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UniProtKB - Q8IWZ5 (TRI42_HUMAN)

Entry version 147 (26 Feb 2020)
Sequence version 2 (18 May 2010)
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Protein

Tripartite motif-containing protein 42

Gene

TRIM42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri146 – 192RING-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri235 – 280B box-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri285 – 326B box-type 2PROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM42
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19014 TRIM42

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWZ5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		287015

Open Targets

More...OpenTargetsi		ENSG00000155890

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134894780

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWZ5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM42

Domain mapping of disease mutations (DMDM)

More...DMDMi		296452851

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562631 – 723Tripartite motif-containing protein 42Add BLAST723

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWZ5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWZ5

PeptideAtlas

More...PeptideAtlasi		Q8IWZ5

PRoteomics IDEntifications database

More...PRIDEi		Q8IWZ5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70941 [Q8IWZ5-1]
70942 [Q8IWZ5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000155890 Expressed in testis and 10 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWZ5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA003581
HPA022481

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P0DI813EBI-5235829,EBI-5663373
Q6UY14-33EBI-5235829,EBI-10173507
Q9H6L43EBI-5235829,EBI-742909
Q96B673EBI-5235829,EBI-2875665
A0A0S2Z4M13EBI-5235829,EBI-16429430
Q9BXY83EBI-5235829,EBI-745073
Q9NX043EBI-5235829,EBI-8643161
Q9H2573EBI-5235829,EBI-751319
Q8IYA83EBI-5235829,EBI-8638439
Q96GN53EBI-5235829,EBI-5278764
Q8NHQ13EBI-5235829,EBI-739624
Q5JST63EBI-5235829,EBI-2349927
P504026EBI-5235829,EBI-489887
P081513EBI-5235829,EBI-308084
O760036EBI-5235829,EBI-374781
Q8IVS83EBI-5235829,EBI-748515
Q083793EBI-5235829,EBI-618309
P4963910EBI-5235829,EBI-740785
Q9UKT93EBI-5235829,EBI-747204
Q8NA543EBI-5235829,EBI-10220600
Q7L2735EBI-5235829,EBI-4397613
Q2WGJ65EBI-5235829,EBI-6426443
A1A4E93EBI-5235829,EBI-10171552
P190123EBI-5235829,EBI-739566
Q6A1623EBI-5235829,EBI-10171697
P604093EBI-5235829,EBI-10172290
P604116EBI-5235829,EBI-10172052
Q6PEX33EBI-5235829,EBI-3957672
Q9BYR73EBI-5235829,EBI-751260
Q9BYR56EBI-5235829,EBI-10172511
Q969R53EBI-5235829,EBI-739909
Q5T7P34EBI-5235829,EBI-10245913
Q5T7544EBI-5235829,EBI-11958008
Q5TA814EBI-5235829,EBI-11973993
Q17RB87EBI-5235829,EBI-2341787
Q9BRK43EBI-5235829,EBI-741037
Q96A723EBI-5235829,EBI-746778
P502223EBI-5235829,EBI-748397
P550813EBI-5235829,EBI-1048159
Q9UJV3-23EBI-5235829,EBI-10172526
Q5JR593EBI-5235829,EBI-742948
Q7Z3S98EBI-5235829,EBI-945833
O151623EBI-5235829,EBI-740019
Q8ND903EBI-5235829,EBI-302345
P257863EBI-5235829,EBI-359352
O002333EBI-5235829,EBI-750973
P43115-123EBI-5235829,EBI-10234038
Q9BTL33EBI-5235829,EBI-744023
Q9P2K33EBI-5235829,EBI-743428
Q06455-43EBI-5235829,EBI-10224192
Q9BWG63EBI-5235829,EBI-748391
Q8NA613EBI-5235829,EBI-741724
Q9Y2D83EBI-5235829,EBI-2212028
O757165EBI-5235829,EBI-749295
Q5VWN6-23EBI-5235829,EBI-10172380
Q130773EBI-5235829,EBI-359224
Q129333EBI-5235829,EBI-355744
P364063EBI-5235829,EBI-740098
P143733EBI-5235829,EBI-719493
Q86UY05EBI-5235829,EBI-2825190
Q8NEZ2-23EBI-5235829,EBI-10270911
P273483EBI-5235829,EBI-359854
Q9Y2K13EBI-5235829,EBI-2682961

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		130425, 66 interactors

Protein interaction database and analysis system

More...IntActi		Q8IWZ5, 134 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000286349

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWZ5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IWZ5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini434 – 492COSPROSITE-ProRule annotationAdd BLAST59
Domaini603 – 701Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili382 – 407Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 96Cys-richAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 192RING-typePROSITE-ProRule annotationAdd BLAST47
Zinc fingeri235 – 280B box-type 1PROSITE-ProRule annotationAdd BLAST46
Zinc fingeri285 – 326B box-type 2PROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410ITF3 Eukaryota
ENOG410YJTN LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00530000064220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023245_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWZ5

KEGG Orthology (KO)

More...KOi		K12018

Identification of Orthologs from Complete Genome Data

More...OMAi		SRIIEYC

Database of Orthologous Groups

More...OrthoDBi		207616at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IWZ5

TreeFam database of animal gene trees

More...TreeFami		TF336556

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 1 hit
cd16578 RING-HC_TRIM42_C-III, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR042765 TRIM42_RING-HC
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 1 hit
PF00643 zf-B_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC 
        60         70         80         90        100
QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI 
       110        120        130        140        150
ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS 
       160        170        180        190        200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS 
       210        220        230        240        250
NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR 
       260        270        280        290        300
CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE 
       310        320        330        340        350
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE 
       360        370        380        390        400
IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN 
       410        420        430        440        450
LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV 
       460        470        480        490        500
DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS 
       510        520        530        540        550
GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK 
       560        570        580        590        600
VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS 
       610        620        630        640        650
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM 
       660        670        680        690        700
ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD 
       710        720 
GHGKNRAKWG LLKNIQSALQ KHF
Length:723
Mass (Da):82,745
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40897D5AF9B186A9
GO
Isoform 2 (identifier: Q8IWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-369: VRYEIDNDLMEFNILKNSFKADK → GPPLFHSFSLTSSSGTHGEDGVG
     370-723: Missing.

Show »
Length:369
Mass (Da):42,200
Checksum:i0824C770CC920AD5
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05042 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti516I → T in BAC05042 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052143244K → R5 PublicationsCorresponds to variant dbSNP:rs698673Ensembl.1
Natural variantiVAR_034468475V → M1 PublicationCorresponds to variant dbSNP:rs28594654Ensembl.1
Natural variantiVAR_034469579A → E1 PublicationCorresponds to variant dbSNP:rs9876490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012066347 – 369VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedAdd BLAST23
Alternative sequenceiVSP_012067370 – 723Missing in isoform 2. CuratedAdd BLAST354

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF521868 mRNA Translation: AAO14945.1
AK097416 mRNA Translation: BAC05042.1 Sequence problems.
AC026324 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79015.1
BC130472 mRNA Translation: AAI30473.1
BC130474 mRNA Translation: AAI30475.1
AL833848 mRNA Translation: CAD38707.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3113.1 [Q8IWZ5-1]

NCBI Reference Sequences

More...RefSeqi		NP_689829.3, NM_152616.4 [Q8IWZ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000286349; ENSP00000286349; ENSG00000155890 [Q8IWZ5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		287015

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:287015

UCSC genome browser

More...UCSCi		uc003eto.3 human [Q8IWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521868 mRNA Translation: AAO14945.1
AK097416 mRNA Translation: BAC05042.1 Sequence problems.
AC026324 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79015.1
BC130472 mRNA Translation: AAI30473.1
BC130474 mRNA Translation: AAI30475.1
AL833848 mRNA Translation: CAD38707.1
CCDSiCCDS3113.1 [Q8IWZ5-1]
RefSeqiNP_689829.3, NM_152616.4 [Q8IWZ5-1]

3D structure databases

SMRiQ8IWZ5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi130425, 66 interactors
IntActiQ8IWZ5, 134 interactors
STRINGi9606.ENSP00000286349

PTM databases

iPTMnetiQ8IWZ5
PhosphoSitePlusiQ8IWZ5

Polymorphism and mutation databases

BioMutaiTRIM42
DMDMi296452851

Proteomic databases

jPOSTiQ8IWZ5
MassIVEiQ8IWZ5
PaxDbiQ8IWZ5
PeptideAtlasiQ8IWZ5
PRIDEiQ8IWZ5
ProteomicsDBi70941 [Q8IWZ5-1]
70942 [Q8IWZ5-2]

Genome annotation databases

EnsembliENST00000286349; ENSP00000286349; ENSG00000155890 [Q8IWZ5-1]
GeneIDi287015
KEGGihsa:287015
UCSCiuc003eto.3 human [Q8IWZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		287015
DisGeNETi287015

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM42
HGNCiHGNC:19014 TRIM42
HPAiHPA003581
HPA022481
neXtProtiNX_Q8IWZ5
OpenTargetsiENSG00000155890
PharmGKBiPA134894780

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410ITF3 Eukaryota
ENOG410YJTN LUCA
GeneTreeiENSGT00530000064220
HOGENOMiCLU_023245_0_0_1
InParanoidiQ8IWZ5
KOiK12018
OMAiSRIIEYC
OrthoDBi207616at2759
PhylomeDBiQ8IWZ5
TreeFamiTF336556

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		287015
PharosiQ8IWZ5 Tdark

Protein Ontology

More...PROi		PR:Q8IWZ5
RNActiQ8IWZ5 protein

Gene expression databases

BgeeiENSG00000155890 Expressed in testis and 10 other tissues
GenevisibleiQ8IWZ5 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
cd16578 RING-HC_TRIM42_C-III, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR042765 TRIM42_RING-HC
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00041 fn3, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 2 hits
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI42_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWZ5
Secondary accession number(s): A1L4B4
, A1L4B6, Q8N832, Q8NDL3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: February 26, 2020
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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