Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q8IWY9 (CDAN1_HUMAN)

Entry version 148 (23 Feb 2022)
Sequence version 4 (18 May 2010)
Previous versions | rss
Add a publicationFeedback
Protein

Codanin-1

Gene

CDAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a negative regulator of ASF1 in chromatin assembly.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IWY9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IWY9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Codanin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDAN1
ORF Names:UNQ664/PRO1295
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1713, CDAN1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607465, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWY9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140326

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anemia, congenital dyserythropoietic, 1A (CDAN1A)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017218599N → S in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074166EnsemblClinVar.1
Natural variantiVAR_017219672P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074167EnsemblClinVar.1
Natural variantiVAR_017220698E → K in CDAN1A. 1 Publication1
Natural variantiVAR_017221714R → W in CDAN1A; partially disrupts ASF1 binding and loss the ability to arrest cells in S phase and inhibit DNA synthesis. 2 PublicationsCorresponds to variant dbSNP:rs80338696EnsemblClinVar.1
Natural variantiVAR_017222868F → I in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074168EnsemblClinVar.1
Natural variantiVAR_017223869V → M in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs370895637EnsemblClinVar.1
Natural variantiVAR_0172241042R → W in CDAN1A; partially disrupts ASF1 binding. 2 PublicationsCorresponds to variant dbSNP:rs80338697EnsemblClinVar.1
Natural variantiVAR_0172251043D → V in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338698EnsemblClinVar.1
Natural variantiVAR_0172261130P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338699EnsemblClinVar.1

Keywords - Diseasei

Congenital dyserythropoietic anemia, Disease variant, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...DisGeNETi		146059

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CDAN1

MalaCards human disease database

More...MalaCardsi		CDAN1
MIMi224120, phenotype

Open Targets

More...OpenTargetsi		ENSG00000140326

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		98869, Congenital dyserythropoietic anemia type I

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26249

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWY9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CDAN1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894392 – 1227Codanin-1Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei71PhosphothreonineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IWY9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWY9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWY9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IWY9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWY9

PeptideAtlas

More...PeptideAtlasi		Q8IWY9

PRoteomics IDEntifications database

More...PRIDEi		Q8IWY9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70932 [Q8IWY9-2]
70933 [Q8IWY9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWY9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Isoform 3 is not found in erythroid cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140326, Expressed in sural nerve and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IWY9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWY9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140326, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126963, 29 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8IWY9

Database of interacting proteins

More...DIPi		DIP-24225N

Protein interaction database and analysis system

More...IntActi		Q8IWY9, 6 interactors

Molecular INTeraction database

More...MINTi		Q8IWY9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348564

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWY9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 294DisorderedSequence analysisAdd BLAST232
Regioni188 – 208Interaction with ASF1A/B1 PublicationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 137Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi158 – 172Polar residuesSequence analysisAdd BLAST15
Compositional biasi193 – 233Polar residuesSequence analysisAdd BLAST41
Compositional biasi260 – 284Polar residuesSequence analysisAdd BLAST25

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPWR, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007378_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWY9

Identification of Orthologs from Complete Genome Data

More...OMAi		CVVKDAQ

Database of Orthologous Groups

More...OrthoDBi		664227at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IWY9

TreeFam database of animal gene trees

More...TreeFami		TF328405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040031, Codanin-1
IPR028171, Codanin-1_C

The PANTHER Classification System

More...PANTHERi		PTHR28678, PTHR28678, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15296, Codanin-1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q8IWY9-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVLESLLR EEVSVAAVVR WIARSTQGSE DNAGEAAALS SLRALRKEFV 
        60         70         80         90        100
PFLLNFLREQ SSRVLPQGPP TPAKTPGASA ALPGRPGGPP RGSRGARSQL 
       110        120        130        140        150
FPPTEAQSTA AEAPLARRGG RRRGPGPARE RGGRGLEEGV SGESLPGAGG 
       160        170        180        190        200
RRLRGSGSPS RPSLTLSDPP NLSNLEEFPP VGSVPPGPTG TKPSRRINPT 
       210        220        230        240        250
PVSEERSLSK PKTCFTSPPI SCVPSSQPSA LDTSPWGLGL PPGCRSLQEE 
       260        270        280        290        300
REMLRKERSK QLQQSPTPTC PTPELGSPLP SRTGSLTDEP ADPARVSSRQ 
       310        320        330        340        350
RLELVALVYS SCIAENLVPN LFLELFFVFQ LLTARRMVTA KDSDPELSPA 
       360        370        380        390        400
VLDSLESPLF QSIHDCVFFA VQVLECHFQV LSNLDKGTLK LLAENERLLC 
       410        420        430        440        450
FSPALQGRLR AAYEGSVAKV SLVMPPSTQA VSFQPETDNR ANFSSDRAFH 
       460        470        480        490        500
TFKKQRDVFY EVLREWEDHH EEPGWDFEKG LGSRIRAMMG QLSAACSHSH 
       510        520        530        540        550
FVRLFQKQLL QMCQSPGGAG GTVLGEAPDV LSMLGADKLG RLWRLQERLM 
       560        570        580        590        600
APQSSGGPCP PPTFPGCQGF FRDFILSASS FQFNQHLMDS LSLKIQELNG 
       610        620        630        640        650
LALPQHEPND EDGESDVDWQ GERKQFAVVL LSLRLLAKFL GFVAFLPYRG 
       660        670        680        690        700
PEPPPTGELQ DSILALRSQV PPVLDVRTLL QRGLQARRAV LTVPWLVEFL 
       710        720        730        740        750
SFADHVVPLL EYYRDIFTLL LRLHRSLVLS QESEGKMCFL NKLLLLAVLG 
       760        770        780        790        800
WLFQIPTVPE DLFFLEEGPS YAFEVDTVAP EHGLDNAPVV DQQLLYTCCP 
       810        820        830        840        850
YIGELRKLLA SWVSGSSGRS GGFMRKITPT TTTSLGAQPS QTSQGLQAQL 
       860        870        880        890        900
AQAFFHNQPP SLRRTVEFVA ERIGSNCVKH IKATLVADLV RQAESLLQEQ 
       910        920        930        940        950
LVTQGEEGGD PAQLLEILCS QLCPHGAQAL ALGREFCQRK SPGAVRALLP 
       960        970        980        990       1000
EETPAAVLSS AENIAVGLAT EKACAWLSAN ITALIRREVK AAVSRTLRAQ 
      1010       1020       1030       1040       1050
GPEPAARGER RGCSRACEHH APLPSHLISE IKDVLSLAVG PRDPDEGVSP 
      1060       1070       1080       1090       1100
EHLEQLLGQL GQTLRCRQFL CPPAEQHLAK CSVELASLLV ADQIPILGPP 
      1110       1120       1130       1140       1150
AQYRLERGQA RRLLHMLLSL WKEDFQGPVP LQLLLSPRNV GLLADTRPRE 
      1160       1170       1180       1190       1200
WDLLLFLLRE LVEKGLMGRM EIEACLGSLH QAQWPGDFAE ELATLSNLFL 
      1210       1220 
AEPHLPEPQL RACELVQPNR GTVLAQS
Length:1,227
Mass (Da):134,120
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2BC04ACD669DF6F
GO
Isoform 1 (identifier: Q8IWY9-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: G → GETQLSCRRWVPRRLWGVSHSSSALRSGAPGCR
     226-258: Missing.

Show »
Length:1,226
Mass (Da):133,992
Checksum:i0674D569F19BCD52
GO
Isoform 3 (identifier: Q8IWY9-3)
Sequence is not available
Length:–
Mass (Da):–

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BM60H3BM60_HUMAN
Codanin-1
CDAN1
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPZ6H3BPZ6_HUMAN
Codanin-1
CDAN1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5C2A0A2R8Y5C2_HUMAN
Codanin-1
CDAN1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52568 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAO14994 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAQ88832 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31 – 32DN → VT in AAO14994 (PubMed:12434312).Curated2
Sequence conflicti39L → V in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti42 – 45LRAL → FGAW in AAO14994 (PubMed:12434312).Curated4
Sequence conflicti51 – 52PF → RS in AAO14994 (PubMed:12434312).Curated2
Sequence conflicti55N → T in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti73A → P in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti76P → R in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti82L → C in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti93S → T in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti380V → F in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti421S → F in AAH52568 (PubMed:15489334).Curated1
Sequence conflicti421S → F in AAH66640 (PubMed:15489334).Curated1
Sequence conflicti669Q → P in AAQ88832 (PubMed:12975309).Curated1
Sequence conflicti726S → C in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti946R → W in AAH01092 (PubMed:15489334).Curated1
Sequence conflicti946R → W in AAH08333 (PubMed:15489334).Curated1
Sequence conflicti946R → W in AAH08334 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059602107Q → L. Corresponds to variant dbSNP:rs4265781EnsemblClinVar.1
Natural variantiVAR_056785596Q → R. Corresponds to variant dbSNP:rs12917189EnsemblClinVar.1
Natural variantiVAR_017218599N → S in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074166EnsemblClinVar.1
Natural variantiVAR_017219672P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074167EnsemblClinVar.1
Natural variantiVAR_017220698E → K in CDAN1A. 1 Publication1
Natural variantiVAR_017221714R → W in CDAN1A; partially disrupts ASF1 binding and loss the ability to arrest cells in S phase and inhibit DNA synthesis. 2 PublicationsCorresponds to variant dbSNP:rs80338696EnsemblClinVar.1
Natural variantiVAR_017222868F → I in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074168EnsemblClinVar.1
Natural variantiVAR_017223869V → M in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs370895637EnsemblClinVar.1
Natural variantiVAR_056786891R → C. Corresponds to variant dbSNP:rs8023524EnsemblClinVar.1
Natural variantiVAR_0172241042R → W in CDAN1A; partially disrupts ASF1 binding. 2 PublicationsCorresponds to variant dbSNP:rs80338697EnsemblClinVar.1
Natural variantiVAR_0172251043D → V in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338698EnsemblClinVar.1
Natural variantiVAR_0172261130P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338699EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027097190G → GETQLSCRRWVPRRLWGVSH SSSALRSGAPGCR in isoform 1. 1 Publication1
Alternative sequenceiVSP_027098226 – 258Missing in isoform 1. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF525398 mRNA Translation: AAO14994.1 Different initiation.
AC090510 Genomic DNA No translation available.
BC001092 mRNA Translation: AAH01092.1
BC008333 mRNA Translation: AAH08333.1
BC008334 mRNA Translation: AAH08334.1
BC052568 mRNA Translation: AAH52568.1 Different initiation.
BC066640 mRNA Translation: AAH66640.1
AY358467 mRNA Translation: AAQ88832.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32209.1 [Q8IWY9-2]

NCBI Reference Sequences

More...RefSeqi		NP_612486.2, NM_138477.2 [Q8IWY9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356231; ENSP00000348564; ENSG00000140326

Database of genes from NCBI RefSeq genomes

More...GeneIDi		146059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:146059

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000356231.4; ENSP00000348564.3; NM_138477.4; NP_612486.2

UCSC genome browser

More...UCSCi		uc001zql.4, human [Q8IWY9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525398 mRNA Translation: AAO14994.1 Different initiation.
AC090510 Genomic DNA No translation available.
BC001092 mRNA Translation: AAH01092.1
BC008333 mRNA Translation: AAH08333.1
BC008334 mRNA Translation: AAH08334.1
BC052568 mRNA Translation: AAH52568.1 Different initiation.
BC066640 mRNA Translation: AAH66640.1
AY358467 mRNA Translation: AAQ88832.1 Different initiation.
CCDSiCCDS32209.1 [Q8IWY9-2]
RefSeqiNP_612486.2, NM_138477.2 [Q8IWY9-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126963, 29 interactors
CORUMiQ8IWY9
DIPiDIP-24225N
IntActiQ8IWY9, 6 interactors
MINTiQ8IWY9
STRINGi9606.ENSP00000348564

PTM databases

iPTMnetiQ8IWY9
PhosphoSitePlusiQ8IWY9

Genetic variation databases

BioMutaiCDAN1
DMDMi296439465

Proteomic databases

EPDiQ8IWY9
jPOSTiQ8IWY9
MassIVEiQ8IWY9
MaxQBiQ8IWY9
PaxDbiQ8IWY9
PeptideAtlasiQ8IWY9
PRIDEiQ8IWY9
ProteomicsDBi70932 [Q8IWY9-2]
70933 [Q8IWY9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42152, 129 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		146059

Genome annotation databases

EnsembliENST00000356231; ENSP00000348564; ENSG00000140326
GeneIDi146059
KEGGihsa:146059
MANE-SelectiENST00000356231.4; ENSP00000348564.3; NM_138477.4; NP_612486.2
UCSCiuc001zql.4, human [Q8IWY9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146059
DisGeNETi146059

GeneCards: human genes, protein and diseases

More...GeneCardsi		CDAN1
GeneReviewsiCDAN1
HGNCiHGNC:1713, CDAN1
HPAiENSG00000140326, Low tissue specificity
MalaCardsiCDAN1
MIMi224120, phenotype
607465, gene
neXtProtiNX_Q8IWY9
OpenTargetsiENSG00000140326
Orphaneti98869, Congenital dyserythropoietic anemia type I
PharmGKBiPA26249
VEuPathDBiHostDB:ENSG00000140326

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPWR, Eukaryota
GeneTreeiENSGT00390000000491
HOGENOMiCLU_007378_0_0_1
InParanoidiQ8IWY9
OMAiCVVKDAQ
OrthoDBi664227at2759
PhylomeDBiQ8IWY9
TreeFamiTF328405

Enzyme and pathway databases

PathwayCommonsiQ8IWY9
SignaLinkiQ8IWY9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		146059, 466 hits in 1055 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CDAN1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		146059
PharosiQ8IWY9, Tbio

Protein Ontology

More...PROi		PR:Q8IWY9
RNActiQ8IWY9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140326, Expressed in sural nerve and 191 other tissues
ExpressionAtlasiQ8IWY9, baseline and differential
GenevisibleiQ8IWY9, HS

Family and domain databases

InterProiView protein in InterPro
IPR040031, Codanin-1
IPR028171, Codanin-1_C
PANTHERiPTHR28678, PTHR28678, 1 hit
PfamiView protein in Pfam
PF15296, Codanin-1_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDAN1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWY9
Secondary accession number(s): Q6NYD0, Q7Z7L5, Q969N3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: May 18, 2010
Last modified: February 23, 2022
This is version 148 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again