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Protein

Ubiquitin-conjugating enzyme E2 variant 3

Gene

UEVLD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible negative regulator of polyubiquitination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 219NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 3
Short name:
UEV-3
Alternative name(s):
EV and lactate/malate dehydrogenase domain-containing protein
Gene namesi
Name:UEVLDImported
Synonyms:UEV3Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151116.16
HGNCiHGNC:30866 UEVLD
MIMi610985 gene
neXtProtiNX_Q8IX04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55293
OpenTargetsiENSG00000151116
PharmGKBiPA147357188

Polymorphism and mutation databases

BioMutaiUEVLD
DMDMi126253820

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002786511 – 471Ubiquitin-conjugating enzyme E2 variant 3Add BLAST471

Proteomic databases

EPDiQ8IX04
MaxQBiQ8IX04
PaxDbiQ8IX04
PeptideAtlasiQ8IX04
PRIDEiQ8IX04
ProteomicsDBi70952
70953 [Q8IX04-2]
70954 [Q8IX04-3]
70955 [Q8IX04-4]
70956 [Q8IX04-5]

PTM databases

iPTMnetiQ8IX04
PhosphoSitePlusiQ8IX04

Expressioni

Tissue specificityi

Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.1 Publication

Gene expression databases

BgeeiENSG00000151116 Expressed in 213 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_UEVLD
ExpressionAtlasiQ8IX04 baseline and differential
GenevisibleiQ8IX04 HS

Organism-specific databases

HPAiHPA047134

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi120580, 8 interactors
IntActiQ8IX04, 7 interactors
STRINGi9606.ENSP00000379500

Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IX04
SMRiQ8IX04
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX04

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145UEVPROSITE-ProRule annotationAdd BLAST144

Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.Curated
In the C-terminal section; belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
KOG2391 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ8IX04
OMAiKGGTMDL
OrthoDBiEOG091G0HRA
PhylomeDBiQ8IX04
TreeFamiTF314963

Family and domain databases

Gene3Di3.10.110.10, 1 hit
3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PF05743 UEV, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54495 SSF54495, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS51322 UEV, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8IX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK
60 70 80 90 100
DLLNFTGTIP VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG
110 120 130 140 150
KHVDAQGRIY LPYLQNWSHP KSVIVGLIKE MIAKFQEELP MYSLSSSDEA
160 170 180 190 200
RQVDLLAYIA KITEGVSDTN SKSWANHENK TVNKITVVGG GELGIACTLA
210 220 230 240 250
ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL SASAHSKVVI
260 270 280 290 300
FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
310 320 330 340 350
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG
360 370 380 390 400
EDKVLTWSGQ EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS
410 420 430 440 450
IVNNKKKVHS VSALAKGYYD INSEVFLSLP CILGTNGVSE VIKTTLKEDT
460 470
VTEKLQSSAS SIHSLQQQLK L
Length:471
Mass (Da):52,264
Last modified:February 20, 2007 - v2
Checksum:i2502659A566E7DDD
GO
Isoform 21 Publication (identifier: Q8IX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:379
Mass (Da):42,292
Checksum:i100BCD1FA295FC60
GO
Isoform 31 Publication (identifier: Q8IX04-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:357
Mass (Da):39,778
Checksum:iB906E3358B342190
GO
Isoform 4 (identifier: Q8IX04-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:341
Mass (Da):37,611
Checksum:i7D5CD535296471FA
GO
Isoform 5 (identifier: Q8IX04-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-215: GIADRLVLLDL → VESRSVTQAGV
     216-471: Missing.

Show »
Length:215
Mass (Da):24,233
Checksum:iB82D7775A32AAB67
GO
Isoform 6 (identifier: Q8IX04-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.

Note: No experimental confirmation available.
Show »
Length:449
Mass (Da):49,750
Checksum:i2B5D772AEA5B1F51
GO
Isoform 7 (identifier: Q8IX04-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-164: Missing.
     239-295: Missing.
     354-470: VLTWSGQEEV...SIHSLQQQLK → GI

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,240
Checksum:iA8FC6744B9B89325
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MYV4A8MYV4_HUMAN
Ubiquitin-conjugating enzyme E2 var...
UEVLD
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148D → G in BAG59405 (PubMed:14702039).Curated1
Sequence conflicti248V → A in BAG59405 (PubMed:14702039).Curated1
Sequence conflicti366H → L in AAN32950 (PubMed:12427560).Curated1
Sequence conflicti366H → L in BAA91985 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0233461 – 38Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_02334743 – 64Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_04598665 – 164Missing in isoform 7. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_023348205 – 215GIADRLVLLDL → VESRSVTQAGV in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023349216 – 471Missing in isoform 5. 1 PublicationAdd BLAST256
Alternative sequenceiVSP_045987239 – 295Missing in isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_045988354 – 470VLTWS…QQQLK → GI in isoform 7. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_023350376 – 379AMEL → DIMI in isoform 2, isoform 3 and isoform 4. 3 Publications4
Alternative sequenceiVSP_023351380 – 471Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503350 mRNA Translation: AAN32950.1
CR616778 mRNA No translation available.
AK001930 mRNA Translation: BAA91985.1
AK296835 mRNA Translation: BAG59405.1
AK314521 mRNA Translation: BAG37116.1
AC027544 Genomic DNA No translation available.
AC112694 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68380.1
BC011011 mRNA Translation: AAH11011.2
BC064566 mRNA Translation: AAH64566.1
CD109744 mRNA No translation available.
CCDSiCCDS41624.1 [Q8IX04-1]
CCDS58122.1 [Q8IX04-4]
CCDS58123.1 [Q8IX04-3]
CCDS58124.1 [Q8IX04-6]
CCDS58125.1 [Q8IX04-7]
CCDS73266.1 [Q8IX04-5]
CCDS7843.1 [Q8IX04-2]
RefSeqiNP_001035787.1, NM_001040697.2 [Q8IX04-1]
NP_001248311.1, NM_001261382.1 [Q8IX04-6]
NP_001248312.1, NM_001261383.1 [Q8IX04-3]
NP_001248314.1, NM_001261385.1 [Q8IX04-4]
NP_001248315.1, NM_001261386.1 [Q8IX04-7]
NP_001284700.1, NM_001297771.1 [Q8IX04-5]
NP_060784.3, NM_018314.4 [Q8IX04-2]
UniGeneiHs.407991

Genome annotation databases

EnsembliENST00000300038; ENSP00000300038; ENSG00000151116 [Q8IX04-5]
ENST00000320750; ENSP00000323353; ENSG00000151116 [Q8IX04-3]
ENST00000379387; ENSP00000368697; ENSG00000151116 [Q8IX04-6]
ENST00000396197; ENSP00000379500; ENSG00000151116 [Q8IX04-1]
ENST00000535484; ENSP00000441092; ENSG00000151116 [Q8IX04-4]
ENST00000541984; ENSP00000437538; ENSG00000151116 [Q8IX04-7]
ENST00000543987; ENSP00000442974; ENSG00000151116 [Q8IX04-2]
GeneIDi55293
KEGGihsa:55293
UCSCiuc001mot.5 human [Q8IX04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503350 mRNA Translation: AAN32950.1
CR616778 mRNA No translation available.
AK001930 mRNA Translation: BAA91985.1
AK296835 mRNA Translation: BAG59405.1
AK314521 mRNA Translation: BAG37116.1
AC027544 Genomic DNA No translation available.
AC112694 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68380.1
BC011011 mRNA Translation: AAH11011.2
BC064566 mRNA Translation: AAH64566.1
CD109744 mRNA No translation available.
CCDSiCCDS41624.1 [Q8IX04-1]
CCDS58122.1 [Q8IX04-4]
CCDS58123.1 [Q8IX04-3]
CCDS58124.1 [Q8IX04-6]
CCDS58125.1 [Q8IX04-7]
CCDS73266.1 [Q8IX04-5]
CCDS7843.1 [Q8IX04-2]
RefSeqiNP_001035787.1, NM_001040697.2 [Q8IX04-1]
NP_001248311.1, NM_001261382.1 [Q8IX04-6]
NP_001248312.1, NM_001261383.1 [Q8IX04-3]
NP_001248314.1, NM_001261385.1 [Q8IX04-4]
NP_001248315.1, NM_001261386.1 [Q8IX04-7]
NP_001284700.1, NM_001297771.1 [Q8IX04-5]
NP_060784.3, NM_018314.4 [Q8IX04-2]
UniGeneiHs.407991

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6TX-ray2.10A/B171-471[»]
3DL2X-ray2.10A/B171-471[»]
ProteinModelPortaliQ8IX04
SMRiQ8IX04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120580, 8 interactors
IntActiQ8IX04, 7 interactors
STRINGi9606.ENSP00000379500

PTM databases

iPTMnetiQ8IX04
PhosphoSitePlusiQ8IX04

Polymorphism and mutation databases

BioMutaiUEVLD
DMDMi126253820

Proteomic databases

EPDiQ8IX04
MaxQBiQ8IX04
PaxDbiQ8IX04
PeptideAtlasiQ8IX04
PRIDEiQ8IX04
ProteomicsDBi70952
70953 [Q8IX04-2]
70954 [Q8IX04-3]
70955 [Q8IX04-4]
70956 [Q8IX04-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300038; ENSP00000300038; ENSG00000151116 [Q8IX04-5]
ENST00000320750; ENSP00000323353; ENSG00000151116 [Q8IX04-3]
ENST00000379387; ENSP00000368697; ENSG00000151116 [Q8IX04-6]
ENST00000396197; ENSP00000379500; ENSG00000151116 [Q8IX04-1]
ENST00000535484; ENSP00000441092; ENSG00000151116 [Q8IX04-4]
ENST00000541984; ENSP00000437538; ENSG00000151116 [Q8IX04-7]
ENST00000543987; ENSP00000442974; ENSG00000151116 [Q8IX04-2]
GeneIDi55293
KEGGihsa:55293
UCSCiuc001mot.5 human [Q8IX04-1]

Organism-specific databases

CTDi55293
DisGeNETi55293
EuPathDBiHostDB:ENSG00000151116.16
GeneCardsiUEVLD
HGNCiHGNC:30866 UEVLD
HPAiHPA047134
MIMi610985 gene
neXtProtiNX_Q8IX04
OpenTargetsiENSG00000151116
PharmGKBiPA147357188
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
KOG2391 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiQ8IX04
OMAiKGGTMDL
OrthoDBiEOG091G0HRA
PhylomeDBiQ8IX04
TreeFamiTF314963

Miscellaneous databases

ChiTaRSiUEVLD human
EvolutionaryTraceiQ8IX04
GenomeRNAii55293
PROiPR:Q8IX04
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151116 Expressed in 213 organ(s), highest expression level in nasal cavity mucosa
CleanExiHS_UEVLD
ExpressionAtlasiQ8IX04 baseline and differential
GenevisibleiQ8IX04 HS

Family and domain databases

Gene3Di3.10.110.10, 1 hit
3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PF05743 UEV, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54495 SSF54495, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS51322 UEV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUEVLD_HUMAN
AccessioniPrimary (citable) accession number: Q8IX04
Secondary accession number(s): B2RB69
, B4DL43, F5H6L6, H7BYD6, Q6P2F0, Q96FF5, Q9NUX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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