UniProtKB - Q8IX01 (SUGP2_HUMAN)
Protein
SURP and G-patch domain-containing protein 2
Gene
SUGP2
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in mRNA splicing.Curated
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- RNA splicing Source: UniProtKB-KW
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q8IX01 |
Names & Taxonomyi
Protein namesi | Recommended name: SURP and G-patch domain-containing protein 2Alternative name(s): Arginine/serine-rich-splicing factor 14 Splicing factor, arginine/serine-rich 14 |
Gene namesi | Name:SUGP2 Synonyms:KIAA0365, SFRS14 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000064607.16 |
HGNCi | HGNC:18641, SUGP2 |
MIMi | 607993, gene |
neXtProti | NX_Q8IX01 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10147 |
OpenTargetsi | ENSG00000064607 |
PharmGKBi | PA165394371 |
Miscellaneous databases
Pharosi | Q8IX01, Tbio |
Polymorphism and mutation databases
BioMutai | SUGP2 |
DMDMi | 308153496 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097708 | 1 – 1082 | SURP and G-patch domain-containing protein 2Add BLAST | 1082 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 96 | PhosphoserineCombined sources | 1 | |
Modified residuei | 224 | PhosphoserineCombined sources | 1 | |
Cross-linki | 228 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 275 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 277 | PhosphoserineCombined sources | 1 | |
Cross-linki | 305 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 315 | PhosphoserineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 603 | PhosphoserineCombined sources | 1 | |
Cross-linki | 650 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 754 | PhosphoserineCombined sources | 1 | |
Modified residuei | 757 | PhosphoserineBy similarity | 1 | |
Modified residuei | 863 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IX01 |
jPOSTi | Q8IX01 |
MassIVEi | Q8IX01 |
MaxQBi | Q8IX01 |
PaxDbi | Q8IX01 |
PeptideAtlasi | Q8IX01 |
PRIDEi | Q8IX01 |
ProteomicsDBi | 70947 [Q8IX01-1] 70948 [Q8IX01-3] 70949 [Q8IX01-4] |
PTM databases
iPTMneti | Q8IX01 |
PhosphoSitePlusi | Q8IX01 |
Expressioni
Tissue specificityi
Detected in adult testis, and in fetal brain and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000064607, Expressed in right testis and 245 other tissues |
ExpressionAtlasi | Q8IX01, baseline and differential |
Genevisiblei | Q8IX01, HS |
Organism-specific databases
HPAi | ENSG00000064607, Low tissue specificity |
Interactioni
Binary interactionsi
Isoform 3 [Q8IX01-3]
With | #Exp. | IntAct |
---|---|---|
GOLGA2 [Q08379] | 3 | EBI-12317645,EBI-618309 |
Protein-protein interaction databases
BioGRIDi | 115449, 115 interactors |
IntActi | Q8IX01, 37 interactors |
MINTi | Q8IX01 |
STRINGi | 9606.ENSP00000472286 |
Miscellaneous databases
RNActi | Q8IX01, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q8IX01 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8IX01 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 590 – 633 | SURP motif 1Add BLAST | 44 | |
Repeati | 787 – 830 | SURP motif 2Add BLAST | 44 | |
Domaini | 1011 – 1057 | G-patchPROSITE-ProRule annotationAdd BLAST | 47 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 995 – 1000 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 738 – 776 | Pro/Ser-richAdd BLAST | 39 | |
Compositional biasi | 869 – 905 | Asp/Glu-richAdd BLAST | 37 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0965, Eukaryota |
GeneTreei | ENSGT00410000025695 |
HOGENOMi | CLU_010012_0_0_1 |
InParanoidi | Q8IX01 |
OrthoDBi | 1232201at2759 |
PhylomeDBi | Q8IX01 |
TreeFami | TF326321 |
Family and domain databases
Gene3Di | 1.10.10.790, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR040169, SUGP1/2 IPR000061, Surp IPR035967, SWAP/Surp_sf |
PANTHERi | PTHR23340, PTHR23340, 1 hit |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF01805, Surp, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00648, SWAP, 2 hits |
SUPFAMi | SSF109905, SSF109905, 2 hits |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50128, SURP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IX01-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR
60 70 80 90 100
AEMYDDVHSD GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD
110 120 130 140 150
SYFRKECGRD LEFSHSDSRD QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH
160 170 180 190 200
PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE KECLEKESRD YDVDHPGEAD
210 220 230 240 250
SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG VGKLVTLRNV
260 270 280 290 300
STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL
310 320 330 340 350
GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL
360 370 380 390 400
FQTLFELETE TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN
410 420 430 440 450
EFLNMLLDKG AVKTKNCFFE IIKPFDKYIM RLQDRLLKSV TPLLMACNAY
460 470 480 490 500
ELSVKMKTLS NPLDLALALE TTNSLCRKSL ALLGQTFSLA SSFRQEKILE
510 520 530 540 550
AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC PLQVKKAEPE
560 570 580 590 600
PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG
610 620 630 640 650
SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK
660 670 680 690 700
PTSADCAVRA MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT
710 720 730 740 750
QTLLSSGTRL KHHGRQAPGL SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS
760 770 780 790 800
LEASGPSPKP AGVDISEAPQ TSSPCPSADI DMKTMETAEK LARFVAQVGP
810 820 830 840 850
EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS ICFTSSPHNL
860 870 880 890 900
HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE
910 920 930 940 950
DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR
960 970 980 990 1000
KRISSKSLKV GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK
1010 1020 1030 1040 1050
DLDFAQQKLT DKNLGFQMLQ KMGWKEGHGL GSLGKGIREP VSVGTPSEGE
1060 1070 1080
GLGADGQEHK EDTFDVFRQR MMQMYRHKRA NK
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R2Z9 | M0R2Z9_HUMAN | SURP and G-patch domain-containing ... | SUGP2 | 1,096 | Annotation score: | ||
M0R3F6 | M0R3F6_HUMAN | SURP and G-patch domain-containing ... | SUGP2 | 841 | Annotation score: | ||
M0R216 | M0R216_HUMAN | SURP and G-patch domain-containing ... | SUGP2 | 170 | Annotation score: | ||
M0R065 | M0R065_HUMAN | SURP and G-patch domain-containing ... | SUGP2 | 111 | Annotation score: | ||
M0R1Y3 | M0R1Y3_HUMAN | SURP and G-patch domain-containing ... | SUGP2 | 53 | Annotation score: | ||
M0R2Y3 | M0R2Y3_HUMAN | SURP and G-patch domain-containing ... | SUGP2 | 65 | Annotation score: |
Sequence cautioni
The sequence AAC06129 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH20586 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA20820 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023711 | 206 | G → S3 PublicationsCorresponds to variant dbSNP:rs4808907Ensembl. | 1 | |
Natural variantiVAR_051341 | 552 | M → T. Corresponds to variant dbSNP:rs10404860Ensembl. | 1 | |
Natural variantiVAR_051342 | 649 | Q → R. Corresponds to variant dbSNP:rs10414535Ensembl. | 1 | |
Natural variantiVAR_051343 | 722 | Q → R. Corresponds to variant dbSNP:rs34540303Ensembl. | 1 | |
Natural variantiVAR_051344 | 881 | R → Q. Corresponds to variant dbSNP:rs35646935Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013112 | 890 – 941 | Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 52 | |
Alternative sequenceiVSP_013113 | 1044 – 1082 | GTPSE…KRANK → YAAGSLGWEWVGPQSFHLQP AAWLLHSQDGLQLAVDFCFL NRRHLQMRS in isoform 3. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF518874 mRNA Translation: AAN77117.1 AB002363 mRNA Translation: BAA20820.2 Different initiation. BX647813 mRNA Translation: CAI46012.1 AL832488 mRNA Translation: CAI46117.1 AC004447 Genomic DNA Translation: AAC06129.1 Sequence problems. BC020586 mRNA Translation: AAH20586.1 Different initiation. |
CCDSi | CCDS12392.1 [Q8IX01-1] |
PIRi | T03030 |
RefSeqi | NP_001017392.2, NM_001017392.4 [Q8IX01-1] NP_001308626.1, NM_001321697.1 [Q8IX01-1] NP_055699.2, NM_014884.4 [Q8IX01-1] XP_016881626.1, XM_017026137.1 |
Genome annotation databases
Ensembli | ENST00000330854; ENSP00000332373; ENSG00000064607 [Q8IX01-4] ENST00000337018; ENSP00000337926; ENSG00000064607 [Q8IX01-1] ENST00000452918; ENSP00000389380; ENSG00000064607 [Q8IX01-1] ENST00000594773; ENSP00000470915; ENSG00000064607 [Q8IX01-3] ENST00000601879; ENSP00000472286; ENSG00000064607 [Q8IX01-1] |
GeneIDi | 10147 |
KEGGi | hsa:10147 |
UCSCi | uc002nkx.3, human [Q8IX01-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF518874 mRNA Translation: AAN77117.1 AB002363 mRNA Translation: BAA20820.2 Different initiation. BX647813 mRNA Translation: CAI46012.1 AL832488 mRNA Translation: CAI46117.1 AC004447 Genomic DNA Translation: AAC06129.1 Sequence problems. BC020586 mRNA Translation: AAH20586.1 Different initiation. |
CCDSi | CCDS12392.1 [Q8IX01-1] |
PIRi | T03030 |
RefSeqi | NP_001017392.2, NM_001017392.4 [Q8IX01-1] NP_001308626.1, NM_001321697.1 [Q8IX01-1] NP_055699.2, NM_014884.4 [Q8IX01-1] XP_016881626.1, XM_017026137.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X4P | NMR | - | A | 587-639 | [»] | |
SMRi | Q8IX01 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115449, 115 interactors |
IntActi | Q8IX01, 37 interactors |
MINTi | Q8IX01 |
STRINGi | 9606.ENSP00000472286 |
PTM databases
iPTMneti | Q8IX01 |
PhosphoSitePlusi | Q8IX01 |
Polymorphism and mutation databases
BioMutai | SUGP2 |
DMDMi | 308153496 |
Proteomic databases
EPDi | Q8IX01 |
jPOSTi | Q8IX01 |
MassIVEi | Q8IX01 |
MaxQBi | Q8IX01 |
PaxDbi | Q8IX01 |
PeptideAtlasi | Q8IX01 |
PRIDEi | Q8IX01 |
ProteomicsDBi | 70947 [Q8IX01-1] 70948 [Q8IX01-3] 70949 [Q8IX01-4] |
Protocols and materials databases
Antibodypediai | 28312, 144 antibodies |
Genome annotation databases
Ensembli | ENST00000330854; ENSP00000332373; ENSG00000064607 [Q8IX01-4] ENST00000337018; ENSP00000337926; ENSG00000064607 [Q8IX01-1] ENST00000452918; ENSP00000389380; ENSG00000064607 [Q8IX01-1] ENST00000594773; ENSP00000470915; ENSG00000064607 [Q8IX01-3] ENST00000601879; ENSP00000472286; ENSG00000064607 [Q8IX01-1] |
GeneIDi | 10147 |
KEGGi | hsa:10147 |
UCSCi | uc002nkx.3, human [Q8IX01-1] |
Organism-specific databases
CTDi | 10147 |
DisGeNETi | 10147 |
EuPathDBi | HostDB:ENSG00000064607.16 |
GeneCardsi | SUGP2 |
HGNCi | HGNC:18641, SUGP2 |
HPAi | ENSG00000064607, Low tissue specificity |
MIMi | 607993, gene |
neXtProti | NX_Q8IX01 |
OpenTargetsi | ENSG00000064607 |
PharmGKBi | PA165394371 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0965, Eukaryota |
GeneTreei | ENSGT00410000025695 |
HOGENOMi | CLU_010012_0_0_1 |
InParanoidi | Q8IX01 |
OrthoDBi | 1232201at2759 |
PhylomeDBi | Q8IX01 |
TreeFami | TF326321 |
Enzyme and pathway databases
PathwayCommonsi | Q8IX01 |
Miscellaneous databases
BioGRID-ORCSi | 10147, 15 hits in 849 CRISPR screens |
ChiTaRSi | SUGP2, human |
EvolutionaryTracei | Q8IX01 |
GeneWikii | SFRS14 |
GenomeRNAii | 10147 |
Pharosi | Q8IX01, Tbio |
PROi | PR:Q8IX01 |
RNActi | Q8IX01, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000064607, Expressed in right testis and 245 other tissues |
ExpressionAtlasi | Q8IX01, baseline and differential |
Genevisiblei | Q8IX01, HS |
Family and domain databases
Gene3Di | 1.10.10.790, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR040169, SUGP1/2 IPR000061, Surp IPR035967, SWAP/Surp_sf |
PANTHERi | PTHR23340, PTHR23340, 1 hit |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF01805, Surp, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00648, SWAP, 2 hits |
SUPFAMi | SSF109905, SSF109905, 2 hits |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50128, SURP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SUGP2_HUMAN | |
Accessioni | Q8IX01Primary (citable) accession number: Q8IX01 Secondary accession number(s): C9JI71 Q8WUF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | October 5, 2010 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations