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Protein

CD302 antigen

Gene

CD302

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.1 Publication

Miscellaneous

Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

GO - Molecular functioni

GO - Biological processi

  • phagocytosis Source: MGI

Keywordsi

Molecular functionReceptor
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
CD302 antigen
Alternative name(s):
C-type lectin BIMLEC
C-type lectin domain family 13 member A
DEC205-associated C-type lectin 1
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen: CD302
Gene namesi
Name:CD302
Synonyms:CLEC13A, DCL1, KIAA0022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000241399.6
HGNCiHGNC:30843 CD302
MIMi612246 gene
neXtProtiNX_Q8IX05

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 168ExtracellularSequence analysisAdd BLAST146
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 232CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9936
OpenTargetsiENSG00000241399
PharmGKBiPA142672141

Polymorphism and mutation databases

BioMutaiCD302
DMDMi74750720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025233223 – 232CD302 antigenAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 143PROSITE-ProRule annotation

Post-translational modificationi

May be heterogeneously N-glycosylated in some cell types.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8IX05
PaxDbiQ8IX05
PeptideAtlasiQ8IX05
PRIDEiQ8IX05
ProteomicsDBi70957

PTM databases

iPTMnetiQ8IX05
PhosphoSitePlusiQ8IX05

Expressioni

Tissue specificityi

Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.2 Publications

Developmental stagei

Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain.1 Publication

Gene expression databases

BgeeiENSG00000241399 Expressed in 228 organ(s), highest expression level in liver
CleanExiHS_CD302
ExpressionAtlasiQ8IX05 baseline and differential
GenevisibleiQ8IX05 HS

Interactioni

Protein-protein interaction databases

BioGridi115262, 2 interactors
IntActiQ8IX05, 7 interactors
STRINGi9606.ENSP00000259053

Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IX05
SMRiQ8IX05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 152C-type lectinPROSITE-ProRule annotationAdd BLAST121

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS40 Eukaryota
ENOG41126J3 LUCA
GeneTreeiENSGT00680000100098
HOGENOMiHOG000232049
HOVERGENiHBG080529
InParanoidiQ8IX05
KOiK06722
OrthoDBiEOG091G0PMQ
PhylomeDBiQ8IX05

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE
60 70 80 90 100
DVRNQCTDHG ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA
110 120 130 140 150
SFKWFDNSNM TFDKWTDQDD DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG
160 170 180 190 200
TLCKTAIPYK RKYLSDNHIL ISALVIASTV ILTVLGAIIW FLYKKHSDSR
210 220 230
FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD
Note: Produced by intergenic splicing of LY75 and CD302.
Length:232
Mass (Da):26,183
Last modified:March 1, 2003 - v1
Checksum:i5C33C708345C3971
GO
Isoform 4 (identifier: O60449-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,722
Mass (Da):198,311
GO
Isoform 5 (identifier: Q8IX05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-156: Missing.
     157-157: I → V

Show »
Length:174
Mass (Da):19,562
Checksum:iAF737C517D8B6931
GO
Isoform 2 (identifier: O60449-2) [UniParc]FASTAAdd to basket
Also known as: Fusion protein variant V34-2
The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by intergenic splicing of LY75 and CD302.
Length:1,873
Mass (Da):215,781
GO
Isoform 3 (identifier: O60449-3) [UniParc]FASTAAdd to basket
Also known as: Fusion protein variant V33-2
The sequence of this isoform can be found in the external entry O60449.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by intergenic splicing of LY75 and CD302.
Length:1,817
Mass (Da):209,438
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT00A0A087WT00_HUMAN
CD302 antigen
CD302
195Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139K → R in BAF83968 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050101200R → S. Corresponds to variant dbSNP:rs34068933Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04425899 – 156Missing in isoform 5. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_044259157I → V in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314007 mRNA Translation: AAP79900.1
AF499000 mRNA Translation: AAN77050.1
AK291279 mRNA Translation: BAF83968.1
AK304422 mRNA Translation: BAG65251.1
AC009961 Genomic DNA Translation: AAY14942.1
D14664 mRNA Translation: BAA03498.1
BC020646 mRNA Translation: AAH20646.1
CCDSiCCDS33308.1 [Q8IX05-1]
CCDS56139.1 [Q8IX05-2]
RefSeqiNP_001185692.1, NM_001198763.1 [Q8IX05-2]
NP_055695.2, NM_014880.4 [Q8IX05-1]
UniGeneiHs.130014
Hs.153563

Genome annotation databases

EnsembliENST00000259053; ENSP00000259053; ENSG00000241399 [Q8IX05-1]
ENST00000429078; ENSP00000394301; ENSG00000241399 [Q8IX05-2]
GeneIDi9936
KEGGihsa:9936
UCSCiuc002uba.4 human [Q8IX05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY314007 mRNA Translation: AAP79900.1
AF499000 mRNA Translation: AAN77050.1
AK291279 mRNA Translation: BAF83968.1
AK304422 mRNA Translation: BAG65251.1
AC009961 Genomic DNA Translation: AAY14942.1
D14664 mRNA Translation: BAA03498.1
BC020646 mRNA Translation: AAH20646.1
CCDSiCCDS33308.1 [Q8IX05-1]
CCDS56139.1 [Q8IX05-2]
RefSeqiNP_001185692.1, NM_001198763.1 [Q8IX05-2]
NP_055695.2, NM_014880.4 [Q8IX05-1]
UniGeneiHs.130014
Hs.153563

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NANNMR-A23-161[»]
ProteinModelPortaliQ8IX05
SMRiQ8IX05
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115262, 2 interactors
IntActiQ8IX05, 7 interactors
STRINGi9606.ENSP00000259053

PTM databases

iPTMnetiQ8IX05
PhosphoSitePlusiQ8IX05

Polymorphism and mutation databases

BioMutaiCD302
DMDMi74750720

Proteomic databases

MaxQBiQ8IX05
PaxDbiQ8IX05
PeptideAtlasiQ8IX05
PRIDEiQ8IX05
ProteomicsDBi70957

Protocols and materials databases

DNASUi9936
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259053; ENSP00000259053; ENSG00000241399 [Q8IX05-1]
ENST00000429078; ENSP00000394301; ENSG00000241399 [Q8IX05-2]
GeneIDi9936
KEGGihsa:9936
UCSCiuc002uba.4 human [Q8IX05-1]

Organism-specific databases

CTDi9936
DisGeNETi9936
EuPathDBiHostDB:ENSG00000241399.6
GeneCardsiCD302
H-InvDBiHIX0002534
HIX0161882
HGNCiHGNC:30843 CD302
MIMi612246 gene
neXtProtiNX_Q8IX05
OpenTargetsiENSG00000241399
PharmGKBiPA142672141
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS40 Eukaryota
ENOG41126J3 LUCA
GeneTreeiENSGT00680000100098
HOGENOMiHOG000232049
HOVERGENiHBG080529
InParanoidiQ8IX05
KOiK06722
OrthoDBiEOG091G0PMQ
PhylomeDBiQ8IX05

Miscellaneous databases

GeneWikiiCD302
GenomeRNAii9936
PROiPR:Q8IX05
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241399 Expressed in 228 organ(s), highest expression level in liver
CleanExiHS_CD302
ExpressionAtlasiQ8IX05 baseline and differential
GenevisibleiQ8IX05 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD302_HUMAN
AccessioniPrimary (citable) accession number: Q8IX05
Secondary accession number(s): A8K5G4, B4E2T9, Q15009
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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