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Entry version 150 (16 Oct 2019)
Sequence version 2 (20 Feb 2007)
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Protein

Ubiquitin-conjugating enzyme E2 variant 3

Gene

UEVLD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible negative regulator of polyubiquitination.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi191 – 219NADBy similarityAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway
LigandNAD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 variant 3
Short name:
UEV-3
Alternative name(s):
EV and lactate/malate dehydrogenase domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UEVLDImported
Synonyms:UEV3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30866 UEVLD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610985 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IX04

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55293

Open Targets

More...
OpenTargetsi
ENSG00000151116

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147357188

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IX04

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UEVLD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126253820

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002786511 – 471Ubiquitin-conjugating enzyme E2 variant 3Add BLAST471

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IX04

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IX04

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IX04

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IX04

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IX04

PeptideAtlas

More...
PeptideAtlasi
Q8IX04

PRoteomics IDEntifications database

More...
PRIDEi
Q8IX04

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
27225
43582
70952 [Q8IX04-1]
70953 [Q8IX04-2]
70954 [Q8IX04-3]
70955 [Q8IX04-4]
70956 [Q8IX04-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IX04

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IX04

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000151116 Expressed in 213 organ(s), highest expression level in nasal cavity mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IX04 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IX04 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047134

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120580, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IX04, 17 interactors

Molecular INTeraction database

More...
MINTi
Q8IX04

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379500

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1471
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IX04

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IX04

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 145UEVPROSITE-ProRule annotationAdd BLAST144

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.Curated
In the C-terminal section; belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1495 Eukaryota
KOG2391 Eukaryota
COG0039 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153903

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000213793

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IX04

Identification of Orthologs from Complete Genome Data

More...
OMAi
PFTPPIC

Database of Orthologous Groups

More...
OrthoDBi
1435538at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IX04

TreeFam database of animal gene trees

More...
TreeFami
TF314963

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.110.10, 1 hit
3.90.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PF05743 UEV, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00086 LLDHDRGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit
SSF54495 SSF54495, 1 hit
SSF56327 SSF56327, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51322 UEV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q8IX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK
60 70 80 90 100
DLLNFTGTIP VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG
110 120 130 140 150
KHVDAQGRIY LPYLQNWSHP KSVIVGLIKE MIAKFQEELP MYSLSSSDEA
160 170 180 190 200
RQVDLLAYIA KITEGVSDTN SKSWANHENK TVNKITVVGG GELGIACTLA
210 220 230 240 250
ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL SASAHSKVVI
260 270 280 290 300
FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
310 320 330 340 350
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG
360 370 380 390 400
EDKVLTWSGQ EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS
410 420 430 440 450
IVNNKKKVHS VSALAKGYYD INSEVFLSLP CILGTNGVSE VIKTTLKEDT
460 470
VTEKLQSSAS SIHSLQQQLK L
Length:471
Mass (Da):52,264
Last modified:February 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2502659A566E7DDD
GO
Isoform 21 Publication (identifier: Q8IX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:379
Mass (Da):42,292
Checksum:i100BCD1FA295FC60
GO
Isoform 31 Publication (identifier: Q8IX04-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:357
Mass (Da):39,778
Checksum:iB906E3358B342190
GO
Isoform 4 (identifier: Q8IX04-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     376-379: AMEL → DIMI
     380-471: Missing.

Show »
Length:341
Mass (Da):37,611
Checksum:i7D5CD535296471FA
GO
Isoform 5 (identifier: Q8IX04-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-215: GIADRLVLLDL → VESRSVTQAGV
     216-471: Missing.

Show »
Length:215
Mass (Da):24,233
Checksum:iB82D7775A32AAB67
GO
Isoform 6 (identifier: Q8IX04-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-64: Missing.

Note: No experimental confirmation available.
Show »
Length:449
Mass (Da):49,750
Checksum:i2B5D772AEA5B1F51
GO
Isoform 7 (identifier: Q8IX04-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-164: Missing.
     239-295: Missing.
     354-470: VLTWSGQEEV...SIHSLQQQLK → GI

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):22,240
Checksum:iA8FC6744B9B89325
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MYV4A8MYV4_HUMAN
Ubiquitin-conjugating enzyme E2 var...
UEVLD
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti148D → G in BAG59405 (PubMed:14702039).Curated1
Sequence conflicti248V → A in BAG59405 (PubMed:14702039).Curated1
Sequence conflicti366H → L in AAN32950 (PubMed:12427560).Curated1
Sequence conflicti366H → L in BAA91985 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233461 – 38Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_02334743 – 64Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST22
Alternative sequenceiVSP_04598665 – 164Missing in isoform 7. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_023348205 – 215GIADRLVLLDL → VESRSVTQAGV in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_023349216 – 471Missing in isoform 5. 1 PublicationAdd BLAST256
Alternative sequenceiVSP_045987239 – 295Missing in isoform 7. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_045988354 – 470VLTWS…QQQLK → GI in isoform 7. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_023350376 – 379AMEL → DIMI in isoform 2, isoform 3 and isoform 4. 3 Publications4
Alternative sequenceiVSP_023351380 – 471Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF503350 mRNA Translation: AAN32950.1
CR616778 mRNA No translation available.
AK001930 mRNA Translation: BAA91985.1
AK296835 mRNA Translation: BAG59405.1
AK314521 mRNA Translation: BAG37116.1
AC027544 Genomic DNA No translation available.
AC112694 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68380.1
BC011011 mRNA Translation: AAH11011.2
BC064566 mRNA Translation: AAH64566.1
CD109744 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41624.1 [Q8IX04-1]
CCDS58122.1 [Q8IX04-4]
CCDS58123.1 [Q8IX04-3]
CCDS58124.1 [Q8IX04-6]
CCDS58125.1 [Q8IX04-7]
CCDS73266.1 [Q8IX04-5]
CCDS7843.1 [Q8IX04-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001035787.1, NM_001040697.2 [Q8IX04-1]
NP_001248311.1, NM_001261382.1 [Q8IX04-6]
NP_001248312.1, NM_001261383.1 [Q8IX04-3]
NP_001248314.1, NM_001261385.1 [Q8IX04-4]
NP_001248315.1, NM_001261386.1 [Q8IX04-7]
NP_001284700.1, NM_001297771.1 [Q8IX04-5]
NP_060784.3, NM_018314.4 [Q8IX04-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300038; ENSP00000300038; ENSG00000151116 [Q8IX04-5]
ENST00000320750; ENSP00000323353; ENSG00000151116 [Q8IX04-3]
ENST00000379387; ENSP00000368697; ENSG00000151116 [Q8IX04-6]
ENST00000396197; ENSP00000379500; ENSG00000151116 [Q8IX04-1]
ENST00000535484; ENSP00000441092; ENSG00000151116 [Q8IX04-4]
ENST00000541984; ENSP00000437538; ENSG00000151116 [Q8IX04-7]
ENST00000543987; ENSP00000442974; ENSG00000151116 [Q8IX04-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55293

UCSC genome browser

More...
UCSCi
uc001mot.5 human [Q8IX04-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503350 mRNA Translation: AAN32950.1
CR616778 mRNA No translation available.
AK001930 mRNA Translation: BAA91985.1
AK296835 mRNA Translation: BAG59405.1
AK314521 mRNA Translation: BAG37116.1
AC027544 Genomic DNA No translation available.
AC112694 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68380.1
BC011011 mRNA Translation: AAH11011.2
BC064566 mRNA Translation: AAH64566.1
CD109744 mRNA No translation available.
CCDSiCCDS41624.1 [Q8IX04-1]
CCDS58122.1 [Q8IX04-4]
CCDS58123.1 [Q8IX04-3]
CCDS58124.1 [Q8IX04-6]
CCDS58125.1 [Q8IX04-7]
CCDS73266.1 [Q8IX04-5]
CCDS7843.1 [Q8IX04-2]
RefSeqiNP_001035787.1, NM_001040697.2 [Q8IX04-1]
NP_001248311.1, NM_001261382.1 [Q8IX04-6]
NP_001248312.1, NM_001261383.1 [Q8IX04-3]
NP_001248314.1, NM_001261385.1 [Q8IX04-4]
NP_001248315.1, NM_001261386.1 [Q8IX04-7]
NP_001284700.1, NM_001297771.1 [Q8IX04-5]
NP_060784.3, NM_018314.4 [Q8IX04-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6TX-ray2.10A/B171-471[»]
3DL2X-ray2.10A/B171-471[»]
SMRiQ8IX04
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120580, 9 interactors
IntActiQ8IX04, 17 interactors
MINTiQ8IX04
STRINGi9606.ENSP00000379500

PTM databases

iPTMnetiQ8IX04
PhosphoSitePlusiQ8IX04

Polymorphism and mutation databases

BioMutaiUEVLD
DMDMi126253820

Proteomic databases

EPDiQ8IX04
jPOSTiQ8IX04
MassIVEiQ8IX04
MaxQBiQ8IX04
PaxDbiQ8IX04
PeptideAtlasiQ8IX04
PRIDEiQ8IX04
ProteomicsDBi27225
43582
70952 [Q8IX04-1]
70953 [Q8IX04-2]
70954 [Q8IX04-3]
70955 [Q8IX04-4]
70956 [Q8IX04-5]

Genome annotation databases

EnsembliENST00000300038; ENSP00000300038; ENSG00000151116 [Q8IX04-5]
ENST00000320750; ENSP00000323353; ENSG00000151116 [Q8IX04-3]
ENST00000379387; ENSP00000368697; ENSG00000151116 [Q8IX04-6]
ENST00000396197; ENSP00000379500; ENSG00000151116 [Q8IX04-1]
ENST00000535484; ENSP00000441092; ENSG00000151116 [Q8IX04-4]
ENST00000541984; ENSP00000437538; ENSG00000151116 [Q8IX04-7]
ENST00000543987; ENSP00000442974; ENSG00000151116 [Q8IX04-2]
GeneIDi55293
KEGGihsa:55293
UCSCiuc001mot.5 human [Q8IX04-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55293
DisGeNETi55293

GeneCards: human genes, protein and diseases

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GeneCardsi
UEVLD
HGNCiHGNC:30866 UEVLD
HPAiHPA047134
MIMi610985 gene
neXtProtiNX_Q8IX04
OpenTargetsiENSG00000151116
PharmGKBiPA147357188

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
KOG2391 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00940000153903
HOGENOMiHOG000213793
InParanoidiQ8IX04
OMAiPFTPPIC
OrthoDBi1435538at2759
PhylomeDBiQ8IX04
TreeFamiTF314963

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UEVLD human
EvolutionaryTraceiQ8IX04

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55293
PharosiQ8IX04

Protein Ontology

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PROi
PR:Q8IX04

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151116 Expressed in 213 organ(s), highest expression level in nasal cavity mucosa
ExpressionAtlasiQ8IX04 baseline and differential
GenevisibleiQ8IX04 HS

Family and domain databases

Gene3Di3.10.110.10, 1 hit
3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PF05743 UEV, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54495 SSF54495, 1 hit
SSF56327 SSF56327, 1 hit
PROSITEiView protein in PROSITE
PS51322 UEV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUEVLD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX04
Secondary accession number(s): B2RB69
, B4DL43, F5H6L6, H7BYD6, Q6P2F0, Q96FF5, Q9NUX7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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