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Entry version 142 (22 Apr 2020)
Sequence version 2 (15 Mar 2005)
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Protein

SURP and G-patch domain-containing protein 1

Gene

SUGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in pre-mRNA splicing.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SURP and G-patch domain-containing protein 1
Alternative name(s):
RNA-binding protein RBP
Splicing factor 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUGP1
Synonyms:SF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18643 SUGP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607992 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWZ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57794

Open Targets

More...
OpenTargetsi
ENSG00000105705

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394338

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWZ8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUGP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61216666

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977011 – 645SURP and G-patch domain-containing protein 1Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphothreonineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWZ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWZ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IWZ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWZ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWZ8

PeptideAtlas

More...
PeptideAtlasi
Q8IWZ8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWZ8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70945 [Q8IWZ8-1]
70946 [Q8IWZ8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWZ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105705 Expressed in testis and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWZ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWZ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105705 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the spliceosome.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121767, 74 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWZ8, 27 interactors

Molecular INTeraction database

More...
MINTi
Q8IWZ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000247001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWZ8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWZ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati191 – 233SURP motif 1Add BLAST43
Repeati266 – 309SURP motif 2Add BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini562 – 609G-patchPROSITE-ProRule annotationAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi380 – 386Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi330 – 373Pro-richAdd BLAST44
Compositional biasi441 – 480Gln/Met-richAdd BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0965 Eukaryota
ENOG410ZSH4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028403_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWZ8

KEGG Orthology (KO)

More...
KOi
K13096

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYVHAKQ

Database of Orthologous Groups

More...
OrthoDBi
1232201at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWZ8

TreeFam database of animal gene trees

More...
TreeFami
TF326321

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.790, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000467 G_patch_dom
IPR040169 SUGP1/2
IPR000061 Surp
IPR035967 SWAP/Surp_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23340 PTHR23340, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01585 G-patch, 1 hit
PF01805 Surp, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443 G_patch, 1 hit
SM00648 SWAP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109905 SSF109905, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50128 SURP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWZ8-1) [UniParc]FASTAAdd to basket
Also known as: RNA-binding protein splice variant A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLKMDNRDV AGKANRWFGV APPKSGKMNM NILHQEELIA QKKREIEAKM
60 70 80 90 100
EQKAKQNQVA SPQPPHPGEI TNAHNSSCIS NKFANDGSFL QQFLKLQKAQ
110 120 130 140 150
TSTDAPTSAP SAPPSTPTPS AGKRSLLISR RTGLGLASLP GPVKSYSHAK
160 170 180 190 200
QLPVAHRPSV FQSPDEDEEE DYEQWLEIKV SPPEGAETRK VIEKLARFVA
210 220 230 240 250
EGGPELEKVA MEDYKDNPAF AFLHDKNSRE FLYYRKKVAE IRKEAQKSQA
260 270 280 290 300
ASQKVSPPED EEVKNLAEKL ARFIADGGPE VETIALQNNR ENQAFSFLYE
310 320 330 340 350
PNSQGYKYYR QKLEEFRKAK ASSTGSFTAP DPGLKRKSPP EALSGSLPPA
360 370 380 390 400
TTCPASSTPA PTIIPAPAAP GKPASAATVK RKRKSRWGPE EDKVELPPAE
410 420 430 440 450
LVQRDVDASP SPLSVQDLKG LGYEKGKPVG LVGVTELSDA QKKQLKEQQE
460 470 480 490 500
MQQMYDMIMQ HKRAMQDMQL LWEKAVQQHQ HGYDSDEEVD SELGTWEHQL
510 520 530 540 550
RRMEMDKTRE WAEQLTKMGR GKHFIGDFLP PDELEKFMET FKALKEGREP
560 570 580 590 600
DYSEYKEFKL TVENIGYQML MKMGWKEGEG LGSEGQGIKN PVNKGTTTVD
610 620 630 640
GAGFGIDRPA ELSKEDDEYE AFRKRMMLAY RFRPNPLNNP RRPYY
Length:645
Mass (Da):72,471
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27AF5ED41DFDDCB7
GO
Isoform 2 (identifier: Q8IWZ8-2) [UniParc]FASTAAdd to basket
Also known as: RNA-binding protein splice variant B

The sequence of this isoform differs from the canonical sequence as follows:
     181-222: SPPEGAETRK...DYKDNPAFAF → CLTKTVRPTP...SPHPLCRCGP
     223-645: Missing.

Show »
Length:222
Mass (Da):24,297
Checksum:i6CA11F2F5AC40E8E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GZ08V9GZ08_HUMAN
SURP and G-patch domain-containing ...
SUGP1
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DVK3B4DVK3_HUMAN
SURP and G-patch domain-containing ...
SUGP1
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM86K7EM86_HUMAN
SURP and G-patch domain-containing ...
SUGP1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELR6K7ELR6_HUMAN
SURP and G-patch domain-containing ...
SUGP1
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESM0K7ESM0_HUMAN
SURP and G-patch domain-containing ...
SUGP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES12K7ES12_HUMAN
SURP and G-patch domain-containing ...
SUGP1
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC08052 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAL68960 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL68961 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti497E → K in AAN77123 (PubMed:12594045).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051339290R → H. Corresponds to variant dbSNP:rs17751061Ensembl.1
Natural variantiVAR_051340568Q → H. Corresponds to variant dbSNP:rs1044980Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013109181 – 222SPPEG…PAFAF → CLTKTVRPTPPSSWCFVPGL GTPDSLLHLTLFSPHPLCRC GP in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_013110223 – 645Missing in isoform 2. 1 PublicationAdd BLAST423

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF521128 mRNA Translation: AAN77123.1
AY072916 mRNA Translation: AAL68960.1 Different initiation.
AY072917 mRNA Translation: AAL68961.1 Different initiation.
AC004475 Genomic DNA Translation: AAC08052.1 Sequence problems.
BC063784 mRNA Translation: AAH63784.1
AL137286 mRNA Translation: CAB70678.1
AL713757 mRNA Translation: CAD28528.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12399.1 [Q8IWZ8-1]

Protein sequence database of the Protein Information Resource

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PIRi
T02299

NCBI Reference Sequences

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RefSeqi
NP_757386.2, NM_172231.3 [Q8IWZ8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000247001; ENSP00000247001; ENSG00000105705 [Q8IWZ8-1]
ENST00000588731; ENSP00000465413; ENSG00000105705 [Q8IWZ8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57794

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57794

UCSC genome browser

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UCSCi
uc002nmh.4 human [Q8IWZ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521128 mRNA Translation: AAN77123.1
AY072916 mRNA Translation: AAL68960.1 Different initiation.
AY072917 mRNA Translation: AAL68961.1 Different initiation.
AC004475 Genomic DNA Translation: AAC08052.1 Sequence problems.
BC063784 mRNA Translation: AAH63784.1
AL137286 mRNA Translation: CAB70678.1
AL713757 mRNA Translation: CAD28528.1
CCDSiCCDS12399.1 [Q8IWZ8-1]
PIRiT02299
RefSeqiNP_757386.2, NM_172231.3 [Q8IWZ8-1]

3D structure databases

SMRiQ8IWZ8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121767, 74 interactors
IntActiQ8IWZ8, 27 interactors
MINTiQ8IWZ8
STRINGi9606.ENSP00000247001

PTM databases

iPTMnetiQ8IWZ8
PhosphoSitePlusiQ8IWZ8

Polymorphism and mutation databases

BioMutaiSUGP1
DMDMi61216666

Proteomic databases

EPDiQ8IWZ8
jPOSTiQ8IWZ8
MassIVEiQ8IWZ8
MaxQBiQ8IWZ8
PaxDbiQ8IWZ8
PeptideAtlasiQ8IWZ8
PRIDEiQ8IWZ8
ProteomicsDBi70945 [Q8IWZ8-1]
70946 [Q8IWZ8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1687 147 antibodies

Genome annotation databases

EnsembliENST00000247001; ENSP00000247001; ENSG00000105705 [Q8IWZ8-1]
ENST00000588731; ENSP00000465413; ENSG00000105705 [Q8IWZ8-2]
GeneIDi57794
KEGGihsa:57794
UCSCiuc002nmh.4 human [Q8IWZ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57794
DisGeNETi57794

GeneCards: human genes, protein and diseases

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GeneCardsi
SUGP1
HGNCiHGNC:18643 SUGP1
HPAiENSG00000105705 Low tissue specificity
MIMi607992 gene
neXtProtiNX_Q8IWZ8
OpenTargetsiENSG00000105705
PharmGKBiPA165394338

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0965 Eukaryota
ENOG410ZSH4 LUCA
GeneTreeiENSGT00410000025695
HOGENOMiCLU_028403_0_0_1
InParanoidiQ8IWZ8
KOiK13096
OMAiNYVHAKQ
OrthoDBi1232201at2759
PhylomeDBiQ8IWZ8
TreeFamiTF326321

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SUGP1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57794
PharosiQ8IWZ8 Tbio

Protein Ontology

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PROi
PR:Q8IWZ8
RNActiQ8IWZ8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105705 Expressed in testis and 212 other tissues
ExpressionAtlasiQ8IWZ8 baseline and differential
GenevisibleiQ8IWZ8 HS

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000467 G_patch_dom
IPR040169 SUGP1/2
IPR000061 Surp
IPR035967 SWAP/Surp_sf
PANTHERiPTHR23340 PTHR23340, 3 hits
PfamiView protein in Pfam
PF01585 G-patch, 1 hit
PF01805 Surp, 2 hits
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00648 SWAP, 2 hits
SUPFAMiSSF109905 SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50174 G_PATCH, 1 hit
PS50128 SURP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUGP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWZ8
Secondary accession number(s): O60378
, Q6P3X9, Q8TCQ4, Q8WWT4, Q8WWT5, Q9NTG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 22, 2020
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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