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UniProtKB - Q8IX01 (SUGP2_HUMAN)

Protein

SURP and G-patch domain-containing protein 2

Gene

SUGP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in mRNA splicing.Curated

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 2
Alternative name(s):
Arginine/serine-rich-splicing factor 14
Splicing factor, arginine/serine-rich 14
Gene namesi
Name:SUGP2
Synonyms:KIAA0365, SFRS14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000064607.16
HGNCiHGNC:18641 SUGP2
MIMi607993 gene
neXtProtiNX_Q8IX01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064607
PharmGKBiPA165394371

Polymorphism and mutation databases

BioMutaiSUGP2
DMDMi308153496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977081 – 1082SURP and G-patch domain-containing protein 2Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphothreonineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei275PhosphothreonineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei315PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Cross-linki650Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei754PhosphoserineCombined sources1
Modified residuei757PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IX01
MaxQBiQ8IX01
PaxDbiQ8IX01
PeptideAtlasiQ8IX01
PRIDEiQ8IX01
ProteomicsDBi70947
70948 [Q8IX01-3]
70949 [Q8IX01-4]

PTM databases

iPTMnetiQ8IX01
PhosphoSitePlusiQ8IX01

Expressioni

Tissue specificityi

Detected in adult testis, and in fetal brain and kidney.1 Publication

Gene expression databases

BgeeiENSG00000064607 Expressed in 232 organ(s), highest expression level in right testis
CleanExiHS_SFRS14
ExpressionAtlasiQ8IX01 baseline and differential
GenevisibleiQ8IX01 HS

Organism-specific databases

HPAiHPA041557
HPA061111

Interactioni

Protein-protein interaction databases

BioGridi115449, 94 interactors
IntActiQ8IX01, 29 interactors
MINTiQ8IX01
STRINGi9606.ENSP00000337926

Structurei

Secondary structure

11082
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8IX01
SMRiQ8IX01
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IX01

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati590 – 633SURP motif 1Add BLAST44
Repeati787 – 830SURP motif 2Add BLAST44
Domaini1011 – 1057G-patchPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi995 – 1000Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi738 – 776Pro/Ser-richAdd BLAST39
Compositional biasi869 – 905Asp/Glu-richAdd BLAST37

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0965 Eukaryota
ENOG4111IFE LUCA
GeneTreeiENSGT00410000025695
HOGENOMiHOG000168519
HOVERGENiHBG079176
InParanoidiQ8IX01
KOiK13166
PhylomeDBiQ8IX01
TreeFamiTF326321

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR000061 Surp
IPR035967 SWAP/Surp_sf
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF01805 Surp, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00648 SWAP, 2 hits
SUPFAMiSSF109905 SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50128 SURP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR 
        60         70         80         90        100
AEMYDDVHSD GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD 
       110        120        130        140        150
SYFRKECGRD LEFSHSDSRD QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH 
       160        170        180        190        200
PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE KECLEKESRD YDVDHPGEAD 
       210        220        230        240        250
SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG VGKLVTLRNV 
       260        270        280        290        300
STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL 
       310        320        330        340        350
GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL 
       360        370        380        390        400
FQTLFELETE TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN 
       410        420        430        440        450
EFLNMLLDKG AVKTKNCFFE IIKPFDKYIM RLQDRLLKSV TPLLMACNAY 
       460        470        480        490        500
ELSVKMKTLS NPLDLALALE TTNSLCRKSL ALLGQTFSLA SSFRQEKILE 
       510        520        530        540        550
AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC PLQVKKAEPE 
       560        570        580        590        600
PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG 
       610        620        630        640        650
SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK 
       660        670        680        690        700
PTSADCAVRA MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT 
       710        720        730        740        750
QTLLSSGTRL KHHGRQAPGL SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS 
       760        770        780        790        800
LEASGPSPKP AGVDISEAPQ TSSPCPSADI DMKTMETAEK LARFVAQVGP 
       810        820        830        840        850
EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS ICFTSSPHNL 
       860        870        880        890        900
HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE 
       910        920        930        940        950
DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR 
       960        970        980        990       1000
KRISSKSLKV GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK 
      1010       1020       1030       1040       1050
DLDFAQQKLT DKNLGFQMLQ KMGWKEGHGL GSLGKGIREP VSVGTPSEGE 
      1060       1070       1080 
GLGADGQEHK EDTFDVFRQR MMQMYRHKRA NK
Length:1,082
Mass (Da):120,207
Last modified:October 5, 2010 - v2
Checksum:i619AE0AC087761BD
GO
Isoform 3 (identifier: Q8IX01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.
     1044-1082: GTPSEGEGLG...QMYRHKRANK → YAAGSLGWEW...LNRRHLQMRS

Note: No experimental confirmation available.
Show »
Length:1,040
Mass (Da):116,286
Checksum:i4C4AF9C44F68DA88
GO
Isoform 4 (identifier: Q8IX01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.

Note: No experimental confirmation available.
Show »
Length:1,030
Mass (Da):115,186
Checksum:iDBC51336F08F75F9
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2Z9M0R2Z9_HUMAN
SURP and G-patch domain-containing ...
SUGP2
1,096Annotation score:
M0R3F6M0R3F6_HUMAN
SURP and G-patch domain-containing ...
SUGP2
841Annotation score:
M0R065M0R065_HUMAN
SURP and G-patch domain-containing ...
SUGP2
111Annotation score:
M0R216M0R216_HUMAN
SURP and G-patch domain-containing ...
SUGP2
170Annotation score:
M0R1Y3M0R1Y3_HUMAN
SURP and G-patch domain-containing ...
SUGP2
53Annotation score:
M0R2Y3M0R2Y3_HUMAN
SURP and G-patch domain-containing ...
SUGP2
65Annotation score:

Sequence cautioni

The sequence AAC06129 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH20586 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA20820 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023711206G → S3 PublicationsCorresponds to variant dbSNP:rs4808907Ensembl.1
Natural variantiVAR_051341552M → T. Corresponds to variant dbSNP:rs10404860Ensembl.1
Natural variantiVAR_051342649Q → R. Corresponds to variant dbSNP:rs10414535Ensembl.1
Natural variantiVAR_051343722Q → R. Corresponds to variant dbSNP:rs34540303Ensembl.1
Natural variantiVAR_051344881R → Q. Corresponds to variant dbSNP:rs35646935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013112890 – 941Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_0131131044 – 1082GTPSE…KRANK → YAAGSLGWEWVGPQSFHLQP AAWLLHSQDGLQLAVDFCFL NRRHLQMRS in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA Translation: AAN77117.1
AB002363 mRNA Translation: BAA20820.2 Different initiation.
BX647813 mRNA Translation: CAI46012.1
AL832488 mRNA Translation: CAI46117.1
AC004447 Genomic DNA Translation: AAC06129.1 Sequence problems.
BC020586 mRNA Translation: AAH20586.1 Different initiation.
CCDSiCCDS12392.1 [Q8IX01-1]
PIRiT03030
RefSeqiNP_001017392.2, NM_001017392.4 [Q8IX01-1]
NP_001308626.1, NM_001321697.1 [Q8IX01-1]
NP_055699.2, NM_014884.4 [Q8IX01-1]
XP_016881626.1, XM_017026137.1
UniGeneiHs.515271
Hs.732621
Hs.77876

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607 [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607 [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607 [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607 [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607 [Q8IX01-1]
GeneIDi10147
KEGGihsa:10147
UCSCiuc002nkx.3 human [Q8IX01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA Translation: AAN77117.1
AB002363 mRNA Translation: BAA20820.2 Different initiation.
BX647813 mRNA Translation: CAI46012.1
AL832488 mRNA Translation: CAI46117.1
AC004447 Genomic DNA Translation: AAC06129.1 Sequence problems.
BC020586 mRNA Translation: AAH20586.1 Different initiation.
CCDSiCCDS12392.1 [Q8IX01-1]
PIRiT03030
RefSeqiNP_001017392.2, NM_001017392.4 [Q8IX01-1]
NP_001308626.1, NM_001321697.1 [Q8IX01-1]
NP_055699.2, NM_014884.4 [Q8IX01-1]
XP_016881626.1, XM_017026137.1
UniGeneiHs.515271
Hs.732621
Hs.77876

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4PNMR-A587-639[»]
ProteinModelPortaliQ8IX01
SMRiQ8IX01
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115449, 94 interactors
IntActiQ8IX01, 29 interactors
MINTiQ8IX01
STRINGi9606.ENSP00000337926

PTM databases

iPTMnetiQ8IX01
PhosphoSitePlusiQ8IX01

Polymorphism and mutation databases

BioMutaiSUGP2
DMDMi308153496

Proteomic databases

EPDiQ8IX01
MaxQBiQ8IX01
PaxDbiQ8IX01
PeptideAtlasiQ8IX01
PRIDEiQ8IX01
ProteomicsDBi70947
70948 [Q8IX01-3]
70949 [Q8IX01-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607 [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607 [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607 [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607 [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607 [Q8IX01-1]
GeneIDi10147
KEGGihsa:10147
UCSCiuc002nkx.3 human [Q8IX01-1]

Organism-specific databases

CTDi10147
EuPathDBiHostDB:ENSG00000064607.16
GeneCardsiSUGP2
H-InvDBiHIX0014931
HGNCiHGNC:18641 SUGP2
HPAiHPA041557
HPA061111
MIMi607993 gene
neXtProtiNX_Q8IX01
OpenTargetsiENSG00000064607
PharmGKBiPA165394371
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0965 Eukaryota
ENOG4111IFE LUCA
GeneTreeiENSGT00410000025695
HOGENOMiHOG000168519
HOVERGENiHBG079176
InParanoidiQ8IX01
KOiK13166
PhylomeDBiQ8IX01
TreeFamiTF326321

Miscellaneous databases

ChiTaRSiSUGP2 human
EvolutionaryTraceiQ8IX01
GeneWikiiSFRS14
GenomeRNAii10147
PROiPR:Q8IX01
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064607 Expressed in 232 organ(s), highest expression level in right testis
CleanExiHS_SFRS14
ExpressionAtlasiQ8IX01 baseline and differential
GenevisibleiQ8IX01 HS

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR000061 Surp
IPR035967 SWAP/Surp_sf
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF01805 Surp, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00648 SWAP, 2 hits
SUPFAMiSSF109905 SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50128 SURP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUGP2_HUMAN
AccessioniPrimary (citable) accession number: Q8IX01
Secondary accession number(s): C9JI71
, O15071, O60369, Q5JPH7, Q8WUF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 5, 2010
Last modified: September 12, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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