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Entry version 148 (22 Apr 2020)
Sequence version 2 (18 May 2010)
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Protein

Tripartite motif-containing protein 42

Gene

TRIM42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri146 – 192RING-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri235 – 280B box-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri285 – 326B box-type 2PROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19014 TRIM42

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWZ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
287015

Open Targets

More...
OpenTargetsi
ENSG00000155890

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134894780

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWZ5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM42

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452851

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562631 – 723Tripartite motif-containing protein 42Add BLAST723

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IWZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWZ5

PeptideAtlas

More...
PeptideAtlasi
Q8IWZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWZ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70941 [Q8IWZ5-1]
70942 [Q8IWZ5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155890 Expressed in testis and 10 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWZ5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000155890 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q8IWZ5
With#Exp.IntAct
P0DI813EBI-5235829,EBI-5663373
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-5235829,EBI-10173507
AQP1 [P29972]3EBI-5235829,EBI-745213
ARMC7 [Q9H6L4]3EBI-5235829,EBI-742909
ARRDC3 [Q96B67]3EBI-5235829,EBI-2875665
ATG9A - isoform 3 [Q7Z3C6-3]3EBI-5235829,EBI-12006308
AXIN1 [A0A0S2Z4M1]3EBI-5235829,EBI-16429430
BACH2 [Q9BYV9]3EBI-5235829,EBI-1642333
BEX2 [Q9BXY8]3EBI-5235829,EBI-745073
C1orf109 [Q9NX04]3EBI-5235829,EBI-8643161
CARD9 [Q9H257]3EBI-5235829,EBI-751319
CATSPER1 [Q8NEC5]3EBI-5235829,EBI-744545
CCDC120 [Q96HB5]3EBI-5235829,EBI-744556
CCDC24 [Q8N4L8]3EBI-5235829,EBI-1104933
CCDC36 [Q8IYA8]3EBI-5235829,EBI-8638439
CDCA7L [Q96GN5]3EBI-5235829,EBI-5278764
CEP70 [Q8NHQ1]3EBI-5235829,EBI-739624
CERK [Q8TCT0]3EBI-5235829,EBI-10274247
CHCHD2 [Q9Y6H1]3EBI-5235829,EBI-2321769
CHRD [Q9H2X0]5EBI-5235829,EBI-947551
CREB5 - isoform 3 [Q02930-3]6EBI-5235829,EBI-10192698
CYSRT1 [A8MQ03]3EBI-5235829,EBI-3867333
EFEMP2 [O95967]5EBI-5235829,EBI-743414
EFHC2 [Q5JST6]3EBI-5235829,EBI-2349927
EMD [P50402]6EBI-5235829,EBI-489887
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-5235829,EBI-11986315
FAM90A1 [Q86YD7]3EBI-5235829,EBI-6658203
FBLN1 - isoform C [P23142-4]3EBI-5235829,EBI-11956479
FCHO1 [A0A0C3SFZ9]3EBI-5235829,EBI-11977403
FNDC3B - isoform 3 [Q53EP0-3]3EBI-5235829,EBI-10242151
GLI1 [P08151]3EBI-5235829,EBI-308084
GLRX3 [O76003]6EBI-5235829,EBI-374781
GLYCTK [Q8IVS8]3EBI-5235829,EBI-748515
GNE - isoform 2 [Q9Y223-2]3EBI-5235829,EBI-11975289
GOLGA2 [Q08379]3EBI-5235829,EBI-618309
GUCD1 - isoform 2 [Q96NT3-2]3EBI-5235829,EBI-11978177
HOXA1 [P49639]12EBI-5235829,EBI-740785
HOXC8 [P31273]3EBI-5235829,EBI-1752118
HSD3B7 [Q9H2F3]5EBI-5235829,EBI-3918847
IGFN1 - isoform 5 [Q86VF2-5]3EBI-5235829,EBI-11955401
IKZF3 [Q9UKT9]3EBI-5235829,EBI-747204
IL16 - isoform 2 [Q14005-2]3EBI-5235829,EBI-17178971
IQUB [Q8NA54]3EBI-5235829,EBI-10220600
KCTD9 [Q7L273]6EBI-5235829,EBI-4397613
KLHL38 [Q2WGJ6]6EBI-5235829,EBI-6426443
KPRP [Q5T749]3EBI-5235829,EBI-10981970
KRT13 [A1A4E9]3EBI-5235829,EBI-10171552
KRT15 [P19012]3EBI-5235829,EBI-739566
KRT34 [O76011]3EBI-5235829,EBI-1047093
KRT40 [Q6A162]3EBI-5235829,EBI-10171697
KRTAP10-5 [P60370]3EBI-5235829,EBI-10172150
KRTAP10-7 [P60409]3EBI-5235829,EBI-10172290
KRTAP10-8 [P60410]3EBI-5235829,EBI-10171774
KRTAP10-9 [P60411]6EBI-5235829,EBI-10172052
KRTAP12-2 [P59991]3EBI-5235829,EBI-10176379
KRTAP2-4 [Q9BYR9]3EBI-5235829,EBI-14065470
KRTAP26-1 [Q6PEX3]3EBI-5235829,EBI-3957672
KRTAP3-2 [Q9BYR7]3EBI-5235829,EBI-751260
KRTAP4-2 [Q9BYR5]6EBI-5235829,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-5235829,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-5235829,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-5235829,EBI-11993296
KRTAP5-7 [Q6L8G8]3EBI-5235829,EBI-11987425
KRTAP9-3 [Q9BYQ3]3EBI-5235829,EBI-1043191
L3MBTL2 [Q969R5]3EBI-5235829,EBI-739909
LCE1A [Q5T7P2]3EBI-5235829,EBI-11962058
LCE1B [Q5T7P3]6EBI-5235829,EBI-10245913
LCE1C [Q5T751]3EBI-5235829,EBI-12224199
LCE1D [Q5T752]3EBI-5235829,EBI-11741311
LCE1E [Q5T753]3EBI-5235829,EBI-11955335
LCE1F [Q5T754]6EBI-5235829,EBI-11958008
LCE2A [Q5TA79]3EBI-5235829,EBI-10246607
LCE2B [O14633]5EBI-5235829,EBI-11478468
LCE2C [Q5TA81]8EBI-5235829,EBI-11973993
LCE2D [Q5TA82]3EBI-5235829,EBI-10246750
LCE3A [Q5TA76]5EBI-5235829,EBI-9394625
LCE3C [Q5T5A8]5EBI-5235829,EBI-10245291
LCE3D [Q9BYE3]3EBI-5235829,EBI-6658837
LCE3E [Q5T5B0]3EBI-5235829,EBI-10245456
LCE4A [Q5TA78]3EBI-5235829,EBI-10246358
LCE5A [Q5TCM9]5EBI-5235829,EBI-11955689
LNX1 [Q8TBB1]3EBI-5235829,EBI-739832
LONRF1 [Q17RB8]8EBI-5235829,EBI-2341787
LZTS2 [Q9BRK4]3EBI-5235829,EBI-741037
MAGOHB [Q96A72]3EBI-5235829,EBI-746778
MAPKBP1 [O60336]3EBI-5235829,EBI-947402
MEIS2 - isoform 4 [O14770-4]3EBI-5235829,EBI-8025850
MEOX2 [P50222]3EBI-5235829,EBI-748397
MEOX2 [Q6FHY5]3EBI-5235829,EBI-16439278
MFAP1 [P55081]3EBI-5235829,EBI-1048159
MID2 - isoform 2 [Q9UJV3-2]3EBI-5235829,EBI-10172526
MTUS2 [Q5JR59]3EBI-5235829,EBI-742948
NEK8 [Q86SG6]3EBI-5235829,EBI-1752987
NOTCH2NLA [Q7Z3S9]6EBI-5235829,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-5235829,EBI-22310682
OTX1 [P32242]3EBI-5235829,EBI-740446
PCSK5 - isoform PC6A [Q92824-2]3EBI-5235829,EBI-11956269
PHLDA1 [A2BDE7]3EBI-5235829,EBI-14084211
PLSCR1 [O15162]3EBI-5235829,EBI-740019
PLSCR4 [Q9NRQ2]5EBI-5235829,EBI-769257
PNMA1 [Q8ND90]3EBI-5235829,EBI-302345
POU4F2 [Q12837]5EBI-5235829,EBI-17236143
PRKAB2 [O43741]3EBI-5235829,EBI-1053424
PROP1 [O75360]3EBI-5235829,EBI-9027467
PSMA1 [P25786]3EBI-5235829,EBI-359352
PSMD9 [O00233]3EBI-5235829,EBI-750973
PTGER3 - isoform 12 [P43115-12]3EBI-5235829,EBI-10234038
R3HDM2 [Q9Y2K5]3EBI-5235829,EBI-948428
RAMAC [Q9BTL3]3EBI-5235829,EBI-744023
RCOR3 [Q9P2K3]3EBI-5235829,EBI-743428
RUNX1T1 - isoform 4 [Q06455-4]3EBI-5235829,EBI-10224192
SCNM1 [Q9BWG6]3EBI-5235829,EBI-748391
SHFL - isoform 4 [Q9NUL5-4]3EBI-5235829,EBI-11955083
SLIT1 [O75093]3EBI-5235829,EBI-947791
SMARCC1 [Q92922]3EBI-5235829,EBI-355653
SMCP [P49901]3EBI-5235829,EBI-750494
SPAG8 - isoform 2 [Q99932-2]5EBI-5235829,EBI-11959123
SPERT [Q8NA61]3EBI-5235829,EBI-741724
SSX2IP [Q9Y2D8]3EBI-5235829,EBI-2212028
STK16 [O75716]6EBI-5235829,EBI-749295
TASOR2 - isoform 2 [Q5VWN6-2]3EBI-5235829,EBI-10172380
TCAF1 - isoform 2 [Q9Y4C2-2]3EBI-5235829,EBI-11974855
TFAP2D [Q7Z6R9]3EBI-5235829,EBI-11952651
TLX3 [O43711]3EBI-5235829,EBI-3939165
TMEM150A [Q86TG1]3EBI-5235829,EBI-2799342
TRAF1 [Q13077]3EBI-5235829,EBI-359224
TRAF2 [Q12933]3EBI-5235829,EBI-355744
TRIM23 [P36406]3EBI-5235829,EBI-740098
TRIM27 [P14373]3EBI-5235829,EBI-719493
TXNDC5 [Q86UY0]3EBI-5235829,EBI-2825190
VGLL3 - isoform 2 [A8MV65-2]3EBI-5235829,EBI-11957216
VPS37A - isoform 2 [Q8NEZ2-2]3EBI-5235829,EBI-10270911
VWC2L [B2RUY7]3EBI-5235829,EBI-11747707
YIPF3 [Q9GZM5]3EBI-5235829,EBI-743787
YWHAQ [P27348]4EBI-5235829,EBI-359854
YY1 [P25490]3EBI-5235829,EBI-765538
ZBTB1 [Q9Y2K1]3EBI-5235829,EBI-2682961
ZNF330 [Q9Y3S2]3EBI-5235829,EBI-373456
ZNF414 [Q96IQ9]3EBI-5235829,EBI-744257

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
130425, 66 interactors

Protein interaction database and analysis system

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IntActi
Q8IWZ5, 142 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000286349

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWZ5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWZ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini434 – 492COSPROSITE-ProRule annotationAdd BLAST59
Domaini603 – 701Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili382 – 407Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 96Cys-richAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 192RING-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri235 – 280B box-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri285 – 326B box-type 2PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITF3 Eukaryota
ENOG410YJTN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023245_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWZ5

KEGG Orthology (KO)

More...
KOi
K12018

Identification of Orthologs from Complete Genome Data

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OMAi
SRIIEYC

Database of Orthologous Groups

More...
OrthoDBi
207616at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWZ5

TreeFam database of animal gene trees

More...
TreeFami
TF336556

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit
cd16578 RING-HC_TRIM42_C-III, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR042765 TRIM42_RING-HC
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 1 hit
PF00643 zf-B_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC
60 70 80 90 100
QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI
110 120 130 140 150
ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS
160 170 180 190 200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS
210 220 230 240 250
NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR
260 270 280 290 300
CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
310 320 330 340 350
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE
360 370 380 390 400
IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN
410 420 430 440 450
LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV
460 470 480 490 500
DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS
510 520 530 540 550
GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK
560 570 580 590 600
VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
610 620 630 640 650
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM
660 670 680 690 700
ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD
710 720
GHGKNRAKWG LLKNIQSALQ KHF
Length:723
Mass (Da):82,745
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40897D5AF9B186A9
GO
Isoform 2 (identifier: Q8IWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.

Show »
Length:369
Mass (Da):42,200
Checksum:i0824C770CC920AD5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05042 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti516I → T in BAC05042 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052143244K → R5 PublicationsCorresponds to variant dbSNP:rs698673Ensembl.1
Natural variantiVAR_034468475V → M1 PublicationCorresponds to variant dbSNP:rs28594654Ensembl.1
Natural variantiVAR_034469579A → E1 PublicationCorresponds to variant dbSNP:rs9876490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012066347 – 369VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_012067370 – 723Missing in isoform 2. CuratedAdd BLAST354

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF521868 mRNA Translation: AAO14945.1
AK097416 mRNA Translation: BAC05042.1 Sequence problems.
AC026324 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79015.1
BC130472 mRNA Translation: AAI30473.1
BC130474 mRNA Translation: AAI30475.1
AL833848 mRNA Translation: CAD38707.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3113.1 [Q8IWZ5-1]

NCBI Reference Sequences

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RefSeqi
NP_689829.3, NM_152616.4 [Q8IWZ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286349; ENSP00000286349; ENSG00000155890 [Q8IWZ5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
287015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:287015

UCSC genome browser

More...
UCSCi
uc003eto.3 human [Q8IWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521868 mRNA Translation: AAO14945.1
AK097416 mRNA Translation: BAC05042.1 Sequence problems.
AC026324 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79015.1
BC130472 mRNA Translation: AAI30473.1
BC130474 mRNA Translation: AAI30475.1
AL833848 mRNA Translation: CAD38707.1
CCDSiCCDS3113.1 [Q8IWZ5-1]
RefSeqiNP_689829.3, NM_152616.4 [Q8IWZ5-1]

3D structure databases

SMRiQ8IWZ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi130425, 66 interactors
IntActiQ8IWZ5, 142 interactors
STRINGi9606.ENSP00000286349

PTM databases

iPTMnetiQ8IWZ5
PhosphoSitePlusiQ8IWZ5

Polymorphism and mutation databases

BioMutaiTRIM42
DMDMi296452851

Proteomic databases

jPOSTiQ8IWZ5
MassIVEiQ8IWZ5
PaxDbiQ8IWZ5
PeptideAtlasiQ8IWZ5
PRIDEiQ8IWZ5
ProteomicsDBi70941 [Q8IWZ5-1]
70942 [Q8IWZ5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1220 87 antibodies

Genome annotation databases

EnsembliENST00000286349; ENSP00000286349; ENSG00000155890 [Q8IWZ5-1]
GeneIDi287015
KEGGihsa:287015
UCSCiuc003eto.3 human [Q8IWZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
287015
DisGeNETi287015

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM42
HGNCiHGNC:19014 TRIM42
HPAiENSG00000155890 Tissue enriched (testis)
neXtProtiNX_Q8IWZ5
OpenTargetsiENSG00000155890
PharmGKBiPA134894780

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITF3 Eukaryota
ENOG410YJTN LUCA
GeneTreeiENSGT00530000064220
HOGENOMiCLU_023245_0_0_1
InParanoidiQ8IWZ5
KOiK12018
OMAiSRIIEYC
OrthoDBi207616at2759
PhylomeDBiQ8IWZ5
TreeFamiTF336556

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
287015
PharosiQ8IWZ5 Tdark

Protein Ontology

More...
PROi
PR:Q8IWZ5
RNActiQ8IWZ5 protein

Gene expression databases

BgeeiENSG00000155890 Expressed in testis and 10 other tissues
GenevisibleiQ8IWZ5 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
cd16578 RING-HC_TRIM42_C-III, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR042765 TRIM42_RING-HC
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI42_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4
, A1L4B6, Q8N832, Q8NDL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: April 22, 2020
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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