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UniProtKB - Q8IWY8 (ZSC29_HUMAN)

Entry version 155 (25 May 2022)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
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Protein

Zinc finger and SCAN domain-containing protein 29

Gene

ZSCAN29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri678 – 700C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8IWY8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8IWY8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 29
Alternative name(s):
Zinc finger protein 690
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN29
Synonyms:ZNF690
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26673, ZSCAN29

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8IWY8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140265

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000140265

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162411015

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8IWY8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZSCAN29

Domain mapping of disease mutations (DMDM)

More...DMDMi		259016454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340111 – 852Zinc finger and SCAN domain-containing protein 29Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153PhosphoserineCombined sources1
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei561PhosphoserineCombined sources1
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8IWY8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8IWY8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8IWY8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8IWY8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8IWY8

PeptideAtlas

More...PeptideAtlasi		Q8IWY8

PRoteomics IDEntifications database

More...PRIDEi		Q8IWY8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70928 [Q8IWY8-1]
70929 [Q8IWY8-2]
70930 [Q8IWY8-3]
70931 [Q8IWY8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8IWY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8IWY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140265, Expressed in secondary oocyte and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8IWY8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8IWY8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140265, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126960, 27 interactors

Protein interaction database and analysis system

More...IntActi		Q8IWY8, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380174

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8IWY8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8IWY8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8IWY8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 100SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 182DisorderedSequence analysisAdd BLAST87
Regioni347 – 400DisorderedSequence analysisAdd BLAST54
Regioni502 – 557DisorderedSequence analysisAdd BLAST56
Regioni603 – 625DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi141 – 155Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi362 – 376Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi508 – 522Polar residuesSequence analysisAdd BLAST15
Compositional biasi528 – 546Acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri678 – 700C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161523

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_88_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8IWY8

Identification of Orthologs from Complete Genome Data

More...OMAi		SERKIPC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8IWY8

TreeFam database of animal gene trees

More...TreeFami		TF336839

Family and domain databases

Conserved Domains Database

More...CDDi		cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044822, Myb_DNA-bind_4
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13837, Myb_DNA-bind_4, 2 hits
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAKSALREN GTNSETFRQR FRRFHYQEVA GPREAFSQLW ELCCRWLRPE 
        60         70         80         90        100
VRTKEQIVEL LVLEQFLTVL PGEIQNWVQE QCPENGEEAV TLVEDLEREP 
       110        120        130        140        150
GRPRSSVTVS VKGQEVRLEK MTPPKSSQEL LSVRQESVEP QPRGVPKKER 
       160        170        180        190        200
ARSPDLGPQE QMNPKEKLKP FQRSGLPFPK SGVVSRLEQG EPWIPDLLGS 
       210        220        230        240        250
KEKELPSGSH IGDRRVHADL LPSKKDRRSW VEQDHWSFED EKVAGVHWGY 
       260        270        280        290        300
EETRTLLAIL SQTEFYEALR NCHRNSQVYG AVAERLREYG FLRTLEQCRT 
       310        320        330        340        350
KFKGLQKSYR KVKSGHPPET CPFFEEMEAL MSAQVIALPS NGLEAAASHS 
       360        370        380        390        400
GLVGSDAETE EPGQRGWQHE EGAEEAVAQE SDSDDMDLEA TPQDPNSAAP 
       410        420        430        440        450
VVFRSPGGVH WGYEETKTYL AILSETQFYE ALRNCHRNSQ LYGAVAERLW 
       460        470        480        490        500
EYGFLRTPEQ CRTKFKSLQT SYRKVKNGQA PETCPFFEEM DALVSVRVAA 
       510        520        530        540        550
PPNDGQEETA SCPVQGTSEA EAQKQAEEAD EATEEDSDDD EEDTEIPPGA 
       560        570        580        590        600
VITRAPVLFQ SPRGFEAGFE NEDNSKRDIS EEVQLHRTLL ARSERKIPRY 
       610        620        630        640        650
LHQGKGNESD CRSGRQWAKT SGEKRGKLTL PEKSLSEVLS QQRPCLGERP 
       660        670        680        690        700
YKYLKYSKSF GPNSLLMHQV SHQVENPYKC ADCGKSFSRS ARLIRHRRIH 
       710        720        730        740        750
TGEKPYKCLD CGKSFRDSSN FITHRRIHTG EKPYQCGECG KCFNQSSSLI 
       760        770        780        790        800
IHQRTHTGEK PYQCEECGKS FNNSSHFSAH RRIHTGERPH VCPDCGKSFS 
       810        820        830        840        850
KSSDLRAHHR THTGEKPYGC HDCGKCFSKS SALNKHGEIH AREKLLTQSA 

PK
Length:852
Mass (Da):96,719
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB92BE704821F8EC8
GO
Isoform 2 (identifier: Q8IWY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:732
Mass (Da):82,648
Checksum:iA5A7F252E61FA07D
GO
Isoform 3 (identifier: Q8IWY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-557: SVRVAAPPND...PGAVITRAPV → LKLDLRMKII...QRPQGRKEEN
     558-852: Missing.

Show »
Length:557
Mass (Da):63,856
Checksum:iE948F6EBC8BE2A5D
GO
Isoform 4 (identifier: Q8IWY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-564: Missing.

Show »
Length:463
Mass (Da):53,209
Checksum:i901979E3BA4759DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9K0J8C9K0J8_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUW4H3BUW4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGM2A0A0C4DGM2_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMU4H3BMU4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182G → S in AAI09271 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059949104R → G1 PublicationCorresponds to variant dbSNP:rs3809482Ensembl.1
Natural variantiVAR_057459199G → S1 PublicationCorresponds to variant dbSNP:rs3917221Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0181791 – 120Missing in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_018180176 – 564Missing in isoform 4. 1 PublicationAdd BLAST389
Alternative sequenceiVSP_018181495 – 557SVRVA…TRAPV → LKLDLRMKIIQNGIFLRKYN CIGHYLQDLKGKFPGIFIRV KAMRVTVDQEDSGQRPQGRK EEN in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_018182558 – 852Missing in isoform 3. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK093186 mRNA Translation: BAC04088.1
AK122788 mRNA Translation: BAG53731.1
AF525399 mRNA Translation: AAO14995.1
BC109270 mRNA Translation: AAI09271.1
BC109271 mRNA Translation: AAI09272.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10095.2 [Q8IWY8-1]

NCBI Reference Sequences

More...RefSeqi		NP_689668.3, NM_152455.3 [Q8IWY8-1]
XP_006720464.1, XM_006720401.3
XP_011519568.1, XM_011521266.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396976.6; ENSP00000380174.2; ENSG00000140265.14
ENST00000684362.1; ENSP00000507363.1; ENSG00000140265.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		146050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:146050

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000684362.1; ENSP00000507363.1; NM_001372080.1; NP_001359009.1

UCSC genome browser

More...UCSCi		uc001zrk.2, human [Q8IWY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093186 mRNA Translation: BAC04088.1
AK122788 mRNA Translation: BAG53731.1
AF525399 mRNA Translation: AAO14995.1
BC109270 mRNA Translation: AAI09271.1
BC109271 mRNA Translation: AAI09272.1
CCDSiCCDS10095.2 [Q8IWY8-1]
RefSeqiNP_689668.3, NM_152455.3 [Q8IWY8-1]
XP_006720464.1, XM_006720401.3
XP_011519568.1, XM_011521266.2

3D structure databases

AlphaFoldDBiQ8IWY8
SMRiQ8IWY8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126960, 27 interactors
IntActiQ8IWY8, 12 interactors
STRINGi9606.ENSP00000380174

PTM databases

iPTMnetiQ8IWY8
PhosphoSitePlusiQ8IWY8

Genetic variation databases

BioMutaiZSCAN29
DMDMi259016454

Proteomic databases

EPDiQ8IWY8
jPOSTiQ8IWY8
MassIVEiQ8IWY8
MaxQBiQ8IWY8
PaxDbiQ8IWY8
PeptideAtlasiQ8IWY8
PRIDEiQ8IWY8
ProteomicsDBi70928 [Q8IWY8-1]
70929 [Q8IWY8-2]
70930 [Q8IWY8-3]
70931 [Q8IWY8-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q8IWY8, 10 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11192, 114 antibodies from 21 providers

The DNASU plasmid repository

More...DNASUi		146050

Genome annotation databases

EnsembliENST00000396976.6; ENSP00000380174.2; ENSG00000140265.14
ENST00000684362.1; ENSP00000507363.1; ENSG00000140265.14
GeneIDi146050
KEGGihsa:146050
MANE-SelectiENST00000684362.1; ENSP00000507363.1; NM_001372080.1; NP_001359009.1
UCSCiuc001zrk.2, human [Q8IWY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		146050

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZSCAN29
HGNCiHGNC:26673, ZSCAN29
HPAiENSG00000140265, Low tissue specificity
neXtProtiNX_Q8IWY8
OpenTargetsiENSG00000140265
PharmGKBiPA162411015
VEuPathDBiHostDB:ENSG00000140265

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161523
HOGENOMiCLU_002678_88_0_1
InParanoidiQ8IWY8
OMAiSERKIPC
PhylomeDBiQ8IWY8
TreeFamiTF336839

Enzyme and pathway databases

PathwayCommonsiQ8IWY8
SignaLinkiQ8IWY8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		146050, 13 hits in 1099 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZSCAN29, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		146050
PharosiQ8IWY8, Tdark

Protein Ontology

More...PROi		PR:Q8IWY8
RNActiQ8IWY8, protein

Gene expression databases

BgeeiENSG00000140265, Expressed in secondary oocyte and 225 other tissues
ExpressionAtlasiQ8IWY8, baseline and differential
GenevisibleiQ8IWY8, HS

Family and domain databases

CDDicd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR044822, Myb_DNA-bind_4
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF13837, Myb_DNA-bind_4, 2 hits
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 6 hits
SUPFAMiSSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 6 hits
PS50157, ZINC_FINGER_C2H2_2, 6 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC29_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWY8
Secondary accession number(s): B3KVB9
, Q32M75, Q32M76, Q8NA40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 22, 2009
Last modified: May 25, 2022
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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