Zinc finger protein ZFPM1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II activating transcription factor binding Source: Ensembl
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "X-linked thrombocytopenia caused by a novel mutation of GATA-1."
    Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G.
    Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.1

    "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GATA1 AND GATA2.

GO - Biological processⁱ

• T-helper cell lineage commitment Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Zinc finger protein, multitype 1, suppresses human Th2 development via downregulation of IL-4."
    Kitamura N., Mori A., Tatsumi H., Nemoto S., Hiroi T., Kaminuma O.
    Int. Arch. Allergy Immunol. 155 Suppl 1:53-56(2011) [PubMed] [Europe PMC] [Abstract]
• atrial septum morphogenesis Source: BHF-UCL
• atrioventricular valve morphogenesis Source: BHF-UCL
• blood coagulation Source: Reactome
• cardiac muscle tissue morphogenesis Source: BHF-UCL
• definitive erythrocyte differentiation Source: Ensembl
• embryonic hemopoiesis Source: BHF-UCL
• erythrocyte differentiation Source: BHF-UCL
• granulocyte differentiation Source: Ensembl
• heart development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• megakaryocyte development Source: Ensembl
• megakaryocyte differentiation Source: BHF-UCL
• mitral valve formation Source: BHF-UCL
• negative regulation of fat cell differentiation Source: BHF-UCL
• negative regulation of interleukin-4 biosynthetic process Source: BHF-UCLInferred from direct assayⁱ
  • "Zinc finger protein, multitype 1, suppresses human Th2 development via downregulation of IL-4."
    Kitamura N., Mori A., Tatsumi H., Nemoto S., Hiroi T., Kaminuma O.
    Int. Arch. Allergy Immunol. 155 Suppl 1:53-56(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mast cell differentiation Source: BHF-UCL
• negative regulation of protein binding Source: BHF-UCL
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from genetic interactionⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: BHF-UCL
• platelet formation Source: BHF-UCLInferred from genetic interactionⁱ
  • "X-linked thrombocytopenia caused by a novel mutation of GATA-1."
    Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G.
    Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma biosynthetic process Source: BHF-UCLInferred from direct assayⁱ
  • "Zinc finger protein, multitype 1, suppresses human Th2 development via downregulation of IL-4."
    Kitamura N., Mori A., Tatsumi H., Nemoto S., Hiroi T., Kaminuma O.
    Int. Arch. Allergy Immunol. 155 Suppl 1:53-56(2011) [PubMed] [Europe PMC] [Abstract]
• primitive erythrocyte differentiation Source: Ensembl
• regulation of chemokine production Source: Ensembl
• regulation of definitive erythrocyte differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of megakaryocyte differentiation Source: Reactome
• transcriptional activation by promoter-enhancer looping Source: BHF-UCL
• tricuspid valve formation Source: BHF-UCL
• ventricular septum morphogenesis Source: BHF-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• RNA polymerase II activating transcription factor binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "X-linked thrombocytopenia caused by a novel mutation of GATA-1."
    Mehaffey M.G., Newton A.L., Gandhi M.J., Crossley M., Drachman J.G.
    Blood 98:2681-2688(2001) [PubMed] [Europe PMC] [Abstract]
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • Ref.1

    "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions."
    Freson K., Thys C., Wittewrongel C., Vermylen J., Hoylaerts M.F., Van Geet C.
    Hum. Genet. 112:42-49(2003) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH GATA1 AND GATA2.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSRRKQSNPR QIKRSLGDME AREEVQLVGA SHMEQKATAP EAPSPPSADV 
        60         70         80         90        100
NSPPPLPPPT SPGGPKELEG QEPEPRPTEE EPGSPWSGPD ELEPVVQDGQ 
       110        120        130        140        150
RRIRARLSLA TGLSWGPFHG SVQTRASSPR QAEPSPALTL LLVDEACWLR 
       160        170        180        190        200
TLPQALTEAE ANTEIHRKDD ALWCRVTKPV PAGGLLSVLL TAEPHSTPGH 
       210        220        230        240        250
PVKKEPAEPT CPAPAHDLQL LPQQAGMASI LATAVINKDV FPCKDCGIWY 
       260        270        280        290        300
RSERNLQAHL LYYCASRQGT GSPAAAATDE KPKETYPNER VCPFPQCRKS 
       310        320        330        340        350
CPSASSLEIH MRSHSGERPF VCLICLSAFT TKANCERHLK VHTDTLSGVC 
       360        370        380        390        400
HSCGFISTTR DILYSHLVTN HMVCQPGSKG EIYSPGAGHP ATKLPPDSLG 
       410        420        430        440        450
SFQQQHTALQ GPLASADLGL APTPSPGLDR KALAEATNGE ARAEPLAQNG 
       460        470        480        490        500
GSSEPPAAPR SIKVEAVEEP EAAPILGPGE PGPQAPSRTP SPRSPAPARV 
       510        520        530        540        550
KAELSSPTPG SSPVPGELGL AGALFLPQYV FGPDAAPPAS EILAKMSELV 
       560        570        580        590        600
HSRLQQGAGA GAGGAQTGLF PGAPKGATCF ECEITFSNVN NYYVHKRLYC 
       610        620        630        640        650
SGRRAPEDAP AARRPKAPPG PARAPPGQPA EPDAPRSSPG PGAREEGAGG 
       660        670        680        690        700
AATPEDGAGG RGSEGSQSPG SSVDDAEDDP SRTLCEACNI RFSRHETYTV 
       710        720        730        740        750
HKRYYCASRH DPPPRRPAAP PGPPGPAAPP APSPAAPVRT RRRRKLYELH 
       760        770        780        790        800
AAGAPPPPPP GHAPAPESPR PGSGSGSGPG LAPARSPGPA ADGPIDLSKK 
       810        820        830        840        850
PRRPLPGAPA PALADYHECT ACRVSFHSLE AYLAHKKYSC PAAPPPGALG 
       860        870        880        890        900
LPAAACPYCP PNGPVRGDLL EHFRLAHGLL LGAPLAGPGV EARTPADRGP 
       910        920        930        940        950
SPAPAPAASP QPGSRGPRDG LGPEPQEPPP GPPPSPAAAP EAVPPPPAPP 
       960        970        980        990       1000
SYSDKGVQTP SKGTPAPLPN GNHRYCRLCN IKFSSLSTFI AHKKYYCSSH 

AAEHVK                                                 

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. Human chromosome 16
   Human chromosome 16: entries, gene names and cross-references to MIM