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Entry version 144 (26 Feb 2020)
Sequence version 2 (22 Sep 2009)
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Protein

Zinc finger and SCAN domain-containing protein 29

Gene

ZSCAN29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri678 – 700C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 29
Alternative name(s):
Zinc finger protein 690
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN29
Synonyms:ZNF690
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26673 ZSCAN29

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWY8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000140265

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162411015

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8IWY8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSCAN29

Domain mapping of disease mutations (DMDM)

More...
DMDMi
259016454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002340111 – 852Zinc finger and SCAN domain-containing protein 29Add BLAST852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki112Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153PhosphoserineCombined sources1
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei561PhosphoserineCombined sources1
Cross-linki576Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWY8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWY8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8IWY8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWY8

PeptideAtlas

More...
PeptideAtlasi
Q8IWY8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWY8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
70928 [Q8IWY8-1]
70929 [Q8IWY8-2]
70930 [Q8IWY8-3]
70931 [Q8IWY8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140265 Expressed in secondary oocyte and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWY8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007241
HPA011109

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126960, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8IWY8, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380174

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8IWY8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWY8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 100SCAN boxPROSITE-ProRule annotationAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri678 – 700C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri790 – 812C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri818 – 840C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161523

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_88_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWY8

KEGG Orthology (KO)

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KOi
K09230

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRFRKFH

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWY8

TreeFam database of animal gene trees

More...
TreeFami
TF336839

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8IWY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAKSALREN GTNSETFRQR FRRFHYQEVA GPREAFSQLW ELCCRWLRPE
60 70 80 90 100
VRTKEQIVEL LVLEQFLTVL PGEIQNWVQE QCPENGEEAV TLVEDLEREP
110 120 130 140 150
GRPRSSVTVS VKGQEVRLEK MTPPKSSQEL LSVRQESVEP QPRGVPKKER
160 170 180 190 200
ARSPDLGPQE QMNPKEKLKP FQRSGLPFPK SGVVSRLEQG EPWIPDLLGS
210 220 230 240 250
KEKELPSGSH IGDRRVHADL LPSKKDRRSW VEQDHWSFED EKVAGVHWGY
260 270 280 290 300
EETRTLLAIL SQTEFYEALR NCHRNSQVYG AVAERLREYG FLRTLEQCRT
310 320 330 340 350
KFKGLQKSYR KVKSGHPPET CPFFEEMEAL MSAQVIALPS NGLEAAASHS
360 370 380 390 400
GLVGSDAETE EPGQRGWQHE EGAEEAVAQE SDSDDMDLEA TPQDPNSAAP
410 420 430 440 450
VVFRSPGGVH WGYEETKTYL AILSETQFYE ALRNCHRNSQ LYGAVAERLW
460 470 480 490 500
EYGFLRTPEQ CRTKFKSLQT SYRKVKNGQA PETCPFFEEM DALVSVRVAA
510 520 530 540 550
PPNDGQEETA SCPVQGTSEA EAQKQAEEAD EATEEDSDDD EEDTEIPPGA
560 570 580 590 600
VITRAPVLFQ SPRGFEAGFE NEDNSKRDIS EEVQLHRTLL ARSERKIPRY
610 620 630 640 650
LHQGKGNESD CRSGRQWAKT SGEKRGKLTL PEKSLSEVLS QQRPCLGERP
660 670 680 690 700
YKYLKYSKSF GPNSLLMHQV SHQVENPYKC ADCGKSFSRS ARLIRHRRIH
710 720 730 740 750
TGEKPYKCLD CGKSFRDSSN FITHRRIHTG EKPYQCGECG KCFNQSSSLI
760 770 780 790 800
IHQRTHTGEK PYQCEECGKS FNNSSHFSAH RRIHTGERPH VCPDCGKSFS
810 820 830 840 850
KSSDLRAHHR THTGEKPYGC HDCGKCFSKS SALNKHGEIH AREKLLTQSA

PK
Length:852
Mass (Da):96,719
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB92BE704821F8EC8
GO
Isoform 2 (identifier: Q8IWY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:732
Mass (Da):82,648
Checksum:iA5A7F252E61FA07D
GO
Isoform 3 (identifier: Q8IWY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     495-557: SVRVAAPPND...PGAVITRAPV → LKLDLRMKII...QRPQGRKEEN
     558-852: Missing.

Show »
Length:557
Mass (Da):63,856
Checksum:iE948F6EBC8BE2A5D
GO
Isoform 4 (identifier: Q8IWY8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-564: Missing.

Show »
Length:463
Mass (Da):53,209
Checksum:i901979E3BA4759DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGM2A0A0C4DGM2_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
462Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0J8C9K0J8_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
556Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUW4H3BUW4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMU4H3BMU4_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BVH1H3BVH1_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS73A0A0A0MS73_HUMAN
Zinc finger and SCAN domain-contain...
ZSCAN29
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182G → S in AAI09271 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059949104R → G1 PublicationCorresponds to variant dbSNP:rs3809482Ensembl.1
Natural variantiVAR_057459199G → S1 PublicationCorresponds to variant dbSNP:rs3917221Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0181791 – 120Missing in isoform 2. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_018180176 – 564Missing in isoform 4. 1 PublicationAdd BLAST389
Alternative sequenceiVSP_018181495 – 557SVRVA…TRAPV → LKLDLRMKIIQNGIFLRKYN CIGHYLQDLKGKFPGIFIRV KAMRVTVDQEDSGQRPQGRK EEN in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_018182558 – 852Missing in isoform 3. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093186 mRNA Translation: BAC04088.1
AK122788 mRNA Translation: BAG53731.1
AF525399 mRNA Translation: AAO14995.1
BC109270 mRNA Translation: AAI09271.1
BC109271 mRNA Translation: AAI09272.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10095.2 [Q8IWY8-1]

NCBI Reference Sequences

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RefSeqi
NP_689668.3, NM_152455.3 [Q8IWY8-1]
XP_006720464.1, XM_006720401.3
XP_011519568.1, XM_011521266.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000396976; ENSP00000380174; ENSG00000140265 [Q8IWY8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
146050

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:146050

UCSC genome browser

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UCSCi
uc001zrk.2 human [Q8IWY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093186 mRNA Translation: BAC04088.1
AK122788 mRNA Translation: BAG53731.1
AF525399 mRNA Translation: AAO14995.1
BC109270 mRNA Translation: AAI09271.1
BC109271 mRNA Translation: AAI09272.1
CCDSiCCDS10095.2 [Q8IWY8-1]
RefSeqiNP_689668.3, NM_152455.3 [Q8IWY8-1]
XP_006720464.1, XM_006720401.3
XP_011519568.1, XM_011521266.2

3D structure databases

SMRiQ8IWY8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126960, 15 interactors
IntActiQ8IWY8, 12 interactors
STRINGi9606.ENSP00000380174

PTM databases

iPTMnetiQ8IWY8
PhosphoSitePlusiQ8IWY8

Polymorphism and mutation databases

BioMutaiZSCAN29
DMDMi259016454

Proteomic databases

EPDiQ8IWY8
jPOSTiQ8IWY8
MassIVEiQ8IWY8
MaxQBiQ8IWY8
PaxDbiQ8IWY8
PeptideAtlasiQ8IWY8
PRIDEiQ8IWY8
ProteomicsDBi70928 [Q8IWY8-1]
70929 [Q8IWY8-2]
70930 [Q8IWY8-3]
70931 [Q8IWY8-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q8IWY8

Genome annotation databases

EnsembliENST00000396976; ENSP00000380174; ENSG00000140265 [Q8IWY8-1]
GeneIDi146050
KEGGihsa:146050
UCSCiuc001zrk.2 human [Q8IWY8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
146050

GeneCards: human genes, protein and diseases

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GeneCardsi
ZSCAN29
HGNCiHGNC:26673 ZSCAN29
HPAiHPA007241
HPA011109
neXtProtiNX_Q8IWY8
OpenTargetsiENSG00000140265
PharmGKBiPA162411015

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161523
HOGENOMiCLU_002678_88_0_1
InParanoidiQ8IWY8
KOiK09230
OMAiQRFRKFH
OrthoDBi1318335at2759
PhylomeDBiQ8IWY8
TreeFamiTF336839

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZSCAN29 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
146050
PharosiQ8IWY8 Tdark

Protein Ontology

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PROi
PR:Q8IWY8
RNActiQ8IWY8 protein

Gene expression databases

BgeeiENSG00000140265 Expressed in secondary oocyte and 206 other tissues
ExpressionAtlasiQ8IWY8 baseline and differential
GenevisibleiQ8IWY8 HS

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC29_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWY8
Secondary accession number(s): B3KVB9
, Q32M75, Q32M76, Q8NA40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: September 22, 2009
Last modified: February 26, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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