UniProtKB - Q8IX07 (FOG1_HUMAN)

BLAST

>sp|Q8IX07|FOG1_HUMAN Zinc finger protein ZFPM1 OS=Homo sapiens OX=9606 GN=ZFPM1 PE=1 SV=2
MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPT
SPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHG
SVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEIHRKDDALWCRVTKPV
PAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDLQLLPQQAGMASILATAVINKDV
FPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAAATDEKPKETYPNERVCPFPQCRKS
CPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHSCGFISTTR
DILYSHLVTNHMVCQPGSKGEIYSPGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGL
APTPSPGLDRKALAEATNGEARAEPLAQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGE
PGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPAS
EILAKMSELVHSRLQQGAGAGAGGAQTGLFPGAPKGATCFECEITFSNVNNYYVHKRLYC
SGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGG
RGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAP
PGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPG
LAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSC
PAAPPPGALGLPAAACPYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGP
SPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTP
SKGTPAPLPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK

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History
Entry version 144 (07 Nov 2018)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger protein ZFPM1

Gene

ZFPM1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	235 – 268	CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	290 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	320 – 342	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	348 – 371	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	571 – 604	CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	677 – 710	CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	811 – 844	CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	854 – 877	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	968 – 1001	CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST	34

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 15920471
metal ion binding Source: UniProtKB-KW
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II activating transcription factor binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 15920471
RNA polymerase II transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11675338
- 15920471
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12483298

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

atrial septum morphogenesis Source: BHF-UCL
atrioventricular valve morphogenesis Source: BHF-UCL
blood coagulation Source: Reactome
cardiac muscle tissue morphogenesis Source: BHF-UCL
definitive erythrocyte differentiation Source: Ensembl
embryonic hemopoiesis Source: BHF-UCL
erythrocyte differentiation Source: BHF-UCL
granulocyte differentiation Source: Ensembl
heart development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
megakaryocyte development Source: Ensembl
megakaryocyte differentiation Source: BHF-UCL
mitral valve formation Source: BHF-UCL
negative regulation of fat cell differentiation Source: BHF-UCL
negative regulation of interleukin-4 biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 21646796
negative regulation of mast cell differentiation Source: BHF-UCL
negative regulation of protein binding Source: BHF-UCL
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 15920471
outflow tract morphogenesis Source: BHF-UCL
platelet formation
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 11675338
positive regulation of interferon-gamma biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 21646796
primitive erythrocyte differentiation Source: Ensembl
regulation of chemokine production Source: Ensembl
regulation of definitive erythrocyte differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15920471
regulation of megakaryocyte differentiation Source: Reactome
T-helper cell lineage commitment
Source: BHF-UCL
Inferred by curatorⁱ
- 21646796
transcriptional activation by promoter-enhancer looping Source: BHF-UCL
tricuspid valve formation Source: BHF-UCL
ventricular septum morphogenesis Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORⁱ	Q8IX07

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein ZFPM1 Alternative name(s): Friend of GATA protein 1 Short name: FOG-1 Short name: Friend of GATA 1 Zinc finger protein 89A Zinc finger protein multitype 1
Gene namesⁱ	Name:ZFPM1 Synonyms:FOG1, ZFN89A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179588.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19762 ZFPM1
MIMⁱ	601950 gene
neXtProtⁱ	NX_Q8IX07

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	161882
Open Targets More...OpenTargetsⁱ	ENSG00000179588
PharmGKBⁱ	PA134920282

Polymorphism and mutation databases

BioMutaⁱ	ZFPM1
DMDMⁱ	296434508

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000221041	1 – 1006	Zinc finger protein ZFPM1Add BLAST		1006

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	84	PhosphoserineCombined sources	1
Modified residueⁱ	128	PhosphoserineBy similarity	1
Modified residueⁱ	272	PhosphoserineCombined sources	1
Modified residueⁱ	384	PhosphoserineCombined sources	1
Modified residueⁱ	491	PhosphoserineBy similarity	1
Modified residueⁱ	494	PhosphoserineCombined sources	1
Modified residueⁱ	638	PhosphoserineCombined sources	1
Modified residueⁱ	671	PhosphoserineCombined sources	1
Modified residueⁱ	786	PhosphoserineCombined sources	1
Modified residueⁱ	901	PhosphoserineCombined sources	1
Modified residueⁱ	909	PhosphoserineCombined sources	1
Modified residueⁱ	914	PhosphoserineCombined sources	1
Modified residueⁱ	935	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8IX07
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8IX07
PaxDbⁱ	Q8IX07
PeptideAtlas More...PeptideAtlasⁱ	Q8IX07
PRIDEⁱ	Q8IX07
ProteomicsDBⁱ	70959

PTM databases

iPTMnetⁱ	Q8IX07
PhosphoSitePlusⁱ	Q8IX07

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000179588 Expressed in 173 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_ZFPM1
ExpressionAtlasⁱ	Q8IX07 baseline and differential
Genevisibleⁱ	Q8IX07 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046603

HPAⁱ

HPA046603

Interactionⁱ

Subunit structureⁱ

Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
GATA1	P15976	2	EBI-3942619,EBI-3909284
GSK3B	P49841	2	EBI-3942619,EBI-373586
RBBP4	Q09028	4	EBI-3942619,EBI-620823

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127806, 10 interactors
Database of interacting proteins More...DIPⁱ	DIP-48415N
ELMⁱ	Q8IX07
IntActⁱ	Q8IX07, 4 interactors
STRINGⁱ	9606.ENSP00000326630

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8IX07
SMRⁱ	Q8IX07
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	330 – 341	Interaction with TACC3By similarityAdd BLAST		12
Regionⁱ	794 – 800	Interaction with CTBP2By similarity		7

Domainⁱ

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	235 – 268	CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	290 – 314	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	320 – 342	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	348 – 371	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	571 – 604	CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	677 – 710	CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	811 – 844	CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST	34
Zinc fingerⁱ	854 – 877	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	968 – 1001	CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST	34

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063823
HOGENOMⁱ	HOG000112626
HOVERGENⁱ	HBG101018
InParanoidⁱ	Q8IX07
KEGG Orthology (KO) More...KOⁱ	K17441
OMAⁱ	DVNEEHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00RC
PhylomeDBⁱ	Q8IX07
TreeFamⁱ	TF331342

Family and domain databases

InterProⁱ	View protein in InterPro IPR039746 FOG IPR034731 ZF_CCHC_FOG IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR12958 PTHR12958, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS51810 ZF_CCHC_FOG, 5 hits PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q8IX07-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSRRKQSNPR QIKRSLGDME AREEVQLVGA SHMEQKATAP EAPSPPSADV 
        60         70         80         90        100
NSPPPLPPPT SPGGPKELEG QEPEPRPTEE EPGSPWSGPD ELEPVVQDGQ 
       110        120        130        140        150
RRIRARLSLA TGLSWGPFHG SVQTRASSPR QAEPSPALTL LLVDEACWLR 
       160        170        180        190        200
TLPQALTEAE ANTEIHRKDD ALWCRVTKPV PAGGLLSVLL TAEPHSTPGH 
       210        220        230        240        250
PVKKEPAEPT CPAPAHDLQL LPQQAGMASI LATAVINKDV FPCKDCGIWY 
       260        270        280        290        300
RSERNLQAHL LYYCASRQGT GSPAAAATDE KPKETYPNER VCPFPQCRKS 
       310        320        330        340        350
CPSASSLEIH MRSHSGERPF VCLICLSAFT TKANCERHLK VHTDTLSGVC 
       360        370        380        390        400
HSCGFISTTR DILYSHLVTN HMVCQPGSKG EIYSPGAGHP ATKLPPDSLG 
       410        420        430        440        450
SFQQQHTALQ GPLASADLGL APTPSPGLDR KALAEATNGE ARAEPLAQNG 
       460        470        480        490        500
GSSEPPAAPR SIKVEAVEEP EAAPILGPGE PGPQAPSRTP SPRSPAPARV 
       510        520        530        540        550
KAELSSPTPG SSPVPGELGL AGALFLPQYV FGPDAAPPAS EILAKMSELV 
       560        570        580        590        600
HSRLQQGAGA GAGGAQTGLF PGAPKGATCF ECEITFSNVN NYYVHKRLYC 
       610        620        630        640        650
SGRRAPEDAP AARRPKAPPG PARAPPGQPA EPDAPRSSPG PGAREEGAGG 
       660        670        680        690        700
AATPEDGAGG RGSEGSQSPG SSVDDAEDDP SRTLCEACNI RFSRHETYTV 
       710        720        730        740        750
HKRYYCASRH DPPPRRPAAP PGPPGPAAPP APSPAAPVRT RRRRKLYELH 
       760        770        780        790        800
AAGAPPPPPP GHAPAPESPR PGSGSGSGPG LAPARSPGPA ADGPIDLSKK 
       810        820        830        840        850
PRRPLPGAPA PALADYHECT ACRVSFHSLE AYLAHKKYSC PAAPPPGALG 
       860        870        880        890        900
LPAAACPYCP PNGPVRGDLL EHFRLAHGLL LGAPLAGPGV EARTPADRGP 
       910        920        930        940        950
SPAPAPAASP QPGSRGPRDG LGPEPQEPPP GPPPSPAAAP EAVPPPPAPP 
       960        970        980        990       1000
SYSDKGVQTP SKGTPAPLPN GNHRYCRLCN IKFSSLSTFI AHKKYYCSSH 

AAEHVK

Length:1,006

Mass (Da):104,888

Last modified:May 18, 2010 - v2

Checksum:ⁱE9C2363503A64898

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WZP1	A0A087WZP1_HUMAN	Zinc finger protein ZFPM1 Zinc finger protein ZFPM1 (Zinc finger protein, multitype 1, isoform CRA_c)	ZFPM1 hCG_1811670	158	Annotation score:
A0A087WWQ0	A0A087WWQ0_HUMAN	Zinc finger protein ZFPM1 Zinc finger protein ZFPM1 (Zinc finger protein, multitype 1, isoform CRA_b)	ZFPM1 hCG_1811670	151	Annotation score:
A0A087X1H8	A0A087X1H8_HUMAN	Zinc finger protein ZFPM1 Zinc finger protein ZFPM1	ZFPM1	117	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	22	R → G in AAN45858 (PubMed:12483298).Curated		1
Sequence conflictⁱ	444 – 447	EPLA → AP in AAN45858 (PubMed:12483298).Curated		4

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_057491	70	G → A. Corresponds to variant dbSNP:rs34916016Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF488691 mRNA Translation: AAN45858.1 AC116552 Genomic DNA No translation available. AC135049 Genomic DNA No translation available. CH471184 Genomic DNA Translation: EAW66806.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32502.1
NCBI Reference Sequences More...RefSeqⁱ	NP_722520.2, NM_153813.2
UniGeneⁱ	Hs.632218

Genome annotation databases

Ensemblⁱ	ENST00000319555; ENSP00000326630; ENSG00000179588
GeneIDⁱ	161882
KEGGⁱ	hsa:161882
UCSC genome browser More...UCSCⁱ	uc002fkv.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8IX07	Uncharacterized protein		PAPAN		1002	UniRef90_Q8IX07
Uncharacterized protein		Cebus capucinus imitator		1001
ZFPM1 isoform 1		PANTR		997
Zinc finger protein, FOG family member 1		CHLSB		992
Uncharacterized protein		MACNE		976
+18

Protein	Similar proteins		Species	Score	Length	Source
Q8IX07	Zinc finger protein ZFPM1	)	MOUSE		995	UniRef50_O35615
Zinc finger protein, multitype 1		RAT		997
Uncharacterized protein		FELCA		992
Uncharacterized protein		PAPAN		1002
Uncharacterized protein		Cebus capucinus imitator		1001
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF488691 mRNA Translation: AAN45858.1 AC116552 Genomic DNA No translation available. AC135049 Genomic DNA No translation available. CH471184 Genomic DNA Translation: EAW66806.1
CCDSⁱ	CCDS32502.1
RefSeqⁱ	NP_722520.2, NM_153813.2
UniGeneⁱ	Hs.632218

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2XU7	X-ray	1.90	C/D	1-15	[»]
ProteinModelPortalⁱ	Q8IX07
SMRⁱ	Q8IX07
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127806, 10 interactors
DIPⁱ	DIP-48415N
ELMⁱ	Q8IX07
IntActⁱ	Q8IX07, 4 interactors
STRINGⁱ	9606.ENSP00000326630

PTM databases

iPTMnetⁱ	Q8IX07
PhosphoSitePlusⁱ	Q8IX07

Polymorphism and mutation databases

BioMutaⁱ	ZFPM1
DMDMⁱ	296434508

Proteomic databases

EPDⁱ	Q8IX07
MaxQBⁱ	Q8IX07
PaxDbⁱ	Q8IX07
PeptideAtlasⁱ	Q8IX07
PRIDEⁱ	Q8IX07
ProteomicsDBⁱ	70959

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000319555; ENSP00000326630; ENSG00000179588
GeneIDⁱ	161882
KEGGⁱ	hsa:161882
UCSCⁱ	uc002fkv.4 human

Organism-specific databases

CTDⁱ	161882
DisGeNETⁱ	161882
EuPathDBⁱ	HostDB:ENSG00000179588.8
GeneCardsⁱ	ZFPM1
HGNCⁱ	HGNC:19762 ZFPM1
HPAⁱ	HPA046603
MIMⁱ	601950 gene
neXtProtⁱ	NX_Q8IX07
OpenTargetsⁱ	ENSG00000179588
PharmGKBⁱ	PA134920282
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063823
HOGENOMⁱ	HOG000112626
HOVERGENⁱ	HBG101018
InParanoidⁱ	Q8IX07
KOⁱ	K17441
OMAⁱ	DVNEEHY
OrthoDBⁱ	EOG091G00RC
PhylomeDBⁱ	Q8IX07
TreeFamⁱ	TF331342

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORⁱ	Q8IX07

Miscellaneous databases

ChiTaRSⁱ	ZFPM1 human
GeneWikiⁱ	ZFPM1
GenomeRNAiⁱ	161882
Protein Ontology More...PROⁱ	PR:Q8IX07
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179588 Expressed in 173 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_ZFPM1
ExpressionAtlasⁱ	Q8IX07 baseline and differential
Genevisibleⁱ	Q8IX07 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR039746 FOG IPR034731 ZF_CCHC_FOG IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR12958 PTHR12958, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 9 hits
SUPFAMⁱ	SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS51810 ZF_CCHC_FOG, 5 hits PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOG1_HUMAN
Accessionⁱ	Q8IX07Primary (citable) accession number: Q8IX07
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - Q8IX07 (FOG1_HUMAN)

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Zinc finger protein ZFPM1

ZFPM1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ