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Protein

Zinc finger protein ZFPM1

Gene

ZFPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri235 – 268CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri290 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri320 – 342C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri571 – 604CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri677 – 710CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri811 – 844CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri854 – 877C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri968 – 1001CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiQ8IX07

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFPM1
Alternative name(s):
Friend of GATA protein 1
Short name:
FOG-1
Short name:
Friend of GATA 1
Zinc finger protein 89A
Zinc finger protein multitype 1
Gene namesi
Name:ZFPM1
Synonyms:FOG1, ZFN89A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000179588.8
HGNCiHGNC:19762 ZFPM1
MIMi601950 gene
neXtProtiNX_Q8IX07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi161882
OpenTargetsiENSG00000179588
PharmGKBiPA134920282

Polymorphism and mutation databases

BioMutaiZFPM1
DMDMi296434508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002210411 – 1006Zinc finger protein ZFPM1Add BLAST1006

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineCombined sources1
Modified residuei128PhosphoserineBy similarity1
Modified residuei272PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei491PhosphoserineBy similarity1
Modified residuei494PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei786PhosphoserineCombined sources1
Modified residuei901PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei935PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IX07
MaxQBiQ8IX07
PaxDbiQ8IX07
PeptideAtlasiQ8IX07
PRIDEiQ8IX07
ProteomicsDBi70959

PTM databases

iPTMnetiQ8IX07
PhosphoSitePlusiQ8IX07

Expressioni

Tissue specificityi

Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.1 Publication

Gene expression databases

BgeeiENSG00000179588 Expressed in 173 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_ZFPM1
ExpressionAtlasiQ8IX07 baseline and differential
GenevisibleiQ8IX07 HS

Organism-specific databases

HPAiHPA046603

Interactioni

Subunit structurei

Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127806, 10 interactors
DIPiDIP-48415N
ELMiQ8IX07
IntActiQ8IX07, 4 interactors
STRINGi9606.ENSP00000326630

Structurei

3D structure databases

ProteinModelPortaliQ8IX07
SMRiQ8IX07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni330 – 341Interaction with TACC3By similarityAdd BLAST12
Regioni794 – 800Interaction with CTBP2By similarity7

Domaini

The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).By similarity

Sequence similaritiesi

Belongs to the FOG (Friend of GATA) family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri235 – 268CCHC FOG-type 1PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri290 – 314C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri320 – 342C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri571 – 604CCHC FOG-type 2PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri677 – 710CCHC FOG-type 3PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri811 – 844CCHC FOG-type 4PROSITE-ProRule annotationAdd BLAST34
Zinc fingeri854 – 877C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri968 – 1001CCHC FOG-type 5PROSITE-ProRule annotationAdd BLAST34

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000112626
HOVERGENiHBG101018
InParanoidiQ8IX07
KOiK17441
OMAiDVNEEHY
OrthoDBiEOG091G00RC
PhylomeDBiQ8IX07
TreeFamiTF331342

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8IX07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRKQSNPR QIKRSLGDME AREEVQLVGA SHMEQKATAP EAPSPPSADV
60 70 80 90 100
NSPPPLPPPT SPGGPKELEG QEPEPRPTEE EPGSPWSGPD ELEPVVQDGQ
110 120 130 140 150
RRIRARLSLA TGLSWGPFHG SVQTRASSPR QAEPSPALTL LLVDEACWLR
160 170 180 190 200
TLPQALTEAE ANTEIHRKDD ALWCRVTKPV PAGGLLSVLL TAEPHSTPGH
210 220 230 240 250
PVKKEPAEPT CPAPAHDLQL LPQQAGMASI LATAVINKDV FPCKDCGIWY
260 270 280 290 300
RSERNLQAHL LYYCASRQGT GSPAAAATDE KPKETYPNER VCPFPQCRKS
310 320 330 340 350
CPSASSLEIH MRSHSGERPF VCLICLSAFT TKANCERHLK VHTDTLSGVC
360 370 380 390 400
HSCGFISTTR DILYSHLVTN HMVCQPGSKG EIYSPGAGHP ATKLPPDSLG
410 420 430 440 450
SFQQQHTALQ GPLASADLGL APTPSPGLDR KALAEATNGE ARAEPLAQNG
460 470 480 490 500
GSSEPPAAPR SIKVEAVEEP EAAPILGPGE PGPQAPSRTP SPRSPAPARV
510 520 530 540 550
KAELSSPTPG SSPVPGELGL AGALFLPQYV FGPDAAPPAS EILAKMSELV
560 570 580 590 600
HSRLQQGAGA GAGGAQTGLF PGAPKGATCF ECEITFSNVN NYYVHKRLYC
610 620 630 640 650
SGRRAPEDAP AARRPKAPPG PARAPPGQPA EPDAPRSSPG PGAREEGAGG
660 670 680 690 700
AATPEDGAGG RGSEGSQSPG SSVDDAEDDP SRTLCEACNI RFSRHETYTV
710 720 730 740 750
HKRYYCASRH DPPPRRPAAP PGPPGPAAPP APSPAAPVRT RRRRKLYELH
760 770 780 790 800
AAGAPPPPPP GHAPAPESPR PGSGSGSGPG LAPARSPGPA ADGPIDLSKK
810 820 830 840 850
PRRPLPGAPA PALADYHECT ACRVSFHSLE AYLAHKKYSC PAAPPPGALG
860 870 880 890 900
LPAAACPYCP PNGPVRGDLL EHFRLAHGLL LGAPLAGPGV EARTPADRGP
910 920 930 940 950
SPAPAPAASP QPGSRGPRDG LGPEPQEPPP GPPPSPAAAP EAVPPPPAPP
960 970 980 990 1000
SYSDKGVQTP SKGTPAPLPN GNHRYCRLCN IKFSSLSTFI AHKKYYCSSH

AAEHVK
Length:1,006
Mass (Da):104,888
Last modified:May 18, 2010 - v2
Checksum:iE9C2363503A64898
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZP1A0A087WZP1_HUMAN
Zinc finger protein ZFPM1
ZFPM1 hCG_1811670
158Annotation score:
A0A087WWQ0A0A087WWQ0_HUMAN
Zinc finger protein ZFPM1
ZFPM1 hCG_1811670
151Annotation score:
A0A087X1H8A0A087X1H8_HUMAN
Zinc finger protein ZFPM1
ZFPM1
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22R → G in AAN45858 (PubMed:12483298).Curated1
Sequence conflicti444 – 447EPLA → AP in AAN45858 (PubMed:12483298).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05749170G → A. Corresponds to variant dbSNP:rs34916016Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488691 mRNA Translation: AAN45858.1
AC116552 Genomic DNA No translation available.
AC135049 Genomic DNA No translation available.
CH471184 Genomic DNA Translation: EAW66806.1
CCDSiCCDS32502.1
RefSeqiNP_722520.2, NM_153813.2
UniGeneiHs.632218

Genome annotation databases

EnsembliENST00000319555; ENSP00000326630; ENSG00000179588
GeneIDi161882
KEGGihsa:161882
UCSCiuc002fkv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF488691 mRNA Translation: AAN45858.1
AC116552 Genomic DNA No translation available.
AC135049 Genomic DNA No translation available.
CH471184 Genomic DNA Translation: EAW66806.1
CCDSiCCDS32502.1
RefSeqiNP_722520.2, NM_153813.2
UniGeneiHs.632218

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XU7X-ray1.90C/D1-15[»]
ProteinModelPortaliQ8IX07
SMRiQ8IX07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127806, 10 interactors
DIPiDIP-48415N
ELMiQ8IX07
IntActiQ8IX07, 4 interactors
STRINGi9606.ENSP00000326630

PTM databases

iPTMnetiQ8IX07
PhosphoSitePlusiQ8IX07

Polymorphism and mutation databases

BioMutaiZFPM1
DMDMi296434508

Proteomic databases

EPDiQ8IX07
MaxQBiQ8IX07
PaxDbiQ8IX07
PeptideAtlasiQ8IX07
PRIDEiQ8IX07
ProteomicsDBi70959

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319555; ENSP00000326630; ENSG00000179588
GeneIDi161882
KEGGihsa:161882
UCSCiuc002fkv.4 human

Organism-specific databases

CTDi161882
DisGeNETi161882
EuPathDBiHostDB:ENSG00000179588.8
GeneCardsiZFPM1
HGNCiHGNC:19762 ZFPM1
HPAiHPA046603
MIMi601950 gene
neXtProtiNX_Q8IX07
OpenTargetsiENSG00000179588
PharmGKBiPA134920282
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063823
HOGENOMiHOG000112626
HOVERGENiHBG101018
InParanoidiQ8IX07
KOiK17441
OMAiDVNEEHY
OrthoDBiEOG091G00RC
PhylomeDBiQ8IX07
TreeFamiTF331342

Enzyme and pathway databases

ReactomeiR-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiQ8IX07

Miscellaneous databases

ChiTaRSiZFPM1 human
GeneWikiiZFPM1
GenomeRNAii161882
PROiPR:Q8IX07
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179588 Expressed in 173 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_ZFPM1
ExpressionAtlasiQ8IX07 baseline and differential
GenevisibleiQ8IX07 HS

Family and domain databases

InterProiView protein in InterPro
IPR039746 FOG
IPR034731 ZF_CCHC_FOG
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR12958 PTHR12958, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS51810 ZF_CCHC_FOG, 5 hits
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFOG1_HUMAN
AccessioniPrimary (citable) accession number: Q8IX07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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