UniProtKB - Q8IWZ5 (TRI42_HUMAN)
Protein
Tripartite motif-containing protein 42
Gene
TRIM42
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 146 – 192 | RING-typePROSITE-ProRule annotationAdd BLAST | 47 | |
Zinc fingeri | 235 – 280 | B box-type 1PROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 285 – 326 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IWZ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 42 |
Gene namesi | Name:TRIM42 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000155890.3 |
HGNCi | HGNC:19014, TRIM42 |
neXtProti | NX_Q8IWZ5 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 287015 |
OpenTargetsi | ENSG00000155890 |
PharmGKBi | PA134894780 |
Miscellaneous databases
Pharosi | Q8IWZ5, Tdark |
Polymorphism and mutation databases
BioMutai | TRIM42 |
DMDMi | 296452851 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056263 | 1 – 723 | Tripartite motif-containing protein 42Add BLAST | 723 |
Proteomic databases
MassIVEi | Q8IWZ5 |
PaxDbi | Q8IWZ5 |
PeptideAtlasi | Q8IWZ5 |
PRIDEi | Q8IWZ5 |
ProteomicsDBi | 70941 [Q8IWZ5-1] 70942 [Q8IWZ5-2] |
PTM databases
iPTMneti | Q8IWZ5 |
PhosphoSitePlusi | Q8IWZ5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155890, Expressed in testis and 13 other tissues |
Genevisiblei | Q8IWZ5, HS |
Organism-specific databases
HPAi | ENSG00000155890, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Q8IWZ5
Protein-protein interaction databases
BioGRIDi | 130425, 147 interactors |
IntActi | Q8IWZ5, 142 interactors |
STRINGi | 9606.ENSP00000286349 |
Miscellaneous databases
RNActi | Q8IWZ5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 434 – 492 | COSPROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 603 – 701 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 99 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 382 – 407 | Sequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 6 – 96 | Cys-richAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 146 – 192 | RING-typePROSITE-ProRule annotationAdd BLAST | 47 | |
Zinc fingeri | 235 – 280 | B box-type 1PROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 285 – 326 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00530000064220 |
HOGENOMi | CLU_023245_0_0_1 |
InParanoidi | Q8IWZ5 |
OMAi | SRIIEYC |
OrthoDBi | 207616at2759 |
PhylomeDBi | Q8IWZ5 |
TreeFami | TF336556 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit cd16578, RING-HC_TRIM42_C-III, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR017903, COS_domain IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR042765, TRIM42_RING-HC IPR000315, Znf_B-box IPR001841, Znf_RING IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF00643, zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00336, BBOX, 2 hits SM00060, FN3, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS51262, COS, 1 hit PS50853, FN3, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8IWZ5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METAMCVCCP CCTWQRCCPQ LCSCLCCKFI FTSERNCTCF PCPYKDERNC
60 70 80 90 100
QFCHCTCSES PNCHWCCCSW ANDPNCKCCC TASSNLNCYY YESRCCRNTI
110 120 130 140 150
ITFHKGRLRS IHTSSKTALR TGSSDTQVDE VKSIPANSHL VNHLNCPMCS
160 170 180 190 200
RLRLHSFMLP CNHSLCEKCL RQLQKHAEVT ENFFILICPV CDRSHCMPYS
210 220 230 240 250
NKMQLPENYL HGRLTKRYMQ EHGYLKWRFD RSSGPILCQV CRNKRIAYKR
260 270 280 290 300
CITCRLNLCN DCLKAFHSDV AMQDHVFVDT SAEEQDEKIC IHHPSSRIIE
310 320 330 340 350
YCRNDNKLLC TFCKFSFHNG HDTISLIDAC SERAASLFSA IAKFKAVRYE
360 370 380 390 400
IDNDLMEFNI LKNSFKADKE AKRKEIRNGF LKLRSILQEK EKIIMEQIEN
410 420 430 440 450
LEVSRQKEIE KYVYVTTMKV NEMDGLIAYS KEALKETGQV AFLQSAKILV
460 470 480 490 500
DQIEDGIQTT YRPDPQLRLH SINYVPLDFV ELSSAIHELF PTGPKKVRSS
510 520 530 540 550
GDSLPSPYPV HSETMIARKV TFSTHSLGNQ HIYQRSSSML SFSNTDKKAK
560 570 580 590 600
VGLEACGRAQ SATPAKPTDG LYTYWSAGAD SQSVQNSSSF HNWYSFNDGS
610 620 630 640 650
VKTPGPIVIY QTLVYPRAAK VYWTCPAEDV DSFEMEFYEV ITSPPNNVQM
660 670 680 690 700
ELCGQIRDIM QQNLELHNLT PNTEYVFKVR AINDNGPGQW SDICKVVTPD
710 720
GHGKNRAKWG LLKNIQSALQ KHF
Sequence cautioni
The sequence BAC05042 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 516 | I → T in BAC05042 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052143 | 244 | K → R5 PublicationsCorresponds to variant dbSNP:rs698673Ensembl. | 1 | |
Natural variantiVAR_034468 | 475 | V → M1 PublicationCorresponds to variant dbSNP:rs28594654Ensembl. | 1 | |
Natural variantiVAR_034469 | 579 | A → E1 PublicationCorresponds to variant dbSNP:rs9876490Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012066 | 347 – 369 | VRYEI…FKADK → GPPLFHSFSLTSSSGTHGED GVG in isoform 2. CuratedAdd BLAST | 23 | |
Alternative sequenceiVSP_012067 | 370 – 723 | Missing in isoform 2. CuratedAdd BLAST | 354 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF521868 mRNA Translation: AAO14945.1 AK097416 mRNA Translation: BAC05042.1 Sequence problems. AC026324 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79015.1 BC130472 mRNA Translation: AAI30473.1 BC130474 mRNA Translation: AAI30475.1 AL833848 mRNA Translation: CAD38707.1 |
CCDSi | CCDS3113.1 [Q8IWZ5-1] |
RefSeqi | NP_689829.3, NM_152616.4 [Q8IWZ5-1] |
Genome annotation databases
Ensembli | ENST00000286349; ENSP00000286349; ENSG00000155890 [Q8IWZ5-1] |
GeneIDi | 287015 |
KEGGi | hsa:287015 |
UCSCi | uc003eto.3, human [Q8IWZ5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF521868 mRNA Translation: AAO14945.1 AK097416 mRNA Translation: BAC05042.1 Sequence problems. AC026324 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79015.1 BC130472 mRNA Translation: AAI30473.1 BC130474 mRNA Translation: AAI30475.1 AL833848 mRNA Translation: CAD38707.1 |
CCDSi | CCDS3113.1 [Q8IWZ5-1] |
RefSeqi | NP_689829.3, NM_152616.4 [Q8IWZ5-1] |
3D structure databases
SMRi | Q8IWZ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 130425, 147 interactors |
IntActi | Q8IWZ5, 142 interactors |
STRINGi | 9606.ENSP00000286349 |
PTM databases
iPTMneti | Q8IWZ5 |
PhosphoSitePlusi | Q8IWZ5 |
Polymorphism and mutation databases
BioMutai | TRIM42 |
DMDMi | 296452851 |
Proteomic databases
MassIVEi | Q8IWZ5 |
PaxDbi | Q8IWZ5 |
PeptideAtlasi | Q8IWZ5 |
PRIDEi | Q8IWZ5 |
ProteomicsDBi | 70941 [Q8IWZ5-1] 70942 [Q8IWZ5-2] |
Protocols and materials databases
Antibodypediai | 1220, 87 antibodies |
Genome annotation databases
Ensembli | ENST00000286349; ENSP00000286349; ENSG00000155890 [Q8IWZ5-1] |
GeneIDi | 287015 |
KEGGi | hsa:287015 |
UCSCi | uc003eto.3, human [Q8IWZ5-1] |
Organism-specific databases
CTDi | 287015 |
DisGeNETi | 287015 |
EuPathDBi | HostDB:ENSG00000155890.3 |
GeneCardsi | TRIM42 |
HGNCi | HGNC:19014, TRIM42 |
HPAi | ENSG00000155890, Tissue enriched (testis) |
neXtProti | NX_Q8IWZ5 |
OpenTargetsi | ENSG00000155890 |
PharmGKBi | PA134894780 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00530000064220 |
HOGENOMi | CLU_023245_0_0_1 |
InParanoidi | Q8IWZ5 |
OMAi | SRIIEYC |
OrthoDBi | 207616at2759 |
PhylomeDBi | Q8IWZ5 |
TreeFami | TF336556 |
Enzyme and pathway databases
PathwayCommonsi | Q8IWZ5 |
Miscellaneous databases
BioGRID-ORCSi | 287015, 1 hit in 839 CRISPR screens |
GenomeRNAii | 287015 |
Pharosi | Q8IWZ5, Tdark |
PROi | PR:Q8IWZ5 |
RNActi | Q8IWZ5, protein |
Gene expression databases
Bgeei | ENSG00000155890, Expressed in testis and 13 other tissues |
Genevisiblei | Q8IWZ5, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit cd16578, RING-HC_TRIM42_C-III, 1 hit |
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR017903, COS_domain IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR042765, TRIM42_RING-HC IPR000315, Znf_B-box IPR001841, Znf_RING IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF00041, fn3, 1 hit PF00643, zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00336, BBOX, 2 hits SM00060, FN3, 1 hit |
SUPFAMi | SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS51262, COS, 1 hit PS50853, FN3, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRI42_HUMAN | |
Accessioni | Q8IWZ5Primary (citable) accession number: Q8IWZ5 Secondary accession number(s): A1L4B4 Q8NDL3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations