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Entry version 136 (13 Feb 2019)
Sequence version 3 (18 May 2010)
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Protein

Calcium homeostasis endoplasmic reticulum protein

Gene

CHERP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in calcium homeostasis, growth and proliferation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-72163 mRNA Splicing - Major Pathway

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q8IWX8 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium homeostasis endoplasmic reticulum protein
Alternative name(s):
ERPROT 213-21
SR-related CTD-associated factor 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHERPImported
Synonyms:DAN26Imported, SCAF6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000085872.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16930 CHERP

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8IWX8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10523

Open Targets

More...
OpenTargetsi
ENSG00000085872

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26459

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHERP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439404

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002994921 – 916Calcium homeostasis endoplasmic reticulum proteinAdd BLAST916

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei18N6-acetyllysineCombined sources1
Modified residuei714PhosphotyrosineBy similarity1
Modified residuei813PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei819PhosphothreonineCombined sources1
Modified residuei828PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki844Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei855PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Cross-linki872Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei879N6-acetyllysineCombined sources1
Modified residuei904PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8IWX8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8IWX8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8IWX8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8IWX8

PeptideAtlas

More...
PeptideAtlasi
Q8IWX8

PRoteomics IDEntifications database

More...
PRIDEi
Q8IWX8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
70925

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8IWX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8IWX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085872 Expressed in 228 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8IWX8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8IWX8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050647

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115778, 90 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8IWX8

Protein interaction database and analysis system

More...
IntActi
Q8IWX8, 62 interactors

Molecular INTeraction database

More...
MINTi
Q8IWX8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000439856

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8IWX8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8IWX8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati15 – 57SURP motifSequence analysisAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 289CIDPROSITE-ProRule annotationAdd BLAST141
Domaini841 – 891G-patchPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi279 – 346Gln-richSequence analysisAdd BLAST68
Compositional biasi355 – 682Pro-richSequence analysisAdd BLAST328
Compositional biasi718 – 816Arg-richSequence analysisAdd BLAST99

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4368 Eukaryota
ENOG410YVN1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111147

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000010294

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052716

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8IWX8

KEGG Orthology (KO)

More...
KOi
K12841

Database of Orthologous Groups

More...
OrthoDBi
1256232at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8IWX8

TreeFam database of animal gene trees

More...
TreeFami
TF318512

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.790, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039037 CHERP
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR000467 G_patch_dom
IPR006903 RNA_pol_II-bd
IPR000061 Surp
IPR035967 SWAP/Surp_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12323 PTHR12323, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818 CTD_bind, 1 hit
PF01585 G-patch, 1 hit
PF01805 Surp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443 G_patch, 1 hit
SM00648 SWAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109905 SSF109905, 1 hit
SSF48464 SSF48464, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391 CID, 1 hit
PS50174 G_PATCH, 1 hit
PS50128 SURP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q8IWX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMPLPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG
60 70 80 90 100
EFYSYYKCKL ALEQQQLICK QQTPELEPAA TMPPLPQPPL APAAPIPPAQ
110 120 130 140 150
GAPSMDELIQ QSQWNLQQQE QHLLALRQEQ VTAAVAHAVE QQMQKLLEET
160 170 180 190 200
QLDMNEFDNL LQPIIDTCTK DAISAGKNWM FSNAKSPPHC ELMAGHLRNR
210 220 230 240 250
ITADGAHFEL RLHLIYLIND VLHHCQRKQA RELLAALQKV VVPIYCTSFL
260 270 280 290 300
AVEEDKQQKI ARLLQLWEKN GYFDDSIIQQ LQSPALGLGQ YQATLINEYS
310 320 330 340 350
SVVQPVQLAF QQQIQTLKTQ HEEFVTSLAQ QQQQQQQQQQ QLQMPQMEAE
360 370 380 390 400
VKATPPPPAP PPAPAPAPAI PPTTQPDDSK PPIQMPGSSE YEAPGGVQDP
410 420 430 440 450
AAAGPRGPGP HDQIPPNKPP WFDQPHPVAP WGQQQPPEQP PYPHHQGGPP
460 470 480 490 500
HCPPWNNSHE GMWGEQRGDP GWNGQRDAPW NNQPDAAWNS QFEGPWNSQH
510 520 530 540 550
EQPPWGGGQR EPPFRMQRPP HFRGPFPPHQ QHPQFNQPPH PHNFNRFPPR
560 570 580 590 600
FMQDDFPPRH PFERPPYPHR FDYPQGDFPA EMGPPHHHPG HRMPHPGINE
610 620 630 640 650
HPPWAGPQHP DFGPPPHGFN GQPPHMRRQG PPHINHDDPS LVPNVPYFDL
660 670 680 690 700
PAGLMAPLVK LEDHEYKPLD PKDIRLPPPM PPSERLLAAV EAFYSPPSHD
710 720 730 740 750
RPRNSEGWEQ NGLYEFFRAK MRARRRKGQE KRNSGPSRSR SRSKSRGRSS
760 770 780 790 800
SRSNSRSSKS SGSYSRSRSR SCSRSYSRSR SRSRSRSRSS RSRSRSQSRS
810 820 830 840 850
RSKSYSPGRR RRSRSRSPTP PSSAGLGSNS APPIPDSRLG EENKGHQMLV
860 870 880 890 900
KMGWSGSGGL GAKEQGIQDP IKGGDVRDKW DQYKGVGVAL DDPYENYRRN
910
KSYSFIARMK ARDECK
Length:916
Mass (Da):103,702
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C5D56F4DE4C5B9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QK89J3QK89_HUMAN
Calcium homeostasis endoplasmic ret...
CHERP
927Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB53327 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21294 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA69591 differs from that shown. Reason: Frameshift at position 450.Curated
The sequence CAA69591 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99A → D in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti175A → G in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti185K → T in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti189H → Y in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti203A → V in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti418K → N in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti490S → N in CAA69591 (PubMed:8896557).Curated1
Sequence conflicti776Y → S in AAN77183 (Ref. 1) Curated1
Sequence conflicti778R → C in AAN77183 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034833199N → H2 PublicationsCorresponds to variant dbSNP:rs1043448Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF536542 mRNA Translation: AAN77183.1
AC008764 Genomic DNA No translation available.
BC021294 mRNA Translation: AAH21294.1 Different initiation.
Y08265 mRNA Translation: CAA69591.1 Sequence problems.
U94836 mRNA Translation: AAB53327.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42518.1

NCBI Reference Sequences

More...
RefSeqi
NP_006378.3, NM_006387.5

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.740364

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000546361; ENSP00000439856; ENSG00000085872

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10523

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10523

UCSC genome browser

More...
UCSCi
uc002nei.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF536542 mRNA Translation: AAN77183.1
AC008764 Genomic DNA No translation available.
BC021294 mRNA Translation: AAH21294.1 Different initiation.
Y08265 mRNA Translation: CAA69591.1 Sequence problems.
U94836 mRNA Translation: AAB53327.1 Different initiation.
CCDSiCCDS42518.1
RefSeqiNP_006378.3, NM_006387.5
UniGeneiHs.740364

3D structure databases

ProteinModelPortaliQ8IWX8
SMRiQ8IWX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115778, 90 interactors
CORUMiQ8IWX8
IntActiQ8IWX8, 62 interactors
MINTiQ8IWX8
STRINGi9606.ENSP00000439856

Protein family/group databases

MoonDBiQ8IWX8 Predicted

PTM databases

iPTMnetiQ8IWX8
PhosphoSitePlusiQ8IWX8

Polymorphism and mutation databases

BioMutaiCHERP
DMDMi296439404

Proteomic databases

EPDiQ8IWX8
jPOSTiQ8IWX8
MaxQBiQ8IWX8
PaxDbiQ8IWX8
PeptideAtlasiQ8IWX8
PRIDEiQ8IWX8
ProteomicsDBi70925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000546361; ENSP00000439856; ENSG00000085872
GeneIDi10523
KEGGihsa:10523
UCSCiuc002nei.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10523
DisGeNETi10523
EuPathDBiHostDB:ENSG00000085872.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CHERP
HGNCiHGNC:16930 CHERP
HPAiHPA050647
neXtProtiNX_Q8IWX8
OpenTargetsiENSG00000085872
PharmGKBiPA26459

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4368 Eukaryota
ENOG410YVN1 LUCA
GeneTreeiENSGT00730000111147
HOGENOMiHOG000010294
HOVERGENiHBG052716
InParanoidiQ8IWX8
KOiK12841
OrthoDBi1256232at2759
PhylomeDBiQ8IWX8
TreeFamiTF318512

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10523

Protein Ontology

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PROi
PR:Q8IWX8

Gene expression databases

BgeeiENSG00000085872 Expressed in 228 organ(s), highest expression level in female gonad
ExpressionAtlasiQ8IWX8 baseline and differential
GenevisibleiQ8IWX8 HS

Family and domain databases

Gene3Di1.10.10.790, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR039037 CHERP
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR000467 G_patch_dom
IPR006903 RNA_pol_II-bd
IPR000061 Surp
IPR035967 SWAP/Surp_sf
PANTHERiPTHR12323 PTHR12323, 1 hit
PfamiView protein in Pfam
PF04818 CTD_bind, 1 hit
PF01585 G-patch, 1 hit
PF01805 Surp, 1 hit
SMARTiView protein in SMART
SM00443 G_patch, 1 hit
SM00648 SWAP, 1 hit
SUPFAMiSSF109905 SSF109905, 1 hit
SSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
PS50174 G_PATCH, 1 hit
PS50128 SURP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHERP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8IWX8
Secondary accession number(s): O00302
, Q4G0Y5, Q8WU30, Q99492
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 136 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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