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UniProtKB - Q8IX01 (SUGP2_HUMAN)

Entry version 154 (02 Dec 2020)
Sequence version 2 (05 Oct 2010)
Previous versions | rss
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Protein

SURP and G-patch domain-containing protein 2

Gene

SUGP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in mRNA splicing.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IX01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 2
Alternative name(s):
Arginine/serine-rich-splicing factor 14
Splicing factor, arginine/serine-rich 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUGP2
Synonyms:KIAA0365, SFRS14
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000064607.16

Human Gene Nomenclature Database

More...HGNCi		HGNC:18641, SUGP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607993, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IX01

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10147

Open Targets

More...OpenTargetsi		ENSG00000064607

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165394371

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IX01, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SUGP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977081 – 1082SURP and G-patch domain-containing protein 2Add BLAST1082

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphothreonineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei275PhosphothreonineCombined sources1
Modified residuei277PhosphoserineCombined sources1
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei315PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Cross-linki650Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei754PhosphoserineCombined sources1
Modified residuei757PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IX01

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IX01

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IX01

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IX01

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IX01

PeptideAtlas

More...PeptideAtlasi		Q8IX01

PRoteomics IDEntifications database

More...PRIDEi		Q8IX01

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70947 [Q8IX01-1]
70948 [Q8IX01-3]
70949 [Q8IX01-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IX01

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IX01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult testis, and in fetal brain and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000064607, Expressed in right testis and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IX01, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IX01, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000064607, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115449, 115 interactors

Protein interaction database and analysis system

More...IntActi		Q8IX01, 37 interactors

Molecular INTeraction database

More...MINTi		Q8IX01

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000472286

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IX01, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11082
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IX01

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8IX01

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati590 – 633SURP motif 1Add BLAST44
Repeati787 – 830SURP motif 2Add BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1011 – 1057G-patchPROSITE-ProRule annotationAdd BLAST47

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi995 – 1000Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi738 – 776Pro/Ser-richAdd BLAST39
Compositional biasi869 – 905Asp/Glu-richAdd BLAST37

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0965, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00410000025695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010012_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IX01

Database of Orthologous Groups

More...OrthoDBi		1232201at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IX01

TreeFam database of animal gene trees

More...TreeFami		TF326321

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.790, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000467, G_patch_dom
IPR040169, SUGP1/2
IPR000061, Surp
IPR035967, SWAP/Surp_sf

The PANTHER Classification System

More...PANTHERi		PTHR23340, PTHR23340, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01585, G-patch, 1 hit
PF01805, Surp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00443, G_patch, 1 hit
SM00648, SWAP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109905, SSF109905, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50174, G_PATCH, 1 hit
PS50128, SURP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IX01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR 
        60         70         80         90        100
AEMYDDVHSD GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD 
       110        120        130        140        150
SYFRKECGRD LEFSHSDSRD QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH 
       160        170        180        190        200
PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE KECLEKESRD YDVDHPGEAD 
       210        220        230        240        250
SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG VGKLVTLRNV 
       260        270        280        290        300
STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL 
       310        320        330        340        350
GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL 
       360        370        380        390        400
FQTLFELETE TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN 
       410        420        430        440        450
EFLNMLLDKG AVKTKNCFFE IIKPFDKYIM RLQDRLLKSV TPLLMACNAY 
       460        470        480        490        500
ELSVKMKTLS NPLDLALALE TTNSLCRKSL ALLGQTFSLA SSFRQEKILE 
       510        520        530        540        550
AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC PLQVKKAEPE 
       560        570        580        590        600
PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG 
       610        620        630        640        650
SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK 
       660        670        680        690        700
PTSADCAVRA MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT 
       710        720        730        740        750
QTLLSSGTRL KHHGRQAPGL SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS 
       760        770        780        790        800
LEASGPSPKP AGVDISEAPQ TSSPCPSADI DMKTMETAEK LARFVAQVGP 
       810        820        830        840        850
EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS ICFTSSPHNL 
       860        870        880        890        900
HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE 
       910        920        930        940        950
DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR 
       960        970        980        990       1000
KRISSKSLKV GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK 
      1010       1020       1030       1040       1050
DLDFAQQKLT DKNLGFQMLQ KMGWKEGHGL GSLGKGIREP VSVGTPSEGE 
      1060       1070       1080 
GLGADGQEHK EDTFDVFRQR MMQMYRHKRA NK
Length:1,082
Mass (Da):120,207
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i619AE0AC087761BD
GO
Isoform 3 (identifier: Q8IX01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.
     1044-1082: GTPSEGEGLG...QMYRHKRANK → YAAGSLGWEW...LNRRHLQMRS

Show »
Length:1,040
Mass (Da):116,286
Checksum:i4C4AF9C44F68DA88
GO
Isoform 4 (identifier: Q8IX01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-941: Missing.

Show »
Length:1,030
Mass (Da):115,186
Checksum:iDBC51336F08F75F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2Z9M0R2Z9_HUMAN
SURP and G-patch domain-containing ...
SUGP2
1,096Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3F6M0R3F6_HUMAN
SURP and G-patch domain-containing ...
SUGP2
841Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R216M0R216_HUMAN
SURP and G-patch domain-containing ...
SUGP2
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R065M0R065_HUMAN
SURP and G-patch domain-containing ...
SUGP2
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1Y3M0R1Y3_HUMAN
SURP and G-patch domain-containing ...
SUGP2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2Y3M0R2Y3_HUMAN
SURP and G-patch domain-containing ...
SUGP2
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC06129 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH20586 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA20820 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023711206G → S3 PublicationsCorresponds to variant dbSNP:rs4808907Ensembl.1
Natural variantiVAR_051341552M → T. Corresponds to variant dbSNP:rs10404860Ensembl.1
Natural variantiVAR_051342649Q → R. Corresponds to variant dbSNP:rs10414535Ensembl.1
Natural variantiVAR_051343722Q → R. Corresponds to variant dbSNP:rs34540303Ensembl.1
Natural variantiVAR_051344881R → Q. Corresponds to variant dbSNP:rs35646935Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013112890 – 941Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST52
Alternative sequenceiVSP_0131131044 – 1082GTPSE…KRANK → YAAGSLGWEWVGPQSFHLQP AAWLLHSQDGLQLAVDFCFL NRRHLQMRS in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF518874 mRNA Translation: AAN77117.1
AB002363 mRNA Translation: BAA20820.2 Different initiation.
BX647813 mRNA Translation: CAI46012.1
AL832488 mRNA Translation: CAI46117.1
AC004447 Genomic DNA Translation: AAC06129.1 Sequence problems.
BC020586 mRNA Translation: AAH20586.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12392.1 [Q8IX01-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T03030

NCBI Reference Sequences

More...RefSeqi		NP_001017392.2, NM_001017392.4 [Q8IX01-1]
NP_001308626.1, NM_001321697.1 [Q8IX01-1]
NP_055699.2, NM_014884.4 [Q8IX01-1]
XP_016881626.1, XM_017026137.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000330854; ENSP00000332373; ENSG00000064607 [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607 [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607 [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607 [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607 [Q8IX01-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10147

UCSC genome browser

More...UCSCi		uc002nkx.3, human [Q8IX01-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF518874 mRNA Translation: AAN77117.1
AB002363 mRNA Translation: BAA20820.2 Different initiation.
BX647813 mRNA Translation: CAI46012.1
AL832488 mRNA Translation: CAI46117.1
AC004447 Genomic DNA Translation: AAC06129.1 Sequence problems.
BC020586 mRNA Translation: AAH20586.1 Different initiation.
CCDSiCCDS12392.1 [Q8IX01-1]
PIRiT03030
RefSeqiNP_001017392.2, NM_001017392.4 [Q8IX01-1]
NP_001308626.1, NM_001321697.1 [Q8IX01-1]
NP_055699.2, NM_014884.4 [Q8IX01-1]
XP_016881626.1, XM_017026137.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4PNMR-A587-639[»]
SMRiQ8IX01
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115449, 115 interactors
IntActiQ8IX01, 37 interactors
MINTiQ8IX01
STRINGi9606.ENSP00000472286

PTM databases

iPTMnetiQ8IX01
PhosphoSitePlusiQ8IX01

Polymorphism and mutation databases

BioMutaiSUGP2
DMDMi308153496

Proteomic databases

EPDiQ8IX01
jPOSTiQ8IX01
MassIVEiQ8IX01
MaxQBiQ8IX01
PaxDbiQ8IX01
PeptideAtlasiQ8IX01
PRIDEiQ8IX01
ProteomicsDBi70947 [Q8IX01-1]
70948 [Q8IX01-3]
70949 [Q8IX01-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28312, 144 antibodies

Genome annotation databases

EnsembliENST00000330854; ENSP00000332373; ENSG00000064607 [Q8IX01-4]
ENST00000337018; ENSP00000337926; ENSG00000064607 [Q8IX01-1]
ENST00000452918; ENSP00000389380; ENSG00000064607 [Q8IX01-1]
ENST00000594773; ENSP00000470915; ENSG00000064607 [Q8IX01-3]
ENST00000601879; ENSP00000472286; ENSG00000064607 [Q8IX01-1]
GeneIDi10147
KEGGihsa:10147
UCSCiuc002nkx.3, human [Q8IX01-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10147
DisGeNETi10147
EuPathDBiHostDB:ENSG00000064607.16

GeneCards: human genes, protein and diseases

More...GeneCardsi		SUGP2
HGNCiHGNC:18641, SUGP2
HPAiENSG00000064607, Low tissue specificity
MIMi607993, gene
neXtProtiNX_Q8IX01
OpenTargetsiENSG00000064607
PharmGKBiPA165394371

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0965, Eukaryota
GeneTreeiENSGT00410000025695
HOGENOMiCLU_010012_0_0_1
InParanoidiQ8IX01
OrthoDBi1232201at2759
PhylomeDBiQ8IX01
TreeFamiTF326321

Enzyme and pathway databases

PathwayCommonsiQ8IX01

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10147, 15 hits in 849 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SUGP2, human
EvolutionaryTraceiQ8IX01

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SFRS14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10147
PharosiQ8IX01, Tbio

Protein Ontology

More...PROi		PR:Q8IX01
RNActiQ8IX01, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000064607, Expressed in right testis and 245 other tissues
ExpressionAtlasiQ8IX01, baseline and differential
GenevisibleiQ8IX01, HS

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000467, G_patch_dom
IPR040169, SUGP1/2
IPR000061, Surp
IPR035967, SWAP/Surp_sf
PANTHERiPTHR23340, PTHR23340, 1 hit
PfamiView protein in Pfam
PF01585, G-patch, 1 hit
PF01805, Surp, 1 hit
SMARTiView protein in SMART
SM00443, G_patch, 1 hit
SM00648, SWAP, 2 hits
SUPFAMiSSF109905, SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50174, G_PATCH, 1 hit
PS50128, SURP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUGP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IX01
Secondary accession number(s): C9JI71
, O15071, O60369, Q5JPH7, Q8WUF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 5, 2010
Last modified: December 2, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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