptideAtlasi | Q8IX12 |
PRIDEi | Q8IX12 |
ProteomicsDBi | 70961 [Q8IX12-1] 70962 [Q8IX12-2] |
Protocols and materials databases
Antibodypediai | 2118, 202 antibodies from 31 providers |
DNASUi | 55749 |
Genome annotation databases
Ensembli | ENST00000265872; ENSP00000265872; ENSG00000060339 ENST00000543719; ENSP00000445254; ENSG00000060339 [Q8IX12-2] |
GeneIDi | 55749 |
KEGGi | hsa:55749 |
MANE-Selecti | ENST00000265872.11; ENSP00000265872.6; NM_018237.4; NP_060707.2 |
UCSCi | uc001joo.5, human [Q8IX12-1] |
Organism-specific databases
CTDi | 55749 |
DisGeNETi | 55749 |
GeneCardsi | CCAR1 |
HGNCi | HGNC:24236, CCAR1 |
HPAi | ENSG00000060339, Low tissue specificity |
MIMi | 612569, gene |
neXtProti | NX_Q8IX12 |
OpenTargetsi | ENSG00000060339 |
PharmGKBi | PA134920227 |
VEuPathDBi | HostDB:ENSG00000060339 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4246, Eukaryota |
GeneTreei | ENSGT00530000063672 |
InParanoidi | Q8IX12 |
OMAi | LRYSDMH |
OrthoDBi | 614048at2759 |
PhylomeDBi | Q8IX12 |
TreeFami | TF316387 |
Enzyme and pathway databases
PathwayCommonsi | Q8IX12 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
SignaLinki | Q8IX12 |
Miscellaneous databases
BioGRID-ORCSi | 55749, 506 hits in 1052 CRISPR screens |
ChiTaRSi | CCAR1, human |
GeneWikii | CCAR1 |
GenomeRNAii | 55749 |
Pharosi | Q8IX12, Tbio |
PROi | PR:Q8IX12 |
RNActi | Q8IX12, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000060339, Expressed in testis and 217 other tissues |
ExpressionAtlasi | Q8IX12, baseline and differential |
Genevisiblei | Q8IX12, HS |
Family and domain databases
Gene3Di | 1.10.720.30, 1 hit |
InterProi | View protein in InterPro IPR045354, BURAN IPR025224, CCAR1/CCAR2 IPR025954, DBC1/CARP1_inactive_NUDIX_dom IPR011992, EF-hand-dom_pair IPR045353, LAIKA IPR012340, NA-bd_OB-fold IPR025223, S1-like_RNA-bd_dom IPR003034, SAP_dom IPR036361, SAP_dom_sf |
PANTHERi | PTHR14304, PTHR14304, 1 hit |
Pfami | View protein in Pfam PF19257, BURAN, 1 hit PF14443, DBC1, 1 hit PF19256, LAIKA, 1 hit PF14444, S1-like, 1 hit PF02037, SAP, 1 hit |
SMARTi | View protein in SMART SM01122, DBC1, 1 hit SM00513, SAP, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF50249, SSF50249, 1 hit SSF68906, SSF68906, 1 hit |
PROSITEi | View protein in PROSITE PS50800, SAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCAR1_HUMAN | |
Accessioni | Q8IX12Primary (citable) accession number: Q8IX12 Secondary accession number(s): A0JLT7 Q9NWM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | May 2, 2006 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot