The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q8IWY8 (ZSC29_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 29
Gene
ZSCAN29
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 678 – 700 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 706 – 728 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 734 – 756 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 762 – 784 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 790 – 812 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 818 – 840 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8IWY8 |
SignaLinki | Q8IWY8 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 29Alternative name(s): Zinc finger protein 690 |
Gene namesi | Name:ZSCAN29 Synonyms:ZNF690 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26673, ZSCAN29 |
neXtProti | NX_Q8IWY8 |
VEuPathDBi | HostDB:ENSG00000140265 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000140265 |
PharmGKBi | PA162411015 |
Miscellaneous databases
Pharosi | Q8IWY8, Tdark |
Genetic variation databases
BioMutai | ZSCAN29 |
DMDMi | 259016454 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234011 | 1 – 852 | Zinc finger and SCAN domain-containing protein 29Add BLAST | 852 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 112 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 153 | PhosphoserineCombined sources | 1 | |
Cross-linki | 180 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 561 | PhosphoserineCombined sources | 1 | |
Cross-linki | 576 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 652 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q8IWY8 |
jPOSTi | Q8IWY8 |
MassIVEi | Q8IWY8 |
MaxQBi | Q8IWY8 |
PaxDbi | Q8IWY8 |
PeptideAtlasi | Q8IWY8 |
PRIDEi | Q8IWY8 |
ProteomicsDBi | 70928 [Q8IWY8-1] 70929 [Q8IWY8-2] 70930 [Q8IWY8-3] 70931 [Q8IWY8-4] |
PTM databases
iPTMneti | Q8IWY8 |
PhosphoSitePlusi | Q8IWY8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000140265, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | Q8IWY8, baseline and differential |
Genevisiblei | Q8IWY8, HS |
Organism-specific databases
HPAi | ENSG00000140265, Low tissue specificity |
Interactioni
Binary interactionsi
Isoform 3 [Q8IWY8-3]
With | #Exp. | IntAct |
---|---|---|
SEC22C [Q9BRL7] | 3 | EBI-14188237,EBI-10297029 |
ZNF446 - isoform 2 [Q9NWS9-2] | 3 | EBI-14188237,EBI-740232 |
Protein-protein interaction databases
BioGRIDi | 126960, 27 interactors |
IntActi | Q8IWY8, 12 interactors |
STRINGi | 9606.ENSP00000380174 |
Miscellaneous databases
RNActi | Q8IWY8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 100 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 96 – 182 | DisorderedSequence analysisAdd BLAST | 87 | |
Regioni | 347 – 400 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 502 – 557 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 603 – 625 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 141 – 155 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 362 – 376 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 508 – 522 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 528 – 546 | Acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 678 – 700 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 706 – 728 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 734 – 756 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 762 – 784 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 790 – 812 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 818 – 840 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161523 |
HOGENOMi | CLU_002678_88_0_1 |
InParanoidi | Q8IWY8 |
OMAi | SERKIPC |
PhylomeDBi | Q8IWY8 |
TreeFami | TF336839 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR044822, Myb_DNA-bind_4 IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 2 hits PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8IWY8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMAKSALREN GTNSETFRQR FRRFHYQEVA GPREAFSQLW ELCCRWLRPE
60 70 80 90 100
VRTKEQIVEL LVLEQFLTVL PGEIQNWVQE QCPENGEEAV TLVEDLEREP
110 120 130 140 150
GRPRSSVTVS VKGQEVRLEK MTPPKSSQEL LSVRQESVEP QPRGVPKKER
160 170 180 190 200
ARSPDLGPQE QMNPKEKLKP FQRSGLPFPK SGVVSRLEQG EPWIPDLLGS
210 220 230 240 250
KEKELPSGSH IGDRRVHADL LPSKKDRRSW VEQDHWSFED EKVAGVHWGY
260 270 280 290 300
EETRTLLAIL SQTEFYEALR NCHRNSQVYG AVAERLREYG FLRTLEQCRT
310 320 330 340 350
KFKGLQKSYR KVKSGHPPET CPFFEEMEAL MSAQVIALPS NGLEAAASHS
360 370 380 390 400
GLVGSDAETE EPGQRGWQHE EGAEEAVAQE SDSDDMDLEA TPQDPNSAAP
410 420 430 440 450
VVFRSPGGVH WGYEETKTYL AILSETQFYE ALRNCHRNSQ LYGAVAERLW
460 470 480 490 500
EYGFLRTPEQ CRTKFKSLQT SYRKVKNGQA PETCPFFEEM DALVSVRVAA
510 520 530 540 550
PPNDGQEETA SCPVQGTSEA EAQKQAEEAD EATEEDSDDD EEDTEIPPGA
560 570 580 590 600
VITRAPVLFQ SPRGFEAGFE NEDNSKRDIS EEVQLHRTLL ARSERKIPRY
610 620 630 640 650
LHQGKGNESD CRSGRQWAKT SGEKRGKLTL PEKSLSEVLS QQRPCLGERP
660 670 680 690 700
YKYLKYSKSF GPNSLLMHQV SHQVENPYKC ADCGKSFSRS ARLIRHRRIH
710 720 730 740 750
TGEKPYKCLD CGKSFRDSSN FITHRRIHTG EKPYQCGECG KCFNQSSSLI
760 770 780 790 800
IHQRTHTGEK PYQCEECGKS FNNSSHFSAH RRIHTGERPH VCPDCGKSFS
810 820 830 840 850
KSSDLRAHHR THTGEKPYGC HDCGKCFSKS SALNKHGEIH AREKLLTQSA
PK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9K0J8 | C9K0J8_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN29 | 556 | Annotation score: | ||
H3BUW4 | H3BUW4_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN29 | 199 | Annotation score: | ||
A0A0C4DGM2 | A0A0C4DGM2_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN29 | 462 | Annotation score: | ||
H3BMU4 | H3BMU4_HUMAN | Zinc finger and SCAN domain-contain... | ZSCAN29 | 330 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 182 | G → S in AAI09271 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059949 | 104 | R → G1 PublicationCorresponds to variant dbSNP:rs3809482Ensembl. | 1 | |
Natural variantiVAR_057459 | 199 | G → S1 PublicationCorresponds to variant dbSNP:rs3917221Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018179 | 1 – 120 | Missing in isoform 2. 1 PublicationAdd BLAST | 120 | |
Alternative sequenceiVSP_018180 | 176 – 564 | Missing in isoform 4. 1 PublicationAdd BLAST | 389 | |
Alternative sequenceiVSP_018181 | 495 – 557 | SVRVA…TRAPV → LKLDLRMKIIQNGIFLRKYN CIGHYLQDLKGKFPGIFIRV KAMRVTVDQEDSGQRPQGRK EEN in isoform 3. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_018182 | 558 – 852 | Missing in isoform 3. 1 PublicationAdd BLAST | 295 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093186 mRNA Translation: BAC04088.1 AK122788 mRNA Translation: BAG53731.1 AF525399 mRNA Translation: AAO14995.1 BC109270 mRNA Translation: AAI09271.1 BC109271 mRNA Translation: AAI09272.1 |
CCDSi | CCDS10095.2 [Q8IWY8-1] |
RefSeqi | NP_689668.3, NM_152455.3 [Q8IWY8-1] XP_006720464.1, XM_006720401.3 XP_011519568.1, XM_011521266.2 |
Genome annotation databases
Ensembli | ENST00000396976.6; ENSP00000380174.2; ENSG00000140265.14 ENST00000684362.1; ENSP00000507363.1; ENSG00000140265.14 |
GeneIDi | 146050 |
KEGGi | hsa:146050 |
MANE-Selecti | ENST00000684362.1; ENSP00000507363.1; NM_001372080.1; NP_001359009.1 |
UCSCi | uc001zrk.2, human [Q8IWY8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093186 mRNA Translation: BAC04088.1 AK122788 mRNA Translation: BAG53731.1 AF525399 mRNA Translation: AAO14995.1 BC109270 mRNA Translation: AAI09271.1 BC109271 mRNA Translation: AAI09272.1 |
CCDSi | CCDS10095.2 [Q8IWY8-1] |
RefSeqi | NP_689668.3, NM_152455.3 [Q8IWY8-1] XP_006720464.1, XM_006720401.3 XP_011519568.1, XM_011521266.2 |
3D structure databases
AlphaFoldDBi | Q8IWY8 |
SMRi | Q8IWY8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126960, 27 interactors |
IntActi | Q8IWY8, 12 interactors |
STRINGi | 9606.ENSP00000380174 |
PTM databases
iPTMneti | Q8IWY8 |
PhosphoSitePlusi | Q8IWY8 |
Genetic variation databases
BioMutai | ZSCAN29 |
DMDMi | 259016454 |
Proteomic databases
EPDi | Q8IWY8 |
jPOSTi | Q8IWY8 |
MassIVEi | Q8IWY8 |
MaxQBi | Q8IWY8 |
PaxDbi | Q8IWY8 |
PeptideAtlasi | Q8IWY8 |
PRIDEi | Q8IWY8 |
ProteomicsDBi | 70928 [Q8IWY8-1] 70929 [Q8IWY8-2] 70930 [Q8IWY8-3] 70931 [Q8IWY8-4] |
Protocols and materials databases
ABCDi | Q8IWY8, 10 sequenced antibodies |
Antibodypediai | 11192, 114 antibodies from 21 providers |
DNASUi | 146050 |
Genome annotation databases
Ensembli | ENST00000396976.6; ENSP00000380174.2; ENSG00000140265.14 ENST00000684362.1; ENSP00000507363.1; ENSG00000140265.14 |
GeneIDi | 146050 |
KEGGi | hsa:146050 |
MANE-Selecti | ENST00000684362.1; ENSP00000507363.1; NM_001372080.1; NP_001359009.1 |
UCSCi | uc001zrk.2, human [Q8IWY8-1] |
Organism-specific databases
CTDi | 146050 |
GeneCardsi | ZSCAN29 |
HGNCi | HGNC:26673, ZSCAN29 |
HPAi | ENSG00000140265, Low tissue specificity |
neXtProti | NX_Q8IWY8 |
OpenTargetsi | ENSG00000140265 |
PharmGKBi | PA162411015 |
VEuPathDBi | HostDB:ENSG00000140265 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161523 |
HOGENOMi | CLU_002678_88_0_1 |
InParanoidi | Q8IWY8 |
OMAi | SERKIPC |
PhylomeDBi | Q8IWY8 |
TreeFami | TF336839 |
Enzyme and pathway databases
PathwayCommonsi | Q8IWY8 |
SignaLinki | Q8IWY8 |
Miscellaneous databases
BioGRID-ORCSi | 146050, 13 hits in 1099 CRISPR screens |
ChiTaRSi | ZSCAN29, human |
GenomeRNAii | 146050 |
Pharosi | Q8IWY8, Tdark |
PROi | PR:Q8IWY8 |
RNActi | Q8IWY8, protein |
Gene expression databases
Bgeei | ENSG00000140265, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | Q8IWY8, baseline and differential |
Genevisiblei | Q8IWY8, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR044822, Myb_DNA-bind_4 IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF13837, Myb_DNA-bind_4, 2 hits PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSC29_HUMAN | |
Accessioni | Q8IWY8Primary (citable) accession number: Q8IWY8 Secondary accession number(s): B3KVB9 Q8NA40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | September 22, 2009 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families