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Entry version 138 (11 Dec 2019)
Sequence version 4 (18 May 2010)
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Protein

Codanin-1

Gene

CDAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a negative regulator of ASF1 in chromatin assembly.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Codanin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDAN1
ORF Names:UNQ664/PRO1295
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000140326.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1713 CDAN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607465 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWY9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Transmembranei626 – 646HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Anemia, congenital dyserythropoietic, 1A (CDAN1A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017218599N → S in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074166EnsemblClinVar.1
Natural variantiVAR_017219672P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074167EnsemblClinVar.1
Natural variantiVAR_017220698E → K in CDAN1A. 1 Publication1
Natural variantiVAR_017221714R → W in CDAN1A; partially disrupts ASF1 binding and loss the ability to arrest cells in S phase and inhibit DNA synthesis. 2 PublicationsCorresponds to variant dbSNP:rs80338696EnsemblClinVar.1
Natural variantiVAR_017222868F → I in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074168EnsemblClinVar.1
Natural variantiVAR_017223869V → M in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs370895637Ensembl.1
Natural variantiVAR_0172241042R → W in CDAN1A; partially disrupts ASF1 binding. 2 PublicationsCorresponds to variant dbSNP:rs80338697EnsemblClinVar.1
Natural variantiVAR_0172251043D → V in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338698EnsemblClinVar.1
Natural variantiVAR_0172261130P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338699EnsemblClinVar.1

Keywords - Diseasei

Congenital dyserythropoietic anemia, Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
146059

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CDAN1

MalaCards human disease database

More...
MalaCardsi
CDAN1
MIMi224120 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000140326

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98869 Congenital dyserythropoietic anemia type I

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26249

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWY9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDAN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000894392 – 1227Codanin-1Add BLAST1226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei71PhosphothreonineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWY9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWY9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IWY9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWY9

PeptideAtlas

More...
PeptideAtlasi
Q8IWY9

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWY9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70932 [Q8IWY9-2]
70933 [Q8IWY9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWY9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Isoform 3 is not found in erythroid cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140326 Expressed in 178 organ(s), highest expression level in left ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWY9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWY9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039404
HPA040787

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a cytosolic complex with ASF1A, ASF1B, IPO4 and histones H3.1 and H4.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126963, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IWY9

Database of interacting proteins

More...
DIPi
DIP-24225N

Protein interaction database and analysis system

More...
IntActi
Q8IWY9, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8IWY9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348564

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWY9 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni188 – 208Interaction with ASF1A/B1 PublicationAdd BLAST21

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGHV Eukaryota
ENOG410XXWY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111492

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWY9

KEGG Orthology (KO)

More...
KOi
K19531

Identification of Orthologs from Complete Genome Data

More...
OMAi
CVVKDAQ

Database of Orthologous Groups

More...
OrthoDBi
664227at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWY9

TreeFam database of animal gene trees

More...
TreeFami
TF328405

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040031 Codanin-1
IPR028171 Codanin-1_C

The PANTHER Classification System

More...
PANTHERi
PTHR28678 PTHR28678, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15296 Codanin-1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q8IWY9-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVLESLLR EEVSVAAVVR WIARSTQGSE DNAGEAAALS SLRALRKEFV
60 70 80 90 100
PFLLNFLREQ SSRVLPQGPP TPAKTPGASA ALPGRPGGPP RGSRGARSQL
110 120 130 140 150
FPPTEAQSTA AEAPLARRGG RRRGPGPARE RGGRGLEEGV SGESLPGAGG
160 170 180 190 200
RRLRGSGSPS RPSLTLSDPP NLSNLEEFPP VGSVPPGPTG TKPSRRINPT
210 220 230 240 250
PVSEERSLSK PKTCFTSPPI SCVPSSQPSA LDTSPWGLGL PPGCRSLQEE
260 270 280 290 300
REMLRKERSK QLQQSPTPTC PTPELGSPLP SRTGSLTDEP ADPARVSSRQ
310 320 330 340 350
RLELVALVYS SCIAENLVPN LFLELFFVFQ LLTARRMVTA KDSDPELSPA
360 370 380 390 400
VLDSLESPLF QSIHDCVFFA VQVLECHFQV LSNLDKGTLK LLAENERLLC
410 420 430 440 450
FSPALQGRLR AAYEGSVAKV SLVMPPSTQA VSFQPETDNR ANFSSDRAFH
460 470 480 490 500
TFKKQRDVFY EVLREWEDHH EEPGWDFEKG LGSRIRAMMG QLSAACSHSH
510 520 530 540 550
FVRLFQKQLL QMCQSPGGAG GTVLGEAPDV LSMLGADKLG RLWRLQERLM
560 570 580 590 600
APQSSGGPCP PPTFPGCQGF FRDFILSASS FQFNQHLMDS LSLKIQELNG
610 620 630 640 650
LALPQHEPND EDGESDVDWQ GERKQFAVVL LSLRLLAKFL GFVAFLPYRG
660 670 680 690 700
PEPPPTGELQ DSILALRSQV PPVLDVRTLL QRGLQARRAV LTVPWLVEFL
710 720 730 740 750
SFADHVVPLL EYYRDIFTLL LRLHRSLVLS QESEGKMCFL NKLLLLAVLG
760 770 780 790 800
WLFQIPTVPE DLFFLEEGPS YAFEVDTVAP EHGLDNAPVV DQQLLYTCCP
810 820 830 840 850
YIGELRKLLA SWVSGSSGRS GGFMRKITPT TTTSLGAQPS QTSQGLQAQL
860 870 880 890 900
AQAFFHNQPP SLRRTVEFVA ERIGSNCVKH IKATLVADLV RQAESLLQEQ
910 920 930 940 950
LVTQGEEGGD PAQLLEILCS QLCPHGAQAL ALGREFCQRK SPGAVRALLP
960 970 980 990 1000
EETPAAVLSS AENIAVGLAT EKACAWLSAN ITALIRREVK AAVSRTLRAQ
1010 1020 1030 1040 1050
GPEPAARGER RGCSRACEHH APLPSHLISE IKDVLSLAVG PRDPDEGVSP
1060 1070 1080 1090 1100
EHLEQLLGQL GQTLRCRQFL CPPAEQHLAK CSVELASLLV ADQIPILGPP
1110 1120 1130 1140 1150
AQYRLERGQA RRLLHMLLSL WKEDFQGPVP LQLLLSPRNV GLLADTRPRE
1160 1170 1180 1190 1200
WDLLLFLLRE LVEKGLMGRM EIEACLGSLH QAQWPGDFAE ELATLSNLFL
1210 1220
AEPHLPEPQL RACELVQPNR GTVLAQS
Length:1,227
Mass (Da):134,120
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2BC04ACD669DF6F
GO
Isoform 1 (identifier: Q8IWY9-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-190: G → GETQLSCRRWVPRRLWGVSHSSSALRSGAPGCR
     226-258: Missing.

Show »
Length:1,226
Mass (Da):133,992
Checksum:i0674D569F19BCD52
GO
Isoform 3 (identifier: Q8IWY9-3)
Sequence is not available
Length:
Mass (Da):

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BM60H3BM60_HUMAN
Codanin-1
CDAN1
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPZ6H3BPZ6_HUMAN
Codanin-1
CDAN1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5C2A0A2R8Y5C2_HUMAN
Codanin-1
CDAN1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52568 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAO14994 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAQ88832 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti31 – 32DN → VT in AAO14994 (PubMed:12434312).Curated2
Sequence conflicti39L → V in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti42 – 45LRAL → FGAW in AAO14994 (PubMed:12434312).Curated4
Sequence conflicti51 – 52PF → RS in AAO14994 (PubMed:12434312).Curated2
Sequence conflicti55N → T in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti73A → P in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti76P → R in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti82L → C in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti93S → T in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti380V → F in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti421S → F in AAH52568 (PubMed:15489334).Curated1
Sequence conflicti421S → F in AAH66640 (PubMed:15489334).Curated1
Sequence conflicti669Q → P in AAQ88832 (PubMed:12975309).Curated1
Sequence conflicti726S → C in AAO14994 (PubMed:12434312).Curated1
Sequence conflicti946R → W in AAH01092 (PubMed:15489334).Curated1
Sequence conflicti946R → W in AAH08333 (PubMed:15489334).Curated1
Sequence conflicti946R → W in AAH08334 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059602107Q → L. Corresponds to variant dbSNP:rs4265781EnsemblClinVar.1
Natural variantiVAR_056785596Q → R. Corresponds to variant dbSNP:rs12917189EnsemblClinVar.1
Natural variantiVAR_017218599N → S in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074166EnsemblClinVar.1
Natural variantiVAR_017219672P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074167EnsemblClinVar.1
Natural variantiVAR_017220698E → K in CDAN1A. 1 Publication1
Natural variantiVAR_017221714R → W in CDAN1A; partially disrupts ASF1 binding and loss the ability to arrest cells in S phase and inhibit DNA synthesis. 2 PublicationsCorresponds to variant dbSNP:rs80338696EnsemblClinVar.1
Natural variantiVAR_017222868F → I in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs120074168EnsemblClinVar.1
Natural variantiVAR_017223869V → M in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs370895637Ensembl.1
Natural variantiVAR_056786891R → C. Corresponds to variant dbSNP:rs8023524EnsemblClinVar.1
Natural variantiVAR_0172241042R → W in CDAN1A; partially disrupts ASF1 binding. 2 PublicationsCorresponds to variant dbSNP:rs80338697EnsemblClinVar.1
Natural variantiVAR_0172251043D → V in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338698EnsemblClinVar.1
Natural variantiVAR_0172261130P → L in CDAN1A. 1 PublicationCorresponds to variant dbSNP:rs80338699EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027097190G → GETQLSCRRWVPRRLWGVSH SSSALRSGAPGCR in isoform 1. 1 Publication1
Alternative sequenceiVSP_027098226 – 258Missing in isoform 1. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF525398 mRNA Translation: AAO14994.1 Different initiation.
AC090510 Genomic DNA No translation available.
BC001092 mRNA Translation: AAH01092.1
BC008333 mRNA Translation: AAH08333.1
BC008334 mRNA Translation: AAH08334.1
BC052568 mRNA Translation: AAH52568.1 Different initiation.
BC066640 mRNA Translation: AAH66640.1
AY358467 mRNA Translation: AAQ88832.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32209.1 [Q8IWY9-2]

NCBI Reference Sequences

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RefSeqi
NP_612486.2, NM_138477.2 [Q8IWY9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356231; ENSP00000348564; ENSG00000140326 [Q8IWY9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
146059

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:146059

UCSC genome browser

More...
UCSCi
uc001zql.4 human [Q8IWY9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525398 mRNA Translation: AAO14994.1 Different initiation.
AC090510 Genomic DNA No translation available.
BC001092 mRNA Translation: AAH01092.1
BC008333 mRNA Translation: AAH08333.1
BC008334 mRNA Translation: AAH08334.1
BC052568 mRNA Translation: AAH52568.1 Different initiation.
BC066640 mRNA Translation: AAH66640.1
AY358467 mRNA Translation: AAQ88832.1 Different initiation.
CCDSiCCDS32209.1 [Q8IWY9-2]
RefSeqiNP_612486.2, NM_138477.2 [Q8IWY9-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126963, 12 interactors
CORUMiQ8IWY9
DIPiDIP-24225N
IntActiQ8IWY9, 5 interactors
MINTiQ8IWY9
STRINGi9606.ENSP00000348564

PTM databases

iPTMnetiQ8IWY9
PhosphoSitePlusiQ8IWY9

Polymorphism and mutation databases

BioMutaiCDAN1
DMDMi296439465

Proteomic databases

EPDiQ8IWY9
jPOSTiQ8IWY9
MassIVEiQ8IWY9
PaxDbiQ8IWY9
PeptideAtlasiQ8IWY9
PRIDEiQ8IWY9
ProteomicsDBi70932 [Q8IWY9-2]
70933 [Q8IWY9-1]

Genome annotation databases

EnsembliENST00000356231; ENSP00000348564; ENSG00000140326 [Q8IWY9-2]
GeneIDi146059
KEGGihsa:146059
UCSCiuc001zql.4 human [Q8IWY9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146059
DisGeNETi146059
EuPathDBiHostDB:ENSG00000140326.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDAN1
GeneReviewsiCDAN1
HGNCiHGNC:1713 CDAN1
HPAiHPA039404
HPA040787
MalaCardsiCDAN1
MIMi224120 phenotype
607465 gene
neXtProtiNX_Q8IWY9
OpenTargetsiENSG00000140326
Orphaneti98869 Congenital dyserythropoietic anemia type I
PharmGKBiPA26249

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGHV Eukaryota
ENOG410XXWY LUCA
GeneTreeiENSGT00390000000491
HOGENOMiHOG000111492
InParanoidiQ8IWY9
KOiK19531
OMAiCVVKDAQ
OrthoDBi664227at2759
PhylomeDBiQ8IWY9
TreeFamiTF328405

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDAN1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
146059
PharosiQ8IWY9 Tbio

Protein Ontology

More...
PROi
PR:Q8IWY9
RNActiQ8IWY9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140326 Expressed in 178 organ(s), highest expression level in left ovary
ExpressionAtlasiQ8IWY9 baseline and differential
GenevisibleiQ8IWY9 HS

Family and domain databases

InterProiView protein in InterPro
IPR040031 Codanin-1
IPR028171 Codanin-1_C
PANTHERiPTHR28678 PTHR28678, 1 hit
PfamiView protein in Pfam
PF15296 Codanin-1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDAN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWY9
Secondary accession number(s): Q6NYD0, Q7Z7L5, Q969N3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 138 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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