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UniProtKB - Q8IWY8 (ZSC29_HUMAN)

Protein

Zinc finger and SCAN domain-containing protein 29

Gene

ZSCAN29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri678 – 700C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 29
Alternative name(s):
Zinc finger protein 690
Gene namesi
Name:ZSCAN29
Synonyms:ZNF690
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140265.12
HGNCiHGNC:26673 ZSCAN29
neXtProtiNX_Q8IWY8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140265
PharmGKBiPA162411015

Polymorphism and mutation databases

BioMutaiZSCAN29
DMDMi259016454

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002340111 – 852Zinc finger and SCAN domain-containing protein 29Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei153PhosphoserineCombined sources1
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei561PhosphoserineCombined sources1
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IWY8
MaxQBiQ8IWY8
PaxDbiQ8IWY8
PeptideAtlasiQ8IWY8
PRIDEiQ8IWY8
ProteomicsDBi70928
70929 [Q8IWY8-2]
70930 [Q8IWY8-3]
70931 [Q8IWY8-4]

PTM databases

iPTMnetiQ8IWY8
PhosphoSitePlusiQ8IWY8

Expressioni

Gene expression databases

BgeeiENSG00000140265 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZSCAN29
ExpressionAtlasiQ8IWY8 baseline and differential
GenevisibleiQ8IWY8 HS

Organism-specific databases

HPAiHPA007241
HPA011109

Interactioni

Protein-protein interaction databases

BioGridi126960, 15 interactors
IntActiQ8IWY8, 3 interactors
STRINGi9606.ENSP00000380174

Structurei

3D structure databases

ProteinModelPortaliQ8IWY8
SMRiQ8IWY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 100SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri678 – 700C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063287
HOGENOMiHOG000234618
HOVERGENiHBG018163
InParanoidiQ8IWY8
KOiK09230
OMAiGEPWIPD
OrthoDBiEOG091G02KC
PhylomeDBiQ8IWY8
TreeFamiTF336839

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAKSALREN GTNSETFRQR FRRFHYQEVA GPREAFSQLW ELCCRWLRPE 
        60         70         80         90        100
VRTKEQIVEL LVLEQFLTVL PGEIQNWVQE QCPENGEEAV TLVEDLEREP 
       110        120        130        140        150
GRPRSSVTVS VKGQEVRLEK MTPPKSSQEL LSVRQESVEP QPRGVPKKER 
       160        170        180        190        200
ARSPDLGPQE QMNPKEKLKP FQRSGLPFPK SGVVSRLEQG EPWIPDLLGS 
       210        220        230        240        250
KEKELPSGSH IGDRRVHADL LPSKKDRRSW VEQDHWSFED EKVAGVHWGY 
       260        270        280        290        300
EETRTLLAIL SQTEFYEALR NCHRNSQVYG AVAERLREYG FLRTLEQCRT 
       310        320        330        340        350
KFKGLQKSYR KVKSGHPPET CPFFEEMEAL MSAQVIALPS NGLEAAASHS 
       360        370        380        390        400
GLVGSDAETE EPGQRGWQHE EGAEEAVAQE SDSDDMDLEA TPQDPNSAAP 
       410        420        430        440        450
VVFRSPGGVH WGYEETKTYL AILSETQFYE ALRNCHRNSQ LYGAVAERLW 
       460        470        480        490        500
EYGFLRTPEQ CRTKFKSLQT SYRKVKNGQA PETCPFFEEM DALVSVRVAA 
       510        520        530        540        550
PPNDGQEETA SCPVQGTSEA EAQKQAEEAD EATEEDSDDD EEDTEIPPGA 
       560        570        580        590        600
VITRAPVLFQ SPRGFEAGFE NEDNSKRDIS EEVQLHRTLL ARSERKIPRY 
       610        620        630        640        650
LHQGKGNESD CRSGRQWAKT SGEKRGKLTL PEKSLSEVLS QQRPCLGERP 
       660        670        680        690        700
YKYLKYSKSF GPNSLLMHQV SHQVENPYKC ADCGKSFSRS ARLIRHRRIH 
       710        720        730        740        750
TGEKPYKCLD CGKSFRDSSN FITHRRIHTG EKPYQCGECG KCFNQSSSLI 
       760        770        780        790        800
IHQRTHTGEK PYQCEECGKS FNNSSHFSAH RRIHTGERPH VCPDCGKSFS 
       810        820        830        840        850
KSSDLRAHHR THTGEKPYGC HDCGKCFSKS SALNKHGEIH AREKLLTQSA 

PK
Length:852
Mass (Da):96,719
Last modified:September 22, 2009 - v2
Checksum:iB92BE704821F8EC8
GO
Isoform 2 (identifier: Q8IWY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Note: No experimental confirmation available.
Show »
Length:732
Mass (Da):82,648
Checksum:iA5A7F252E61FA07D
GO
Isoform 3 (identifier: Q8IWY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-557: SVRVAAPPND...PGAVITRAPV → LKLDLRMKII...QRPQGRKEEN
     558-852: Missing.

Note: No experimental confirmation available.
Show »
Length:557
Mass (Da):63,856
Checksum:iE948F6EBC8BE2A5D
GO
Isoform 4 (identifier: Q8IWY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-564: Missing.

Note: No experimental confirmation available.
Show »
Length:463
Mass (Da):53,209
Checksum:i901979E3BA4759DB
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGM2A0A0C4DGM2_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
462Annotation score:
C9K0J8C9K0J8_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
556Annotation score:
H3BUW4H3BUW4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
199Annotation score:
H3BMU4H3BMU4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
330Annotation score:
A0A0A0MS73A0A0A0MS73_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
316Annotation score:
H3BVH1H3BVH1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
21Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182G → S in AAI09271 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059949104R → G1 PublicationCorresponds to variant dbSNP:rs3809482Ensembl.1
Natural variantiVAR_057459199G → S1 PublicationCorresponds to variant dbSNP:rs3917221Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0181791 – 120Missing in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_018180176 – 564Missing in isoform 4. 1 PublicationAdd BLAST389
Alternative sequenceiVSP_018181495 – 557SVRVA…TRAPV → LKLDLRMKIIQNGIFLRKYN CIGHYLQDLKGKFPGIFIRV KAMRVTVDQEDSGQRPQGRK EEN in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_018182558 – 852Missing in isoform 3. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093186 mRNA Translation: BAC04088.1
AK122788 mRNA Translation: BAG53731.1
AF525399 mRNA Translation: AAO14995.1
BC109270 mRNA Translation: AAI09271.1
BC109271 mRNA Translation: AAI09272.1
CCDSiCCDS10095.2 [Q8IWY8-1]
RefSeqiNP_689668.3, NM_152455.3 [Q8IWY8-1]
XP_006720464.1, XM_006720401.3
XP_011519568.1, XM_011521266.2 [Q8IWY8-1]
UniGeneiHs.418287

Genome annotation databases

EnsembliENST00000396976; ENSP00000380174; ENSG00000140265 [Q8IWY8-1]
GeneIDi146050
KEGGihsa:146050
UCSCiuc001zrk.2 human [Q8IWY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093186 mRNA Translation: BAC04088.1
AK122788 mRNA Translation: BAG53731.1
AF525399 mRNA Translation: AAO14995.1
BC109270 mRNA Translation: AAI09271.1
BC109271 mRNA Translation: AAI09272.1
CCDSiCCDS10095.2 [Q8IWY8-1]
RefSeqiNP_689668.3, NM_152455.3 [Q8IWY8-1]
XP_006720464.1, XM_006720401.3
XP_011519568.1, XM_011521266.2 [Q8IWY8-1]
UniGeneiHs.418287

3D structure databases

ProteinModelPortaliQ8IWY8
SMRiQ8IWY8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126960, 15 interactors
IntActiQ8IWY8, 3 interactors
STRINGi9606.ENSP00000380174

PTM databases

iPTMnetiQ8IWY8
PhosphoSitePlusiQ8IWY8

Polymorphism and mutation databases

BioMutaiZSCAN29
DMDMi259016454

Proteomic databases

EPDiQ8IWY8
MaxQBiQ8IWY8
PaxDbiQ8IWY8
PeptideAtlasiQ8IWY8
PRIDEiQ8IWY8
ProteomicsDBi70928
70929 [Q8IWY8-2]
70930 [Q8IWY8-3]
70931 [Q8IWY8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396976; ENSP00000380174; ENSG00000140265 [Q8IWY8-1]
GeneIDi146050
KEGGihsa:146050
UCSCiuc001zrk.2 human [Q8IWY8-1]

Organism-specific databases

CTDi146050
EuPathDBiHostDB:ENSG00000140265.12
GeneCardsiZSCAN29
HGNCiHGNC:26673 ZSCAN29
HPAiHPA007241
HPA011109
neXtProtiNX_Q8IWY8
OpenTargetsiENSG00000140265
PharmGKBiPA162411015
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063287
HOGENOMiHOG000234618
HOVERGENiHBG018163
InParanoidiQ8IWY8
KOiK09230
OMAiGEPWIPD
OrthoDBiEOG091G02KC
PhylomeDBiQ8IWY8
TreeFamiTF336839

Miscellaneous databases

ChiTaRSiZSCAN29 human
GenomeRNAii146050
PROiPR:Q8IWY8

Gene expression databases

BgeeiENSG00000140265 Expressed in 207 organ(s), highest expression level in secondary oocyte
CleanExiHS_ZSCAN29
ExpressionAtlasiQ8IWY8 baseline and differential
GenevisibleiQ8IWY8 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZSC29_HUMAN
AccessioniPrimary (citable) accession number: Q8IWY8
Secondary accession number(s): B3KVB9
, Q32M75, Q32M76, Q8NA40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 22, 2009
Last modified: October 10, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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