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Entry version 143 (12 Aug 2020)
Sequence version 1 (01 Mar 2003)
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Protein

Protein KIBRA

Gene

WWC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q8IX03

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2028269, Signaling by Hippo
R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8IX03

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8IX03

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein KIBRA
Alternative name(s):
HBeAg-binding protein 3
Kidney and brain protein
Short name:
KIBRA
WW domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WWC1
Synonyms:KIAA0869
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000113645.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29435, WWC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610533, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IX03

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23286

MalaCards human disease database

More...
MalaCardsi
WWC1
MIMi615602, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000113645

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485670

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IX03, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WWC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74714457

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002421531 – 1113Protein KIBRAAdd BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei141PhosphoserineBy similarity1
Modified residuei535PhosphoserineCombined sources1
Modified residuei542Phosphoserine; by CDK11 Publication1
Modified residuei899PhosphoserineCombined sources1
Modified residuei912PhosphothreonineCombined sources1
Modified residuei927PhosphoserineBy similarity1
Modified residuei929PhosphothreonineCombined sources1
Modified residuei931Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei947PhosphoserineCombined sources1
Modified residuei975Phosphoserine; by PKC/PRKCZ1 Publication1
Modified residuei978Phosphoserine; by PKC/PRKCZ1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IX03

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8IX03

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8IX03

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IX03

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IX03

PeptideAtlas

More...
PeptideAtlasi
Q8IX03

PRoteomics IDEntifications database

More...
PRIDEi
Q8IX03

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70950 [Q8IX03-1]
70951 [Q8IX03-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q8IX03

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IX03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IX03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly up-regulated by progestin treatment.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113645, Expressed in oviduct epithelium and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8IX03, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IX03, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000113645, Tissue enhanced (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with DDN.

Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin.

Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner.

Interacts with PRKCZ (via the protein kinase domain).

Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen.

Interacts (via the ADDV motif) with PATJ (via PDZ domain 8).

Interacts (via WW domains) with SYNPO (via PPxY motifs).

Interacts with NF2 and SNX4.

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116884, 64 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q8IX03

Database of interacting proteins

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DIPi
DIP-35287N

Protein interaction database and analysis system

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IntActi
Q8IX03, 49 interactors

Molecular INTeraction database

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MINTi
Q8IX03

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427772

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IX03, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8IX03

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8IX03

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 39WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini53 – 86WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini658 – 781C2PROSITE-ProRule annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni839 – 1113Interaction with histone H3Add BLAST275
Regioni953 – 996Interaction with PRKCZAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 193Sequence analysisAdd BLAST87
Coiled coili293 – 431Sequence analysisAdd BLAST139
Coiled coili1001 – 1032Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1111 – 1113ADDV motif3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi261 – 265Poly-Ser5
Compositional biasi819 – 873Glu-richAdd BLAST55

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2-domain mediates homodimerization. It is a calcium-sensitive lipid-binding domain with preference for PI3P.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WWC family. KIBRA subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3209, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005420_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IX03

KEGG Orthology (KO)

More...
KOi
K16685

Identification of Orthologs from Complete Genome Data

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OMAi
HHTHIPR

Database of Orthologous Groups

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OrthoDBi
364990at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IX03

TreeFam database of animal gene trees

More...
TreeFami
TF324040

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08680, C2_Kibra, 1 hit
cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035892, C2_domain_sf
IPR037771, C2_WWC
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045, SSF51045, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRPELPLPE GWEEARDFDG KVYYIDHTNR TTSWIDPRDR YTKPLTFADC
60 70 80 90 100
ISDELPLGWE EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL
110 120 130 140 150
VVAQEALSAQ KEIYQVKQQR LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS
160 170 180 190 200
SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQHELQFKER GFQTLKKIDK
210 220 230 240 250
KMSDAQGSYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR
260 270 280 290 300
TDRGSHSDLW SSSSSLESSS FPLPKQYLDV SSQTDISGSF GINSNNQLAE
310 320 330 340 350
KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL
360 370 380 390 400
LKEMRFISPR KWTQGEVEQL EMARKRLEKD LQAARDTQSK ALTERLKLNS
410 420 430 440 450
KRNQLVRELE EATRQVATLH SQLKSLSSSM QSLSSGSSPG SLTSSRGSLV
460 470 480 490 500
ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VEFLLLEGAT GFRPSGCITT
510 520 530 540 550
IHEDEVAKTQ KAEGGGRLQA LRSLSGTPKS MTSLSPRSSL SSPSPPCSPL
560 570 580 590 600
MADPLLAGDA FLNSLEFEDP ELSATLCELS LGNSAQERYR LEEPGTEGKQ
610 620 630 640 650
LGQAVNTAQG CGLKVACVSA AVSDESVAGD SGVYEASVQR LGASEAAAFD
660 670 680 690 700
SDESEAVGAT RIQIALKYDE KNKQFAILII QLSNLSALLQ QQDQKVNIRV
710 720 730 740 750
AVLPCSESTT CLFRTRPLDA SDTLVFNEVF WVSMSYPALH QKTLRVDVCT
760 770 780 790 800
TDRSHLEECL GGAQISLAEV CRSGERSTRW YNLLSYKYLK KQSRELKPVG
810 820 830 840 850
VMAPASGPAS TDAVSALLEQ TAVELEKRQE GRSSTQTLED SWRYEETSEN
860 870 880 890 900
EAVAEEEEEE VEEEEGEEDV FTEKASPDMD GYPALKVDKE TNTETPAPSP
910 920 930 940 950
TVVRPKDRRV GTPSQGPFLR GSTIIRSKTF SPGPQSQYVC RLNRSDSDSS
960 970 980 990 1000
TLSKKPPFVR NSLERRSVRM KRPSSVKSLR SERLIRTSLD LELDLQATRT
1010 1020 1030 1040 1050
WHSQLTQEIS VLKELKEQLE QAKSHGEKEL PQWLREDERF RLLLRMLEKR
1060 1070 1080 1090 1100
QMDRAEHKGE LQTDKMMRAA AKDVHRLRGQ SCKEPPEVQS FREKMAFFTR
1110
PRMNIPALSA DDV
Length:1,113
Mass (Da):125,301
Last modified:March 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9010B9C127129165
GO
Isoform 2 (identifier: Q8IX03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     974-974: S → SPPPQPS

Show »
Length:1,119
Mass (Da):125,905
Checksum:i0AB48E74AB261693
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLZ3H3BLZ3_HUMAN
Protein KIBRA
WWC1
1,080Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAU4H0YAU4_HUMAN
Protein KIBRA
WWC1
444Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBE8H0YBE8_HUMAN
Protein KIBRA
WWC1
889Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti561F → L in CAE45903 (PubMed:17974005).Curated1
Sequence conflicti759C → R in CAE45903 (PubMed:17974005).Curated1
Sequence conflicti811T → TVSWDQ in AAO73817 (Ref. 6) Curated1
Sequence conflicti834S → N in CAE45903 (PubMed:17974005).Curated1
Sequence conflicti865Missing in AAO73817 (Ref. 6) Curated1
Sequence conflicti1051Missing in CAE45903 (PubMed:17974005).Curated1
Sequence conflicti1051Missing in BAA74892 (PubMed:10048485).Curated1
Sequence conflicti1064 – 1065DK → AR in AAO73817 (Ref. 6) Curated2

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in WWC1 define the memory quantitative trait locus (MEMRYQTL) [MIMi:615602].2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026844250R → C. Corresponds to variant dbSNP:rs17551608Ensembl.1
Natural variantiVAR_053449734M → I Polymorphism; associated with Ala-735; affects KIBRA lipid-binding specificity showing stronger interactions with PI(4)P and PI(5)P. 1 PublicationCorresponds to variant dbSNP:rs3822660Ensembl.1
Natural variantiVAR_053450735S → A Polymorphism; associated with Ile-734; affects KIBRA lipid-binding specificity showing stronger interactions with PI(4)P and PI(5)P. 1 PublicationCorresponds to variant dbSNP:rs3822659Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019448974S → SPPPQPS in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF506799 mRNA Translation: AAO15881.1
AK296323 mRNA Translation: BAG59017.1
AC020894 Genomic DNA No translation available.
AC026689 Genomic DNA No translation available.
BX640827 mRNA Translation: CAE45903.1
AB020676 mRNA Translation: BAA74892.1
AF530058 mRNA Translation: AAQ09942.1
AY189820 mRNA Translation: AAO73817.1
BC004394 mRNA Translation: AAH04394.1
BC017746 mRNA Translation: AAH17746.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4366.1 [Q8IX03-1]
CCDS54945.1 [Q8IX03-2]

NCBI Reference Sequences

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RefSeqi
NP_001155133.1, NM_001161661.1 [Q8IX03-2]
NP_001155134.1, NM_001161662.1
NP_056053.1, NM_015238.2 [Q8IX03-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265293; ENSP00000265293; ENSG00000113645 [Q8IX03-1]
ENST00000521089; ENSP00000427772; ENSG00000113645 [Q8IX03-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23286

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23286

UCSC genome browser

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UCSCi
uc003lzu.4, human [Q8IX03-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506799 mRNA Translation: AAO15881.1
AK296323 mRNA Translation: BAG59017.1
AC020894 Genomic DNA No translation available.
AC026689 Genomic DNA No translation available.
BX640827 mRNA Translation: CAE45903.1
AB020676 mRNA Translation: BAA74892.1
AF530058 mRNA Translation: AAQ09942.1
AY189820 mRNA Translation: AAO73817.1
BC004394 mRNA Translation: AAH04394.1
BC017746 mRNA Translation: AAH17746.1
CCDSiCCDS4366.1 [Q8IX03-1]
CCDS54945.1 [Q8IX03-2]
RefSeqiNP_001155133.1, NM_001161661.1 [Q8IX03-2]
NP_001155134.1, NM_001161662.1
NP_056053.1, NM_015238.2 [Q8IX03-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z0UX-ray2.20A/B638-785[»]
6FB4X-ray2.42A/B658-785[»]
6FD0X-ray2.64A/B658-785[»]
6FJCX-ray2.60A/B658-785[»]
6FJDX-ray2.90A/B658-785[»]
SMRiQ8IX03
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116884, 64 interactors
CORUMiQ8IX03
DIPiDIP-35287N
IntActiQ8IX03, 49 interactors
MINTiQ8IX03
STRINGi9606.ENSP00000427772

PTM databases

CarbonylDBiQ8IX03
iPTMnetiQ8IX03
PhosphoSitePlusiQ8IX03

Polymorphism and mutation databases

BioMutaiWWC1
DMDMi74714457

Proteomic databases

EPDiQ8IX03
jPOSTiQ8IX03
MassIVEiQ8IX03
MaxQBiQ8IX03
PaxDbiQ8IX03
PeptideAtlasiQ8IX03
PRIDEiQ8IX03
ProteomicsDBi70950 [Q8IX03-1]
70951 [Q8IX03-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
48675, 209 antibodies

The DNASU plasmid repository

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DNASUi
23286

Genome annotation databases

EnsembliENST00000265293; ENSP00000265293; ENSG00000113645 [Q8IX03-1]
ENST00000521089; ENSP00000427772; ENSG00000113645 [Q8IX03-2]
GeneIDi23286
KEGGihsa:23286
UCSCiuc003lzu.4, human [Q8IX03-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23286
DisGeNETi23286
EuPathDBiHostDB:ENSG00000113645.13

GeneCards: human genes, protein and diseases

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GeneCardsi
WWC1
HGNCiHGNC:29435, WWC1
HPAiENSG00000113645, Tissue enhanced (salivary)
MalaCardsiWWC1
MIMi610533, gene
615602, phenotype
neXtProtiNX_Q8IX03
OpenTargetsiENSG00000113645
PharmGKBiPA143485670

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3209, Eukaryota
GeneTreeiENSGT00410000025556
HOGENOMiCLU_005420_0_0_1
InParanoidiQ8IX03
KOiK16685
OMAiHHTHIPR
OrthoDBi364990at2759
PhylomeDBiQ8IX03
TreeFamiTF324040

Enzyme and pathway databases

PathwayCommonsiQ8IX03
ReactomeiR-HSA-2028269, Signaling by Hippo
R-HSA-9013508, NOTCH3 Intracellular Domain Regulates Transcription
SignaLinkiQ8IX03
SIGNORiQ8IX03

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23286, 3 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WWC1, human
EvolutionaryTraceiQ8IX03

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WWC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23286
PharosiQ8IX03, Tbio

Protein Ontology

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PROi
PR:Q8IX03
RNActiQ8IX03, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113645, Expressed in oviduct epithelium and 212 other tissues
ExpressionAtlasiQ8IX03, baseline and differential
GenevisibleiQ8IX03, HS

Family and domain databases

CDDicd08680, C2_Kibra, 1 hit
cd00201, WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR035892, C2_domain_sf
IPR037771, C2_WWC
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIBRA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX03
Secondary accession number(s): B4DK05
, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: August 12, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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